The network for 'endosome to lysosome transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endosome to lysosome transport

The directed movement of substances from endosomes to lysosomes.

NameDescriptionProbabilityFunc Analog Organism
slc30a7solute carrier family 30 (zinc transporter), member 70.372
bonbonnie and clyde0.136
clcn7chloride channel 70.082
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.052
bmpr1aabone morphogenetic protein receptor, type 1aa0.049
atp6v1fATPase, H+ transporting, V1 subunit F0.045
vps18vacuolar protein sorting protein 180.045
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.044
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.038
sqstm1sequestosome 10.037
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.033
chmp4bchromatin modifying protein 4B0.033
b4galt6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 60.033
litaflipopolysaccharide-induced TNF factor0.031
creb3l3lcAMP responsive element binding protein 3-like 3 like0.030
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.028
cltcaclathrin, heavy polypeptide a (Hc)0.028
rnf2ring finger protein 20.027
extl3exostoses (multiple)-like 30.027
viparvps33b interacting protein, apical-basolateral polarity regulator0.026
stxbp2syntaxin binding protein 20.026
rab5cRAB5C, member RAS oncogene family0.026
usp33ubiquitin specific peptidase 330.025
slc39a3solute carrier family 39 (zinc transporter), member 30.024
ext2exostoses (multiple) 20.024
itm2bbintegral membrane protein 2Bb0.023
ythdf3YTH domain family 30.023
slc39a4solute carrier family 39 (zinc transporter), member 40.022
arl8baADP-ribosylation factor-like 8Ba0.022
sec24cSEC24 family, member C (S. cerevisiae)0.022
cul2cullin 20.022
eaf1ELL associated factor 10.020
slc30a5solute carrier family 30 (zinc transporter), member 50.020
klhl11kelch-like 11 (Drosophila)0.019
actr1ARP1 actin-related protein 1, centractin (yeast)0.019
supt6hsuppressor of Ty 6 homolog0.019
serinc2serine incorporator 20.018
arl6ip1ADP-ribosylation factor-like 6 interacting protein 10.018
cds2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 20.018
mppe1metallophosphoesterase 10.018
prkciprotein kinase C, iota0.018
slc9a7solute carrier family 9 (sodium/hydrogen exchanger), member 70.017
vps53vacuolar protein sorting 53 homolog (S. cerevisiae)0.017
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.017
slc39a1solute carrier family 39 (zinc transporter), member 10.016
gtpbp1GTP binding protein 10.016
inppl1ainositol polyphosphate phosphatase-like 1a0.016
maeamacrophage erythroblast attacher0.016
mtmr6myotubularin related protein 60.016
vps26blvacuolar protein sorting 26 homolog B, like0.016
rabac1Rab acceptor 1 (prenylated)0.016
slc30a6solute carrier family 30 (zinc transporter), member 60.016
ankra2ankyrin repeat, family A (RFXANK-like), 20.016
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.016
asb8ankyrin repeat and SOCS box-containing 80.015
ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.015
slc39a11solute carrier family 39 (metal ion transporter), member 110.015
tax1bp1bTax1 (human T-cell leukemia virus type I) binding protein 1b0.015
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.015
fanceFanconi anemia, complementation group E0.015
ctsccathepsin C0.015
nap1l4bnucleosome assembly protein 1-like 4b0.015
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.014
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.014
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.014
exoc3exocyst complex component 30.014
rnf103ring finger protein 1030.014
ppp2r5dprotein phosphatase 2, regulatory subunit B', delta0.014
tubgcp5tubulin, gamma complex associated protein 50.014
mef2cbmyocyte enhancer factor 2cb0.014
pdcd6ipprogrammed cell death 6 interacting protein0.014
smyd2bSET and MYND domain containing 2b0.014
fuca2fucosidase, alpha-L- 2, plasma0.014
march6membrane-associated ring finger (C3HC4) 60.014
glb1galactosidase, beta 10.014
macf1microtubule-actin crosslinking factor 10.013
pdap1pdgfa associated protein 10.013
ppme1protein phosphatase methylesterase 10.013
etnk1ethanolamine kinase 10.013
cndp2CNDP dipeptidase 2 (metallopeptidase M20 family)0.013
rab5aaRAB5A, member RAS oncogene family, a0.013
dtnbp1adystrobrevin binding protein 1a0.013
tmem198btransmembrane protein 198b0.013
tbc1d15TBC1 domain family, member 150.013
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ehbp-1Protein EHBP-10.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG11347CG11347 gene product from transcript CG11347-RE0.905
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.520
CG10277CG10277 gene product from transcript CG10277-RB0.285
Vps26Vacuolar protein sorting 260.226
CG14980CG14980 gene product from transcript CG14980-RB0.191
Vps16AVacuolar protein sorting 16A0.179
cpacapping protein alpha0.161
TSG101tumor suppressor protein 1010.135
Syx17Syntaxin 170.100
Rab2Rab-protein 20.095
Rab7Rab-protein 70.070
Dap160Dynamin associated protein 1600.053
CG13603CG13603 gene product from transcript CG13603-RA0.051
Tsc1CG6147 gene product from transcript CG6147-RA0.046
Rpn6Proteasome p44.5 subunit0.044
CG12753CG12753 gene product from transcript CG12753-RB0.040
Sop2Suppressor of profilin 20.038
Vti1CG3279 gene product from transcript CG3279-RA0.028
CG10260CG10260 gene product from transcript CG10260-RB0.024
CG5262CG5262 gene product from transcript CG5262-RA0.018
Vps28Vacuolar protein sorting 280.017
Su(Tpl)CG32217 gene product from transcript CG32217-RB0.017
Tis11Tis11 homolog0.016
CG6116CG6116 gene product from transcript CG6116-RA0.016
ird1immune response deficient 10.015
StamSignal transducing adaptor molecule0.014
Vps45Vacuolar protein sorting 450.014
matsmob as tumor suppressor0.014
EndoGEndonuclease G0.013
mGluRAmetabotropic glutamate receptor0.013
fab1CG6355 gene product from transcript CG6355-RA0.013
ponpartner of numb0.012
CG11791CG11791 gene product from transcript CG11791-RB0.012
Pi4KIIalphaCG2929 gene product from transcript CG2929-RC0.012
CG9063CG9063 gene product from transcript CG9063-RA0.012
RagACG11968 gene product from transcript CG11968-RA0.012
Eps-15Epidermal growth factor receptor pathway substrate clone 150.011
CG6707CG6707 gene product from transcript CG6707-RA0.011
Rab5Rab-protein 50.011
Fak56DFocal Adhesion Kinase0.011
Atg7Autophagy-specific gene 70.011
Snap25Synapse protein 250.010
CG18005CG18005 gene product from transcript CG18005-RA0.010
CG4287CG4287 gene product from transcript CG4287-RB0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.989
ARHGAP1Rho GTPase activating protein 10.900
ARMCX3armadillo repeat containing, X-linked 30.871
STAMBPSTAM binding protein0.869
VPS33Bvacuolar protein sorting 33 homolog B (yeast)0.821
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.802
BECN1beclin 1, autophagy related0.702
RAB5ARAB5A, member RAS oncogene family0.694
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.690
SMAD2SMAD family member 20.687
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae)0.631
SYNRGsynergin, gamma0.577
CLASP1cytoplasmic linker associated protein 10.555
SORL1sortilin-related receptor, L(DLR class) A repeats containing0.531
SORT1sortilin 10.530
GPRASP1G protein-coupled receptor associated sorting protein 10.500
CHMP2Bchromatin modifying protein 2B0.389
MTMR9myotubularin related protein 90.382
ANKRD27ankyrin repeat domain 27 (VPS9 domain)0.363
HEXDChexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing0.336
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.331
PIK3C3phosphoinositide-3-kinase, class 30.310
HOOK3hook homolog 3 (Drosophila)0.294
UBE2Wubiquitin-conjugating enzyme E2W (putative)0.278
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C10.255
MTMR6myotubularin related protein 60.254
SNX3sorting nexin 30.228
VAMP8vesicle-associated membrane protein 8 (endobrevin)0.225
IGF2Rinsulin-like growth factor 2 receptor0.215
VPS24vacuolar protein sorting 24 homolog (S. cerevisiae)0.214
STAMsignal transducing adaptor molecule (SH3 domain and ITAM motif) 10.213
AKTIPAKT interacting protein0.198
LAMP2lysosomal-associated membrane protein 20.181
ROCK1Rho-associated, coiled-coil containing protein kinase 10.179
ZFYVE9zinc finger, FYVE domain containing 90.168
GPRASP2G protein-coupled receptor associated sorting protein 20.157
CREB3cAMP responsive element binding protein 30.153
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.145
CHMP1Bchromatin modifying protein 1B0.127
STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.125
UBE2R2ubiquitin-conjugating enzyme E2R 20.120
AGFG1ArfGAP with FG repeats 10.119
EIF1Beukaryotic translation initiation factor 1B0.112
RTN1reticulon 10.107
RABEP1rabaptin, RAB GTPase binding effector protein 10.102
BCL2B-cell CLL/lymphoma 20.099
GOLGA7golgin A70.098
EXOC8exocyst complex component 80.094
OSTM1osteopetrosis associated transmembrane protein 10.094
EXOC5exocyst complex component 50.092
RAB10RAB10, member RAS oncogene family0.088
VAMP7vesicle-associated membrane protein 70.086
SNAP23synaptosomal-associated protein, 23kDa0.077
STX12syntaxin 120.075
EEA1early endosome antigen 10.073
UVRAGUV radiation resistance associated gene0.073
PLDNpallidin homolog (mouse)0.063
WDR47WD repeat domain 470.062
MBIPMAP3K12 binding inhibitory protein 10.062
MOSPD1motile sperm domain containing 10.061
RNF6ring finger protein (C3H2C3 type) 60.060
DTNBP1dystrobrevin binding protein 10.054
HIPK3homeodomain interacting protein kinase 30.054
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.053
KPNA4karyopherin alpha 4 (importin alpha 3)0.052
NBR1neighbor of BRCA1 gene 10.050
REEP6receptor accessory protein 60.049
AMBRA1autophagy/beclin-1 regulator 10.048
ZFYVE26zinc finger, FYVE domain containing 260.048
SMURF1SMAD specific E3 ubiquitin protein ligase 10.045
SLC9A6solute carrier family 9 (sodium/hydrogen exchanger), member 60.044
CAB39calcium binding protein 390.043
CHIC2cysteine-rich hydrophobic domain 20.042
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.040
VPS4Bvacuolar protein sorting 4 homolog B (S. cerevisiae)0.039
SNX2sorting nexin 20.039
VTA1Vps20-associated 1 homolog (S. cerevisiae)0.039
TBC1D1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 10.038
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.037
TGFBR1transforming growth factor, beta receptor 10.037
GPBP1L1GC-rich promoter binding protein 1-like 10.036
ACTR10actin-related protein 10 homolog (S. cerevisiae)0.034
NRBF2nuclear receptor binding factor 20.034
ZNF654zinc finger protein 6540.033
INSRinsulin receptor0.033
EAF1ELL associated factor 10.032
EXOC1exocyst complex component 10.032
GAKcyclin G associated kinase0.032
SMAD9SMAD family member 90.032
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.031
ARL8BADP-ribosylation factor-like 8B0.031
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.031
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.031
UEVLDUEV and lactate/malate dehyrogenase domains0.030
DYNC1I2dynein, cytoplasmic 1, intermediate chain 20.030
VPS37Avacuolar protein sorting 37 homolog A (S. cerevisiae)0.030
RABAC1Rab acceptor 1 (prenylated)0.029
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.029
RANBP9RAN binding protein 90.028
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vps26bvacuolar protein sorting 26 homolog B (yeast)0.227
Vps29vacuolar protein sorting 29 (S. pombe)0.065
Vps26avacuolar protein sorting 26 homolog A (yeast)0.039
Usp8ubiquitin specific peptidase 80.036
Vti1bvesicle transport through interaction with t-SNAREs 1B homolog0.013
Rab18RAB18, member RAS oncogene family0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
JkampJNK1/MAPK8-associated membrane protein0.169
Map2k1mitogen activated protein kinase kinase 10.165
Tmbim6transmembrane BAX inhibitor motif containing 60.144
RragcRas-related GTP binding C0.089
Hsbp1heat shock factor binding protein 10.066
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.039
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.032
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.029
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.027
Arl8bADP-ribosylation factor-like 8B0.025
Errfi1ERBB receptor feedback inhibitor 10.024
Stx12syntaxin 120.023
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.022
Snx6sorting nexin 60.021
Sgk1serum/glucocorticoid regulated kinase 10.020
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.020
Plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.020
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.020
Stard3nlSTARD3 N-terminal like0.018
Adkadenosine kinase0.018
Vps41vacuolar protein sorting 41 homolog (S. cerevisiae)0.017
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.017
Arpc1aactin related protein 2/3 complex, subunit 1A0.017
Trappc1trafficking protein particle complex 10.016
Atp6v1hATPase, H+ transporting, lysosomal V1 subunit H0.016
Ppp1r2protein phosphatase 1, regulatory (inhibitor) subunit 20.015
N-paccytokine-like nuclear factor n-pac0.014
Fkbp1aFK506 binding protein 1a0.014
Gdi1GDP dissociation inhibitor 10.014
Vamp7vesicle-associated membrane protein 70.014
Pitpnaphosphatidylinositol transfer protein, alpha0.013
Criptcysteine-rich PDZ-binding protein0.012
Atp6v1e1ATPase, H+ transporting, lysosomal V1 subunit E10.012
AktipAKT interacting protein0.012
Dync1h1dynein cytoplasmic 1 heavy chain 10.012
Atg12ATG12 autophagy related 12 homolog (S. cerevisiae)0.012
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.012
LOC684800similar to stromal membrane-associated protein 10.011
Slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism