The network for 'negative regulation of ras protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ras protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.

NameDescriptionProbabilityFunc Analog Organism
itgb1b.2integrin, beta 1b.20.917
LOC567638hypothetical LOC5676380.662
lpar1lysophosphatidic acid receptor 10.503
ewsr1aEwing sarcoma breakpoint region 1a0.461
itgb1aintegrin, beta 1a0.426
nf1aneurofibromin 1a0.367
insrbinsulin receptor b0.365
itgb1bintegrin, beta 1b0.338
itgb1b.1integrin, beta 1b.10.317
rbb4retinoblastoma binding protein 40.297
whsc1Wolf-Hirschhorn syndrome candidate 10.249
marcksamyristoylated alanine rich protein kinase C substrate a0.231
lmnb1lamin B10.212
hmga1ahigh mobility group AT-hook 1a0.202
kdm5clysine (K)-specific demethylase 5C0.195
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.193
zgc:56306zgc:563060.167
trim33tripartite motif-containing 330.165
sf3b1splicing factor 3b, subunit 10.165
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.164
cbx2chromobox homolog 2 (Drosophila Pc class)0.164
ogt.2O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 20.157
hmgb2bhigh-mobility group box 2b0.155
pde10aphosphodiesterase 10A0.148
si:ch211-184m19.1si:ch211-184m19.10.144
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.140
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.137
zgc:123194zgc:1231940.136
tubg1tubulin, gamma 10.133
ruvbl2RuvB-like 2 (E. coli)0.131
wu:fi25h02wu:fi25h020.128
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.125
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.124
lbrlamin B receptor0.111
akap8lA kinase (PRKA) anchor protein 8-like0.110
hnrnpkheterogeneous nuclear ribonucleoprotein K0.107
ythdf1YTH domain family, member 10.106
insrainsulin receptor a0.106
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.105
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.104
im:7136220im:71362200.103
igfbp6binsulin-like growth factor binding protein 6b0.103
igfbp6ainsulin-like growth factor binding protein 6a0.102
igf1rbinsulin-like growth factor 1b receptor0.101
b2mbeta-2-microglobulin0.099
rab22aRAB22A, member RAS oncogene family0.099
ilf3ainterleukin enhancer binding factor 3a0.098
mtmr8myotubularin related protein 80.097
prpf8pre-mRNA processing factor 80.096
otud7bOTU domain containing 7B0.096
setdb1bSET domain, bifurcated 1b0.095
znf346zinc finger protein 3460.095
mc5rbmelanocortin 5b receptor0.095
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.093
zgc:114199zgc:1141990.093
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.087
slc12a9solute carrier family 12 (potassium/chloride transporters), member 90.085
marcksbmyristoylated alanine rich protein kinase C substrate b0.085
lsm14abLSM14 homolog Ab (SCD6, S. cerevisiae)0.084
rif1RAP1 interacting factor homolog (yeast)0.081
nf1bneurofibromin 1b0.079
sephs1selenophosphate synthetase 10.078
mxi1max interacting protein0.078
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.077
atxn7l3ataxin 7-like 30.076
tuba1tubulin, alpha 10.075
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.075
mfn2mitofusin 20.074
rbm39aRNA binding motif protein 39a0.073
pcsk5bproprotein convertase subtilisin/kexin type 5b0.073
cnot1CCR4-NOT transcription complex, subunit 10.072
zgc:112425zgc:1124250.070
tubb5tubulin, beta 50.069
mpp6bmembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)0.068
hey1hairy/enhancer-of-split related with YRPW motif 10.068
smc3structural maintenance of chromosomes 30.067
LOC568230similar to CHD30.067
gatad2aGATA zinc finger domain containing 2A0.066
nucks1anuclear casein kinase and cyclin-dependent kinase substrate 1a0.064
ptger2aprostaglandin E receptor 2a (subtype EP2)0.063
zgc:66440zgc:664400.063
gdf6agrowth differentiation factor 6a0.063
puf60bpoly-U binding splicing factor b0.063
ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.063
zgc:55888zgc:558880.062
zbtb22bzinc finger and BTB domain containing 22b0.062
fcho2FCH domain only 20.061
nup107nucleoporin 1070.061
rhpn2rhophilin, Rho GTPase binding protein 20.061
gpr19G protein-coupled receptor 190.060
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.060
si:ch73-60i13.2si:ch73-60i13.20.060
hist1h4lhistone 1, H4, like0.060
ankrd13cankyrin repeat domain 13C0.060
ca15bcarbonic anhydrase XV b0.060
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.060
tfdp1atranscription factor Dp-1, a0.060
ocrloculocerebrorenal syndrome of Lowe0.059
sox11bSRY-box containing gene 11b0.059
LOC100003330melanocortin-2 receptor accessory protein 2-like0.059
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Atg1Autophagy-specific gene 10.144
NFATNFAT homolog0.131
Ten-mTenascin major0.087
CG4813CG4813 gene product from transcript CG4813-RA0.079
Dsor1Downstream of raf10.061
CG14667CG14667 gene product from transcript CG14667-RA0.061
Rho1CG8416 gene product from transcript CG8416-RB0.058
scbscab0.047
CG15436CG15436 gene product from transcript CG15436-RA0.046
kaykayak0.042
SdcSyndecan0.042
CG7928CG7928 gene product from transcript CG7928-RA0.041
CG12424CG12424 gene product from transcript CG12424-RC0.040
CG10267CG10267 gene product from transcript CG10267-RB0.040
S6kIIRPS6-protein kinase-II0.039
CG5180CG5180 gene product from transcript CG5180-RB0.038
CG10825CG10825 gene product from transcript CG10825-RC0.032
hipkhomeodomain interacting protein kinase0.032
Pk61CProtein kinase 61C0.031
lqfliquid facets0.030
Eip63EEcdysone-induced protein 63E0.028
rodrough deal0.027
inscinscuteable0.027
wdbwiderborst0.026
dmdiminutive0.025
pallpallbearer0.025
Cip4CG15015 gene product from transcript CG15015-RA0.023
CG2662CG2662 gene product from transcript CG2662-RA0.023
rgrugose0.022
Mkp3Mitogen-activated protein kinase phosphatase 30.022
CG4424CG4424 gene product from transcript CG4424-RA0.022
mrimrityu0.021
Cul-3Cullin-30.020
svpseven up0.020
mbtmushroom bodies tiny0.019
CG4730CG4730 gene product from transcript CG4730-RA0.019
cdicenter divider0.018
ShcSHC-adaptor protein0.017
PknProtein kinase related to protein kinase N0.017
nufnuclear fallout0.017
Rbf2Retinoblastoma-family protein 20.016
CG14711CG14711 gene product from transcript CG14711-RA0.016
CG17568CG17568 gene product from transcript CG17568-RA0.016
alphalphabet0.015
bossbride of sevenless0.015
cnocanoe0.015
jebjelly belly0.015
CTCFCG8591 gene product from transcript CG8591-RA0.015
Smg5CG8954 gene product from transcript CG8954-RA0.015
CG6792CG6792 gene product from transcript CG6792-RA0.015
CG10133CG10133 gene product from transcript CG10133-RA0.015
FimFimbrin0.015
B-H1BarH10.015
Gem2Gemin20.014
CG8965CG8965 gene product from transcript CG8965-RA0.014
Chd1Chromodomain-helicase-DNA-binding protein 10.014
AlkCG8250 gene product from transcript CG8250-RA0.014
LnkCG17367 gene product from transcript CG17367-RC0.014
Su(z)2Suppressor of zeste 20.014
CG32086CG32086 gene product from transcript CG32086-RA0.014
CG7239CG7239 gene product from transcript CG7239-RA0.013
Bub1Bub1 homologue0.013
Tip60CG6121 gene product from transcript CG6121-RA0.013
CG11403CG11403 gene product from transcript CG11403-RA0.013
az2CG1605 gene product from transcript CG1605-RA0.013
tutlturtle0.013
CG11560CG11560 gene product from transcript CG11560-RA0.013
klarklarsicht0.012
FsFollistatin0.012
Su(dx)Suppressor of deltex0.012
Sh3betaCG8582 gene product from transcript CG8582-RD0.012
l(2)k16918lethal (2) k169180.012
CG15601CG15601 gene product from transcript CG15601-RA0.012
CG8273CG8273 gene product from transcript CG8273-RA0.012
CG2129CG2129 gene product from transcript CG2129-RA0.012
Rip11Rab11 interacting protein0.012
tostosca0.012
htshu li tai shao0.012
CG10743CG10743 gene product from transcript CG10743-RB0.011
pucpuckered0.011
chicoCG5686 gene product from transcript CG5686-RB0.011
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.011
cindrCIN85 and CD2AP orthologue0.011
CG13367CG13367 gene product from transcript CG13367-RA0.011
vrivrille0.011
CG6506CG6506 gene product from transcript CG6506-RA0.011
edlETS-domain lacking0.011
CG15167CG15167 gene product from transcript CG15167-RA0.011
mndminidiscs0.011
retnretained0.010
wechCG42396 gene product from transcript CG42396-RC0.010
CG6985CG6985 gene product from transcript CG6985-RA0.010
Sema-1aCG18405 gene product from transcript CG18405-RD0.010
RhoLrho-like0.010
PtpmegCG1228 gene product from transcript CG1228-RD0.010
LIMK1LIM-kinase10.010
RanBPMRan-binding protein M0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPK14mitogen-activated protein kinase 140.992
MAPK1mitogen-activated protein kinase 10.961
CBX5chromobox homolog 50.501
RB1retinoblastoma 10.431
DUSP1dual specificity phosphatase 10.316
HDAC1histone deacetylase 10.309
GBP3guanylate binding protein 30.228
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.196
GSK3Bglycogen synthase kinase 3 beta0.180
DUSP7dual specificity phosphatase 70.140
ATF2activating transcription factor 20.139
KCTD10potassium channel tetramerisation domain containing 100.122
E2F4E2F transcription factor 4, p107/p130-binding0.119
HDAC2histone deacetylase 20.115
RIN1Ras and Rab interactor 10.103
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.102
NCOR2nuclear receptor corepressor 20.088
C19orf50chromosome 19 open reading frame 500.083
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.078
RBBP4retinoblastoma binding protein 40.074
E2F6E2F transcription factor 60.071
MAP2K4mitogen-activated protein kinase kinase 40.062
FHL2four and a half LIM domains 20.060
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.056
KIF1Bkinesin family member 1B0.055
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.047
RANBP3RAN binding protein 30.043
MAP3K5mitogen-activated protein kinase kinase kinase 50.042
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.041
MAPK3mitogen-activated protein kinase 30.041
DUSP3dual specificity phosphatase 30.039
NCOA1nuclear receptor coactivator 10.038
ARRB1arrestin, beta 10.036
ARRB2arrestin, beta 20.032
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.027
MAP2K1mitogen-activated protein kinase kinase 10.027
CSNK2A1casein kinase 2, alpha 1 polypeptide0.024
STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.023
PCDH9protocadherin 90.023
VIMvimentin0.023
ARHGAP9Rho GTPase activating protein 90.022
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.021
RHOBras homolog gene family, member B0.020
PTPRRprotein tyrosine phosphatase, receptor type, R0.020
ITGB4integrin, beta 40.020
STK24serine/threonine kinase 240.019
SLMAPsarcolemma associated protein0.019
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.017
PPAP2Bphosphatidic acid phosphatase type 2B0.017
ZFP36L1zinc finger protein 36, C3H type-like 10.017
LBRlamin B receptor0.016
LIN9lin-9 homolog (C. elegans)0.016
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.016
SOX4SRY (sex determining region Y)-box 40.015
SPTBN4spectrin, beta, non-erythrocytic 40.015
PXNpaxillin0.015
XPO6exportin 60.014
RBL2retinoblastoma-like 2 (p130)0.014
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.013
SH3KBP1SH3-domain kinase binding protein 10.013
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.013
PEA15phosphoprotein enriched in astrocytes 150.012
MAP2K6mitogen-activated protein kinase kinase 60.012
EIF4G1eukaryotic translation initiation factor 4 gamma, 10.012
ARMC7armadillo repeat containing 70.012
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.012
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.012
C10orf116chromosome 10 open reading frame 1160.011
SIN3ASIN3 homolog A, transcription regulator (yeast)0.011
CUX1cut-like homeobox 10.011
C19orf46chromosome 19 open reading frame 460.011
MKNK1MAP kinase interacting serine/threonine kinase 10.011
E2F3E2F transcription factor 30.010
SPRY2sprouty homolog 2 (Drosophila)0.010
DUSP6dual specificity phosphatase 60.010
EEF2Keukaryotic elongation factor-2 kinase0.010
PTPN7protein tyrosine phosphatase, non-receptor type 70.010
RICTORRPTOR independent companion of MTOR, complex 20.010
ENGendoglin0.010
PLECplectin0.010
RASA1RAS p21 protein activator (GTPase activating protein) 10.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.978
Ptpn11protein tyrosine phosphatase, non-receptor type 110.954
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.904
Lama5laminin, alpha 50.870
Spry4sprouty homolog 4 (Drosophila)0.740
Mtormechanistic target of rapamycin (serine/threonine kinase)0.725
Spry2sprouty homolog 2 (Drosophila)0.718
Itgb3integrin beta 30.709
Mapk11mitogen-activated protein kinase 110.667
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.621
Hdac2histone deacetylase 20.589
Nf1neurofibromatosis 10.539
Inpp5dinositol polyphosphate-5-phosphatase D0.485
BrafBraf transforming gene0.476
CblCasitas B-lineage lymphoma0.455
SrcRous sarcoma oncogene0.427
Itga3integrin alpha 30.427
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.371
FynFyn proto-oncogene0.364
Ezh2enhancer of zeste homolog 2 (Drosophila)0.358
RictorRPTOR independent companion of MTOR, complex 20.350
Pxnpaxillin0.338
Bcar1breast cancer anti-estrogen resistance 10.330
Tgfbr2transforming growth factor, beta receptor II0.295
Hspg2perlecan (heparan sulfate proteoglycan 2)0.265
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.259
Ptk2PTK2 protein tyrosine kinase 20.245
Hdac1histone deacetylase 10.244
Myo1fmyosin IF0.226
Kdm2blysine (K)-specific demethylase 2B0.226
Dok1docking protein 10.224
Bmi1Bmi1 polycomb ring finger oncogene0.205
Pdgfbplatelet derived growth factor, B polypeptide0.200
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.197
Col12a1collagen, type XII, alpha 10.188
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.186
Hmha1histocompatibility (minor) HA-10.185
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.181
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.181
Gab2growth factor receptor bound protein 2-associated protein 20.175
Pcdhgb1protocadherin gamma subfamily B, 10.173
Itgb1integrin beta 1 (fibronectin receptor beta)0.170
Apcadenomatosis polyposis coli0.156
Tgfb1transforming growth factor, beta 10.146
WaslWiskott-Aldrich syndrome-like (human)0.144
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.143
Vav2vav 2 oncogene0.141
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.139
BtkBruton agammaglobulinemia tyrosine kinase0.139
Adam17a disintegrin and metallopeptidase domain 170.138
Engendoglin0.137
Arid1aAT rich interactive domain 1A (SWI-like)0.136
Itga5integrin alpha 5 (fibronectin receptor alpha)0.130
Arid1bAT rich interactive domain 1B (SWI-like)0.129
Nckap1lNCK associated protein 1 like0.126
Acvrl1activin A receptor, type II-like 10.126
Mapk3mitogen-activated protein kinase 30.124
Selplgselectin, platelet (p-selectin) ligand0.120
Spry1sprouty homolog 1 (Drosophila)0.118
Mapk14mitogen-activated protein kinase 140.113
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.113
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.112
Vegfavascular endothelial growth factor A0.110
Itgalintegrin alpha L0.108
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.107
Cd151CD151 antigen0.105
Ets1E26 avian leukemia oncogene 1, 5' domain0.104
Trim28tripartite motif-containing 280.103
Tcf4transcription factor 40.101
Retret proto-oncogene0.100
Mapk1mitogen-activated protein kinase 10.097
Ptpreprotein tyrosine phosphatase, receptor type, E0.096
Ggta1glycoprotein galactosyltransferase alpha 1, 30.094
Smad1MAD homolog 1 (Drosophila)0.093
Nos3nitric oxide synthase 3, endothelial cell0.092
Dock2dedicator of cyto-kinesis 20.087
Dok2docking protein 20.087
Tbx21T-box 210.084
Egfrepidermal growth factor receptor0.083
Lrrc58leucine rich repeat containing 580.083
Bcl6bB-cell CLL/lymphoma 6, member B0.079
Basp1brain abundant, membrane attached signal protein 10.079
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.078
Trim24tripartite motif-containing 240.077
Dnmt1DNA methyltransferase (cytosine-5) 10.076
Fli1Friend leukemia integration 10.075
Sh3bp1SH3-domain binding protein 10.072
C5ar1complement component 5a receptor 10.071
Rgs14regulator of G-protein signaling 140.069
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.069
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.065
Nr3c1nuclear receptor subfamily 3, group C, member 10.064
Itgamintegrin alpha M0.064
Aplnrapelin receptor0.062
Prkceprotein kinase C, epsilon0.062
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.058
Sh3kbp1SH3-domain kinase binding protein 10.058
Ptk2bPTK2 protein tyrosine kinase 2 beta0.058
Smad4MAD homolog 4 (Drosophila)0.057
Elk4ELK4, member of ETS oncogene family0.057
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC24Cdc24p0.154
IRA2Ira2p0.057
CDC25Cdc25p0.054
RHO1Rho1p0.047
PKC1Pkc1p0.046
ROM2Rom2p0.042
MKK1Mkk1p0.041
BEM3Bem3p0.041
IRA1Ira1p0.039
BEM2Bem2p0.028
GIC2Gic2p0.028
FYV8Fyv8p0.025
KEL1Kel1p0.024
TAO3Tao3p0.021
ACK1Ack1p0.020
GPR1Gpr1p0.020
BST1Bst1p0.019
STE5Ste5p0.018
IQG1Iqg1p0.017
MDS3Mds3p0.016
SRD1Srd1p0.016
YDR186Chypothetical protein0.016
GPB2Gpb2p0.016
SAC7Sac7p0.015
LEU2Leu2p0.015
ARG8Arg8p0.014
ARP10Arp10p0.014
YOL038C-Ahypothetical protein0.014
YLR162Whypothetical protein0.014
MER1Mer1p0.014
YPL066Whypothetical protein0.014
YLR264C-Ahypothetical protein0.013
CYK3Cyk3p0.013
CLA4Cla4p0.013
YAR068Whypothetical protein0.012
CUP1-1Cup1-1p0.012
PRS2Prs2p0.012
SPL2Spl2p0.012
DOT6Dot6p0.012
CYR1Cyr1p0.012
KIC1Kic1p0.012
KAP120Kap120p0.011
HKR1Hkr1p0.011
YBR013Chypothetical protein0.011
BIT61Bit61p0.011
ATP6Atp6p0.011
ICS2Ics2p0.011
HXT3Hxt3p0.011
OPT2Opt2p0.011
CPD1Cpd1p0.011
CAM1Cam1p0.011
AUA1Aua1p0.011
TOM1Tom1p0.011
HPF1Hpf1p0.011
ZPS1Zps1p0.011
YLR042Chypothetical protein0.011
YNL058Chypothetical protein0.011
PEP5Pep5p0.011
YOL013W-Ahypothetical protein0.010
FMT1Fmt1p0.010
AFI1Afi1p0.010
YPR157Whypothetical protein0.010
SPR6Spr6p0.010
YIL151Chypothetical protein0.010
TIP1Tip1p0.010