The network for 'determination of left right symmetry' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

determination of left right symmetry

The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

NameDescriptionProbabilityFunc Analog Organism
pax2apaired box gene 2a0.999
hnf1baHNF1 homeobox Ba0.998
fgf8afibroblast growth factor 8 a0.997
chdchordin0.990
gata3GATA-binding protein 30.989
tbx16T-box gene 160.988
tbx1T-box 10.987
shhasonic hedgehog a0.987
ift88intraflagellar transport 88 homolog0.984
ntlano tail a0.984
bmp4bone morphogenetic protein 40.968
aldh1a2aldehyde dehydrogenase 1 family, member A20.967
lrrc6leucine rich repeat containing 60.964
zic1zic family member 1 (odd-paired homolog, Drosophila)0.962
tbx20T-box 200.958
cdh2cadherin 2, neuronal0.941
pkd2polycystic kidney disease 20.941
smosmoothened homolog (Drosophila)0.937
sulf1sulfatase 10.934
wnt11wingless-type MMTV integration site family, member 110.917
six4bsine oculis homeobox homolog 4b0.908
fzd10frizzled homolog 100.906
sox9aSRY-box containing gene 9a0.902
flhfloating head0.890
bmp2bbone morphogenetic protein 2b0.887
wnt11rwingless-type MMTV integration site family, member 11, related0.887
shhbsonic hedgehog b0.884
ndr2nodal-related 20.884
snai1bsnail homolog 1b (Drosophila)0.881
oepone-eyed pinhead0.875
myf5myogenic factor 50.871
msxcmuscle segment homeobox C0.865
nkx2.5NK2 transcription factor related 50.864
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.858
fzd8afrizzled homolog 8a0.853
gro1groucho 10.852
gata5GATA-binding protein 50.850
dlddeltaD0.842
sox17SRY-box containing gene 170.837
lhx1aLIM homeobox 1a0.835
foxa2forkhead box A20.822
dccdeleted in colorectal carcinoma0.819
rfx2regulatory factor X, 2 (influences HLA class II expression)0.818
twist1btwist1b0.813
jag2jagged 20.796
smad9MAD homolog 9 (Drosophila)0.795
hspb7heat shock protein family, alpha-crystallin-related, b70.786
zgc:100838zgc:1008380.767
pcdh8protocadherin 80.740
ephb4beph receptor B4b0.739
gli2aGLI-Kruppel family member GLI2a0.729
arl13bADP-ribosylation factor-like 13b0.727
twist1atwist1a0.722
lft1lefty10.693
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.691
lfnglunatic fringe homolog0.682
wnt1wingless-type MMTV integration site family, member 10.677
lrrc50leucine rich repeat containing 500.676
si:ch211-173o4.2si:ch211-173o4.20.669
tbx2bT-box 2b0.668
sox32SRY-box containing gene 320.668
ccdc40coiled-coil domain containing 400.665
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.664
gdf6agrowth differentiation factor 6a0.664
foxe3forkhead box E30.663
lft2lefty20.649
notch1bnotch homolog 1b0.643
prdm5PR domain containing 50.635
neo1neogenin 10.631
robo3roundabout homolog 30.628
cc2d2acoiled-coil and C2 domain containing 2A0.626
kif17kinesin family member 170.614
foxg1aforkhead box G1a0.612
hoxa13bhomeo box A13b0.610
eya4eyes absent homolog 4 (Drosophila)0.608
gpc4glypican 40.607
fgf4fibroblast growth factor 40.605
dmrt2adoublesex and mab-3 related transcription factor 2a0.598
fgf3fibroblast growth factor 30.594
wnt3wingless-type MMTV integration site family, member 30.592
gpiaglucose phosphate isomerase a0.591
hey2hairy/enhancer-of-split related with YRPW motif 20.590
tbx18T-box 180.588
wnt9bwingless-type MMTV integration site family, member 9B0.570
runx2brunt-related transcription factor 2b0.569
vcanaversican a0.568
tp53tumor protein p530.567
npntnephronectin0.552
bmp2abone morphogenetic protein 2a0.549
mapk1mitogen-activated protein kinase 10.548
her7hairy and enhancer of split related-70.545
mibmind bomb0.543
foxh1forkhead box H10.541
ift57intraflagellar transport protein 570.539
mef2cbmyocyte enhancer factor 2cb0.531
sox3SRY-box containing gene 30.528
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.523
foxi1forkhead box I10.520
dkk1bdickkopf 1b0.514
atoh1batonal homolog 1b0.513
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
che-13Protein CHE-130.133
osm-5Protein OSM-50.121
mec-2Protein MEC-20.087
lin-29Protein LIN-290.084
unc-7Protein UNC-70.072
che-2Protein CHE-20.070
che-3Protein CHE-30.066
egl-18Protein EGL-180.063
nhr-143Protein NHR-1430.055
inx-4Protein INX-40.053
bar-1Protein BAR-10.050
lin-17Protein LIN-170.046
eat-4Protein EAT-40.042
daf-10Protein DAF-100.039
madd-4Protein MADD-40.030
hlh-2Protein HLH-20.030
glp-1Protein GLP-10.025
unc-73Protein UNC-730.024
che-11Protein CHE-110.024
pdfr-1Protein PDFR-10.024
nphp-1Protein NPHP-10.024
unc-62Protein UNC-620.023
osm-6Protein OSM-60.022
T27A3.1Protein T27A3.10.021
unc-6Protein UNC-60.020
lin-11Protein LIN-110.018
CELE_H12D21.9Protein H12D21.90.018
vab-3Protein VAB-30.017
ric-3Protein RIC-30.016
unc-9Protein UNC-90.016
rig-6Protein RIG-60.015
prmt-3Protein PRMT-30.015
unc-115Protein UNC-1150.015
cam-1Protein CAM-10.014
K08E3.5Protein K08E3.50.014
arl-6Protein ARL-60.014
bli-1Protein BLI-10.014
cdf-1Protein CDF-10.013
nmgp-1Protein NMGP-10.013
hlh-1Protein HLH-10.013
CELE_Y11D7A.5Protein Y11D7A.50.013
sop-3Protein SOP-30.013
CELE_W05H12.1Protein W05H12.10.013
sdha-1Protein SDHA-10.012
dhs-21Protein DHS-210.012
C45G9.6Protein C45G9.60.012
che-14Protein CHE-140.012
daf-12Protein DAF-120.012
kin-3Protein KIN-30.012
efn-2Protein EFN-20.011
nhr-67Protein NHR-670.011
cgef-2Protein CGEF-20.011
lbp-7Protein LBP-70.010
let-756Protein LET-7560.010
ahr-1Protein AHR-10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
tkvthickveins0.491
dshdishevelled0.386
G-oalpha47AG protein oalpha 47A0.383
armarmadillo0.363
DlDelta0.360
Myo31DFMyosin 31DF0.282
wgwingless0.233
fngfringe0.196
bazbazooka0.183
ifinflated0.149
stumpsCG31317 gene product from transcript CG31317-RC0.137
dppdecapentaplegic0.137
linlines0.131
comtcomatose0.121
emcextra macrochaetae0.113
cicubitus interruptus0.113
shishibire0.103
twitwist0.094
enengrailed0.094
cindrCIN85 and CD2AP orthologue0.094
ovoCG6824 gene product from transcript CG6824-RE0.092
bsblistered0.083
Lim1CG11354 gene product from transcript CG11354-RA0.075
apapterous0.075
Cdc42CG12530 gene product from transcript CG12530-RA0.072
slouslouch0.070
Syx1ASyntaxin 1A0.070
knknot0.065
HHairless0.062
fjfour-jointed0.061
WASpCG1520 gene product from transcript CG1520-RA0.050
rheaCG6831 gene product from transcript CG6831-RA0.049
mysmyospheroid0.047
eveeven skipped0.047
Rac1CG2248 gene product from transcript CG2248-RA0.045
PpcsPhosphopantothenoylcysteine synthetase0.043
scbscab0.042
kstkarst0.041
dallydivision abnormally delayed0.041
hhhedgehog0.040
PvrPDGF- and VEGF-receptor related0.040
crbcrumbs0.040
rokRho-kinase0.039
snsinged0.036
bowlbrother of odd with entrails limited0.035
Doc2Dorsocross20.035
shashavenoid0.034
fzfrizzled0.033
MedMedea0.032
lblladybird late0.032
diadiaphanous0.031
kibrakibra ortholog0.031
kirrekin of irre0.025
tintinman0.024
ttktramtrack0.023
pbproboscipedia0.023
jarjaguar0.023
ftfat0.023
opaodd paired0.023
smosmoothened0.022
ash2absent, small, or homeotic discs 20.022
flwflapwing0.022
HmgcrHMG Coenzyme A reductase0.021
drmdrumstick0.021
zfh1Zn finger homeodomain 10.020
encencore0.020
htlheartless0.020
wunwunen0.019
Snap25Synapse protein 250.019
trctricornered0.019
uncuncoordinated0.018
neurneuralized0.018
CblCG7037 gene product from transcript CG7037-RB0.018
pblpebble0.018
Wnt4Wnt oncogene analog 40.018
invinvected0.018
rempAreduced mechanoreceptor potential A0.018
putpunt0.017
Caf1Chromatin assembly factor 1 subunit0.017
Myo61FMyosin 61F0.016
abd-Aabdominal A0.016
Cul-5Cullin-50.016
nompAno mechanoreceptor potential A0.015
beat-Iabeaten path Ia0.015
HLH54FCG5005 gene product from transcript CG5005-RA0.014
defldeflated0.014
KrKruppel0.014
LLobe0.014
mewmultiple edematous wings0.013
Vha55Vacuolar H[+]-ATPase 55kD B subunit0.013
saxsaxophone0.013
eyaeyes absent0.013
MadMothers against dpp0.013
bibifid0.013
p38bCG7393 gene product from transcript CG7393-RA0.013
Nelf-ENegative elongation factor E0.012
enaenabled0.012
DadDaughters against dpp0.012
hkbhuckebein0.012
GluRIIAGlutamate receptor IIA0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RHOAras homolog gene family, member A0.918
BMPR1Abone morphogenetic protein receptor, type IA0.433
SMAD3SMAD family member 30.430
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.394
SMAD2SMAD family member 20.377
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.375
MAPK8mitogen-activated protein kinase 80.367
SMAD1SMAD family member 10.357
NOTCH1notch 10.265
ATF2activating transcription factor 20.215
SMAD7SMAD family member 70.169
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.145
TJP1tight junction protein 1 (zona occludens 1)0.137
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.132
TBX5T-box 50.123
JUNjun proto-oncogene0.118
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.116
GSK3Bglycogen synthase kinase 3 beta0.114
ARHGAP1Rho GTPase activating protein 10.105
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.098
MAP2K4mitogen-activated protein kinase kinase 40.093
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.088
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.083
MARK3MAP/microtubule affinity-regulating kinase 30.073
SMAD5SMAD family member 50.069
FLNCfilamin C, gamma0.067
SMAD4SMAD family member 40.059
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.056
CD44CD44 molecule (Indian blood group)0.052
GATA4GATA binding protein 40.050
BMP2bone morphogenetic protein 20.042
MKL1megakaryoblastic leukemia (translocation) 10.041
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.040
SIN3ASIN3 homolog A, transcription regulator (yeast)0.037
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.036
SASS6spindle assembly 6 homolog (C. elegans)0.033
PSEN2presenilin 2 (Alzheimer disease 4)0.031
EP300E1A binding protein p3000.030
PCM1pericentriolar material 10.029
TSC2tuberous sclerosis 20.028
FZD1frizzled homolog 1 (Drosophila)0.027
JAG1jagged 10.027
FGF10fibroblast growth factor 100.026
SEPT2septin 20.025
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.024
HIPK2homeodomain interacting protein kinase 20.024
EXOC7exocyst complex component 70.023
HMGA1high mobility group AT-hook 10.023
GLI1GLI family zinc finger 10.022
SMURF2SMAD specific E3 ubiquitin protein ligase 20.022
BBS7Bardet-Biedl syndrome 70.022
PELP1proline, glutamate and leucine rich protein 10.022
PTCH1patched 10.021
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.021
FSTL1follistatin-like 10.021
TGFB1transforming growth factor, beta 10.020
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.017
LRP6low density lipoprotein receptor-related protein 60.017
PKD1polycystic kidney disease 1 (autosomal dominant)0.017
LMAN1lectin, mannose-binding, 10.016
CENPJcentromere protein J0.016
CXXC5CXXC finger protein 50.016
MAML1mastermind-like 1 (Drosophila)0.015
SNX5sorting nexin 50.014
FGF1fibroblast growth factor 1 (acidic)0.014
NOGnoggin0.014
PMLpromyelocytic leukemia0.014
BMP1bone morphogenetic protein 10.014
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.013
SORBS3sorbin and SH3 domain containing 30.013
PRKG1protein kinase, cGMP-dependent, type I0.013
NCF2neutrophil cytosolic factor 20.013
YY1YY1 transcription factor0.013
HDAC9histone deacetylase 90.012
FOSFBJ murine osteosarcoma viral oncogene homolog0.012
PLXNB1plexin B10.012
SP1Sp1 transcription factor0.012
BBS2Bardet-Biedl syndrome 20.011
ZEB2zinc finger E-box binding homeobox 20.011
CLIC4chloride intracellular channel 40.011
RHOGras homolog gene family, member G (rho G)0.010
EGLN1egl nine homolog 1 (C. elegans)0.010
NLKnemo-like kinase0.010
CANXcalnexin0.010
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.010
MKL2MKL/myocardin-like 20.010
ACVR1activin A receptor, type I0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pitx2paired-like homeodomain transcription factor 21.000
Nodalnodal1.000
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 20.999
Vangl2vang-like 2 (van gogh, Drosophila)0.998
Fgf8fibroblast growth factor 80.997
Zic3zinc finger protein of the cerebellum 30.997
Otx2orthodenticle homolog 2 (Drosophila)0.997
Pax2paired box gene 20.995
Pax3paired box gene 30.995
Meox2mesenchyme homeobox 20.994
Foxh1forkhead box H10.994
Tbx3T-box 30.994
Gata4GATA binding protein 40.993
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.992
Invsinversin0.992
Gli3GLI-Kruppel family member GLI30.989
Hoxa13homeobox A130.984
Gli2GLI-Kruppel family member GLI20.977
Hoxa1homeobox A10.975
Kif3akinesin family member 3A0.973
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.970
Sox9SRY-box containing gene 90.958
Fgf10fibroblast growth factor 100.952
Foxc1forkhead box C10.950
Ctnnb1catenin (cadherin associated protein), beta 10.948
Fgfr1fibroblast growth factor receptor 10.947
Bmp4bone morphogenetic protein 40.945
Rargretinoic acid receptor, gamma0.931
Chrdchordin0.929
Dnahc11dynein, axonemal, heavy chain 110.922
Hand1heart and neural crest derivatives expressed transcript 10.909
Foxc2forkhead box C20.906
Mks1Meckel syndrome, type 10.906
Smad6MAD homolog 6 (Drosophila)0.900
UncxUNC homeobox0.885
Notch1Notch gene homolog 1 (Drosophila)0.881
Psen1presenilin 10.875
Wnt3awingless-related MMTV integration site 3A0.873
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.873
Jag1jagged 10.839
Lmx1aLIM homeobox transcription factor 1 alpha0.833
Pitx1paired-like homeodomain transcription factor 10.833
Wt1Wilms tumor 1 homolog0.821
Chd7chromodomain helicase DNA binding protein 70.809
Acvr1activin A receptor, type 10.806
Ror2receptor tyrosine kinase-like orphan receptor 20.793
Lhx1LIM homeobox protein 10.792
Hoxd13homeobox D130.791
Tgfb2transforming growth factor, beta 20.781
Vegfavascular endothelial growth factor A0.776
Msx1homeobox, msh-like 10.774
Nognoggin0.773
Hoxa11homeobox A110.766
Bbs4Bardet-Biedl syndrome 4 (human)0.756
Pbx1pre B-cell leukemia transcription factor 10.747
Hoxa3homeobox A30.737
Gscgoosecoid homeobox0.711
Tgfbr2transforming growth factor, beta receptor II0.698
Hoxa10homeobox A100.696
Notch2Notch gene homolog 2 (Drosophila)0.696
Eya1eyes absent 1 homolog (Drosophila)0.692
Zfpm2zinc finger protein, multitype 20.665
Foxf1aforkhead box F1a0.663
Pax7paired box gene 70.661
Acvr2bactivin receptor IIB0.637
Nos3nitric oxide synthase 3, endothelial cell0.634
Cfc1cripto, FRL-1, cryptic family 10.624
Mesp1mesoderm posterior 10.618
Hoxd11homeobox D110.596
Lrp6low density lipoprotein receptor-related protein 60.592
Smad4MAD homolog 4 (Drosophila)0.585
Tcf21transcription factor 210.577
Nr5a1nuclear receptor subfamily 5, group A, member 10.565
Pcsk5proprotein convertase subtilisin/kexin type 50.565
Foxa2forkhead box A20.557
Rarbretinoic acid receptor, beta0.555
Scn5asodium channel, voltage-gated, type V, alpha0.550
Ptf1apancreas specific transcription factor, 1a0.546
Smad3MAD homolog 3 (Drosophila)0.546
En1engrailed 10.536
Snai1snail homolog 1 (Drosophila)0.532
Ptk7PTK7 protein tyrosine kinase 70.521
Gata6GATA binding protein 60.517
Smosmoothened homolog (Drosophila)0.515
Btbd17BTB (POZ) domain containing 170.510
Twist2twist homolog 2 (Drosophila)0.509
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.505
Ascl1achaete-scute complex homolog 1 (Drosophila)0.500
Hoxa2homeobox A20.498
Rac1RAS-related C3 botulinum substrate 10.496
Sox7SRY-box containing gene 70.495
Bmpr1abone morphogenetic protein receptor, type 1A0.495
Pax8paired box gene 80.495
Fgf3fibroblast growth factor 30.494
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.494
Isl1ISL1 transcription factor, LIM/homeodomain0.492
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.485
Pou3f3POU domain, class 3, transcription factor 30.479
Hand2heart and neural crest derivatives expressed transcript 20.479
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism