The network for 'negative regulation of synapse assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of synapse assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.

NameDescriptionProbabilityFunc Analog Organism
nf1aneurofibromin 1a0.612
robo2roundabout homolog 20.534
slit2slit (Drosophila) homolog 20.457
slit3slit (Drosophila) homolog 30.436
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.418
ptpraprotein tyrosine phosphatase, receptor type, A0.364
lhx2bLIM homeobox 2b0.349
lama4laminin, alpha 40.327
pcdh8protocadherin 80.282
ikzf5IKAROS family zinc finger 50.282
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.273
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.253
antxr1anthrax toxin receptor 10.235
kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.232
btr30bloodthirsty-related gene family, member 300.213
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.208
plxnb2aplexin b2a0.203
cd99l2CD99 antigen-like 20.191
robo3roundabout homolog 30.190
btkBruton agammaglobulinemia tyrosine kinase0.178
lppLIM domain containing preferred translocation partner in lipoma0.166
mef2dmyocyte enhancer factor 2d0.153
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.151
slit1bslit homolog 1b (Drosophila)0.150
skianuclear oncoprotein skia0.148
ldb2aLIM-domain binding factor 2a0.145
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.142
tcf12transcription factor 120.137
spna2spectrin alpha 20.135
cyfip2cytoplasmic FMR1 interacting protein 20.134
gnao1aguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a0.132
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.128
antxr2aanthrax toxin receptor 2a0.123
zdhhc8bzinc finger, DHHC-type containing 8b0.115
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.115
tmem88atransmembrane protein 88 a0.114
srsf2serine/arginine-rich splicing factor 20.111
slit1aslit homolog 1a (Drosophila)0.110
cstf3cleavage stimulation factor, 3' pre-RNA, subunit 30.110
ss18synovial sarcoma translocation, chromosome 18 (H. sapiens)0.109
col14a1collagen, type XIV, alpha 10.108
mapk1mitogen-activated protein kinase 10.107
efnb2aephrin B2a0.105
pacsin3protein kinase C and casein kinase substrate in neurons 30.102
bocbrother of CDO0.101
agtr2angiotensin II receptor, type 20.101
znf703zinc finger protein 7030.100
gsnagelsolin a0.093
trim8tripartite motif-containing 80.091
zbtb4zinc finger and BTB domain containing 40.090
ncor2nuclear receptor co-repressor 20.089
fli1bfriend leukemia integration 1b0.089
acvr1lactivin A receptor, type I like0.089
gng3guanine nucleotide binding protein (G protein), gamma 30.086
tnctenascin C0.086
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.085
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.083
nf1bneurofibromin 1b0.081
msxdmuscle segment homeobox D0.081
angpt1angiopoietin 10.079
prpf40aPRP40 pre-mRNA processing factor 40 homolog A (yeast)0.076
axin1axin 10.076
hoxd3ahomeo box D3a0.076
ndel1anudE nuclear distribution gene E homolog like 1 (A. nidulans) A0.074
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.073
vaspvasodilator-stimulated phosphoprotein0.071
esyt3extended synaptotagmin-like protein 30.070
gng5guanine nucleotide binding protein (G protein), gamma 50.069
rbl1retinoblastoma-like 1 (p107)0.069
scn1labsodium channel, voltage-gated, type I like, alpha b0.068
phc2polyhomeotic-like 2 (Drosophila)0.068
fcho2FCH domain only 20.068
copz1coatomer protein complex, subunit zeta 10.067
hgdhomogentisate 1,2-dioxygenase0.067
ube2v2ubiquitin-conjugating enzyme E2 variant 20.066
rnf128aring finger protein 128a0.066
kpna4karyopherin alpha 4 (importin alpha 3)0.066
sardhsarcosine dehydrogenase0.065
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.065
eomesbeomesodermin homolog b0.064
ptprbprotein tyrosine phosphatase, receptor type, b0.064
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.062
ptk2.1protein tyrosine kinase 2a0.062
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.061
styk1serine/threonine/tyrosine kinase 10.061
ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.061
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.061
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.061
cd8aCD8 antigen, alpha polypeptide0.061
nrarpbnotch-regulated ankyrin repeat protein b0.060
psen1presenilin 10.060
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CaMKIICalcium/calmodulin-dependent protein kinase II0.954
Ras85DRas oncogene at 85D0.896
trioCG18214 gene product from transcript CG18214-RA0.804
witwishful thinking0.778
PtenCG5671 gene product from transcript CG5671-RB0.763
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.704
neuroliginCG13772 gene product from transcript CG13772-RA0.678
MadMothers against dpp0.631
Pi3K92ECG4141 gene product from transcript CG4141-RB0.584
Pk61CProtein kinase 61C0.534
DadDaughters against dpp0.461
jebjelly belly0.439
Dap160Dynamin associated protein 1600.434
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.419
EphrinCG1862 gene product from transcript CG1862-RA0.411
RhebCG1081 gene product from transcript CG1081-RA0.394
cpbcapping protein beta0.348
Fak56DFocal Adhesion Kinase0.345
Vap-33-1CG5014 gene product from transcript CG5014-RB0.323
Eps-15Epidermal growth factor receptor pathway substrate clone 150.312
G-oalpha47AG protein oalpha 47A0.308
unc-104CG8566 gene product from transcript CG8566-RB0.295
nwknervous wreck0.291
faffat facets0.291
Ank2Ankyrin 20.234
Hip14Huntingtin-interacting protein 140.232
skpACG16983 gene product from transcript CG16983-RD0.220
Mob2CG11711 gene product from transcript CG11711-RC0.186
chbchromosome bows0.180
Nrx-1Neurexin 10.176
Sema-1aCG18405 gene product from transcript CG18405-RD0.164
cv-ccrossveinless c0.163
tbcetubulin-specific chaperone E0.151
rapretina aberrant in pattern0.138
Rac1CG2248 gene product from transcript CG2248-RA0.122
beta4GalNAcTACG8536 gene product from transcript CG8536-RA0.122
wbwing blister0.115
Ent2Equilibrative nucleoside transporter 20.115
CG17184CG17184 gene product from transcript CG17184-RB0.114
shotshort stop0.102
myoglianinCG1838 gene product from transcript CG1838-RD0.100
GluRIIAGlutamate receptor IIA0.100
plexBplexin B0.097
beta-Specbeta Spectrin0.092
Rab3Rab-protein 30.090
fogfolded gastrulation0.090
JraJun-related antigen0.084
plexAplexin A0.084
numbCG3779 gene product from transcript CG3779-RB0.083
Pak3CG14895 gene product from transcript CG14895-RA0.082
TBPHCG10327 gene product from transcript CG10327-RC0.081
htshu li tai shao0.080
oa2octopamine receptor 20.078
MicalMolecule interacting with CasL0.078
Stat92ESignal-transducer and activator of transcription protein at 92E0.077
Snap25Synapse protein 250.077
ewgerect wing0.076
mewmultiple edematous wings0.076
CG13253CG13253 gene product from transcript CG13253-RB0.076
twinCG31137 gene product from transcript CG31137-RB0.075
drkdownstream of receptor kinase0.074
pAbppolyA-binding protein0.074
DscamDown syndrome cell adhesion molecule0.074
WnkCG7177 gene product from transcript CG7177-RA0.071
stnBstoned B0.068
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ephb2Eph receptor B20.984
Wnt7bwingless-related MMTV integration site 7B0.981
Axin1axin 10.977
Gdnfglial cell line derived neurotrophic factor0.967
Retret proto-oncogene0.941
Enahenabled homolog (Drosophila)0.933
Robo1roundabout homolog 1 (Drosophila)0.933
Epha4Eph receptor A40.916
Akt1thymoma viral proto-oncogene 10.906
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.890
Ptprcprotein tyrosine phosphatase, receptor type, C0.860
Slit2slit homolog 2 (Drosophila)0.852
Efnb2ephrin B20.849
Lhx1LIM homeobox protein 10.848
Bcar1breast cancer anti-estrogen resistance 10.778
FasFas (TNF receptor superfamily member 6)0.776
Gli2GLI-Kruppel family member GLI20.735
Lama5laminin, alpha 50.733
Vaspvasodilator-stimulated phosphoprotein0.716
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.707
Ptk2PTK2 protein tyrosine kinase 20.699
Slit3slit homolog 3 (Drosophila)0.664
Apcadenomatosis polyposis coli0.653
Itgb1integrin beta 1 (fibronectin receptor beta)0.632
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.620
Csnk1g2casein kinase 1, gamma 20.620
Irs1insulin receptor substrate 10.574
Efnb1ephrin B10.546
Ephb3Eph receptor B30.540
Inpp5dinositol polyphosphate-5-phosphatase D0.521
Col4a3collagen, type IV, alpha 30.519
SrcRous sarcoma oncogene0.513
Gli3GLI-Kruppel family member GLI30.509
Prkceprotein kinase C, epsilon0.496
Gli1GLI-Kruppel family member GLI10.489
EvlEna-vasodilator stimulated phosphoprotein0.488
CblCasitas B-lineage lymphoma0.485
Ptk7PTK7 protein tyrosine kinase 70.484
Stx12syntaxin 120.479
Bnc1basonuclin 10.476
Ptpreprotein tyrosine phosphatase, receptor type, E0.475
Nf2neurofibromatosis 20.458
Efna4ephrin A40.449
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.439
Cd22CD22 antigen0.427
Fgfr4fibroblast growth factor receptor 40.419
Mapkap1mitogen-activated protein kinase associated protein 10.419
Rasa1RAS p21 protein activator 10.409
Rargretinoic acid receptor, gamma0.399
Itgalintegrin alpha L0.391
Gsk3bglycogen synthase kinase 3 beta0.389
L1camL1 cell adhesion molecule0.384
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.384
Wipf1WAS/WASL interacting protein family, member 10.383
Wnt2bwingless related MMTV integration site 2b0.380
FynFyn proto-oncogene0.376
Fjx1four jointed box 1 (Drosophila)0.373
Tsc1tuberous sclerosis 10.364
Pax2paired box gene 20.358
Chrm1cholinergic receptor, muscarinic 1, CNS0.356
Ilkintegrin linked kinase0.355
Fzd1frizzled homolog 1 (Drosophila)0.353
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.345
Gata5GATA binding protein 50.343
Plcg2phospholipase C, gamma 20.339
Hcls1hematopoietic cell specific Lyn substrate 10.335
Adra2cadrenergic receptor, alpha 2c0.328
Pou3f3POU domain, class 3, transcription factor 30.327
Tbx2T-box 20.323
Ptenphosphatase and tensin homolog0.323
WasWiskott-Aldrich syndrome homolog (human)0.312
Fzd2frizzled homolog 2 (Drosophila)0.309
Tbx3T-box 30.308
Lcp2lymphocyte cytosolic protein 20.308
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.304
Myo1fmyosin IF0.303
Pou3f1POU domain, class 3, transcription factor 10.303
Fgf5fibroblast growth factor 50.303
Ror1receptor tyrosine kinase-like orphan receptor 10.301
Smurf1SMAD specific E3 ubiquitin protein ligase 10.296
Wt1Wilms tumor 1 homolog0.294
Cdk14cyclin-dependent kinase 140.283
Ptpn14protein tyrosine phosphatase, non-receptor type 140.278
Rassf5Ras association (RalGDS/AF-6) domain family member 50.278
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.274
Col13a1collagen, type XIII, alpha 10.258
Itga3integrin alpha 30.257
Efna5ephrin A50.254
Fgf8fibroblast growth factor 80.253
Dctn1dynactin 10.249
Bcl2B-cell leukemia/lymphoma 20.244
Fgfr1fibroblast growth factor receptor 10.243
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.242
Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.241
Wnt10bwingless related MMTV integration site 10b0.240
Sema5asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.240
Itgb2integrin beta 20.237
Efsembryonal Fyn-associated substrate0.234
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.233
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism