The network for 'regulation of blood pressure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

NameDescriptionProbabilityFunc Analog Organism
smyhc2slow myosin heavy chain 20.407
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.338
jag1bjagged 1b0.325
mc5rbmelanocortin 5b receptor0.276
mc4rmelanocortin 4 receptor0.272
ddcdopa decarboxylase0.255
ryr2bryanodine receptor 2b (cardiac)0.249
adrb2aadrenergic receptor, beta 2a0.241
ret1receptor tyrosine kinase0.235
vipr2vasoactive intestinal peptide receptor 20.233
ros1v-ros UR2 sarcoma virus oncogene homolog 1 (avian)0.215
bhlhe40basic helix-loop-helix family, member e400.200
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.198
zgc:101614zgc:1016140.179
starsteroidogenic acute regulatory protein0.177
adrb2badrenergic receptor, beta 2b0.175
ckmacreatine kinase, muscle a0.173
gpiaglucose phosphate isomerase a0.170
mc2rmelanocortin 2 receptor0.168
aqp1a.1aquaporin 1a, tandem duplicate 10.167
drd2bdopamine receptor D2b0.160
smyhc1slow myosin heavy chain 10.158
LOC100003330melanocortin-2 receptor accessory protein 2-like0.158
aqp7aquaporin 70.158
cfdlcomplement factor D (adipsin) like0.150
selpselectin P0.150
atp6v1fATPase, H+ transporting, V1 subunit F0.150
wt1bwilms tumor 1b0.149
fgf13bfibroblast growth factor 13b0.148
tshbthyroid stimulating hormone, beta subunit0.147
tnnc1atroponin C type 1a (slow)0.142
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.140
acta1bactin, alpha 1b, skeletal muscle0.139
leprleptin receptor0.134
adra2cadrenergic, alpha-2C-, receptor0.131
epas1bendothelial PAS domain protein 1b0.128
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.126
smyhc3slow myosin heavy chain 30.124
cx36.7connexin 36.70.123
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.122
smchd1structural maintenance of chromosomes flexible hinge domain containing 10.121
gfra1agdnf family receptor alpha 1a0.120
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.118
drd2ldopamine receptor D2 like0.118
spg11spastic paraplegia 110.117
hbbe1.1hemoglobin beta embryonic-1.10.117
egfl6EGF-like-domain, multiple 60.114
spon1aspondin 1a0.112
lrrc50leucine rich repeat containing 500.111
trpv6transient receptor potential cation channel, subfamily V, member 60.109
nkx2.2bNK2 transcription factor related 2b0.109
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.105
ca2carbonic anhydrase II0.102
spon1bspondin 1b0.102
dbhdopamine beta hydroxylase0.101
ttnatitin a0.100
tnni1btroponin I, skeletal, slow b0.100
ccm2cerebral cavernous malformation 20.099
zgc:92217zgc:922170.098
anxa11aannexin A11a0.097
tnni1altroponin I, skeletal, slow like0.097
adra2badrenergic, alpha-2B-, receptor0.095
chrnb3bcholinergic receptor, nicotinic, beta polypeptide 3b0.094
uts1urotensin 10.093
cldnkclaudin k0.093
prph2aperipherin 2a (retinal degeneration, slow)0.091
si:dkey-8l13.4si:dkey-8l13.40.090
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.090
sst3somatostatin 30.089
mc1rmelanocortin 1 receptor0.089
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.088
tnnc1btroponin C type 1b (slow)0.088
nos1nitric oxide synthase 1 (neuronal)0.087
sim1asingle-minded homolog 1a (Drosophila)0.086
copebcore promoter element binding protein0.085
mt2metallothionein 20.085
emx3empty spiracles homeobox 30.082
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.081
myocmyocilin0.081
thtyrosine hydroxylase0.080
npc2Niemann-Pick disease, type C20.080
stab2stabilin 20.079
duoxdual oxidase0.079
etv2ets variant gene 20.077
nppanatriuretic peptide precursor A0.077
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.076
gfra2glial cell line derived neurotrophic factor family receptor alpha 20.073
ihhaIndian hedgehog homolog a0.072
thbs1thrombospondin 10.072
zgc:112056zgc:1120560.072
tnnt2atroponin T2a, cardiac0.071
cd248aCD248 molecule, endosialin a0.071
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.070
synpo2lbsynaptopodin 2-like b0.070
neurog3neurogenin 30.070
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.069
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.069
zgc:85746zgc:857460.068
spns2spinster homolog 2 (Drosophila)0.068
cpla2cytosolic phospholipase a20.067
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.963
ENGendoglin0.796
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.766
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.741
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 20.638
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 40.550
COL1A1collagen, type I, alpha 10.531
TGFB1transforming growth factor, beta 10.511
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.478
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.472
FKBP1AFK506 binding protein 1A, 12kDa0.468
ADORA2Aadenosine A2a receptor0.430
COL3A1collagen, type III, alpha 10.394
BMP2bone morphogenetic protein 20.393
HBBhemoglobin, beta0.375
AXLAXL receptor tyrosine kinase0.354
NOSTRINnitric oxide synthase trafficker0.345
RARAretinoic acid receptor, alpha0.313
COL4A1collagen, type IV, alpha 10.264
HNF4Ahepatocyte nuclear factor 4, alpha0.262
DDR2discoidin domain receptor tyrosine kinase 20.257
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.255
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.203
VAC14Vac14 homolog (S. cerevisiae)0.200
THBS1thrombospondin 10.195
PLCG1phospholipase C, gamma 10.186
COL1A2collagen, type I, alpha 20.185
C1QCcomplement component 1, q subcomponent, C chain0.176
CAV2caveolin 20.171
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.167
HBG2hemoglobin, gamma G0.162
IL8interleukin 80.159
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.145
PTPN1protein tyrosine phosphatase, non-receptor type 10.131
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.128
COL5A2collagen, type V, alpha 20.120
HIPK2homeodomain interacting protein kinase 20.119
NCF1neutrophil cytosolic factor 10.117
SMAD7SMAD family member 70.110
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.109
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.101
C1QBcomplement component 1, q subcomponent, B chain0.101
NCF4neutrophil cytosolic factor 4, 40kDa0.094
PRKCAprotein kinase C, alpha0.092
COL6A1collagen, type VI, alpha 10.091
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.090
NCOR2nuclear receptor corepressor 20.088
CXCL2chemokine (C-X-C motif) ligand 20.088
TGFB3transforming growth factor, beta 30.085
PAX8paired box 80.084
RXRAretinoid X receptor, alpha0.084
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.083
ARNTaryl hydrocarbon receptor nuclear translocator0.075
CAV1caveolin 1, caveolae protein, 22kDa0.073
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.071
COL5A1collagen, type V, alpha 10.070
GDF5growth differentiation factor 50.068
FSTL1follistatin-like 10.062
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.061
NAMPTnicotinamide phosphoribosyltransferase0.058
CYBAcytochrome b-245, alpha polypeptide0.058
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.053
GRB2growth factor receptor-bound protein 20.051
PRKG1protein kinase, cGMP-dependent, type I0.048
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.047
VEGFAvascular endothelial growth factor A0.046
PTENphosphatase and tensin homolog0.045
HRhairless homolog (mouse)0.043
BGNbiglycan0.042
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.039
GRNgranulin0.039
LAMP2lysosomal-associated membrane protein 20.039
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.038
SHC1SHC (Src homology 2 domain containing) transforming protein 10.038
TIMP3TIMP metallopeptidase inhibitor 30.037
ACVR1activin A receptor, type I0.036
TNFAIP6tumor necrosis factor, alpha-induced protein 60.036
LOXlysyl oxidase0.036
CXCL3chemokine (C-X-C motif) ligand 30.035
IGF1insulin-like growth factor 1 (somatomedin C)0.034
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.033
ZMYND11zinc finger, MYND-type containing 110.033
COL6A2collagen, type VI, alpha 20.032
SKILSKI-like oncogene0.031
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.031
GAAglucosidase, alpha; acid0.031
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.031
SDF2L1stromal cell-derived factor 2-like 10.030
DPYSL4dihydropyrimidinase-like 40.030
GLIS2GLIS family zinc finger 20.030
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.029
STAB1stabilin 10.029
NCOR1nuclear receptor corepressor 10.028
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.028
SH3BP2SH3-domain binding protein 20.028
EDN3endothelin 30.028
COL6A3collagen, type VI, alpha 30.028
BMPR1Abone morphogenetic protein receptor, type IA0.026
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.026
DKK1dickkopf homolog 1 (Xenopus laevis)0.026
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc12a1solute carrier family 12, member 10.997
Nos3nitric oxide synthase 3, endothelial cell0.995
Agtr1aangiotensin II receptor, type 1a0.994
Ren1renin 1 structural0.984
Esr1estrogen receptor 1 (alpha)0.958
Klklotho0.956
Ghrgrowth hormone receptor0.917
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.907
Tgfbr2transforming growth factor, beta receptor II0.895
Lepleptin0.890
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.822
Klk1b5kallikrein 1-related peptidase b50.814
Acvrl1activin A receptor, type II-like 10.806
Umoduromodulin0.805
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.803
Klk1b21kallikrein 1-related peptidase b210.791
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.780
Klk1b26kallikrein 1-related petidase b260.772
Htr75-hydroxytryptamine (serotonin) receptor 70.770
Agtr2angiotensin II receptor, type 20.769
Grxcr1glutaredoxin, cysteine rich 10.762
Leprleptin receptor0.742
Drd2dopamine receptor D20.740
Npy1rneuropeptide Y receptor Y10.706
Tgthyroglobulin0.700
Mas1MAS1 oncogene0.700
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.692
Ush1cUsher syndrome 1C homolog (human)0.674
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.664
Crhr1corticotropin releasing hormone receptor 10.650
Nos2nitric oxide synthase 2, inducible0.647
Arandrogen receptor0.646
Id3inhibitor of DNA binding 30.637
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.595
Pcdh15protocadherin 150.565
Cnn1calponin 10.562
Cdh23cadherin 23 (otocadherin)0.558
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.557
Fbn1fibrillin 10.556
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.556
Klk1b11kallikrein 1-related peptidase b110.545
Cacna1dcalcium channel, voltage-dependent, L type, alpha 1D subunit0.529
Ptpn11protein tyrosine phosphatase, non-receptor type 110.526
Oprm1opioid receptor, mu 10.521
Pnpla2patatin-like phospholipase domain containing 20.514
Crhr2corticotropin releasing hormone receptor 20.508
Cckbrcholecystokinin B receptor0.507
Hsd3b4hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 40.505
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.503
G6pcglucose-6-phosphatase, catalytic0.488
Ctrb1chymotrypsinogen B10.486
Kcnk4potassium channel, subfamily K, member 40.466
Cela2achymotrypsin-like elastase family, member 2A0.461
Ush1gUsher syndrome 1G homolog (human)0.457
Prima1proline rich membrane anchor 10.446
Cma1chymase 1, mast cell0.441
Mesp1mesoderm posterior 10.439
Id1inhibitor of DNA binding 10.438
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.426
Calcacalcitonin/calcitonin-related polypeptide, alpha0.426
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.420
Myl9myosin, light polypeptide 9, regulatory0.419
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.411
Taglntransgelin0.403
Mpzmyelin protein zero0.394
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.387
Thrbthyroid hormone receptor beta0.387
Prss3protease, serine, 30.381
Ednrbendothelin receptor type B0.377
Klk1b27kallikrein 1-related peptidase b270.374
Gnrh1gonadotropin releasing hormone 10.374
Slc16a8solute carrier family 16 (monocarboxylic acid transporters), member 80.369
Bmpr1abone morphogenetic protein receptor, type 1A0.369
Adrb1adrenergic receptor, beta 10.363
U46068cDNA sequence U460680.361
Tacr1tachykinin receptor 10.361
Nos1nitric oxide synthase 1, neuronal0.357
Apoeapolipoprotein E0.352
Mc5rmelanocortin 5 receptor0.351
Tgfb1transforming growth factor, beta 10.350
Klk4kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)0.346
Sstr1somatostatin receptor 10.340
Fzd4frizzled homolog 4 (Drosophila)0.339
Srrm4serine/arginine repetitive matrix 40.337
Cx3cr1chemokine (C-X3-C) receptor 10.336
Nt5e5' nucleotidase, ecto0.334
Neurog3neurogenin 30.333
Pgrprogesterone receptor0.332
Klk1b8kallikrein 1-related peptidase b80.331
Ntsr1neurotensin receptor 10.330
Mbmyoglobin0.327
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.325
Chrngcholinergic receptor, nicotinic, gamma polypeptide0.325
Kiss1KiSS-1 metastasis-suppressor0.323
2210010C04RikRIKEN cDNA 2210010C04 gene0.320
Svaseminal vesicle antigen0.319
Adam17a disintegrin and metallopeptidase domain 170.319
Actc1actin, alpha, cardiac muscle 10.316
S1pr2sphingosine-1-phosphate receptor 20.313
Hbb-b1hemoglobin, beta adult major chain0.310
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Htr75-hydroxytryptamine (serotonin) receptor 70.726
LOC689064beta-globin0.659
Hbbhemoglobin, beta0.536
Alas2aminolevulinate, delta-, synthase 20.516
Folh1folate hydrolase 10.515
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.494
Il4interleukin 40.461
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.448
Tpbpatrophoblast specific protein alpha0.424
LOC100134871beta globin minor gene0.408
Oxtroxytocin receptor0.401
Lifleukemia inhibitory factor0.380
Galgalanin prepropeptide0.361
Fgf2fibroblast growth factor 20.355
Drd1adopamine receptor D1A0.346
Cmklr1chemokine-like receptor 10.310
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.303
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.292
Agtr2angiotensin II receptor, type 20.285
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.283
Insl3insulin-like 30.267
Hbb-b1hemoglobin, beta adult major chain0.267
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.254
LOC287167globin, alpha0.252
Lim2lens intrinsic membrane protein 20.251
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.240
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.237
Calcacalcitonin-related polypeptide alpha0.226
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.224
Olr287olfactory receptor 2870.223
Akr1c18aldo-keto reductase family 1, member C180.220
Apoa5apolipoprotein A-V0.216
Sstsomatostatin0.215
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.215
Slc9a3solute carrier family 9 (sodium/hydrogen exchanger), member 30.211
LOC60591calcium-activated potassium channel beta subunit0.210
Pnlippancreatic lipase0.209
Pla2g5phospholipase A2, group V0.204
Ednraendothelin receptor type A0.201
Trhthyrotropin releasing hormone0.199
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.198
Nrp2neuropilin 20.196
Ptgfrprostaglandin F receptor0.194
Ghrhgrowth hormone releasing hormone0.192
Chrm2cholinergic receptor, muscarinic 20.192
Ppypancreatic polypeptide0.188
Foxi2forkhead box I20.186
Slc4a1solute carrier family 4 (anion exchanger), member 10.183
Mmp9matrix metallopeptidase 90.179
Gata1GATA binding protein 10.175
Hba-a2hemoglobin alpha, adult chain 20.174
Gpr6G protein-coupled receptor 60.168
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.167
Adora2aadenosine A2a receptor0.167
Ptafrplatelet-activating factor receptor0.166
MrgprfMAS-related GPR, member F0.165
Crybb1crystallin, beta B10.165
Tacr2tachykinin receptor 20.164
Olr1082olfactory receptor 10820.164
Olr416olfactory receptor 4160.163
Sisucrase-isomaltase (alpha-glucosidase)0.163
Aqp2aquaporin 2 (collecting duct)0.162
Hrh2histamine receptor H 20.157
Il1rninterleukin 1 receptor antagonist0.156
Chrna7cholinergic receptor, nicotinic, alpha 70.156
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.153
Drd2dopamine receptor D20.146
Cckarcholecystokinin A receptor0.146
Chrna9cholinergic receptor, nicotinic, alpha 90.146
Nos3nitric oxide synthase 3, endothelial cell0.143
Itgamintegrin, alpha M0.143
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.142
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.142
Adra1aadrenergic, alpha-1A-, receptor0.141
Elnelastin0.139
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.136
Apoa4apolipoprotein A-IV0.136
Tff1trefoil factor 10.133
Fgf14fibroblast growth factor 140.131
Ucnurocortin0.130
Cntn5contactin 50.129
Lepleptin0.128
Acot12acyl-CoA thioesterase 120.124
Sox13SRY (sex determining region Y)-box 130.122
Crhr2corticotropin releasing hormone receptor 20.122
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.122
Trhr2thyrotropin releasing hormone receptor 20.121
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.118
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.117
Bdkrb2bradykinin receptor B20.116
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.116
Hcrthypocretin0.115
Gja5gap junction protein, alpha 50.114
Nmuneuromedin U0.114
Hrh3histamine receptor H30.113
Mef2dmyocyte enhancer factor 2D0.113
Slc22a8solute carrier family 22 (organic anion transporter), member 80.112
Cdh6cadherin 60.111
Clec4fC-type lectin domain family 4, member f0.110
Ghrlghrelin/obestatin prepropeptide0.109
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism