The network for 'negative regulation of gene silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of gene silencing

Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.

NameDescriptionProbabilityFunc Analog Organism
pcnaproliferating cell nuclear antigen0.036
nanos3nanos homolog 30.031
bucbucky ball0.028
otulOTU like protein0.020
rrm1ribonucleotide reductase M1 polypeptide0.017
dnmt7DNA (cytosine-5-)-methyltransferase 70.016
zgc:113210zgc:1132100.015
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.015
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.015
si:ch1073-351m12.1si:ch1073-351m12.10.014
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.013
vasavasa homolog0.013
ppp1cblprotein phosphatase 1, catalytic subunit, beta isoform, like0.012
piwil1piwi-like 1 (Drosophila)0.012
sybusyntabulin (syntaxin-interacting)0.011
tdrd7tudor domain containing 70.010
msh2mutS homolog 2 (E. coli)0.010
ca15bcarbonic anhydrase XV b0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SP1Sp1 transcription factor0.090
SMAD4SMAD family member 40.079
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.051
NCOR1nuclear receptor corepressor 10.031
PBRM1polybromo 10.030
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.030
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.028
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.026
MBD1methyl-CpG binding domain protein 10.016
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.013
EP300E1A binding protein p3000.013
ARID1AAT rich interactive domain 1A (SWI-like)0.012
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.011
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.011
WWP2WW domain containing E3 ubiquitin protein ligase 20.011
BCORBCL6 corepressor0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sall4sal-like 4 (Drosophila)0.914
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.569
Arid1aAT rich interactive domain 1A (SWI-like)0.562
NanogNanog homeobox0.403
Hdac1histone deacetylase 10.227
Tcfcp2l1transcription factor CP2-like 10.217
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.142
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.085
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.078
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.077
Ncor1nuclear receptor co-repressor 10.066
Kdm5blysine (K)-specific demethylase 5B0.066
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.064
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.062
Sp1trans-acting transcription factor 10.058
Pldnpallidin0.058
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.056
Hist1h2bchistone cluster 1, H2bc0.055
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.051
Sh3gl2SH3-domain GRB2-like 20.049
Brd4bromodomain containing 40.044
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.042
Rnf220ring finger protein 2200.040
Sap25sin3 associated polypeptide0.040
Cdk2cyclin-dependent kinase 20.038
Ep300E1A binding protein p3000.035
Lig1ligase I, DNA, ATP-dependent0.032
Dnmt1DNA methyltransferase (cytosine-5) 10.032
Sox2SRY-box containing gene 20.031
Baz2abromodomain adjacent to zinc finger domain, 2A0.030
Mta1metastasis associated 10.029
Hdac2histone deacetylase 20.029
Pld3phospholipase D family, member 30.029
Ep400E1A binding protein p4000.027
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.027
Nr0b1nuclear receptor subfamily 0, group B, member 10.027
Trp53transformation related protein 530.026
Cdt1chromatin licensing and DNA replication factor 10.026
Timelesstimeless homolog (Drosophila)0.026
Mutedmuted0.025
Esrrbestrogen related receptor, beta0.025
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.024
Kdm2blysine (K)-specific demethylase 2B0.024
Cnot6CCR4-NOT transcription complex, subunit 60.023
Rcor1REST corepressor 10.023
Pou2f1POU domain, class 2, transcription factor 10.023
Bod1lbiorientation of chromosomes in cell division 1-like0.023
BlnkB-cell linker0.022
Rad21RAD21 homolog (S. pombe)0.022
Gatad2aGATA zinc finger domain containing 2A0.022
Gtf3c2general transcription factor IIIC, polypeptide 2, beta0.022
Ccna2cyclin A20.022
Chd4chromodomain helicase DNA binding protein 40.022
Actn4actinin alpha 40.022
Sall3sal-like 3 (Drosophila)0.021
Pias1protein inhibitor of activated STAT 10.021
Asxl1additional sex combs like 1 (Drosophila)0.021
Foxp1forkhead box P10.021
Parp14poly (ADP-ribose) polymerase family, member 140.021
Rrm1ribonucleotide reductase M10.020
Sall1sal-like 1 (Drosophila)0.020
2210018M11RikRIKEN cDNA 2210018M11 gene0.020
Zfp42zinc finger protein 420.020
Pmlpromyelocytic leukemia0.020
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.020
CrebbpCREB binding protein0.019
Arid3bAT rich interactive domain 3B (BRIGHT-like)0.019
Nischnischarin0.019
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.019
Tcf3transcription factor 30.019
Phf12PHD finger protein 120.019
Dync1i1dynein cytoplasmic 1 intermediate chain 10.019
Numa1nuclear mitotic apparatus protein 10.018
Cabin1calcineurin binding protein 10.018
Tnrc6atrinucleotide repeat containing 6a0.018
Hcfc1host cell factor C10.018
Tet1tet oncogene 10.018
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.018
Myst2MYST histone acetyltransferase 20.018
Pum2pumilio 2 (Drosophila)0.018
Smad4MAD homolog 4 (Drosophila)0.017
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.017
Tcte2t-complex-associated testis expressed 20.017
NipblNipped-B homolog (Drosophila)0.017
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.017
Rfc5replication factor C (activator 1) 50.017
Yy1YY1 transcription factor0.017
Tk1thymidine kinase 10.017
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.017
Ammecr1lAMME chromosomal region gene 1-like0.017
Ccne1cyclin E10.017
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.017
Gabarapgamma-aminobutyric acid receptor associated protein0.017
Sycp1synaptonemal complex protein 10.017
Flot1flotillin 10.016
Lystlysosomal trafficking regulator0.016
Prkd3protein kinase D30.016
Actn3actinin alpha 30.016
Maml1mastermind like 1 (Drosophila)0.016
Naa11N(alpha)-acetyltransferase 11, NatA catalytic subunit0.016
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CTI6Cti6p0.831
SIN3Sin3p0.735
PHO23Pho23p0.616
RXT2Rxt2p0.536
UME1Ume1p0.482
RPD3Rpd3p0.431
RNR2Rnr2p0.406
SAP30Sap30p0.318
SDS3Sds3p0.284
NTO1Nto1p0.280
FKH2Fkh2p0.254
CDC6Cdc6p0.230
SUM1Sum1p0.215
MIG2Mig2p0.214
HHT1Hht1p0.197
HOS3Hos3p0.188
SIR2Sir2p0.175
SET3Set3p0.174
UME6Ume6p0.132
EAF3Eaf3p0.127
RCO1Rco1p0.122
AFT1Aft1p0.120
HHO1Hho1p0.120
ROX1Rox1p0.119
ASH1Ash1p0.113
SWI1Swi1p0.109
MIG1Mig1p0.100
HOS4Hos4p0.094
SLX8Slx8p0.088
ZAP1Zap1p0.086
SNT1Snt1p0.082
RAP1Rap1p0.081
MCM3Mcm3p0.079
DEF1Def1p0.077
MMS21Mms21p0.074
HXT3Hxt3p0.073
KIC1Kic1p0.071
YKR075Chypothetical protein0.070
MIG3Mig3p0.068
YML082Whypothetical protein0.068
AGP2Agp2p0.066
NRG1Nrg1p0.066
SLX5Slx5p0.065
SIR4Sir4p0.061
IRA2Ira2p0.059
HHF2Hhf2p0.058
SAN1San1p0.057
YLR455Whypothetical protein0.053
RAD51Rad51p0.051
IXR1Ixr1p0.051
YGR126Whypothetical protein0.048
YKU70Yku70p0.048
HOS2Hos2p0.048
YLR278Chypothetical protein0.047
LYS5Lys5p0.046
HAL5Hal5p0.046
RXT3Rxt3p0.044
YOR390Whypothetical protein0.044
OPI1Opi1p0.044
CAT8Cat8p0.041
STE7Ste7p0.040
SRP54Srp54p0.039
SIW14Siw14p0.039
RGT1Rgt1p0.038
HOHop0.038
HDA3Hda3p0.037
TYW1Tyw1p0.037
DOT6Dot6p0.036
STH1Sth1p0.036
HIR2Hir2p0.036
YMR259Chypothetical protein0.036
SFL1Sfl1p0.035
MPT5Mpt5p0.034
TRA1Tra1p0.034
YDL156Whypothetical protein0.034
YCL042Whypothetical protein0.034
NDD1Ndd1p0.033
ATG15Atg15p0.033
DED1Ded1p0.033
HDA2Hda2p0.033
UBP8Ubp8p0.033
TBS1Tbs1p0.032
IFH1Ifh1p0.031
YKL187Chypothetical protein0.031
HMO1Hmo1p0.030
MOT1Mot1p0.029
SNA4Sna4p0.029
RMA1Rma1p0.028
GAT2Gat2p0.028
GCR2Gcr2p0.028
ARP8Arp8p0.027
NFI1Nfi1p0.027
MET28Met28p0.027
GIC1Gic1p0.026
DEP1Dep1p0.026
IRC23Irc23p0.026
POG1Pog1p0.026
NUP1Nup1p0.026
HXT1Hxt1p0.025
RTF1Rtf1p0.025