The network for 'regulation of cardiac muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cardiac muscle contraction

Any process that modulates the frequency, rate or extent of cardiac muscle contraction.

NameDescriptionProbabilityFunc Analog Organism
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.311
tnnt2atroponin T2a, cardiac0.292
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.286
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.248
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.194
hspb1heat shock protein, alpha-crystallin-related, 10.191
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.161
bonbonnie and clyde0.159
atp2b1aATPase, Ca++ transporting, plasma membrane 1a0.152
unc45bunc-45 homolog B (C. elegans)0.120
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.110
sdprbserum deprivation response b0.105
xirp1xin actin-binding repeat containing 10.103
tp53tumor protein p530.102
fhlafour and a half LIM domains a0.093
cmlc1cardiac myosin light chain-10.093
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.092
agr2anterior gradient homolog 2 (Xenopus laevis)0.085
actc1aactin, alpha, cardiac muscle 1a0.078
adrb2aadrenergic receptor, beta 2a0.074
vmhclventricular myosin heavy chain-like0.070
ckmacreatine kinase, muscle a0.061
mybpc3myosin binding protein C, cardiac0.060
lamb2laminin, beta 2 (laminin S)0.058
rbm24aRNA binding motif protein 24a0.057
cldnhclaudin h0.056
ldb3aLIM-domain binding factor 3a0.055
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.052
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.048
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.047
pkm2apyruvate kinase, muscle, a0.047
btg1B-cell translocation gene 10.044
eya4eyes absent homolog 4 (Drosophila)0.041
flot1bflotillin 1b0.041
adrb2badrenergic receptor, beta 2b0.039
cldnbclaudin b0.039
ldb3bLIM domain binding 3b0.039
fabp11afatty acid binding protein 11a0.038
ttc25tetratricopeptide repeat domain 250.038
mitfamicrophthalmia-associated transcription factor a0.038
mstnamyostatin a0.038
prkceaprotein kinase C, epsilon a0.037
aldoaaaldolase a, fructose-bisphosphate, a0.036
sps2selenophosphate synthetase 20.035
vmhcventricular myosin heavy chain0.035
gpx1bglutathione peroxidase 1b0.035
dnajaDnaJ (Hsp40) homolog, subfamily A member0.035
slc24a5solute carrier family 24, member 50.035
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.034
bcl2l1bcl2-like 10.034
synpo2lbsynaptopodin 2-like b0.033
appbamyloid beta (A4) precursor protein b0.032
ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.032
tnnc1atroponin C type 1a (slow)0.031
hk1hexokinase 10.031
hmgb3ahigh-mobility group box 3a0.031
trpm7transient receptor potential cation channel, subfamily M, member 70.031
pvalb8parvalbumin 80.030
cav3caveolin 30.030
eef2l2eukaryotic translation elongation factor 2, like 20.029
rbm24bRNA binding motif protein 24b0.029
scn4absodium channel, voltage-gated, type IV, alpha, b0.029
tnni1btroponin I, skeletal, slow b0.028
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.028
ctnnb1catenin (cadherin-associated protein), beta 10.028
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.028
pprc1peroxisome proliferator-activated receptor gamma, coactivator-related 10.028
id2binhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b0.027
tnnc1btroponin C type 1b (slow)0.027
tfectranscription factor EC0.027
kif5bbkinesin family member 5B, b0.027
arf1ADP-ribosylation factor 10.027
muskmuscle, skeletal, receptor tyrosine kinase0.026
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.026
ypel1yippee-like 1 (Drosophila)0.026
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.026
dlx4adistal-less homeobox gene 4a0.026
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.026
papss2b3'-phosphoadenosine 5'-phosphosulfate synthase 2b0.025
myl7myosin, light polypeptide 7, regulatory0.025
cxcl14chemokine (C-X-C motif) ligand 140.025
scn4basodium channel, voltage-gated, type IV, beta a0.025
aldoabaldolase a, fructose-bisphosphate, b0.025
ttnatitin a0.025
actn2actinin, alpha 20.025
pmelapremelanosome protein a0.025
ttnbtitin b0.025
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.996
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.996
KCNE1potassium voltage-gated channel, Isk-related family, member 10.991
MPZL2myelin protein zero-like 20.986
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.984
ACTN2actinin, alpha 20.963
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.957
SCN5Asodium channel, voltage-gated, type V, alpha subunit0.952
KCNIP2Kv channel interacting protein 20.948
TBX5T-box 50.946
DTNAdystrobrevin, alpha0.943
MPZL3myelin protein zero-like 30.936
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.910
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.908
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.902
PKP3plakophilin 30.899
JUPjunction plakoglobin0.831
PSEN1presenilin 10.785
SNTG2syntrophin, gamma 20.780
LIN7Blin-7 homolog B (C. elegans)0.742
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.687
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.629
SPTBspectrin, beta, erythrocytic0.604
MAPK12mitogen-activated protein kinase 120.586
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.581
DSC2desmocollin 20.576
CDH3cadherin 3, type 1, P-cadherin (placental)0.501
DSG2desmoglein 20.381
KRT14keratin 140.354
CLCN3chloride channel 30.320
PKD1polycystic kidney disease 1 (autosomal dominant)0.281
BMPR1Bbone morphogenetic protein receptor, type IB0.278
KRT8keratin 80.272
MYOZ1myozenin 10.253
TRIM29tripartite motif containing 290.246
MARK3MAP/microtubule affinity-regulating kinase 30.222
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.219
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.216
PSEN2presenilin 2 (Alzheimer disease 4)0.211
CTNND1catenin (cadherin-associated protein), delta 10.203
MAPK4mitogen-activated protein kinase 40.192
PDCD6programmed cell death 60.183
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.181
GLE1GLE1 RNA export mediator homolog (yeast)0.174
KRT5keratin 50.172
LAD1ladinin 10.172
CTNNBIP1catenin, beta interacting protein 10.164
MEF2Amyocyte enhancer factor 2A0.159
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.149
ADAM11ADAM metallopeptidase domain 110.145
KCNIP1Kv channel interacting protein 10.143
PTPRJprotein tyrosine phosphatase, receptor type, J0.141
PKP2plakophilin 20.140
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.134
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.129
FRMD5FERM domain containing 50.128
OPRD1opioid receptor, delta 10.111
HRH3histamine receptor H30.110
DSG3desmoglein 30.109
KRT18keratin 180.108
KCNB2potassium voltage-gated channel, Shab-related subfamily, member 20.107
DSG1desmoglein 10.107
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.107
HRChistidine rich calcium binding protein0.103
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.095
MYBPC2myosin binding protein C, fast type0.095
NR4A3nuclear receptor subfamily 4, group A, member 30.094
LDB3LIM domain binding 30.092
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.090
GJB3gap junction protein, beta 3, 31kDa0.087
ERBB2IPerbb2 interacting protein0.087
PDZK1PDZ domain containing 10.086
TNNI1troponin I type 1 (skeletal, slow)0.086
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.086
DTNBdystrobrevin, beta0.085
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.083
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.083
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.083
CDH15cadherin 15, type 1, M-cadherin (myotubule)0.080
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.078
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.077
RHAGRh-associated glycoprotein0.075
ACTN3actinin, alpha 30.072
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.069
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.069
SOX7SRY (sex determining region Y)-box 70.066
MYH7myosin, heavy chain 7, cardiac muscle, beta0.066
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.065
FLNBfilamin B, beta0.065
RYR2ryanodine receptor 2 (cardiac)0.064
ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome0.063
TRAPPC1trafficking protein particle complex 10.063
CDH4cadherin 4, type 1, R-cadherin (retinal)0.062
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Ryr2ryanodine receptor 2, cardiac0.997
Scn5asodium channel, voltage-gated, type V, alpha0.996
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.974
Mef2dmyocyte enhancer factor 2D0.971
Tbx5T-box 50.952
Smad4MAD homolog 4 (Drosophila)0.843
Gja1gap junction protein, alpha 10.839
Gata4GATA binding protein 40.757
Hand2heart and neural crest derivatives expressed transcript 20.744
Kcnk3potassium channel, subfamily K, member 30.721
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.680
Ldb3LIM domain binding 30.628
Smad1MAD homolog 1 (Drosophila)0.602
Pthlhparathyroid hormone-like peptide0.572
Mef2cmyocyte enhancer factor 2C0.572
Gata6GATA binding protein 60.516
Mybpc3myosin binding protein C, cardiac0.491
Erbb2ipErbb2 interacting protein0.467
Axin1axin 10.385
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.385
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.352
Tbx3T-box 30.331
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.299
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.293
Xirp1xin actin-binding repeat containing 10.269
Cckbrcholecystokinin B receptor0.269
Smad3MAD homolog 3 (Drosophila)0.258
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.256
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.253
Tjp1tight junction protein 10.251
Gja5gap junction protein, alpha 50.250
Sox9SRY-box containing gene 90.243
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.227
Hey2hairy/enhancer-of-split related with YRPW motif 20.210
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.203
Pcdh12protocadherin 120.197
Rnf112ring finger protein 1120.194
Myom2myomesin 20.188
Zfpm2zinc finger protein, multitype 20.185
Abcc9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.169
Gli2GLI-Kruppel family member GLI20.160
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.154
Casq2calsequestrin 20.150
Pygmmuscle glycogen phosphorylase0.149
Dtnadystrobrevin alpha0.142
Epas1endothelial PAS domain protein 10.142
Bmpr1abone morphogenetic protein receptor, type 1A0.138
Dmpkdystrophia myotonica-protein kinase0.137
Prox1prospero-related homeobox 10.135
Srpk3serine/arginine-rich protein specific kinase 30.126
Cdh13cadherin 130.126
Myl3myosin, light polypeptide 30.125
Phkg1phosphorylase kinase gamma 10.121
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.120
Cox8bcytochrome c oxidase, subunit VIIIb0.113
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.112
Hrchistidine rich calcium binding protein0.108
Hand1heart and neural crest derivatives expressed transcript 10.108
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.107
Dag1dystroglycan 10.104
Hspb7heat shock protein family, member 7 (cardiovascular)0.104
DarcDuffy blood group, chemokine receptor0.100
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.100
Rgs8regulator of G-protein signaling 80.099
Hspa8heat shock protein 80.098
Tcf15transcription factor 150.096
Dmddystrophin, muscular dystrophy0.095
Oprd1opioid receptor, delta 10.094
Tnni2troponin I, skeletal, fast 20.093
Actn2actinin alpha 20.093
Rgs5regulator of G-protein signaling 50.089
Nkx6-1NK6 homeobox 10.086
Adra1badrenergic receptor, alpha 1b0.084
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.084
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.083
Lama2laminin, alpha 20.083
Smurf1SMAD specific E3 ubiquitin protein ligase 10.082
Sstr3somatostatin receptor 30.081
Klk6kallikrein related-peptidase 60.079
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.079
Tgfb2transforming growth factor, beta 20.079
Mmp15matrix metallopeptidase 150.078
Rtn2reticulon 2 (Z-band associated protein)0.077
Cntn4contactin 40.076
Rgs6regulator of G-protein signaling 60.076
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.075
Zfp385azinc finger protein 385A0.075
Prkg1protein kinase, cGMP-dependent, type I0.072
Ckmt2creatine kinase, mitochondrial 20.071
Cux2cut-like homeobox 20.068
Itga7integrin alpha 70.068
Sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.067
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.066
Mobpmyelin-associated oligodendrocytic basic protein0.066
Dnajb5DnaJ (Hsp40) homolog, subfamily B, member 50.065
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hspa8heat shock protein 80.966
Hsph1heat shock 105/110 protein 10.878
Scn5asodium channel, voltage-gated, type V, alpha subunit0.856
LOC100362824caveolin 2-like0.792
Stip1stress-induced phosphoprotein 10.602
Hspd1heat shock protein 1 (chaperonin)0.596
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.524
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.395
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.364
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.356
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.208
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.193
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.191
Ednraendothelin receptor type A0.185
Mchr1melanin-concentrating hormone receptor 10.175
Ncr1natural cytotoxicity triggering receptor 10.158
Lrrc4bleucine rich repeat containing 4B0.153
Fitm1fat storage-inducing transmembrane protein 10.144
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.144
Fgf16fibroblast growth factor 160.138
Appamyloid beta (A4) precursor protein0.136
Fgf7fibroblast growth factor 70.126
Lim2lens intrinsic membrane protein 20.123
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.122
Casq2calsequestrin 2 (cardiac muscle)0.113
Arandrogen receptor0.111
RGD1564327similar to integrin alpha 80.101
Nptxrneuronal pentraxin receptor0.098
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.094
Prdm2PR domain containing 2, with ZNF domain0.091
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.087
Fgf14fibroblast growth factor 140.085
RGD1308165similar to hypothetical protein MGC173370.084
Nos3nitric oxide synthase 3, endothelial cell0.083
Ank2ankyrin 2, neuronal0.081
Grik3glutamate receptor, ionotropic, kainate 30.080
Figfc-fos induced growth factor0.079
Lrrc10leucine-rich repeat-containing 100.077
Adra1aadrenergic, alpha-1A-, receptor0.073
Chrm2cholinergic receptor, muscarinic 20.073
Adora1adenosine A1 receptor0.072
Gja3gap junction protein, alpha 30.070
Foxe1forkhead box E1 (thyroid transcription factor 2)0.069
Prkcgprotein kinase C, gamma0.069
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.067
Inhainhibin alpha0.065
Myl7myosin, light chain 7, regulatory0.062
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.059
Cdh17cadherin 170.056
Myl1myosin, light chain 10.056
Epn3epsin 30.055
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.054
Gad2glutamate decarboxylase 20.053
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.052
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.052
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.051
Vom1r102vomeronasal 1 receptor 1020.049
Csrp3cysteine and glycine-rich protein 30.048
Hoxd9homeo box D90.047
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.047
Tnni1troponin I type 1 (skeletal, slow)0.047
RGD1309036hypothetical LOC2928740.047
Olr416olfactory receptor 4160.047
Pde5aphosphodiesterase 5A, cGMP-specific0.047
Hprt1hypoxanthine phosphoribosyltransferase 10.046
Glg1golgi apparatus protein 10.046
Dock8dedicator of cytokinesis 80.044
Eef2eukaryotic translation elongation factor 20.044
Clec11aC-type lectin domain family 11, member a0.043
Col8a1collagen, type VIII, alpha 10.043
Ckmcreatine kinase, muscle0.043
Rgs8regulator of G-protein signaling 80.042
Cx3cr1chemokine (C-X3-C motif) receptor 10.042
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.041
Kcnk3potassium channel, subfamily K, member 30.041
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.040
Ptgdrprostaglandin D receptor0.040
Cmklr1chemokine-like receptor 10.040
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.039
Hhatlhedgehog acyltransferase-like0.039
Rpl3lribosomal protein L3-like0.039
Sctrsecretin receptor0.039
Aif1lallograft inflammatory factor 1-like0.038
Strnstriatin, calmodulin binding protein0.038
Scn2bsodium channel, voltage-gated, type II, beta0.037
Dpysl3dihydropyrimidinase-like 30.037
Chrm5cholinergic receptor, muscarinic 50.036
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.036
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.036
Gzmkgranzyme K0.036
Tpsb2tryptase beta 20.035
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.035
Wt1Wilms tumor 10.034
Muskmuscle, skeletal, receptor tyrosine kinase0.034
Pla2g5phospholipase A2, group V0.034
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.033
Nr2c2nuclear receptor subfamily 2, group C, member 20.033
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism