The network for 'proteoglycan biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

NameDescriptionProbabilityFunc Analog Organism
smosmoothened homolog (Drosophila)0.942
sec24dSEC24 family, member D (S. cerevisiae)0.857
extl3exostoses (multiple)-like 30.736
zgc:158603zgc:1586030.700
uxs1UDP-glucuronic acid decarboxylase 10.662
xylt1xylosyltransferase 10.606
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.411
tcf7transcription factor 7 (T-cell specific, HMG-box)0.319
hs6st1bheparan sulfate 6-O-sulfotransferase 1b0.245
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.214
hs6st3heparan sulfate 6-O-sulfotransferase 30.209
ext2exostoses (multiple) 20.204
hs6st2heparan sulfate 6-O-sulfotransferase 20.202
ihhaIndian hedgehog homolog a0.189
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.159
csnk1a1casein kinase 1, alpha 10.145
bmp1abone morphogenetic protein 1a0.139
slc35b2solute carrier family 35, member B20.118
wu:fj34h01wu:fj34h010.103
sox9aSRY-box containing gene 9a0.080
rereaarginine-glutamic acid dipeptide (RE) repeats a0.064
furinafurin (paired basic amino acid cleaving enzyme) a0.061
disp1dispatched homolog 1 (Drosophila)0.051
b3gat3beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) and beta3-glucuronyltransferase0.043
atp7aATPase, Cu++ transporting, alpha polypeptide0.039
tjp1tight junction protein 1 (zona occludens 1)0.035
sufusuppressor of fused homolog (Drosophila)0.030
gle1GLE1 RNA export mediator homolog (yeast)0.030
grifingalectin related inter-fiber protein0.029
lhx2bLIM homeobox 2b0.028
ephb4beph receptor B4b0.026
nkd1naked cuticle homolog 1 (Drosophila)0.024
arnt2aryl hydrocarbon receptor nuclear translocator 20.023
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.022
hs2st1aheparan sulfate 2-O-sulfotransferase 1a0.022
chd7chromodomain helicase DNA binding protein 70.020
sec23aSec23 homolog A (S. cerevisiae)0.019
smad3bMAD, mothers against decapentaplegic homolog 3b (Drosophila)0.018
efnb3bephrin B3b0.018
spry2sprouty homolog 20.018
ptpraprotein tyrosine phosphatase, receptor type, A0.017
prdm5PR domain containing 50.015
brpf1bromodomain and PHD finger containing, 10.015
tfe3btranscription factor binding to IGHM enhancer 3b0.015
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.013
rpzrapunzel0.013
wnt3awingless-type MMTV integration site family, member 3A0.012
usp9ubiquitin specific peptidase 90.011
piguphosphatidylinositol glycan anchor biosynthesis, class U0.011
LOC100334210growth/differentiation factor 5-like0.011
fzd5frizzled homolog 50.011
odz4odd Oz/ten-m homolog 40.011
prickle2prickle-like 2 (Drosophila)0.010
acvr1bactivin A receptor, type IB0.010
scospondinsubcommissural organ spondin0.010
vaspvasodilator-stimulated phosphoprotein0.010
si:dkeyp-117b8.1si:dkeyp-117b8.10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ext2CG8433 gene product from transcript CG8433-RA0.882
raspCG11495 gene product from transcript CG11495-RA0.660
sflsulfateless0.645
botvbrother of tout-velu0.557
sglsugarless0.539
CG14837CG14837 gene product from transcript CG14837-RC0.403
porporcupine0.362
sllslalom0.285
smosmoothened0.216
CG3194CG3194 gene product from transcript CG3194-RB0.187
cicubitus interruptus0.179
cgcombgap0.164
Bre1CG10542 gene product from transcript CG10542-RA0.150
Pgant35APolypeptide N-acetylgalactosaminyltransferase 35A0.134
ttvtout-velu0.087
heixheixuedian0.080
CG14506CG14506 gene product from transcript CG14506-RA0.078
Jon99CiJonah 99Ci0.068
LvpHLarval visceral protein H0.066
rumiCG31152 gene product from transcript CG31152-RA0.060
CG13160CG13160 gene product from transcript CG13160-RA0.058
CG6283CG6283 gene product from transcript CG6283-RA0.057
DokDownstream of kinase0.055
Jon65AivJonah 65Aiv0.055
CG6277CG6277 gene product from transcript CG6277-RA0.054
CG18180CG18180 gene product from transcript CG18180-RA0.054
EloAElongin A0.046
DmsR-2Dromyosuppressin receptor 20.043
CG12883CG12883 gene product from transcript CG12883-RA0.041
CG12746CG12746 gene product from transcript CG12746-RD0.039
amxalmondex0.038
ric8aCG15797 gene product from transcript CG15797-RA0.038
LysBLysozyme B0.037
CG6295CG6295 gene product from transcript CG6295-RA0.036
CG9053CG9053 gene product from transcript CG9053-RA0.035
arrarrow0.035
Mo25CG4083 gene product from transcript CG4083-RA0.032
Cyp4d21CG6730 gene product from transcript CG6730-RA0.030
varivaricose0.029
mib1mind bomb 10.029
CG7916CG7916 gene product from transcript CG7916-RA0.026
CG10222CG10222 gene product from transcript CG10222-RA0.025
CG10555CG10555 gene product from transcript CG10555-RA0.025
Hs6stHeparan sulfate 6-O-sulfotransferase0.025
CG1887CG1887 gene product from transcript CG1887-RD0.023
Sp1CG1343 gene product from transcript CG1343-RB0.023
Vhlvon Hippel-Lindau0.023
CG10444CG10444 gene product from transcript CG10444-RA0.022
CG17189CG17189 gene product from transcript CG17189-RA0.022
CG12483CG12483 gene product from transcript CG12483-RA0.022
ash2absent, small, or homeotic discs 20.021
yellow-f2CG8063 gene product from transcript CG8063-RA0.021
PapssPAPS synthetase0.020
CG10361CG10361 gene product from transcript CG10361-RA0.020
CG12374CG12374 gene product from transcript CG12374-RA0.020
CG15549CG15549 gene product from transcript CG15549-RA0.020
CG18745CG18745 gene product from transcript CG18745-RA0.020
CG2837CG2837 gene product from transcript CG2837-RB0.020
KulKuzbanian-like0.019
CG4293CG4293 gene product from transcript CG4293-RD0.019
CG8176CG8176 gene product from transcript CG8176-RD0.019
CG18616CG18616 gene product from transcript CG18616-RA0.018
CG6996CG6996 gene product from transcript CG6996-RB0.017
PxdPeroxidase0.017
dispdispatched0.017
Spn77BbSerpin 77Bb0.017
ImpE1Ecdysone-inducible gene E10.016
CG9672CG9672 gene product from transcript CG9672-RA0.015
sinusinuous0.015
CG1105CG1105 gene product from transcript CG1105-RA0.014
HLH106Helix loop helix protein 1060.014
CG11103CG11103 gene product from transcript CG11103-RB0.014
otkoff-track0.014
CG5945CG5945 gene product from transcript CG5945-RA0.014
CG8690CG8690 gene product from transcript CG8690-RA0.014
CG3631CG3631 gene product from transcript CG3631-RD0.014
Pp2B-14DProtein phosphatase 2B at 14D0.013
CG15650CG15650 gene product from transcript CG15650-RA0.013
Cyp18a1Cytochrome P450-18a10.013
alpha-Est10alpha-Esterase-100.012
CG14196CG14196 gene product from transcript CG14196-RA0.012
CG7213CG7213 gene product from transcript CG7213-RA0.012
CG31559CG31559 gene product from transcript CG31559-RA0.012
CG11029CG11029 gene product from transcript CG11029-RA0.012
Jon25BiJonah 25Bi0.011
CG6462CG6462 gene product from transcript CG6462-RA0.011
Cyp4d20CG16761 gene product from transcript CG16761-RA0.011
CG14820CG14820 gene product from transcript CG14820-RA0.011
CG11127CG11127 gene product from transcript CG11127-RA0.011
CG14119CG14119 gene product from transcript CG14119-RA0.011
CG11816CG11816 gene product from transcript CG11816-RA0.011
CG18135CG18135 gene product from transcript CG18135-RC0.010
l(2)01810lethal (2) 018100.010
CG15555CG15555 gene product from transcript CG15555-RA0.010
CG11391CG11391 gene product from transcript CG11391-RA0.010
CG14470CG14470 gene product from transcript CG14470-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.962
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.717
CTNNBIP1catenin, beta interacting protein 10.635
APCadenomatous polyposis coli0.471
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.300
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.297
TCF4transcription factor 40.239
GLIS2GLIS family zinc finger 20.205
CTNND1catenin (cadherin-associated protein), delta 10.140
PSEN1presenilin 10.120
ITGB1BP3integrin beta 1 binding protein 30.108
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.060
BTRCbeta-transducin repeat containing0.056
PKP4plakophilin 40.042
CNTFciliary neurotrophic factor0.035
ARandrogen receptor0.034
FAF1Fas (TNFRSF6) associated factor 10.033
GSK3Bglycogen synthase kinase 3 beta0.030
AXIN1axin 10.030
HIC1hypermethylated in cancer 10.028
EMDemerin0.027
ERBB2IPerbb2 interacting protein0.026
JUPjunction plakoglobin0.024
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.022
WDYHV1WDYHV motif containing 10.022
ACSL4acyl-CoA synthetase long-chain family member 40.019
TNIKTRAF2 and NCK interacting kinase0.018
VCANversican0.018
KLF10Kruppel-like factor 100.018
NCOA2nuclear receptor coactivator 20.018
DSPdesmoplakin0.017
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.016
HYOU1hypoxia up-regulated 10.016
FNDC3Bfibronectin type III domain containing 3B0.016
PTK7PTK7 protein tyrosine kinase 70.014
LEF1lymphoid enhancer-binding factor 10.014
BMP1bone morphogenetic protein 10.014
RUNX3runt-related transcription factor 30.014
MFSD5major facilitator superfamily domain containing 50.013
CDH5cadherin 5, type 2 (vascular endothelium)0.013
CDH3cadherin 3, type 1, P-cadherin (placental)0.013
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.013
CREBBPCREB binding protein0.012
ARFGAP3ADP-ribosylation factor GTPase activating protein 30.012
PFDN1prefoldin subunit 10.010
HSPA13heat shock protein 70kDa family, member 130.010
FGFR1fibroblast growth factor receptor 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.903
Ins1insulin I0.642
Adam17a disintegrin and metallopeptidase domain 170.521
Egfrepidermal growth factor receptor0.504
Smad4MAD homolog 4 (Drosophila)0.356
Npc1Niemann Pick type C10.350
Ghrgrowth hormone receptor0.303
Fgfr1fibroblast growth factor receptor 10.280
Igf1rinsulin-like growth factor I receptor0.274
Bmpr1abone morphogenetic protein receptor, type 1A0.254
Grb10growth factor receptor bound protein 100.228
Ins2insulin II0.226
Twsg1twisted gastrulation homolog 1 (Drosophila)0.222
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.221
Cdkn1bcyclin-dependent kinase inhibitor 1B0.213
Ahraryl-hydrocarbon receptor0.200
Ptpn11protein tyrosine phosphatase, non-receptor type 110.194
Foxc1forkhead box C10.189
Apcadenomatosis polyposis coli0.188
Pgrprogesterone receptor0.186
Sox9SRY-box containing gene 90.171
Kitkit oncogene0.146
Pitx2paired-like homeodomain transcription factor 20.143
Cabp7calcium binding protein 70.140
Rps6kl1ribosomal protein S6 kinase-like 10.140
Chst2carbohydrate sulfotransferase 20.138
Col11a1collagen, type XI, alpha 10.133
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.130
Foxf2forkhead box F20.118
Leprleptin receptor0.112
Ctnna1catenin (cadherin associated protein), alpha 10.110
Tgfbr2transforming growth factor, beta receptor II0.089
Rarbretinoic acid receptor, beta0.088
Foxo3forkhead box O30.082
IkbipIKBKB interacting protein0.082
Twist2twist homolog 2 (Drosophila)0.081
Numbnumb gene homolog (Drosophila)0.080
Trp53transformation related protein 530.079
Ccdc24coiled-coil domain containing 240.075
Meox2mesenchyme homeobox 20.073
Fgfr2fibroblast growth factor receptor 20.072
Cav1caveolin 1, caveolae protein0.066
Cdx2caudal type homeobox 20.065
Glp1rglucagon-like peptide 1 receptor0.065
Apaf1apoptotic peptidase activating factor 10.064
Bmp4bone morphogenetic protein 40.061
Itgavintegrin alpha V0.061
Tyro3TYRO3 protein tyrosine kinase 30.059
Hif1ahypoxia inducible factor 1, alpha subunit0.059
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.057
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.055
Cdk14cyclin-dependent kinase 140.054
Nckap5lNCK-associated protein 5-like0.054
Cldn11claudin 110.052
B4galt2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 20.051
Rdh10retinol dehydrogenase 10 (all-trans)0.051
Akt1thymoma viral proto-oncogene 10.050
Kif3akinesin family member 3A0.050
Xylt2xylosyltransferase II0.049
Gna11guanine nucleotide binding protein, alpha 110.049
Ptk2PTK2 protein tyrosine kinase 20.049
Foxf1aforkhead box F1a0.047
Kcnk12potassium channel, subfamily K, member 120.047
Tmem132etransmembrane protein 132E0.047
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.047
Cbfbcore binding factor beta0.046
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.045
Adra1badrenergic receptor, alpha 1b0.044
Numblnumb-like0.044
Shroom1shroom family member 10.044
Psen1presenilin 10.043
Abca3ATP-binding cassette, sub-family A (ABC1), member 30.043
Dgcr2DiGeorge syndrome critical region gene 20.041
Colec12collectin sub-family member 120.040
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.040
Crlf1cytokine receptor-like factor 10.040
Klklotho0.039
Tgfbr1transforming growth factor, beta receptor I0.039
Ext1exostoses (multiple) 10.038
Col2a1collagen, type II, alpha 10.038
Gjc3gap junction protein, gamma 30.038
Tcf7l2transcription factor 7-like 2, T-cell specific, HMG-box0.037
Col1a1collagen, type I, alpha 10.037
Epha4Eph receptor A40.037
Fgfr4fibroblast growth factor receptor 40.036
Cyp11b2cytochrome P450, family 11, subfamily b, polypeptide 20.036
Esr1estrogen receptor 1 (alpha)0.036
Rpusd1RNA pseudouridylate synthase domain containing 10.034
Kitlkit ligand0.034
Abca2ATP-binding cassette, sub-family A (ABC1), member 20.034
Fgf18fibroblast growth factor 180.034
Lhcgrluteinizing hormone/choriogonadotropin receptor0.034
Edil3EGF-like repeats and discoidin I-like domains 30.033
Fubp3far upstream element (FUSE) binding protein 30.033
Olig2oligodendrocyte transcription factor 20.033
Tmem121transmembrane protein 1210.033
NrkNik related kinase0.033
Matn4matrilin 40.032
Ptf1apancreas specific transcription factor, 1a0.032
Adam18a disintegrin and metallopeptidase domain 180.032
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism