The network for 'osteoclast development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

osteoclast development

The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

NameDescriptionProbabilityFunc Analog Organism
tie1endothelium-specific receptor tyrosine kinase 10.933
cdh5cadherin 50.901
sox7SRY-box containing gene 70.813
runx1runt-related transcription factor 10.803
kitakit receptor a0.680
mitfamicrophthalmia-associated transcription factor a0.665
cmybtranscription factor cmyb0.620
etv2ets variant gene 20.603
lcp1lymphocyte cytosolic plastin 10.504
tie2endothelium-specific receptor tyrosine kinase 20.311
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.297
gata1aGATA binding protein 1a0.296
trpm7transient receptor potential cation channel, subfamily M, member 70.288
csf1racolony stimulating factor 1 receptor, a0.280
tal1T-cell acute lymphocytic leukemia 10.256
tagln2transgelin 20.247
dll4delta-like 4 (Drosophila)0.238
kdrlkinase insert domain receptor like0.229
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.224
cyp1acytochrome P450, family 1, subfamily A0.206
flt4fms-related tyrosine kinase 40.196
fabp11afatty acid binding protein 11a0.166
fli1afriend leukemia integration 1a0.159
bnc2basonuclin 20.158
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.154
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.132
mmp9matrix metalloproteinase 90.127
slc45a2solute carrier family 45, member 20.106
dusp5dual specificity phosphatase 50.102
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.102
stab2stabilin 20.097
fras1Fraser syndrome 10.083
dab2disabled homolog 2 (Drosophila)0.077
mpxmyeloid-specific peroxidase0.076
prox1prospero-related homeobox gene 10.069
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.067
fanclFanconi anemia, complementation group L0.060
ltkleukocyte tyrosine kinase0.059
gpr182G protein-coupled receptor 1820.058
vegfaavascular endothelial growth factor Aa0.055
hbbe1.1hemoglobin beta embryonic-1.10.049
vegfcvascular endothelial growth factor c0.044
cdh23cadherin-like 230.043
calcrlacalcitonin receptor-like a0.043
pink1PTEN induced putative kinase 10.038
ntn4netrin 40.038
fli1bfriend leukemia integration 1b0.038
vsg1vessel-specific 10.038
aqp1a.1aquaporin 1a, tandem duplicate 10.036
agr2anterior gradient homolog 2 (Xenopus laevis)0.035
klf2aKruppel-like factor 2a0.035
tyrp1btyrosinase-related protein 1b0.034
pmelapremelanosome protein a0.033
dnm2dynamin 20.032
yrkYes-related kinase0.032
mapk3mitogen-activated protein kinase 30.032
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.032
tmem88atransmembrane protein 88 a0.030
s100v2S100 calcium binding protein V20.030
anxa1aannexin A1a0.030
ift88intraflagellar transport 88 homolog0.030
tgfb3transforming growth factor, beta 30.030
pnp4apurine nucleoside phosphorylase 4a0.030
mcambmelanoma cell adhesion molecule b0.029
mvpmajor vault protein0.029
efnb2aephrin B2a0.029
aqp8a.1aquaporin 8a, tandem duplicate 10.028
aplnrbapelin receptor b0.028
ndel1anudE nuclear distribution gene E homolog like 1 (A. nidulans) A0.028
st8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.027
gfi1.1growth factor independent 1.10.027
nrp1aneuropilin 1a0.026
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.026
ccbe1collagen and calcium binding EGF domains 10.026
fcho2FCH domain only 20.026
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.026
cldnbclaudin b0.025
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.025
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.024
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.024
bdnfbrain-derived neurotrophic factor0.024
ikzf1IKAROS family zinc finger 1 (Ikaros)0.023
tbx20T-box 200.023
epas1bendothelial PAS domain protein 1b0.023
gch2GTP cyclohydrolase 20.022
hspa12bheat shock protein 12B0.022
cntn2contactin 20.022
fevFEV (ETS oncogene family)0.022
ednrb1endothelin receptor B0.021
lmo2LIM domain only 2 (rhombotin-like 1)0.021
socs1suppressor of cytokine signaling 10.021
plxnd1plexin D10.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PILRApaired immunoglobin-like type 2 receptor alpha0.964
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.960
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.877
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.875
SMN1survival of motor neuron 1, telomeric0.832
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.731
ANXA1annexin A10.558
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.550
S100A10S100 calcium binding protein A100.437
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.291
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.240
FYNFYN oncogene related to SRC, FGR, YES0.214
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.151
PTAFRplatelet-activating factor receptor0.146
PDCD6programmed cell death 60.142
ANXA5annexin A50.129
SIGLEC7sialic acid binding Ig-like lectin 70.129
HCKhemopoietic cell kinase0.127
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.124
LCKlymphocyte-specific protein tyrosine kinase0.120
PTPN6protein tyrosine phosphatase, non-receptor type 60.120
NMT2N-myristoyltransferase 20.104
S100A11S100 calcium binding protein A110.102
HK3hexokinase 3 (white cell)0.084
FCN1ficolin (collagen/fibrinogen domain containing) 10.068
CD33CD33 molecule0.062
DOCK7dedicator of cytokinesis 70.061
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.055
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi10.054
PTK2PTK2 protein tyrosine kinase 20.053
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.048
GRB7growth factor receptor-bound protein 70.044
CD163CD163 molecule0.042
LGALS1lectin, galactoside-binding, soluble, 10.041
EXT2exostosin 20.041
LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 30.040
C1orf93chromosome 1 open reading frame 930.039
TMSB4Xthymosin beta 4, X-linked0.036
BBS10Bardet-Biedl syndrome 100.033
TSC22D1TSC22 domain family, member 10.033
BIN2bridging integrator 20.031
CYTH4cytohesin 40.030
ANXA2annexin A20.029
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.029
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.028
SIGLEC9sialic acid binding Ig-like lectin 90.027
NLRP3NLR family, pyrin domain containing 30.027
CCR1chemokine (C-C motif) receptor 10.027
TK1thymidine kinase 1, soluble0.026
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.025
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.025
TMSB10thymosin beta 100.024
LILRB4leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 40.024
LGALS3lectin, galactoside-binding, soluble, 30.024
CD63CD63 molecule0.024
TREM1triggering receptor expressed on myeloid cells 10.024
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.023
FPR2formyl peptide receptor 20.023
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.022
GDI1GDP dissociation inhibitor 10.022
LMO4LIM domain only 40.022
ALG2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)0.022
ITGB5integrin, beta 50.022
CYBBcytochrome b-245, beta polypeptide0.022
ANXA4annexin A40.022
ARF4ADP-ribosylation factor 40.021
SNX9sorting nexin 90.021
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.021
CMKLR1chemokine-like receptor 10.021
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.021
ZNF431zinc finger protein 4310.020
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.020
VSIG4V-set and immunoglobulin domain containing 40.020
FPR1formyl peptide receptor 10.020
APLP2amyloid beta (A4) precursor-like protein 20.020
TYMPthymidine phosphorylase0.020
EMR1egf-like module containing, mucin-like, hormone receptor-like 10.020
NPC2Niemann-Pick disease, type C20.020
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.020
CTSBcathepsin B0.020
C7orf64chromosome 7 open reading frame 640.019
MAP3K7mitogen-activated protein kinase kinase kinase 70.019
CD86CD86 molecule0.019
PACSIN3protein kinase C and casein kinase substrate in neurons 30.018
FN1fibronectin 10.018
CASP5caspase 5, apoptosis-related cysteine peptidase0.018
NOD2nucleotide-binding oligomerization domain containing 20.017
HEXBhexosaminidase B (beta polypeptide)0.017
ANXA3annexin A30.017
AOAHacyloxyacyl hydrolase (neutrophil)0.017
SIGLEC10sialic acid binding Ig-like lectin 100.017
EMP1epithelial membrane protein 10.017
GRAP2GRB2-related adaptor protein 20.017
CFPcomplement factor properdin0.017
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.017
PAFAH1B3platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)0.016
MS4A4Amembrane-spanning 4-domains, subfamily A, member 40.016
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.804
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.670
Csf1colony stimulating factor 1 (macrophage)0.554
Cd19CD19 antigen0.451
Map3k14mitogen-activated protein kinase kinase kinase 140.442
Ikzf1IKAROS family zinc finger 10.434
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.358
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.250
Ptprcprotein tyrosine phosphatase, receptor type, C0.234
Cd40CD40 antigen0.219
Ltblymphotoxin B0.217
Plcg2phospholipase C, gamma 20.172
Cd247CD247 antigen0.147
Ltalymphotoxin A0.105
Il2rginterleukin 2 receptor, gamma chain0.092
Ctskcathepsin K0.085
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.073
Il7interleukin 70.073
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.069
Prkceprotein kinase C, epsilon0.064
Grb2growth factor receptor bound protein 20.056
BlnkB-cell linker0.054
Pou2af1POU domain, class 2, associating factor 10.054
Fcgr2bFc receptor, IgG, low affinity IIb0.053
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.049
Csf1rcolony stimulating factor 1 receptor0.040
TyrobpTYRO protein tyrosine kinase binding protein0.039
Cxcr5chemokine (C-X-C motif) receptor 50.038
Il2rbinterleukin 2 receptor, beta chain0.036
Jak3Janus kinase 30.035
Hcsthematopoietic cell signal transducer0.033
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.029
Ifnginterferon gamma0.027
WasWiskott-Aldrich syndrome homolog (human)0.026
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.025
Il4interleukin 40.024
Klrk1killer cell lectin-like receptor subfamily K, member 10.024
CblCasitas B-lineage lymphoma0.022
FybFYN binding protein0.022
S100a10S100 calcium binding protein A10 (calpactin)0.022
Vdrvitamin D receptor0.020
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.020
Toxthymocyte selection-associated high mobility group box0.020
Clnkcytokine-dependent hematopoietic cell linker0.019
Ccr6chemokine (C-C motif) receptor 60.018
BtkBruton agammaglobulinemia tyrosine kinase0.018
Ighimmunoglobulin heavy chain complex0.018
Cd40lgCD40 ligand0.017
Cxcl13chemokine (C-X-C motif) ligand 130.017
AF251705cDNA sequence AF2517050.016
Inpp5dinositol polyphosphate-5-phosphatase D0.016
Il15interleukin 150.014
Cd96CD96 antigen0.014
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.014
Anxa1annexin A10.014
Ptpreprotein tyrosine phosphatase, receptor type, E0.013
Cd22CD22 antigen0.013
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.011
Fcgr1Fc receptor, IgG, high affinity I0.011
Il1binterleukin 1 beta0.011
Zap70zeta-chain (TCR) associated protein kinase0.011
Cd160CD160 antigen0.010
Ccl4chemokine (C-C motif) ligand 40.010
ItkIL2-inducible T-cell kinase0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism