The network for 'response to lipid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to lipid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.816
socs3asuppressor of cytokine signaling 3a0.706
hnf1baHNF1 homeobox Ba0.621
cav1caveolin 10.618
esr1estrogen receptor 10.563
crabp2acellular retinoic acid binding protein 2, a0.536
gata3GATA-binding protein 30.508
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.506
vcanaversican a0.505
ptgs2aprostaglandin-endoperoxide synthase 2a0.473
id1inhibitor of DNA binding 10.460
shhasonic hedgehog a0.423
pcnaproliferating cell nuclear antigen0.401
smad9MAD homolog 9 (Drosophila)0.400
vasavasa homolog0.379
ptmaaprothymosin, alpha a0.354
rxrabretinoid x receptor, alpha b0.341
fgf3fibroblast growth factor 30.329
ndr2nodal-related 20.320
mapk3mitogen-activated protein kinase 30.308
thtyrosine hydroxylase0.298
flhfloating head0.282
il1binterleukin 1, beta and interleukin 1, beta0.273
notch1anotch homolog 1a0.271
acvr2bactivin receptor IIb0.270
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.266
stc1lstanniocalcin 1, like0.251
rag1recombination activating gene 10.247
mkrn4makorin, ring finger protein, 40.243
trpv6transient receptor potential cation channel, subfamily V, member 60.230
gata5GATA-binding protein 50.226
fzd5frizzled homolog 50.224
pycardPYD and CARD domain containing0.223
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.219
ihhaIndian hedgehog homolog a0.217
junjun proto-oncogene0.208
robo3roundabout homolog 30.204
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.202
apoebapolipoprotein Eb0.198
gapdhglyceraldehyde-3-phosphate dehydrogenase0.187
bmp4bone morphogenetic protein 40.182
ptger2aprostaglandin E receptor 2a (subtype EP2)0.180
cahzcarbonic anhydrase0.174
dlx4adistal-less homeobox gene 4a0.174
efnb2aephrin B2a0.174
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.169
tbx16T-box gene 160.163
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.162
otx5orthodenticle homolog 50.162
fn1fibronectin 10.161
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.160
tie1endothelium-specific receptor tyrosine kinase 10.157
egr2bearly growth response 2b0.156
plcg1phospholipase C, gamma 10.155
nkx1.2laNK1 transcription factor related 2-like,a0.154
col5a1procollagen, type V, alpha 10.153
krt15keratin 150.151
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.150
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.148
tbx2bT-box 2b0.146
msxamuscle segment homeobox A0.144
kdrlkinase insert domain receptor like0.144
esr2aestrogen receptor 2a0.141
zfp36l1azinc finger protein 36, C3H type-like 1a0.139
paqr7bprogestin and adipoQ receptor family member VII, b0.138
mcoln1mucolipin 10.137
cry1acryptochrome 1a0.137
vtg3vitellogenin 3, phosvitinless0.133
pitx3paired-like homeodomain transcription factor 30.132
col1a1acollagen, type I, alpha 1a0.132
sulf1sulfatase 10.131
ripk2receptor-interacting serine-threonine kinase 20.131
avplarginine vasopressin-like0.130
junbljun B proto-oncogene, like0.129
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.128
igf3insulin-like growth factor 30.128
fbn2bfibrillin 2b0.127
snai1asnail homolog 1a (Drosophila)0.124
ptgesprostaglandin E synthase0.124
ctsl1acathepsin L, 1 a0.123
hcrthypocretin (orexin) neuropeptide precursor0.123
slit3slit (Drosophila) homolog 30.121
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.120
gamtguanidinoacetate N-methyltransferase0.120
nkx2.5NK2 transcription factor related 50.120
fgfrl1afibroblast growth factor receptor-like 1a0.120
wnt5bwingless-type MMTV integration site family, member 5b0.117
cbr1lcarbonyl reductase 1-like0.117
wnt10awingless-type MMTV integration site family, member 10a0.116
tnfrsfatumor necrosis factor receptor superfamily, member a0.114
bcl2l1bcl2-like 10.114
sox9aSRY-box containing gene 9a0.114
tmprss4atransmembrane protease, serine 4a0.113
ptch2patched 20.112
pomcaproopiomelanocortin a0.111
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.575
EgfrEpidermal growth factor receptor0.484
cicubitus interruptus0.438
Pi3K92ECG4141 gene product from transcript CG4141-RB0.314
EcREcdysone receptor0.230
Fmr1CG6203 gene product from transcript CG6203-RC0.227
Sir2CG5216 gene product from transcript CG5216-RA0.207
Ugt35aUDP-glycosyltransferase 35a0.180
CG6283CG6283 gene product from transcript CG6283-RA0.170
sinaseven in absentia0.165
Cyp12a4CG6042 gene product from transcript CG6042-RA0.151
MadMothers against dpp0.122
IswiImitation SWI0.118
jebjelly belly0.111
TequilaCG4821 gene product from transcript CG4821-RE0.106
InRInsulin-like receptor0.097
HopHsp70/Hsp90 organizing protein homolog0.092
Mpk2CG5475 gene product from transcript CG5475-RB0.089
slmbsupernumerary limbs0.086
Akt1CG4006 gene product from transcript CG4006-RA0.082
slp1sloppy paired 10.078
drkdownstream of receptor kinase0.077
Stat92ESignal-transducer and activator of transcription protein at 92E0.076
oddodd skipped0.075
ftz-f1ftz transcription factor 10.073
PtenCG5671 gene product from transcript CG5671-RB0.067
ScmSex comb on midleg0.060
eveeven skipped0.058
Pink1PTEN-induced putative kinase 10.058
Rac1CG2248 gene product from transcript CG2248-RA0.058
Bap60Brahma associated protein 60kD0.058
Pkc98EProtein C kinase 98E0.056
CG16718CG16718 gene product from transcript CG16718-RA0.056
CG6543CG6543 gene product from transcript CG6543-RA0.056
Nmdar1NMDA receptor 10.055
bowlbrother of odd with entrails limited0.054
Tps1Trehalose-6-phosphate synthase 10.053
LamCLamin C0.053
lolalongitudinals lacking0.053
G9aCG2995 gene product from transcript CG2995-RA0.052
sinahsina homologue0.051
C15CG7937 gene product from transcript CG7937-RA0.051
CG13253CG13253 gene product from transcript CG13253-RB0.050
stcksteamer duck0.049
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.049
CG9394CG9394 gene product from transcript CG9394-RA0.047
CG12672CG12672 gene product from transcript CG12672-RA0.046
TrhTryptophan hydroxylase0.046
CG34400CG34400 gene product from transcript CG34400-RD0.045
ari-2ariadne 20.042
BG4CG12297 gene product from transcript CG12297-RA0.042
eyaeyes absent0.042
grhgrainy head0.041
argosCG4531 gene product from transcript CG4531-RA0.041
cpacapping protein alpha0.041
bab2CG9102 gene product from transcript CG9102-RA0.040
CG13310CG13310 gene product from transcript CG13310-RA0.039
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
CAV1caveolin 1, caveolae protein, 22kDa0.999
PTPN1protein tyrosine phosphatase, non-receptor type 10.999
ESR1estrogen receptor 10.998
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.998
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.996
MYD88myeloid differentiation primary response gene (88)0.991
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.991
CREBBPCREB binding protein0.987
NCOR2nuclear receptor corepressor 20.985
MAPK14mitogen-activated protein kinase 140.982
TRAF2TNF receptor-associated factor 20.982
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.980
TLR4toll-like receptor 40.975
HDAC1histone deacetylase 10.968
ARandrogen receptor0.966
SOCS3suppressor of cytokine signaling 30.964
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.962
RARAretinoic acid receptor, alpha0.946
ANXA1annexin A10.936
SMAD3SMAD family member 30.924
TAL1T-cell acute lymphocytic leukemia 10.918
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.916
XIAPX-linked inhibitor of apoptosis0.904
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.884
ARRB1arrestin, beta 10.881
CCR1chemokine (C-C motif) receptor 10.873
DUSP1dual specificity phosphatase 10.866
SMAD4SMAD family member 40.857
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.856
TRAF1TNF receptor-associated factor 10.855
TP53tumor protein p530.848
TGFB1transforming growth factor, beta 10.834
CCR5chemokine (C-C motif) receptor 50.829
IRAK2interleukin-1 receptor-associated kinase 20.829
IL8interleukin 80.827
IRAK1interleukin-1 receptor-associated kinase 10.826
PRDX4peroxiredoxin 40.825
TRAF6TNF receptor-associated factor 60.824
SMURF2SMAD specific E3 ubiquitin protein ligase 20.824
EPORerythropoietin receptor0.824
NR4A1nuclear receptor subfamily 4, group A, member 10.822
JUNjun proto-oncogene0.822
IL6interleukin 6 (interferon, beta 2)0.820
SMAD2SMAD family member 20.818
MAPK1mitogen-activated protein kinase 10.816
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.809
GSTM1glutathione S-transferase mu 10.801
COL1A1collagen, type I, alpha 10.801
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.799
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.792
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.786
MAPK8mitogen-activated protein kinase 80.783
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.778
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.775
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.757
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.752
IL1Binterleukin 1, beta0.746
MED15mediator complex subunit 150.741
PCGF2polycomb group ring finger 20.740
SMAD1SMAD family member 10.733
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.732
MDM2Mdm2 p53 binding protein homolog (mouse)0.720
DHCR77-dehydrocholesterol reductase0.698
SP1Sp1 transcription factor0.697
NCF1neutrophil cytosolic factor 10.686
FASFas (TNF receptor superfamily, member 6)0.682
THBS1thrombospondin 10.681
KRT18keratin 180.672
TLR2toll-like receptor 20.672
S100A8S100 calcium binding protein A80.669
NRP1neuropilin 10.656
TRADDTNFRSF1A-associated via death domain0.651
BMP2bone morphogenetic protein 20.644
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.641
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.640
BIRC3baculoviral IAP repeat containing 30.637
S100A9S100 calcium binding protein A90.634
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.634
TNFtumor necrosis factor0.631
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.630
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.629
SC4MOLsterol-C4-methyl oxidase-like0.620
SYKspleen tyrosine kinase0.619
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.618
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.618
GSK3Bglycogen synthase kinase 3 beta0.606
METmet proto-oncogene (hepatocyte growth factor receptor)0.602
FDFT1farnesyl-diphosphate farnesyltransferase 10.600
POU5F1POU class 5 homeobox 10.598
RNF144Bring finger protein 144B0.598
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.589
CXCL2chemokine (C-X-C motif) ligand 20.589
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.588
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.581
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.580
CCND3cyclin D30.575
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.571
RUNX1runt-related transcription factor 10.568
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism