The network for 'response to zinc ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to zinc ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.

NameDescriptionProbabilityFunc Analog Organism
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.145
slc39a4solute carrier family 39 (zinc transporter), member 40.142
nrxn3aneurexin 3a0.132
lgals9l1lectin, galactoside-binding, soluble, 9 (galectin 9)-like 10.121
mtm1myotubularin 10.095
slc39a9solute carrier family 39 (zinc transporter), member 90.095
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.093
slc30a6solute carrier family 30 (zinc transporter), member 60.087
fanceFanconi anemia, complementation group E0.084
slc39a11solute carrier family 39 (metal ion transporter), member 110.082
cdkrap3CDK5 regulatory subunit associated protein 30.082
cadm3cell adhesion molecule 30.062
slc30a1solute carrier family 30 (zinc transporter), member 10.058
ddcdopa decarboxylase0.049
vps18vacuolar protein sorting protein 180.044
glb1galactosidase, beta 10.044
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.041
fancfFanconi anemia, complementation group F0.037
dbhdopamine beta hydroxylase0.033
mpzmyelin protein zero0.031
pttg1ipbpituitary tumor-transforming 1 interacting protein b0.030
rp2retinitis pigmentosa 2 (X-linked recessive)0.030
slc30a4solute carrier family 30 (zinc transporter), member 40.026
slc30a7solute carrier family 30 (zinc transporter), member 70.025
copb2coatomer protein complex, subunit beta 20.025
mtmr12myotubularin related protein 120.025
gas6growth arrest-specific 60.024
gfapglial fibrillary acidic protein0.023
mbpmyelin basic protein0.022
mmp9matrix metalloproteinase 90.022
slc30a9solute carrier family 30 (zinc transporter), member 90.022
guca1cguanylate cyclase activator 1C0.021
cd63Cd63 antigen0.021
cadm2acell adhesion molecule 2a0.019
acot11aacyl-CoA thioesterase 11a0.017
stmn2bstathmin-like 2b0.017
fancbFanconi anemia, complementation group B0.016
lgals3llectin, galactoside-binding, soluble, 3 (galectin 3)-like0.015
slc39a10solute carrier family 39 (zinc transporter), member 100.015
slc39a1solute carrier family 39 (zinc transporter), member 10.015
trdmt1tRNA aspartic acid methyltransferase 10.015
npm4nucleophosmin/nucleoplasmin, 40.015
recql5RecQ protein-like 50.014
setdb2SET domain, bifurcated 20.014
clptm1lcleft lip and palate associated transmembrane protein 1, like0.013
golga5golgi autoantigen, golgin subfamily a, 50.013
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
col6a2collagen, type VI, alpha 20.012
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.012
nr2e3nuclear receptor subfamily 2, group E, member 30.012
sla1Src-like-adaptor 10.012
kal1aKallmann syndrome 1a sequence0.011
mospd2motile sperm domain containing 20.011
calrlcalreticulin like0.011
socs3bsuppressor of cytokine signaling 3b0.010
gpr182G protein-coupled receptor 1820.010
stmn4stathmin-like 40.010
bscvbscv (C20orf3) homolog0.010
hspb2heat shock protein, alpha-crystallin-related, b20.010
tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.010
ascl1aachaete-scute complex-like 1a (Drosophila)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
smf-1Protein SMF-10.103
sur-7Protein SUR-70.071
C03A3.2Protein C03A3.20.055
cdf-1Protein CDF-10.053
cat-1Protein CAT-10.039
E02H9.3Protein E02H9.30.034
acdh-11Protein ACDH-110.026
C42D8.1Protein C42D8.10.022
K02G10.1Protein K02G10.10.017
tsp-1Protein TSP-10.017
ttm-5Protein TTM-50.015
C03H12.1Protein C03H12.10.015
nhr-170Protein NHR-1700.014
lin-10Protein LIN-100.011
svh-2Protein SVH-20.011
B0303.7Protein B0303.70.010
K05B2.2Protein K05B2.20.010
T14D7.1Protein T14D7.10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
sbrsmall bristles0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MT1Hmetallothionein 1H1.000
MT1Emetallothionein 1E1.000
MT1Fmetallothionein 1F1.000
MT1Xmetallothionein 1X0.991
S100A8S100 calcium binding protein A80.960
MT2Ametallothionein 2A0.882
S100A9S100 calcium binding protein A90.793
MT1Gmetallothionein 1G0.774
PDZD11PDZ domain containing 110.508
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.166
NCOA3nuclear receptor coactivator 30.084
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.082
KRT5keratin 50.073
MT1Bmetallothionein 1B0.056
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.046
AGXT2alanine--glyoxylate aminotransferase 20.044
BBS1Bardet-Biedl syndrome 10.032
MT1Mmetallothionein 1M0.030
MYOD1myogenic differentiation 10.029
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.024
KCNJ11potassium inwardly-rectifying channel, subfamily J, member 110.021
MT1Ametallothionein 1A0.020
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.020
EDEM3ER degradation enhancer, mannosidase alpha-like 30.017
CREBBPCREB binding protein0.017
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.017
MYL4myosin, light chain 4, alkali; atrial, embryonic0.016
FERMT3fermitin family member 30.016
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.015
CD247CD247 molecule0.014
IGSF21immunoglobin superfamily, member 210.012
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.012
BBS7Bardet-Biedl syndrome 70.012
NCOA1nuclear receptor coactivator 10.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mt1metallothionein 10.753
Mt2metallothionein 20.553
Bglapbone gamma carboxyglutamate protein0.177
Campcathelicidin antimicrobial peptide0.096
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.040
Nfe2l2nuclear factor, erythroid derived 2, like 20.037
Slc31a1solute carrier family 31, member 10.032
Apoeapolipoprotein E0.030
Ngpneutrophilic granule protein0.017
Tgfbr1transforming growth factor, beta receptor I0.015
1100001G20RikRIKEN cDNA 1100001G20 gene0.013
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
Arandrogen receptor0.012
Slc39a4solute carrier family 39 (zinc transporter), member 40.012
Ppt1palmitoyl-protein thioesterase 10.010
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a6S100 calcium binding protein A60.909
Mt2Ametallothionein 2A0.576
Anxa2annexin A20.502
S100a9S100 calcium binding protein A90.451
S100a10S100 calcium binding protein A100.384
S100a8S100 calcium binding protein A80.370
Mgpmatrix Gla protein0.341
Anxa5annexin A50.301
Cripcysteine-rich intestinal protein0.273
Mgst1microsomal glutathione S-transferase 10.266
Lgals1lectin, galactoside-binding, soluble, 10.266
S100a11S100 calcium binding protein A11 (calizzarin)0.239
Neflneurofilament, light polypeptide0.228
Gstm1glutathione S-transferase mu 10.209
S100a4S100 calcium-binding protein A40.189
Anxa1annexin A10.165
Nefmneurofilament, medium polypeptide0.162
Gfapglial fibrillary acidic protein0.154
Haao3-hydroxyanthranilate 3,4-dioxygenase0.150
Ephx1epoxide hydrolase 1, microsomal0.137
Timp1TIMP metallopeptidase inhibitor 10.124
Il18interleukin 180.122
Tspotranslocator protein0.119
Otcornithine carbamoyltransferase0.114
Lgals3lectin, galactoside-binding, soluble, 30.112
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.107
Gnmtglycine N-methyltransferase0.097
Krt5keratin 50.089
Uroduroporphyrinogen decarboxylase0.076
Mbpmyelin basic protein0.076
Cd14CD14 molecule0.076
Nefhneurofilament, heavy polypeptide0.075
Mettl7bmethyltransferase like 7B0.074
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.073
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.072
Kcnk4potassium channel, subfamily K, member 40.070
Ttc36tetratricopeptide repeat domain 360.068
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.065
Prss22protease, serine, 220.064
Gp2glycoprotein 2 (zymogen granule membrane)0.063
CartptCART prepropeptide0.063
Lin7blin-7 homolog b (C. elegans)0.063
Tnni1troponin I type 1 (skeletal, slow)0.062
Gpiglucose phosphate isomerase0.061
Slc30a2solute carrier family 30 (zinc transporter), member 20.060
Pmp22peripheral myelin protein 220.058
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.056
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.056
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.055
Plp2proteolipid protein 2 (colonic epithelium-enriched)0.054
Hpd4-hydroxyphenylpyruvate dioxygenase0.052
Plac8placenta-specific 80.051
Kynukynureninase (L-kynurenine hydrolase)0.051
Gpx8glutathione peroxidase 80.051
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.049
Cyb5acytochrome b5 type A (microsomal)0.048
Nr0b2nuclear receptor subfamily 0, group B, member 20.047
Pklrpyruvate kinase, liver and RBC0.047
Sult2b1sulfotransferase family, cytosolic, 2B, member 10.046
Aqp7aquaporin 70.046
Gstm5glutathione S-transferase, mu 50.045
Kcnk15potassium channel, subfamily K, member 150.045
Slc17a1solute carrier family 17 (sodium phosphate), member 10.044
Thrspthyroid hormone responsive0.044
Cpb2carboxypeptidase B2 (plasma)0.043
Fbp1fructose-1,6-bisphosphatase 10.043
Campcathelicidin antimicrobial peptide0.040
Scg3secretogranin III0.039
Hrsp12heat-responsive protein 120.037
Ptpn18protein tyrosine phosphatase, non-receptor type 180.036
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.035
Gcgroup specific component0.034
Gsta4glutathione S-transferase alpha 40.034
Alox5aparachidonate 5-lipoxygenase activating protein0.033
Capgcapping protein (actin filament), gelsolin-like0.032
Bcmo1beta-carotene 15,15'-monooxygenase 10.032
Aqp8aquaporin 80.032
Itgb4integrin, beta 40.032
Kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.031
Gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.031
AhnakAHNAK nucleoprotein0.030
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.030
Ccl6chemokine (C-C motif) ligand 60.030
Sema6bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B0.029
Csdc2cold shock domain containing C2, RNA binding0.029
Prg2proteoglycan 2, bone marrow0.029
Ptprhprotein tyrosine phosphatase, receptor type, H0.029
Cyp2s1cytochrome P450, family 2, subfamily s, polypeptide 10.028
Aldocaldolase C, fructose-bisphosphate0.028
Fez1fasciculation and elongation protein zeta 1 (zygin I)0.028
Pglyrp1peptidoglycan recognition protein 10.028
Adap1ArfGAP with dual PH domains 10.028
Pkm2pyruvate kinase, muscle0.028
Apoc4apolipoprotein C-IV0.027
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism