The network for 'axial mesodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

axial mesodermal cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

NameDescriptionProbabilityFunc Analog Organism
oepone-eyed pinhead0.849
ndr2nodal-related 20.652
tbx16T-box gene 160.577
lft1lefty10.350
sox32SRY-box containing gene 320.348
fezf2FEZ family zinc finger 20.267
ntlano tail a0.226
flhfloating head0.221
nkx2.2aNK2 transcription factor related 2a0.198
lhx1aLIM homeobox 1a0.196
chdchordin0.190
foxn4forkhead box N40.158
otx1aorthodenticle homolog 1a0.154
pou5f1POU domain, class 5, transcription factor 10.141
olig3oligodendrocyte transcription factor 30.131
nr2e1nuclear receptor subfamily 2, group E, member 10.127
rx3retinal homeobox gene 30.123
dharmadharma0.118
admpanti-dorsalizing morphogenic protein0.111
pax6bpaired box gene 6b0.106
six3asine oculis homeobox homolog 3a0.104
lhx5LIM homeobox 50.097
bmp7abone morphogenetic protein 7a0.091
dladeltaA0.084
mibmind bomb0.084
lft2lefty20.082
barhl2BarH-like 20.076
wnt11wingless-type MMTV integration site family, member 110.068
foxi1forkhead box I10.068
neurod4neurogenic differentiation 40.068
cdx4caudal type homeo box transcription factor 40.067
otpborthopedia homolog b0.065
ndr1nodal-related 10.062
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.061
lhx3LIM homeobox 30.060
ascl1bachaete-scute complex-like 1b (Drosophila)0.059
fgf8afibroblast growth factor 8 a0.058
tbx24T-box 240.057
lhx1bLIM homeobox 1b0.053
ntn1bnetrin 1b0.053
voxventral homeobox0.051
her7hairy and enhancer of split related-70.049
eomesaeomesodermin homolog a0.049
rx2retinal homeobox gene 20.046
pax2apaired box gene 2a0.045
dbx1adeveloping brain homeobox 1a0.043
dazldaz-like gene0.042
foxd5forkhead box D50.041
atoh7atonal homolog 70.040
pou3f3aPOU class 3 homeobox 3a0.037
olig2oligodendrocyte lineage transcription factor 20.035
dzip1DAZ interacting protein 10.034
hnf1baHNF1 homeobox Ba0.034
bonbonnie and clyde0.034
dbx1bdeveloping brain homeobox 1b0.033
vangl2vang-like 2 (van gogh, Drosophila)0.030
dmbx1adiencephalon/mesencephalon homeobox 1a0.029
sox19bSRY-box containing gene 19b0.029
nkx1.2laNK1 transcription factor related 2-like,a0.028
eve1even-skipped-like10.027
zgc:193933zgc:1939330.027
nkx2.1aNK2 homeobox 1a0.027
efna5aephrin A5a0.027
gli1GLI-Kruppel family member 10.027
chrna2acholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)0.026
smosmoothened homolog (Drosophila)0.026
thtyrosine hydroxylase0.026
tll1tolloid-like 10.026
nanos3nanos homolog 30.025
epha4beph receptor A4b0.025
ascl1aachaete-scute complex-like 1a (Drosophila)0.023
shhasonic hedgehog a0.023
tbx6T-box gene 60.023
inabinternexin neuronal intermediate filament protein, alpha b0.023
sim1asingle-minded homolog 1a (Drosophila)0.023
dkk1bdickkopf 1b0.022
lrrc6leucine rich repeat containing 60.021
dlddeltaD0.021
nr2e3nuclear receptor subfamily 2, group E, member 30.021
pax6apaired box gene 6a0.020
ptch1patched 10.020
plp1aproteolipid protein 1a0.020
otx5orthodenticle homolog 50.020
hoxc1ahomeo box C1a0.020
fzd8bfrizzled homolog 8b0.020
foxg1aforkhead box G1a0.019
msgn1mesogenin 10.019
gad1bglutamate decarboxylase 1b0.018
otx1borthodenticle homolog 1b0.018
six3bsine oculis homeobox homolog 3b0.017
otx2orthodenticle homolog 20.017
emx1empty spiracles homeobox 10.017
retsatlretinol saturase (all-trans-retinol 13,14-reductase) like0.017
isl1islet10.017
mespamesoderm posterior a0.017
nkx2.2bNK2 transcription factor related 2b0.017
her5hairy-related 50.016
fechferrochelatase0.016
tbx20T-box 200.016
bhlhe22basic helix-loop-helix family, member e220.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.989
Bmp4bone morphogenetic protein 40.989
Msx1homeobox, msh-like 10.988
Hand1heart and neural crest derivatives expressed transcript 10.983
Foxc1forkhead box C10.971
Nodalnodal0.948
Otx2orthodenticle homolog 2 (Drosophila)0.947
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.940
Prrx1paired related homeobox 10.913
Smosmoothened homolog (Drosophila)0.910
Bmp7bone morphogenetic protein 70.883
Foxh1forkhead box H10.874
Fgfr2fibroblast growth factor receptor 20.870
Pitx2paired-like homeodomain transcription factor 20.869
Gli3GLI-Kruppel family member GLI30.821
Zic3zinc finger protein of the cerebellum 30.821
Msx2homeobox, msh-like 20.794
Hand2heart and neural crest derivatives expressed transcript 20.793
Pax3paired box gene 30.788
Gscgoosecoid homeobox0.758
Dnahc11dynein, axonemal, heavy chain 110.691
Gdf1growth differentiation factor 10.677
Fgf8fibroblast growth factor 80.622
Chrdchordin0.602
Ror2receptor tyrosine kinase-like orphan receptor 20.584
Gli2GLI-Kruppel family member GLI20.584
Gdf5growth differentiation factor 50.556
Tbx1T-box 10.529
Fgfr3fibroblast growth factor receptor 30.468
Mks1Meckel syndrome, type 10.436
Dlx5distal-less homeobox 50.433
Fgfr1fibroblast growth factor receptor 10.417
Vangl2vang-like 2 (van gogh, Drosophila)0.405
Rspo2R-spondin 2 homolog (Xenopus laevis)0.393
Sox9SRY-box containing gene 90.351
Zeb1zinc finger E-box binding homeobox 10.346
Foxc2forkhead box C20.322
Alx4aristaless-like homeobox 40.319
Tbx15T-box 150.302
Cfc1cripto, FRL-1, cryptic family 10.288
Gdf3growth differentiation factor 30.265
Tgfb2transforming growth factor, beta 20.264
Gdf6growth differentiation factor 60.223
Prrx2paired related homeobox 20.199
Lhx1LIM homeobox protein 10.189
Runx2runt related transcription factor 20.183
Alx1ALX homeobox 10.166
Eya1eyes absent 1 homolog (Drosophila)0.162
Bmp2bone morphogenetic protein 20.138
Tcfap2atranscription factor AP-2, alpha0.136
Hoxd13homeobox D130.133
Kif3akinesin family member 3A0.130
Foxj1forkhead box J10.130
Ptch1patched homolog 10.122
Npr2natriuretic peptide receptor 20.118
Lefty1left right determination factor 10.099
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.098
Dnahc5dynein, axonemal, heavy chain 50.093
Gas1growth arrest specific 10.086
Tdgf1teratocarcinoma-derived growth factor 10.079
Slc22a6solute carrier family 22 (organic anion transporter), member 60.076
Pax2paired box gene 20.073
BmperBMP-binding endothelial regulator0.070
Nognoggin0.070
Pcsk5proprotein convertase subtilisin/kexin type 50.065
Lrp6low density lipoprotein receptor-related protein 60.064
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.060
Acvr2bactivin receptor IIB0.059
Megf8multiple EGF-like-domains 80.055
Invsinversin0.054
Eomeseomesodermin homolog (Xenopus laevis)0.054
Emid2EMI domain containing 20.052
Tbx6T-box 60.052
Hoxa13homeobox A130.049
Lmx1bLIM homeobox transcription factor 1 beta0.046
Alx3aristaless-like homeobox 30.045
Mn1meningioma 10.040
Rargretinoic acid receptor, gamma0.040
Wnt3awingless-related MMTV integration site 3A0.038
Pax9paired box gene 90.035
Smad3MAD homolog 3 (Drosophila)0.033
Utf1undifferentiated embryonic cell transcription factor 10.033
Lefty2left-right determination factor 20.033
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.032
Smad6MAD homolog 6 (Drosophila)0.032
Pbx1pre B-cell leukemia transcription factor 10.031
Foxa2forkhead box A20.031
Gpc3glypican 30.030
Npr3natriuretic peptide receptor 30.028
Gdf7growth differentiation factor 70.028
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.027
Dkk1dickkopf homolog 1 (Xenopus laevis)0.027
Evx1even skipped homeotic gene 1 homolog0.027
Meox2mesenchyme homeobox 20.026
Oprm1opioid receptor, mu 10.025
Acvr1activin A receptor, type 10.024
Apcadenomatosis polyposis coli0.023
Col2a1collagen, type II, alpha 10.023
Foxf2forkhead box F20.022
Lrp2low density lipoprotein receptor-related protein 20.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism