The network for 'mesenchyme development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesenchyme development

The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.988
foxa3forkhead box A30.988
tbx1T-box 10.979
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.971
tgfb3transforming growth factor, beta 30.964
cdx4caudal type homeo box transcription factor 40.964
myod1myogenic differentiation 10.962
col15a1bcollagen, type XV, alpha 1b0.954
foxi1forkhead box I10.936
mibmind bomb0.929
aldh1a2aldehyde dehydrogenase 1 family, member A20.923
pax6bpaired box gene 6b0.900
bmp4bone morphogenetic protein 40.884
wnt11wingless-type MMTV integration site family, member 110.883
fgf10afibroblast growth factor 10a0.882
notch1anotch homolog 1a0.878
mecomMDS1 and EVI1 complex locus0.876
six3bsine oculis homeobox homolog 3b0.857
notch2notch homolog 20.851
fn1fibronectin 10.843
jag1bjagged 1b0.841
kdrlkinase insert domain receptor like0.830
oepone-eyed pinhead0.818
rargaretinoic acid receptor gamma a0.807
her1hairy-related 10.796
shhasonic hedgehog a0.747
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.722
pcdh18bprotocadherin 18b0.721
epb4.1l4erythrocyte protein band 4.1-like 40.718
raraaretinoic acid receptor, alpha a0.713
emx3empty spiracles homeobox 30.711
her7hairy and enhancer of split related-70.682
sox2SRY-box containing gene 20.675
lef1lymphocyte enhancer binding factor 10.667
six3asine oculis homeobox homolog 3a0.655
eya1eyes absent homolog 10.635
zic5zic family member 5 (odd-paired homolog, Drosophila)0.628
cxcr4achemokine (C-X-C motif) receptor 4a0.615
etv5bets variant 5b0.605
dccdeleted in colorectal carcinoma0.602
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.601
restRE1-silencing transcription factor0.595
spns2spinster homolog 2 (Drosophila)0.587
sema3aasemaphorin 3aa0.586
mespamesoderm posterior a0.577
tp63tumor protein p630.573
shhbsonic hedgehog b0.563
gbx2gastrulation brain homeo box 20.562
fgfr3fibroblast growth factor receptor 30.556
jag2jagged 20.549
cdh6cadherin 60.546
gro1groucho 10.545
tp53tumor protein p530.542
gpr126G protein-coupled receptor 1260.541
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.540
gria4bglutamate receptor, ionotropic, AMPA 4b0.540
pitx2paired-like homeodomain transcription factor 20.540
snai1bsnail homolog 1b (Drosophila)0.536
per3period homolog 3 (Drosophila)0.532
sox32SRY-box containing gene 320.532
tmem2transmembrane protein 20.530
sox1aSRY-box containing gene 1a0.529
chsy1chondroitin sulfate synthase 10.525
smad1MAD homolog 1 (Drosophila)0.517
wlswntless homolog (Drosophila)0.507
flhfloating head0.500
col1a2collagen, type I, alpha 20.499
epha4beph receptor A4b0.488
neurodneurogenic differentiation0.486
fzd7bfrizzled homolog 7b0.482
egr2bearly growth response 2b0.477
supt6hsuppressor of Ty 6 homolog0.476
edn1endothelin 10.476
ptch1patched 10.475
osr2odd-skipped related 2 (Drosophila)0.471
tll1tolloid-like 10.467
gata3GATA-binding protein 30.458
foxd3forkhead box D30.454
dctdopachrome tautomerase0.453
prickle1aprickle-like 1 (Drosophila) a0.445
traf4atnf receptor-associated factor 4a0.437
lmx1b.1LIM homeobox transcription factor 1, beta 10.433
pax7apaired box gene 7a0.431
prdm5PR domain containing 50.430
msxbmuscle segment homeobox B0.430
dbx1adeveloping brain homeobox 1a0.429
neurog1neurogenin 10.429
spry4sprouty (Drosophila) homolog 40.423
alcamaactivated leukocyte cell adhesion molecule a0.420
irx3airoquois homeobox protein 3a0.417
igf1rbinsulin-like growth factor 1b receptor0.416
rereaarginine-glutamic acid dipeptide (RE) repeats a0.415
vsx2visual system homeobox 20.411
pea3ETS-domain transcription factor pea30.408
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.997
Mef2Myocyte enhancer factor 20.816
Sra-1specifically Rac1-associated protein 10.340
cicubitus interruptus0.318
Ras85DRas oncogene at 85D0.281
zfh1Zn finger homeodomain 10.278
abd-Aabdominal A0.259
nkdnaked cuticle0.156
LanB2Laminin B20.156
eyaeyes absent0.138
bowlbrother of odd with entrails limited0.107
oddodd skipped0.087
Abd-BAbdominal B0.084
PhmPeptidylglycine-alpha-hydroxylating monooxygenase0.084
eveeven skipped0.065
Eip75BEcdysone-induced protein 75B0.063
mewmultiple edematous wings0.052
gcmglial cells missing0.040
slp1sloppy paired 10.040
numbCG3779 gene product from transcript CG3779-RB0.038
osaCG7467 gene product from transcript CG7467-RD0.037
sosine oculis0.034
Lim1CG11354 gene product from transcript CG11354-RA0.033
Stat92ESignal-transducer and activator of transcription protein at 92E0.031
Six4CG3871 gene product from transcript CG3871-RA0.029
MadMothers against dpp0.029
slmbsupernumerary limbs0.026
opaodd paired0.025
Ptp69DProtein tyrosine phosphatase 69D0.024
SmoxSmad on X0.024
emcextra macrochaetae0.023
LanALaminin A0.022
sogshort gastrulation0.022
ImpIGF-II mRNA-binding protein0.021
fasfaint sausage0.019
kirrekin of irre0.017
rictorrapamycin-insensitive companion of Tor0.016
fkhfork head0.016
McrMacroglobulin complement-related0.015
LanB1CG7123 gene product from transcript CG7123-RA0.015
rapretina aberrant in pattern0.015
CG14869CG14869 gene product from transcript CG14869-RB0.014
nocno ocelli0.014
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.998
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.997
SMAD1SMAD family member 10.996
SMAD3SMAD family member 30.993
TGFB1transforming growth factor, beta 10.993
NOTCH1notch 10.991
SMAD4SMAD family member 40.988
JAG1jagged 10.987
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.968
ARandrogen receptor0.965
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.964
PTK2PTK2 protein tyrosine kinase 20.960
SMAD7SMAD family member 70.947
GSK3Bglycogen synthase kinase 3 beta0.946
COL6A1collagen, type VI, alpha 10.945
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.930
GATA4GATA binding protein 40.929
COL1A1collagen, type I, alpha 10.915
BMP2bone morphogenetic protein 20.903
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.892
BMPR1Abone morphogenetic protein receptor, type IA0.889
BBS10Bardet-Biedl syndrome 100.888
FSTL1follistatin-like 10.874
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.867
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.798
POU3F2POU class 3 homeobox 20.797
PDX1pancreatic and duodenal homeobox 10.789
NOTCH3notch 30.785
AXIN1axin 10.781
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.779
FOXF2forkhead box F20.770
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.731
YAP1Yes-associated protein 10.724
FGF1fibroblast growth factor 1 (acidic)0.722
COL2A1collagen, type II, alpha 10.695
COL6A2collagen, type VI, alpha 20.681
SMURF2SMAD specific E3 ubiquitin protein ligase 20.669
FN1fibronectin 10.657
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.653
COL5A1collagen, type V, alpha 10.648
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.646
PAX8paired box 80.581
NR4A1nuclear receptor subfamily 4, group A, member 10.579
PTBP1polypyrimidine tract binding protein 10.573
TAL1T-cell acute lymphocytic leukemia 10.562
COL18A1collagen, type XVIII, alpha 10.553
FOXD3forkhead box D30.534
SMAD6SMAD family member 60.533
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.528
PAX1paired box 10.518
COL5A2collagen, type V, alpha 20.515
TBX5T-box 50.514
COL3A1collagen, type III, alpha 10.496
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.494
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.490
FKBP1AFK506 binding protein 1A, 12kDa0.489
POU5F1POU class 5 homeobox 10.487
FOXF1forkhead box F10.474
MSX1msh homeobox 10.445
FHL2four and a half LIM domains 20.434
HIC1hypermethylated in cancer 10.427
SOX1SRY (sex determining region Y)-box 10.410
FZD1frizzled homolog 1 (Drosophila)0.394
FGFR2fibroblast growth factor receptor 20.392
COL4A2collagen, type IV, alpha 20.366
MYOD1myogenic differentiation 10.366
TGFB3transforming growth factor, beta 30.363
PCOLCEprocollagen C-endopeptidase enhancer0.349
FZD8frizzled homolog 8 (Drosophila)0.348
FGF3fibroblast growth factor 30.348
COL1A2collagen, type I, alpha 20.336
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.335
COL4A1collagen, type IV, alpha 10.331
WNT3Awingless-type MMTV integration site family, member 3A0.322
SMAD2SMAD family member 20.321
PTCH1patched 10.320
CDX2caudal type homeobox 20.319
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.308
BMPR1Bbone morphogenetic protein receptor, type IB0.301
EGFRepidermal growth factor receptor0.298
TGFBR1transforming growth factor, beta receptor 10.296
SOX11SRY (sex determining region Y)-box 110.296
NCK2NCK adaptor protein 20.288
TBX2T-box 20.279
HOXB13homeobox B130.278
FGF8fibroblast growth factor 8 (androgen-induced)0.269
PAPPApregnancy-associated plasma protein A, pappalysin 10.265
COL7A1collagen, type VII, alpha 10.261
WNT6wingless-type MMTV integration site family, member 60.260
RAXretina and anterior neural fold homeobox0.258
WNT1wingless-type MMTV integration site family, member 10.244
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.238
SFRP5secreted frizzled-related protein 50.238
POSTNperiostin, osteoblast specific factor0.230
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.228
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.226
BCL2L1BCL2-like 10.224
TWIST1twist homolog 1 (Drosophila)0.223
MMP11matrix metallopeptidase 11 (stromelysin 3)0.219
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Bmp4bone morphogenetic protein 41.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Tgfb2transforming growth factor, beta 21.000
Foxc1forkhead box C11.000
Pitx2paired-like homeodomain transcription factor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Prrx1paired related homeobox 11.000
Fgfr1fibroblast growth factor receptor 11.000
Gata4GATA binding protein 41.000
Pax3paired box gene 31.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Hoxa1homeobox A11.000
Fgf8fibroblast growth factor 81.000
Pax2paired box gene 20.999
Foxc2forkhead box C20.999
Msx1homeobox, msh-like 10.999
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.999
Tbx1T-box 10.999
Vegfavascular endothelial growth factor A0.999
Smad6MAD homolog 6 (Drosophila)0.999
Pbx1pre B-cell leukemia transcription factor 10.998
Acvr1activin A receptor, type 10.998
Bmp7bone morphogenetic protein 70.998
Jag1jagged 10.997
Gata6GATA binding protein 60.997
Msx2homeobox, msh-like 20.997
Twist2twist homolog 2 (Drosophila)0.996
Tcfap2atranscription factor AP-2, alpha0.996
Hes1hairy and enhancer of split 1 (Drosophila)0.996
Bcl2B-cell leukemia/lymphoma 20.995
Eya1eyes absent 1 homolog (Drosophila)0.995
Foxh1forkhead box H10.995
Rarbretinoic acid receptor, beta0.995
Gscgoosecoid homeobox0.994
Hoxd3homeobox D30.994
Pax6paired box gene 60.994
Efnb2ephrin B20.993
Wt1Wilms tumor 1 homolog0.993
Ror2receptor tyrosine kinase-like orphan receptor 20.993
Lhx1LIM homeobox protein 10.992
Tcf21transcription factor 210.992
Gli2GLI-Kruppel family member GLI20.991
Ednraendothelin receptor type A0.991
Foxg1forkhead box G10.991
Sox9SRY-box containing gene 90.990
Rargretinoic acid receptor, gamma0.990
Notch1Notch gene homolog 1 (Drosophila)0.989
Meox2mesenchyme homeobox 20.989
Ascl1achaete-scute complex homolog 1 (Drosophila)0.988
Ptpn11protein tyrosine phosphatase, non-receptor type 110.987
Tbx3T-box 30.986
Tbx2T-box 20.986
Vangl2vang-like 2 (van gogh, Drosophila)0.985
Gdnfglial cell line derived neurotrophic factor0.983
Foxa2forkhead box A20.983
Prrx2paired related homeobox 20.982
Bmpr1abone morphogenetic protein receptor, type 1A0.976
Dlx5distal-less homeobox 50.976
Smosmoothened homolog (Drosophila)0.975
Hey2hairy/enhancer-of-split related with YRPW motif 20.974
Zic3zinc finger protein of the cerebellum 30.974
Runx2runt related transcription factor 20.971
Apcadenomatosis polyposis coli0.970
Lmx1bLIM homeobox transcription factor 1 beta0.969
Pitx1paired-like homeodomain transcription factor 10.967
Emx1empty spiracles homolog 1 (Drosophila)0.962
Rxraretinoid X receptor alpha0.962
Ece1endothelin converting enzyme 10.962
Ptenphosphatase and tensin homolog0.955
Dkk1dickkopf homolog 1 (Xenopus laevis)0.951
Tgfbr2transforming growth factor, beta receptor II0.950
Tlx3T-cell leukemia, homeobox 30.945
Smad4MAD homolog 4 (Drosophila)0.945
Hoxa5homeobox A50.939
Pax8paired box gene 80.939
Foxf1aforkhead box F1a0.933
Hoxa2homeobox A20.926
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.925
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.922
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.917
Alx4aristaless-like homeobox 40.915
Nkx2-1NK2 homeobox 10.915
Psen1presenilin 10.912
Hoxd13homeobox D130.903
Gbx2gastrulation brain homeobox 20.898
Lef1lymphoid enhancer binding factor 10.896
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.896
Isl1ISL1 transcription factor, LIM/homeodomain0.895
Retret proto-oncogene0.893
Lhx3LIM homeobox protein 30.891
Pou3f3POU domain, class 3, transcription factor 30.889
Notch2Notch gene homolog 2 (Drosophila)0.886
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Unc5bunc-5 homolog B (C. elegans)0.059
Gata6GATA binding protein 60.054
Igfbp5insulin-like growth factor binding protein 50.048
Nfibnuclear factor I/B0.044
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.032
Dchs1dachsous 1 (Drosophila)0.030
Col12a1collagen, type XII, alpha 10.030
Hoxc4homeo box C40.029
Slit3slit homolog 3 (Drosophila)0.028
Tcf4transcription factor 40.026
Jak2Janus kinase 20.023
Ednraendothelin receptor type A0.023
Nfianuclear factor I/A0.022
Nr2f2nuclear receptor subfamily 2, group F, member 20.022
Cand1cullin-associated and neddylation-dissociated 10.021
Col9a1collagen, type IX, alpha 10.021
Nr5a1nuclear receptor subfamily 5, group A, member 10.017
Tgfbr2transforming growth factor, beta receptor II0.016
Uoxurate oxidase0.016
Nos3nitric oxide synthase 3, endothelial cell0.015
Ptpn14protein tyrosine phosphatase, non-receptor type 140.015
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.015
Tcf21transcription factor 210.015
Efnb1ephrin B10.015
Prm2protamine 20.014
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.014
Has2hyaluronan synthase 20.014
Mmp23matrix metallopeptidase 230.013
Epas1endothelial PAS domain protein 10.013
Il11interleukin 110.012
Foxi2forkhead box I20.012
Gja5gap junction protein, alpha 50.012
Slco2a1solute carrier organic anion transporter family, member 2a10.012
Fgf1fibroblast growth factor 10.012
Col3a1collagen, type III, alpha 10.012
Arhgap23Rho GTPase activating protein 230.012
Tarsthreonyl-tRNA synthetase0.012
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
Il1r1interleukin 1 receptor, type I0.012
Tnni1troponin I type 1 (skeletal, slow)0.011
Sox17SRY (sex determining region Y)-box 170.011
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.011
Ahraryl hydrocarbon receptor0.011
Tead3TEA domain family member 30.011
Dbhdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.011
Parp14poly (ADP-ribose) polymerase family, member 140.011
F13a1coagulation factor XIII, A1 polypeptide0.011
Plauplasminogen activator, urokinase0.011
Ednrbendothelin receptor type B0.011
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.010
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.010
Tmem119transmembrane protein 1190.010
Smad7SMAD family member 70.010
Egfl7EGF-like-domain, multiple 70.010
Bmp6bone morphogenetic protein 60.010
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism