The network for 'i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

i kappab kinase nf kappab signaling

The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

NameDescriptionProbabilityFunc Analog Organism
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.885
nod1nucleotide-binding oligomerization domain containing 10.715
tgm2btransglutaminase 2b0.584
klfdKruppel-like factor d0.505
cav1caveolin 10.498
tlr3toll-like receptor 30.390
csf3rcolony stimulating factor 3 receptor (granulocyte)0.381
caspacaspase a0.375
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.306
mmp9matrix metalloproteinase 90.291
vcanbversican b0.279
itm2bbintegral membrane protein 2Bb0.259
nccrp1nonspecific cytotoxic cell receptor protein 10.258
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.258
ip6k2inositol hexaphosphate kinase 20.243
hcrthypocretin (orexin) neuropeptide precursor0.228
cdc42cell division cycle 420.226
junbjun B proto-oncogene0.225
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.216
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.205
socs3asuppressor of cytokine signaling 3a0.203
pbx4pre-B-cell leukemia transcription factor 40.201
adipor1badiponectin receptor 1b0.197
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.190
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.183
tlr9toll-like receptor 90.172
tlr2toll-like receptor 20.171
hbbe1.1hemoglobin beta embryonic-1.10.170
stat1asignal transduction and activation of transcription 1a0.163
LOC100003514protein kinase C alpha type-like0.163
tsen54tRNA splicing endonuclease 54 homolog (S. cerevisiae)0.162
irf9interferon regulatory factor 90.160
metap2methionyl aminopeptidase 20.158
dll4delta-like 4 (Drosophila)0.158
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.157
wlswntless homolog (Drosophila)0.153
prkczprotein kinase C, zeta0.153
junjun proto-oncogene0.149
pdcd6ipprogrammed cell death 6 interacting protein0.148
brd2bbromodomain containing 2b0.146
atf3activating transcription factor 30.146
rhagRhesus blood group-associated glycoprotein0.141
acp5bacid phosphatase 5b, tartrate resistant0.141
adipor2adiponectin receptor 20.139
hbaa1hemoglobin alpha adult-10.139
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.134
adipoqladiponectin, C1Q and collagen domain containing, like0.128
LOC100000934hypothetical protein LOC1000009340.125
foxo3bforkhead box O3b0.125
wnt3wingless-type MMTV integration site family, member 30.123
coro1acoronin, actin binding protein, 1A0.122
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.120
cd63Cd63 antigen0.119
grnagranulin a0.118
cbr1lcarbonyl reductase 1-like0.117
fancd2Fanconi anemia, complementation group D20.116
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.116
il8interleukin 80.116
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.115
myd88myeloid differentiation primary response gene (88)0.115
per3period homolog 3 (Drosophila)0.112
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.112
tmed2transmembrane emp24 domain trafficking protein 20.111
angptl1angiopoietin-like 10.109
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.109
grifingalectin related inter-fiber protein0.108
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.108
btkBruton agammaglobulinemia tyrosine kinase0.108
mmp15bmatrix metallopeptidase 15b0.103
gng5guanine nucleotide binding protein (G protein), gamma 50.102
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.102
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.102
pycardPYD and CARD domain containing0.101
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.101
chukconserved helix-loop-helix ubiquitous kinase0.101
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.100
LOC100003330melanocortin-2 receptor accessory protein 2-like0.098
tm4sf4transmembrane 4 L six family member 40.098
trpv6transient receptor potential cation channel, subfamily V, member 60.097
cps1carbamoyl-phosphate synthase 1, mitochondrial0.095
adrb2aadrenergic receptor, beta 2a0.093
tlr18toll-like receptor 180.093
wnt2bbwingless-type MMTV integration site family, member 2Bb0.091
otcornithine carbamoyltransferase0.091
per2period homolog 2 (Drosophila)0.091
ube2nbubiquitin-conjugating enzyme E2Nb0.090
rbm22RNA binding motif protein 220.089
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.088
litaflipopolysaccharide-induced TNF factor0.087
mipamajor intrinsic protein of lens fiber a0.084
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
l(2)gllethal (2) giant larvae0.253
Hsp27Heat shock protein 270.090
Tak1TGF-beta activated kinase 10.072
Myd88CG2078 gene product from transcript CG2078-RA0.061
ird5immune response deficient 50.058
bratbrain tumor0.056
Akt1CG4006 gene product from transcript CG4006-RA0.053
BG4CG12297 gene product from transcript CG12297-RA0.043
Rac1CG2248 gene product from transcript CG2248-RA0.029
imdimmune deficiency0.026
ftz-f1ftz transcription factor 10.024
inaDinactivation no afterpotential D0.018
18w18 wheeler0.017
aopanterior open0.016
MadMothers against dpp0.014
Vap-33-1CG5014 gene product from transcript CG5014-RB0.013
Ptp69DProtein tyrosine phosphatase 69D0.013
Akap200A kinase anchor protein 2000.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
TRAF6TNF receptor-associated factor 61.000
TRAF2TNF receptor-associated factor 21.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 11.000
BIRC3baculoviral IAP repeat containing 31.000
XIAPX-linked inhibitor of apoptosis1.000
RIPK2receptor-interacting serine-threonine kinase 21.000
UBCubiquitin C1.000
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
MAP3K7mitogen-activated protein kinase kinase kinase 71.000
SQSTM1sequestosome 11.000
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta1.000
TRAF1TNF receptor-associated factor 11.000
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha1.000
TRAF3TNF receptor-associated factor 31.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.999
TNFAIP3tumor necrosis factor, alpha-induced protein 30.998
MDM2Mdm2 p53 binding protein homolog (mouse)0.998
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.996
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.994
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.994
MAP3K14mitogen-activated protein kinase kinase kinase 140.993
FLNAfilamin A, alpha0.993
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.992
MYD88myeloid differentiation primary response gene (88)0.992
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.990
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.990
TRADDTNFRSF1A-associated via death domain0.988
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.988
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.980
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.980
TNIP2TNFAIP3 interacting protein 20.978
CDC37cell division cycle 37 homolog (S. cerevisiae)0.977
BIRC2baculoviral IAP repeat containing 20.976
CFLARCASP8 and FADD-like apoptosis regulator0.974
S100A6S100 calcium binding protein A60.973
SMAD3SMAD family member 30.973
FASFas (TNF receptor superfamily, member 6)0.971
ESR1estrogen receptor 10.964
IRAK2interleukin-1 receptor-associated kinase 20.964
CHUKconserved helix-loop-helix ubiquitous kinase0.961
CARD11caspase recruitment domain family, member 110.956
IRAK1interleukin-1 receptor-associated kinase 10.954
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.951
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.947
FADDFas (TNFRSF6)-associated via death domain0.944
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.939
IL1Binterleukin 1, beta0.933
CASP10caspase 10, apoptosis-related cysteine peptidase0.924
JAG1jagged 10.903
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.888
ZNF43zinc finger protein 430.888
TNFtumor necrosis factor0.884
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.882
PTPN1protein tyrosine phosphatase, non-receptor type 10.875
NOTCH1notch 10.871
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.869
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.867
CASP3caspase 3, apoptosis-related cysteine peptidase0.867
CD40CD40 molecule, TNF receptor superfamily member 50.864
MAP3K3mitogen-activated protein kinase kinase kinase 30.861
IL1R1interleukin 1 receptor, type I0.850
ZNF675zinc finger protein 6750.846
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.840
IRF1interferon regulatory factor 10.836
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.834
S100BS100 calcium binding protein B0.821
TP53tumor protein p530.806
CCL4chemokine (C-C motif) ligand 40.792
PMLpromyelocytic leukemia0.790
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.765
MAP3K8mitogen-activated protein kinase kinase kinase 80.751
S100A9S100 calcium binding protein A90.738
S100A8S100 calcium binding protein A80.726
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.715
TNIP1TNFAIP3 interacting protein 10.712
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.704
IL8interleukin 80.699
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.693
S100A16S100 calcium binding protein A160.676
ANXA1annexin A10.673
CXCL2chemokine (C-X-C motif) ligand 20.656
S100A14S100 calcium binding protein A140.654
MYH9myosin, heavy chain 9, non-muscle0.645
ANXA2annexin A20.640
NLRC4NLR family, CARD domain containing 40.632
BCL3B-cell CLL/lymphoma 30.615
ARRB1arrestin, beta 10.612
CASP9caspase 9, apoptosis-related cysteine peptidase0.612
ZNF253zinc finger protein 2530.612
TRAF5TNF receptor-associated factor 50.609
BCL10B-cell CLL/lymphoma 100.602
TICAM2toll-like receptor adaptor molecule 20.602
TNFAIP2tumor necrosis factor, alpha-induced protein 20.580
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.577
S100A4S100 calcium binding protein A40.576
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.574
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.565
PSEN1presenilin 10.559
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 41.000
Tnftumor necrosis factor1.000
Myd88myeloid differentiation primary response gene 881.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a1.000
Traf6TNF receptor-associated factor 61.000
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.999
Casp4caspase 4, apoptosis-related cysteine peptidase0.999
Map3k7mitogen-activated protein kinase kinase kinase 70.999
Casp1caspase 10.999
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.999
Ikbkginhibitor of kappaB kinase gamma0.999
Il1r1interleukin 1 receptor, type I0.998
Lyz2lysozyme 20.998
Cd44CD44 antigen0.994
Map3k14mitogen-activated protein kinase kinase kinase 140.989
Ltalymphotoxin A0.985
Ticam1toll-like receptor adaptor molecule 10.985
Tnfaip3tumor necrosis factor, alpha-induced protein 30.984
Cd40CD40 antigen0.978
Ccl2chemokine (C-C motif) ligand 20.973
Ikbkbinhibitor of kappaB kinase beta0.970
Ctnnb1catenin (cadherin associated protein), beta 10.968
Casp8caspase 80.961
Birc3baculoviral IAP repeat-containing 30.950
Map3k8mitogen-activated protein kinase kinase kinase 80.946
FasFas (TNF receptor superfamily member 6)0.944
Ikzf1IKAROS family zinc finger 10.929
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.929
Cd19CD19 antigen0.926
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.922
Cd28CD28 antigen0.874
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.865
Il1binterleukin 1 beta0.856
Stat3signal transducer and activator of transcription 30.845
Bcl3B-cell leukemia/lymphoma 30.824
Hif1ahypoxia inducible factor 1, alpha subunit0.811
S100a6S100 calcium binding protein A6 (calcyclin)0.808
Cyldcylindromatosis (turban tumor syndrome)0.805
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.795
Pim1proviral integration site 10.791
Clec4dC-type lectin domain family 4, member d0.746
Ptenphosphatase and tensin homolog0.744
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.743
Tbk1TANK-binding kinase 10.732
Clec4eC-type lectin domain family 4, member e0.720
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.715
Cd14CD14 antigen0.698
Il10interleukin 100.679
Ifnginterferon gamma0.672
Casp12caspase 120.656
Nlrp3NLR family, pyrin domain containing 30.655
Il18rapinterleukin 18 receptor accessory protein0.650
Traf2TNF receptor-associated factor 20.649
Il7interleukin 70.617
Icosinducible T-cell co-stimulator0.613
Socs1suppressor of cytokine signaling 10.608
Chukconserved helix-loop-helix ubiquitous kinase0.606
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.571
Ptprcprotein tyrosine phosphatase, receptor type, C0.529
Ptk2PTK2 protein tyrosine kinase 20.526
Cxcl13chemokine (C-X-C motif) ligand 130.521
Fcgr2bFc receptor, IgG, low affinity IIb0.507
Zfp36zinc finger protein 360.506
Ifnar1interferon (alpha and beta) receptor 10.505
Irf1interferon regulatory factor 10.500
Il6interleukin 60.484
Il1rninterleukin 1 receptor antagonist0.480
Ccr6chemokine (C-C motif) receptor 60.479
Kiss1KiSS-1 metastasis-suppressor0.477
Sqstm1sequestosome 10.457
Ltblymphotoxin B0.453
Ccr1chemokine (C-C motif) receptor 10.447
Rnf31ring finger protein 310.442
Cd86CD86 antigen0.442
TcraT-cell receptor alpha chain0.438
Il2rginterleukin 2 receptor, gamma chain0.436
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.430
EdaraddEDAR (ectodysplasin-A receptor)-associated death domain0.413
Mavsmitochondrial antiviral signaling protein0.411
Clec4nC-type lectin domain family 4, member n0.409
Tnip1TNFAIP3 interacting protein 10.406
Traf3TNF receptor-associated factor 30.406
Csf1colony stimulating factor 1 (macrophage)0.405
Tlr2toll-like receptor 20.401
Slfn4schlafen 40.392
Unc93b1unc-93 homolog B1 (C. elegans)0.389
Il2rbinterleukin 2 receptor, beta chain0.382
Mvpmajor vault protein0.381
Ubcubiquitin C0.380
Notch1Notch gene homolog 1 (Drosophila)0.371
Cav1caveolin 1, caveolae protein0.363
Trim21tripartite motif-containing 210.357
Dok1docking protein 10.354
Gbp5guanylate binding protein 50.354
Cxcl2chemokine (C-X-C motif) ligand 20.352
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.350
Inpp5dinositol polyphosphate-5-phosphatase D0.347
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Parp9poly (ADP-ribose) polymerase family, member 90.034
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.032
Cdk4cyclin-dependent kinase 40.032
Tpm3tropomyosin 3, gamma0.029
Ccl4chemokine (C-C motif) ligand 40.029
Icam1intercellular adhesion molecule 10.025
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.023
Cxcl10chemokine (C-X-C motif) ligand 100.023
Il6interleukin 60.023
Cd86CD86 molecule0.020
Shisa5shisa homolog 5 (Xenopus laevis)0.020
Irf1interferon regulatory factor 10.019
Slfn2schlafen 20.019
Rad23bRAD23 homolog B (S. cerevisiae)0.019
Ccl2chemokine (C-C motif) ligand 20.018
Stat6signal transducer and activator of transcription 60.018
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.017
LOC100362108poly (ADP-ribose) polymerase family, member 100.017
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.016
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.016
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.016
LOC686326similar to Interferon-alpha/beta receptor beta chain precursor (IFN-alpha-REC) (Type I interferon receptor) (IFN-R) (Interferon alpha/beta receptor-2)0.015
Apol3apolipoprotein L, 30.015
Parp14poly (ADP-ribose) polymerase family, member 140.015
Il1binterleukin 1 beta0.015
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.015
Syngr2synaptogyrin 20.014
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.014
Hist1h1ahistone cluster 1, H1a0.014
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.014
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.014
Timp1TIMP metallopeptidase inhibitor 10.013
Usf2upstream transcription factor 2, c-fos interacting0.013
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.013
Mca32mast cell antigen 320.012
Gbp2guanylate binding protein 20.012
Stat3signal transducer and activator of transcription 30.012
Birc3baculoviral IAP repeat-containing 30.012
Il1ainterleukin 1 alpha0.012
Sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.012
Vdac1voltage-dependent anion channel 10.012
Svs3aseminal vesicle secretory protein 3A0.012
Papd5PAP associated domain containing 50.011
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.011
Dtx3ldeltex 3-like (Drosophila)0.011
Il2rginterleukin 2 receptor, gamma0.011
Notch1Notch homolog 1, translocation-associated (Drosophila)0.011
Myh9myosin, heavy chain 9, non-muscle0.011
Traf6Tnf receptor-associated factor 60.010
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.010
Cxcl2chemokine (C-X-C motif) ligand 20.010
Sp140SP140 nuclear body protein0.010
Igtpinterferon gamma induced GTPase0.010
Serinc5serine incorporator 50.010
Stat1signal transducer and activator of transcription 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism