The network for 'cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

NameDescriptionProbabilityFunc Analog Organism
cxcr4bchemokine (C-X-C motif), receptor 4b0.352
fgf3fibroblast growth factor 30.296
kitakit receptor a0.237
mmp9matrix metalloproteinase 90.218
pdgfaaplatelet-derived growth factor alpha a0.193
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.159
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.154
fzd7afrizzled homolog 7a0.147
bmp2bbone morphogenetic protein 2b0.147
tp53tumor protein p530.133
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.131
lcp1lymphocyte cytosolic plastin 10.129
wlswntless homolog (Drosophila)0.090
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.089
npm1nucleophosmin 10.088
sgk1serum/glucocorticoid regulated kinase 10.086
runx3runt-related transcription factor 30.084
cmybtranscription factor cmyb0.080
coro1acoronin, actin binding protein, 1A0.073
lmo4aLIM domain only 4a0.070
tbx2bT-box 2b0.068
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.067
ikzf1IKAROS family zinc finger 1 (Ikaros)0.066
camk2g1calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 10.065
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.064
wnt9bwingless-type MMTV integration site family, member 9B0.063
copebcore promoter element binding protein0.050
tp63tumor protein p630.050
eya2eyes absent homolog 2 (Drosophila)0.048
rbp4retinol binding protein 4, plasma0.047
fn1fibronectin 10.045
rykreceptor-like tyrosine kinase0.044
il7rinterleukin 7 receptor0.043
tbx1T-box 10.043
dnmt4DNA (cytosine-5-)-methyltransferase 40.043
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.042
cdx1bcaudal type homeobox 1 b0.042
pcdh18bprotocadherin 18b0.041
axin1axin 10.040
npc1Niemann-Pick disease, type C10.039
tgm2btransglutaminase 2b0.038
metmet proto-oncogene (hepatocyte growth factor receptor)0.038
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.037
mt2metallothionein 20.037
capns1bcalpain, small subunit 1 b0.037
csrp1acysteine and glycine-rich protein 1a0.036
znf703zinc finger protein 7030.036
cdh1cadherin 1, epithelial0.036
satb2SATB homeobox 20.036
gna12guanine nucleotide binding protein (G protein) alpha 120.035
cdx4caudal type homeo box transcription factor 40.035
fesfeline sarcoma oncogene0.035
gdf6agrowth differentiation factor 6a0.035
notch3notch homolog 30.033
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.032
il12bbinterleukin 12B, b0.031
elovl4belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4b0.030
krt18keratin 180.030
rspo3R-spondin 3 homolog (Xenopus laevis)0.030
ccnd1cyclin D10.028
hoxd4ahomeo box D4a0.027
ptch2patched 20.027
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.027
fgf8afibroblast growth factor 8 a0.026
runx2arunt-related transcription factor 2a0.025
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.025
hoxa13bhomeo box A13b0.024
alcambactivated leukocyte cell adhesion molecule b0.024
kdrlkinase insert domain receptor like0.024
hlxb9lahomeo box HB9 like a0.024
clic2chloride intracellular channel 20.024
wnt4awingless-type MMTV integration site family, member 4a0.024
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.024
ripk2receptor-interacting serine-threonine kinase 20.024
wnt9awingless-type MMTV integration site family, member 9A0.024
enc1ectodermal-neural cortex (with BTB-like domain)0.024
jag1bjagged 1b0.024
srfserum response factor0.024
otx1borthodenticle homolog 1b0.023
atad5aATPase family, AAA domain containing 5a0.023
anxa11aannexin A11a0.023
mapk14amitogen-activated protein kinase 14a0.022
tgfbr2transforming growth factor, beta receptor II0.022
axin2axin 2 (conductin, axil)0.022
pycardPYD and CARD domain containing0.021
hspa5heat shock protein 50.021
ip6k2inositol hexaphosphate kinase 20.021
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.021
ptenaphosphatase and tensin homolog A0.020
foxi3aforkhead box I3a0.020
rpl11ribosomal protein L110.020
mychmyelocytomatosis oncogene homolog0.020
btkBruton agammaglobulinemia tyrosine kinase0.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
aopanterior open0.344
rheaCG6831 gene product from transcript CG6831-RA0.157
EcREcdysone receptor0.140
stcksteamer duck0.134
Sema-1aCG18405 gene product from transcript CG18405-RD0.128
RASSF8CG5053 gene product from transcript CG5053-RA0.124
InRInsulin-like receptor0.099
tefutelomere fusion0.085
Rac1CG2248 gene product from transcript CG2248-RA0.083
Ras85DRas oncogene at 85D0.077
DAAMDishevelled Associated Activator of Morphogenesis0.072
EgfrEpidermal growth factor receptor0.069
mbcmyoblast city0.067
bowlbrother of odd with entrails limited0.065
Vm26AbVitelline membrane 26Ab0.063
DadDaughters against dpp0.063
emcextra macrochaetae0.061
hipkhomeodomain interacting protein kinase0.056
McrMacroglobulin complement-related0.055
Su(H)Suppressor of Hairless0.046
Cdc42CG12530 gene product from transcript CG12530-RA0.045
Cdk4Cyclin-dependent kinase 40.044
l(2)gllethal (2) giant larvae0.043
Rab5Rab-protein 50.043
Stat92ESignal-transducer and activator of transcription protein at 92E0.042
Mpk2CG5475 gene product from transcript CG5475-RB0.042
Tak1TGF-beta activated kinase 10.041
CdsACDP diglyceride synthetase0.041
Ras64BRas oncogene at 64B0.040
ik2IkappaB kinase-like 20.039
Adf1Adh transcription factor 10.039
Ced-12CG5336 gene product from transcript CG5336-RA0.038
Sra-1specifically Rac1-associated protein 10.037
drkdownstream of receptor kinase0.036
Pp2B-14DProtein phosphatase 2B at 14D0.035
Akt1CG4006 gene product from transcript CG4006-RA0.033
dcodiscs overgrown0.033
laceCG4162 gene product from transcript CG4162-RA0.033
sqhspaghetti squash0.032
bratbrain tumor0.032
S6kIIRPS6-protein kinase-II0.032
CG32810CG32810 gene product from transcript CG32810-RB0.031
lqfliquid facets0.029
Myo31DFMyosin 31DF0.029
MadMothers against dpp0.029
cnkconnector enhancer of ksr0.029
sinaseven in absentia0.027
Toll-7CG8595 gene product from transcript CG8595-RA0.027
Tab2TAK1-associated binding protein 20.024
mib1mind bomb 10.024
Mnn1Menin 10.022
wntDwnt inhibitor of Dorsal0.021
fs(1)M3female sterile (1) M30.021
Gs1Glutamine synthetase 10.020
CG4168CG4168 gene product from transcript CG4168-RA0.020
Traf6TNF-receptor-associated factor 60.020
slmbsupernumerary limbs0.020
PezCG9493 gene product from transcript CG9493-RA0.019
A2bp1Ataxin-2 binding protein 10.019
Vm26AaVitelline membrane 26Aa0.018
Pi3K92ECG4141 gene product from transcript CG4141-RB0.017
Vrp1Verprolin 10.017
mei-41meiotic 410.017
Toll-6CG7250 gene product from transcript CG7250-RA0.017
PvrPDGF- and VEGF-receptor related0.017
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
LCKlymphocyte-specific protein tyrosine kinase1.000
SHC1SHC (Src homology 2 domain containing) transforming protein 10.999
SYKspleen tyrosine kinase0.999
EGFRepidermal growth factor receptor0.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
FLNAfilamin A, alpha0.998
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.996
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.996
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.996
GRB2growth factor receptor-bound protein 20.995
LATlinker for activation of T cells0.994
PLCG1phospholipase C, gamma 10.991
PTPN6protein tyrosine phosphatase, non-receptor type 60.990
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.986
RUNX1runt-related transcription factor 10.986
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.983
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.980
CCL5chemokine (C-C motif) ligand 50.977
VCAM1vascular cell adhesion molecule 10.975
PTPN1protein tyrosine phosphatase, non-receptor type 10.972
TNFAIP3tumor necrosis factor, alpha-induced protein 30.970
CCR7chemokine (C-C motif) receptor 70.965
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.964
CCR5chemokine (C-C motif) receptor 50.962
FHL2four and a half LIM domains 20.957
PSEN1presenilin 10.953
VAV1vav 1 guanine nucleotide exchange factor0.941
IL2RBinterleukin 2 receptor, beta0.940
CXCL9chemokine (C-X-C motif) ligand 90.933
IL10RAinterleukin 10 receptor, alpha0.931
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.930
NOTCH1notch 10.928
CCL4chemokine (C-C motif) ligand 40.923
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.920
ICAM1intercellular adhesion molecule 10.920
TEKTEK tyrosine kinase, endothelial0.919
IRF4interferon regulatory factor 40.915
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.909
IL2RGinterleukin 2 receptor, gamma0.903
SOCS3suppressor of cytokine signaling 30.903
CXCL10chemokine (C-X-C motif) ligand 100.901
FGFR1fibroblast growth factor receptor 10.898
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.896
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.894
FGFR2fibroblast growth factor receptor 20.893
LST1leukocyte specific transcript 10.891
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.885
IL1Binterleukin 1, beta0.885
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.882
HCKhemopoietic cell kinase0.878
FGAfibrinogen alpha chain0.875
IFNGinterferon, gamma0.874
CCL22chemokine (C-C motif) ligand 220.863
CD63CD63 molecule0.859
JUNjun proto-oncogene0.858
NCOR2nuclear receptor corepressor 20.851
FCN1ficolin (collagen/fibrinogen domain containing) 10.851
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.848
ABI1abl-interactor 10.848
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.845
BIRC3baculoviral IAP repeat containing 30.840
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.837
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.834
CD2CD2 molecule0.832
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.827
SLAMF1signaling lymphocytic activation molecule family member 10.823
CD86CD86 molecule0.821
BLNKB-cell linker0.819
CD28CD28 molecule0.801
SH2D1ASH2 domain containing 1A0.801
IL4Rinterleukin 4 receptor0.798
TAL1T-cell acute lymphocytic leukemia 10.797
PMLpromyelocytic leukemia0.797
AXLAXL receptor tyrosine kinase0.797
PTPN11protein tyrosine phosphatase, non-receptor type 110.795
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.794
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.780
BRCA1breast cancer 1, early onset0.778
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.777
CAV1caveolin 1, caveolae protein, 22kDa0.776
MYH9myosin, heavy chain 9, non-muscle0.775
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.775
STAT4signal transducer and activator of transcription 40.772
ITKIL2-inducible T-cell kinase0.766
HLA-DMBmajor histocompatibility complex, class II, DM beta0.765
CCR1chemokine (C-C motif) receptor 10.759
INSRinsulin receptor0.756
TLN1talin 10.752
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.748
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.745
BCL2B-cell CLL/lymphoma 20.742
MAPK1mitogen-activated protein kinase 10.740
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.735
RB1retinoblastoma 10.734
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.728
LTAlymphotoxin alpha (TNF superfamily, member 1)0.723
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ptafrplatelet-activating factor receptor0.943
Cd2Cd2 molecule0.939
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.906
Ptprcprotein tyrosine phosphatase, receptor type, C0.854
RT1-BaRT1 class II, locus Ba0.801
Gzmkgranzyme K0.783
Clec9aC-type lectin domain family 9, member a0.747
Cd53Cd53 molecule0.743
Cd4Cd4 molecule0.684
Cd37CD37 molecule0.663
Cd247Cd247 molecule0.659
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.639
Lyz2lysozyme 20.635
Casp1caspase 10.634
Sellselectin L0.623
Ccr5chemokine (C-C motif) receptor 50.586
Inpp5dinositol polyphosphate-5-phosphatase D0.567
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.501
Ly86lymphocyte antigen 860.480
Hckhemopoietic cell kinase0.465
Cd3gCD3 molecule, gamma0.454
Cxcr4chemokine (C-X-C motif) receptor 40.448
Bin2bridging integrator 20.432
Vcam1vascular cell adhesion molecule 10.421
C5ar1complement component 5a receptor 10.416
Tgfbr2transforming growth factor, beta receptor II0.392
Mt1ametallothionein 1a0.391
Cd5Cd5 molecule0.371
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.359
Prm2protamine 20.358
Nkg7natural killer cell group 7 sequence0.356
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.350
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.345
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.342
Evi2aecotropic viral integration site 2A0.337
Mcpt2mast cell protease 20.332
Iappislet amyloid polypeptide0.318
Lst1leukocyte specific transcript 10.311
Calcrlcalcitonin receptor-like0.305
Il2rbinterleukin 2 receptor, beta0.297
Cxcr5chemokine (C-X-C motif) receptor 50.292
Ptpn7protein tyrosine phosphatase, non-receptor type 70.285
Klhl6kelch-like 6 (Drosophila)0.277
RT1-DaRT1 class II, locus Da0.277
Anxa5annexin A50.275
Il7rinterleukin 7 receptor0.273
Itgb1integrin, beta 10.272
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.268
Htr75-hydroxytryptamine (serotonin) receptor 70.268
Itgadintegrin, alpha D0.267
Scn11asodium channel, voltage-gated, type XI, alpha0.264
Il1binterleukin 1 beta0.263
Hcls1hematopoietic cell specific Lyn substrate 10.254
Itgb7integrin, beta 70.254
Tpm2tropomyosin 2, beta0.253
Acta2smooth muscle alpha-actin0.249
Ccl3chemokine (C-C motif) ligand 30.244
RT1-Db1RT1 class II, locus Db10.242
Ptger2prostaglandin E receptor 2 (subtype EP2)0.240
FaslgFas ligand (TNF superfamily, member 6)0.240
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.239
Csn2casein beta0.237
Il8rbinterleukin 8 receptor, beta0.234
Il1r1interleukin 1 receptor, type I0.224
Rassf5Ras association (RalGDS/AF-6) domain family member 50.223
Calm2calmodulin 20.223
Pld4phospholipase D family, member 40.221
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.221
Actbactin, beta0.218
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.209
Ctsscathepsin S0.208
Prp15proline-rich protein 150.207
Cfpcomplement factor properdin0.205
Gmfgglia maturation factor, gamma0.205
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.204
Xcl1chemokine (C motif) ligand 10.203
Cxcr3chemokine (C-X-C motif) receptor 30.201
Metmet proto-oncogene0.197
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.196
Anxa2annexin A20.193
Itpr2inositol 1,4,5-triphosphate receptor, type 20.192
TcrbT-cell receptor beta chain0.191
Igh-6immunoglobulin heavy chain 60.190
Oprm1opioid receptor, mu 10.189
Homer3homer homolog 3 (Drosophila)0.185
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.185
Npy5rneuropeptide Y receptor Y50.185
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.184
Csf1colony stimulating factor 1 (macrophage)0.183
Zbp1Z-DNA binding protein 10.182
Gimap4GTPase, IMAP family member 40.178
Cd38CD38 molecule0.177
Myo1fmyosin IF0.176
Tgfbr3transforming growth factor, beta receptor III0.173
Myo1gmyosin IG0.173
Cd86CD86 molecule0.173
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism