The network for 'rna interference' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rna interference

The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F26A1.1Protein F26A1.10.189
C24G6.8Protein C24G6.80.130
F10C2.4Protein F10C2.40.111
F31C3.3Protein F31C3.30.110
mog-5Protein MOG-50.109
CELE_B0238.11Protein B0238.110.108
cul-2Protein CUL-20.103
prp-4Protein PRP-40.102
W04D2.6Protein W04D2.60.097
F33E11.3Protein F33E11.30.086
ZK1098.1Protein ZK1098.10.085
capg-1Protein CAPG-10.084
lin-66Protein LIN-660.083
F32B6.3Protein F32B6.30.082
pri-1Protein PRI-10.081
CELE_F07E5.5Protein F07E5.50.081
pbrm-1Protein PBRM-10.080
attf-2Protein ATTF-20.079
B0336.3Protein B0336.30.077
snr-5Protein SNR-50.076
cku-80Protein CKU-800.075
frg-1Protein FRG-10.074
dnj-11Protein DNJ-110.074
hpo-9Protein HPO-90.074
cku-70Protein CKU-700.074
npp-10Protein NPP-100.073
clh-5Protein CLH-50.072
npp-5Protein NPP-50.072
smg-2Protein SMG-20.072
R05D11.4Protein R05D11.40.071
gei-4Protein GEI-40.071
lmn-1Protein LMN-10.070
klp-19Protein KLP-190.069
tag-151Protein TAG-1510.069
egg-6Protein EGG-60.068
B0511.6Protein B0511.60.067
dcap-1Protein DCAP-10.067
rde-1Protein RDE-10.067
sin-3Protein SIN-30.067
csn-1Protein CSN-10.067
top-2Protein TOP-20.067
CELE_Y54E10BR.4Protein Y54E10BR.40.067
cul-1Protein CUL-10.066
T28A8.6Protein T28A8.60.066
nst-1Protein NST-10.065
lsm-5Protein LSM-50.065
cids-2Protein CIDS-20.065
hrp-1Protein HRP-10.065
mat-2Protein MAT-20.064
C53B4.4Protein C53B4.40.064
B0361.6Protein B0361.60.063
sacy-1Protein SACY-10.060
F56D2.6Protein F56D2.60.060
fli-1Protein FLI-10.060
C32D5.10Protein C32D5.100.060
gad-1Protein GAD-10.059
teg-1Protein TEG-10.059
lin-35Protein LIN-350.059
ndc-80Protein NDC-800.059
ddx-19Protein DDX-190.059
smg-5Protein SMG-50.059
imb-3Protein IMB-30.058
F10E7.11Protein F10E7.110.058
T12C9.7Protein T12C9.70.058
prp-31Protein PRP-310.058
lin-13Protein LIN-130.058
T08G11.4Protein T08G11.40.058
gla-3Protein GLA-30.057
F25H5.5Protein F25H5.50.057
mrpl-51Protein MRPL-510.057
ZC376.6Protein ZC376.60.056
npp-7Protein NPP-70.056
cyp-31A2Protein CYP-31A20.056
F59E12.9Protein F59E12.90.056
sams-4Protein SAMS-40.055
wrm-1Protein WRM-10.055
gon-14Protein GON-140.055
zyg-9Protein ZYG-90.055
C06G1.5Protein C06G1.50.055
apr-1Protein APR-10.054
lin-36Protein LIN-360.054
F47G3.3Protein F47G3.30.054
CELE_W02F12.4Protein W02F12.40.053
R01H10.7Protein R01H10.70.053
nasp-1Protein NASP-10.053
mog-4Protein MOG-40.053
F13H8.2Protein F13H8.20.053
CELE_T03D3.5Protein T03D3.50.053
age-1Protein AGE-10.053
C05C8.2Protein C05C8.20.053
K09H9.2Protein K09H9.20.052
mog-2Protein MOG-20.052
F42G9.1Protein F42G9.10.052
cdc-7Protein CDC-70.052
CELE_C25A1.4Protein C25A1.40.052
R08D7.1Protein R08D7.10.052
apn-1Protein APN-10.051
dli-1Protein DLI-10.051
csr-1Protein CSR-10.051
CELE_T23B5.3Protein T23B5.30.051
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
lwrlesswright0.510
tratransformer0.442
Rpd3CG7471 gene product from transcript CG7471-RA0.410
piwiCG6122 gene product from transcript CG6122-RA0.297
aubaubergine0.282
pr-set7CG3307 gene product from transcript CG3307-RC0.260
SmD3Small ribonucleoprotein particle protein SmD30.213
Caf1Chromatin assembly factor 1 subunit0.199
reptreptin0.189
feofascetto0.175
Uba1Ubiquitin activating enzyme 10.161
Pp1-87BProtein phosphatase 1 at 87B0.160
Ef1gammaCG11901 gene product from transcript CG11901-RC0.155
HlcHelicase0.137
Atx2Ataxin-20.133
AGO1Argonaute-10.113
B52CG10851 gene product from transcript CG10851-RB0.107
staustaufen0.104
rinrasputin0.104
PcPolycomb0.102
eIF4E-3CG8023 gene product from transcript CG8023-RA0.095
vasvasa0.095
hephhephaestus0.087
ird5immune response deficient 50.085
CG13900CG13900 gene product from transcript CG13900-RA0.083
tsrtwinstar0.077
Mov34CG3416 gene product from transcript CG3416-RA0.077
IswiImitation SWI0.076
eIF3-S10CG9805 gene product from transcript CG9805-RA0.075
Dcp-1Death caspase-10.073
htshu li tai shao0.072
CG2469CG2469 gene product from transcript CG2469-RB0.072
orboo18 RNA-binding protein0.070
Spt5CG7626 gene product from transcript CG7626-RA0.069
Su(z)12CG8013 gene product from transcript CG8013-RA0.069
ypsypsilon schachtel0.068
Mi-2CG8103 gene product from transcript CG8103-RA0.067
CG32685CG32685 gene product from transcript CG32685-RC0.067
mip130Myb-interacting protein 1300.066
CTCFCG8591 gene product from transcript CG8591-RA0.064
CG16941CG16941 gene product from transcript CG16941-RA0.063
scnyscrawny0.061
pelopelota0.061
maelmaelstrom0.058
E(z)Enhancer of zeste0.056
CG10107CG10107 gene product from transcript CG10107-RA0.056
fs(1)Ybfemale sterile (1) Yb0.056
growlCG14648 gene product from transcript CG14648-RA0.054
hydhyperplastic discs0.054
stilstand still0.052
CG5642CG5642 gene product from transcript CG5642-RA0.052
effeffete0.052
crpcropped0.049
Hdac3Histone deacetylase 30.049
oskoskar0.049
l(2)35Bglethal (2) 35Bg0.047
Ef2bElongation factor 2b0.046
HP4Heterochromatin protein 40.045
klarklarsicht0.045
l(1)10Bblethal (1) 10Bb0.045
rdxroadkill0.044
His3.3AHistone H3.3A0.044
CG18811CG18811 gene product from transcript CG18811-RA0.044
RanGapRan GTPase activating protein0.043
Cap-GCG34438 gene product from transcript CG34438-RF0.042
hipkhomeodomain interacting protein kinase0.042
CG5787CG5787 gene product from transcript CG5787-RA0.042
Prp31CG6876 gene product from transcript CG6876-RA0.042
Cbp80cap binding protein 800.041
eIF3-S8CG4954 gene product from transcript CG4954-RA0.041
CG3605CG3605 gene product from transcript CG3605-RA0.040
18w18 wheeler0.040
Dsor1Downstream of raf10.040
pontpontin0.039
cnkconnector enhancer of ksr0.039
CG4849CG4849 gene product from transcript CG4849-RA0.039
CG11417CG11417 gene product from transcript CG11417-RA0.038
CamCalmodulin0.038
Nopp140CG7421 gene product from transcript CG7421-RB0.038
Hsp83Heat shock protein 830.038
ph-ppolyhomeotic proximal0.037
CG8801CG8801 gene product from transcript CG8801-RA0.036
Tango6Transport and Golgi organization 60.036
CG8108CG8108 gene product from transcript CG8108-RA0.036
tsutsunagi0.036
JIL-1CG6297 gene product from transcript CG6297-RA0.035
mbomembers only0.035
Rat1CG10354 gene product from transcript CG10354-RA0.034
CkIalphaCasein kinase Ialpha0.034
csulcapsuleen0.034
tudtudor0.034
CG3363CG3363 gene product from transcript CG3363-RB0.034
eggeggless0.033
Sox14Sox box protein 140.033
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.032
MED20Mediator complex subunit 200.032
eIF3-S9CG4878 gene product from transcript CG4878-RA0.032
Uch-L3Ubiquitin C-terminal hydrolase0.032
chinmoChronologically inappropriate morphogenesis0.031
nocteno circadian temperature entrainment0.031
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RBM10RNA binding motif protein 100.986
HDAC1histone deacetylase 10.986
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.964
DICER1dicer 1, ribonuclease type III0.877
CSNK2A1casein kinase 2, alpha 1 polypeptide0.833
HDAC2histone deacetylase 20.756
EIF2C2eukaryotic translation initiation factor 2C, 20.725
SF3A2splicing factor 3a, subunit 2, 66kDa0.673
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.649
UBQLN1ubiquilin 10.648
SIN3ASIN3 homolog A, transcription regulator (yeast)0.620
SUZ12suppressor of zeste 12 homolog (Drosophila)0.619
UBQLN4ubiquilin 40.596
SF1splicing factor 10.579
HSPA1Aheat shock 70kDa protein 1A0.555
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.516
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.480
HSPA1Bheat shock 70kDa protein 1B0.478
H2AFZH2A histone family, member Z0.468
SNRPA1small nuclear ribonucleoprotein polypeptide A'0.450
SNRPFsmall nuclear ribonucleoprotein polypeptide F0.438
TOP1topoisomerase (DNA) I0.434
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.412
SFPQsplicing factor proline/glutamine-rich0.361
MTA1metastasis associated 10.358
MATR3matrin 30.351
SF3B1splicing factor 3b, subunit 1, 155kDa0.343
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.337
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.317
NCBP1nuclear cap binding protein subunit 1, 80kDa0.309
WWOXWW domain containing oxidoreductase0.297
RECQLRecQ protein-like (DNA helicase Q1-like)0.287
HNRNPKheterogeneous nuclear ribonucleoprotein K0.285
ADRM1adhesion regulating molecule 10.285
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.285
KIAA1377KIAA13770.260
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.249
ACTL6Aactin-like 6A0.247
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.244
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.239
SF3A3splicing factor 3a, subunit 3, 60kDa0.234
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.234
EIF3Beukaryotic translation initiation factor 3, subunit B0.219
EEDembryonic ectoderm development0.216
DTX3Ldeltex 3-like (Drosophila)0.205
FNBP4formin binding protein 40.196
HAT1histone acetyltransferase 10.195
BAG3BCL2-associated athanogene 30.195
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.186
CHD4chromodomain helicase DNA binding protein 40.183
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.181
ACTR6ARP6 actin-related protein 6 homolog (yeast)0.173
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.172
FXR1fragile X mental retardation, autosomal homolog 10.171
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.168
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.168
MAGEH1melanoma antigen family H, 10.164
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.162
IDEinsulin-degrading enzyme0.159
EIF3Jeukaryotic translation initiation factor 3, subunit J0.158
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.158
EIF2C1eukaryotic translation initiation factor 2C, 10.157
RBM17RNA binding motif protein 170.156
MYBBP1AMYB binding protein (P160) 1a0.156
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.155
TARDBPTAR DNA binding protein0.155
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.150
HSPBP1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 10.149
UCHL5ubiquitin carboxyl-terminal hydrolase L50.148
EIF2C3eukaryotic translation initiation factor 2C, 30.145
MAPK14mitogen-activated protein kinase 140.143
MBD3methyl-CpG binding domain protein 30.143
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.141
SUGP1SURP and G patch domain containing 10.140
SKIV2L2superkiller viralicidic activity 2-like 2 (S. cerevisiae)0.140
KPNB1karyopherin (importin) beta 10.138
NXF1nuclear RNA export factor 10.137
PARP9poly (ADP-ribose) polymerase family, member 90.135
ARL6IP1ADP-ribosylation factor-like 6 interacting protein 10.132
U2SURPU2 snRNP-associated SURP domain containing0.130
XPO1exportin 1 (CRM1 homolog, yeast)0.130
SNIP1Smad nuclear interacting protein 10.130
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.129
PSEN1presenilin 10.129
HMGB1high mobility group box 10.128
GATAD2AGATA zinc finger domain containing 2A0.126
TCF4transcription factor 40.126
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.125
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 10.124
PCNAproliferating cell nuclear antigen0.124
BAG1BCL2-associated athanogene0.123
RANBP1RAN binding protein 10.123
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.122
PTNpleiotrophin0.121
EIF3Ieukaryotic translation initiation factor 3, subunit I0.121
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.121
CBX1chromobox homolog 10.117
MAP3K1mitogen-activated protein kinase kinase kinase 10.117
ZNHIT1zinc finger, HIT-type containing 10.117
PARP1poly (ADP-ribose) polymerase 10.117
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hdac2histone deacetylase 20.956
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.915
Ezh2enhancer of zeste homolog 2 (Drosophila)0.850
Hnrnpa2b1heterogeneous nuclear ribonucleoprotein A2/B10.822
Smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.809
Hdac1histone deacetylase 10.757
Lef1lymphoid enhancer binding factor 10.727
TapbpTAP binding protein0.724
H3f3aH3 histone, family 3A0.723
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.686
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.603
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.596
Eedembryonic ectoderm development0.528
Suz12suppressor of zeste 12 homolog (Drosophila)0.502
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.425
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.407
Rbbp4retinoblastoma binding protein 40.401
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.377
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.364
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.338
Hnrnprheterogeneous nuclear ribonucleoprotein R0.334
Arid1aAT rich interactive domain 1A (SWI-like)0.325
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.304
Srsf3serine/arginine-rich splicing factor 30.296
DekDEK oncogene (DNA binding)0.285
Mta2metastasis-associated gene family, member 20.282
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.281
Tcf7transcription factor 7, T-cell specific0.267
Rpgrip1lRpgrip1-like0.261
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.260
Kdm5blysine (K)-specific demethylase 5B0.252
Matr3matrin 30.247
Rbbp7retinoblastoma binding protein 70.243
Serbp1serpine1 mRNA binding protein 10.238
Srsf1serine/arginine-rich splicing factor 10.236
Sumo2SMT3 suppressor of mif two 3 homolog 2 (yeast)0.225
Xpo1exportin 1, CRM1 homolog (yeast)0.221
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.217
Tnrc6btrinucleotide repeat containing 6b0.210
Dnmt1DNA methyltransferase (cytosine-5) 10.203
Jarid2jumonji, AT rich interactive domain 20.199
Suv39h1suppressor of variegation 3-9 homolog 1 (Drosophila)0.184
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.182
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.171
Sin3atranscriptional regulator, SIN3A (yeast)0.169
Pnnpinin0.169
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.168
Sf3b1splicing factor 3b, subunit 10.166
Tcte3t-complex-associated testis expressed 30.163
Thoc2THO complex 20.162
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 90.161
TardbpTAR DNA binding protein0.159
Hnrnpcheterogeneous nuclear ribonucleoprotein C0.156
Usp7ubiquitin specific peptidase 70.154
Sox2SRY-box containing gene 20.153
Mbd3methyl-CpG binding domain protein 30.148
Hmgb1high mobility group box 10.146
Cnot6CCR4-NOT transcription complex, subunit 60.145
Cenpc1centromere protein C10.145
Hnrnph2heterogeneous nuclear ribonucleoprotein H20.143
Pum1pumilio 1 (Drosophila)0.137
Psip1PC4 and SFRS1 interacting protein 10.135
G3bp2GTPase activating protein (SH3 domain) binding protein 20.132
Tfdp1transcription factor Dp 10.131
Ythdf2YTH domain family 20.130
Wdr82WD repeat domain containing 820.130
Bptfbromodomain PHD finger transcription factor0.129
NanogNanog homeobox0.127
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.123
Trim32tripartite motif-containing 320.122
Pargpoly (ADP-ribose) glycohydrolase0.121
FosFBJ osteosarcoma oncogene0.120
Ppp2r4protein phosphatase 2A, regulatory subunit B (PR 53)0.119
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.118
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.117
JunbJun-B oncogene0.116
Ptges3prostaglandin E synthase 3 (cytosolic)0.116
Akap9A kinase (PRKA) anchor protein (yotiao) 90.115
Ctnnb1catenin (cadherin associated protein), beta 10.112
IkIK cytokine0.112
Srsf7serine/arginine-rich splicing factor 70.111
Stat2signal transducer and activator of transcription 20.109
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.109
Rbm25RNA binding motif protein 250.108
Sp1trans-acting transcription factor 10.105
Smad4MAD homolog 4 (Drosophila)0.105
Asna1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.102
Tial1Tia1 cytotoxic granule-associated RNA binding protein-like 10.101
Pcnaproliferating cell nuclear antigen0.101
CtcfCCCTC-binding factor0.101
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.101
Ythdc1YTH domain containing 10.100
Kpna2karyopherin (importin) alpha 20.098
Yy1YY1 transcription factor0.097
Ifi35interferon-induced protein 350.096
Srsf2serine/arginine-rich splicing factor 20.095
Mta1metastasis associated 10.094
Rcor1REST corepressor 10.093
Ppap2bphosphatidic acid phosphatase type 2B0.093
Smad1MAD homolog 1 (Drosophila)0.092
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism