The network for 'response to organic substance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to organic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.994
apoebapolipoprotein Eb0.993
spry4sprouty (Drosophila) homolog 40.964
myod1myogenic differentiation 10.954
robo3roundabout homolog 30.953
notch1anotch homolog 1a0.944
shhasonic hedgehog a0.939
pax6apaired box gene 6a0.910
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.904
foxa2forkhead box A20.884
runx2brunt-related transcription factor 2b0.869
cdh2cadherin 2, neuronal0.863
flhfloating head0.807
dusp6dual specificity phosphatase 60.798
bmp4bone morphogenetic protein 40.792
gata5GATA-binding protein 50.788
otpaorthopedia homolog a0.787
fgf8afibroblast growth factor 8 a0.760
sox17SRY-box containing gene 170.747
cdh1cadherin 1, epithelial0.745
thtyrosine hydroxylase0.742
ptch2patched 20.734
gata3GATA-binding protein 30.731
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.730
efnb2aephrin B2a0.728
rarabretinoic acid receptor, alpha b0.721
wnt5bwingless-type MMTV integration site family, member 5b0.693
vasavasa homolog0.688
ef1aelongation factor 1-alpha0.658
ntlano tail a0.657
ndr2nodal-related 20.657
pax7apaired box gene 7a0.654
wnt11wingless-type MMTV integration site family, member 110.628
xbp1X-box binding protein 10.623
sox32SRY-box containing gene 320.612
gata1aGATA binding protein 1a0.608
hspa5heat shock protein 50.604
bactin2bactin20.603
cdx4caudal type homeo box transcription factor 40.595
oepone-eyed pinhead0.581
dlx2adistal-less homeobox gene 2a0.570
flncbfilamin C, gamma b (actin binding protein 280)0.569
gpiaglucose phosphate isomerase a0.567
pitx3paired-like homeodomain transcription factor 30.557
flt4fms-related tyrosine kinase 40.557
foxa3forkhead box A30.551
snai1asnail homolog 1a (Drosophila)0.549
esr2aestrogen receptor 2a0.546
fabp11afatty acid binding protein 11a0.544
hnf1baHNF1 homeobox Ba0.540
pdgfaaplatelet-derived growth factor alpha a0.534
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.525
notch3notch homolog 30.525
nanos3nanos homolog 30.524
nrp2bneuropilin 2b0.524
nkx2.5NK2 transcription factor related 50.519
lhcgrluteinizing hormone/choriogonadotropin receptor0.514
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.509
ptprkprotein tyrosine phosphatase, receptor type, K0.506
pea3ETS-domain transcription factor pea30.501
dlcdeltaC0.496
fgf4fibroblast growth factor 40.489
chdchordin0.487
esr1estrogen receptor 10.485
sox11aSRY-box containing gene 11a0.480
cx27.5connexin 27.50.466
krt18keratin 180.463
barhl1.1BarH-like 1.10.461
junjun proto-oncogene0.460
bbc3BCL2 binding component 30.459
pcnaproliferating cell nuclear antigen0.459
barhl2BarH-like 20.451
maomonoamine oxidase0.449
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.443
ptenaphosphatase and tensin homolog A0.443
mt2metallothionein 20.439
lef1lymphocyte enhancer binding factor 10.433
wnt1wingless-type MMTV integration site family, member 10.425
ncf1neutrophil cytosolic factor 10.421
sall1asal-like 1a (Drosophila)0.411
zgc:64114zgc:641140.404
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.400
plagl2pleiomorphic adenoma gene-like 20.398
foxp2forkhead box P20.397
anxa1aannexin A1a0.397
igf1rainsulin-like growth factor 1a receptor0.396
il17rdinterleukin 17 receptor D0.396
dmbx1adiencephalon/mesencephalon homeobox 1a0.395
jag2jagged 20.395
cyp1acytochrome P450, family 1, subfamily A0.393
paqr8progestin and adipoQ receptor family member VIII0.392
hsp90b1heat shock protein 90, beta (grp94), member 10.385
fzd7bfrizzled homolog 7b0.384
ptgs2aprostaglandin-endoperoxide synthase 2a0.383
arnt2aryl hydrocarbon receptor nuclear translocator 20.381
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.381
per2period homolog 2 (Drosophila)0.381
mcl1amyeloid cell leukemia sequence 1a0.381
nfe2l2nuclear factor (erythroid-derived 2)-like 20.375
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.373
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.821
hsp-16.2Protein HSP-16.20.647
nhr-67Protein NHR-670.606
F13H6.1Protein F13H6.10.596
mig-15Protein MIG-150.581
hsp-16.1Protein HSP-16.10.545
hsp-3Protein HSP-30.543
pmk-1Protein PMK-10.523
hsp-16.41Protein HSP-16.410.493
egg-6Protein EGG-60.468
let-60Protein LET-600.458
egl-18Protein EGL-180.450
mat-3Protein MAT-30.444
glp-1Protein GLP-10.435
par-5Protein PAR-50.429
acs-4Protein ACS-40.423
tag-320Protein TAG-3200.417
hsp-70Protein HSP-700.410
egl-44Protein EGL-440.407
sma-6Protein SMA-60.398
hsp-4Protein HSP-40.394
cgh-1Protein CGH-10.391
pkg-1Protein PKG-10.367
unc-9Protein UNC-90.366
daf-14Protein DAF-140.355
gpb-2Protein GPB-20.354
egl-13Protein EGL-130.352
osm-3Protein OSM-30.347
osm-5Protein OSM-50.335
ifg-1Protein IFG-10.330
Y47D3B.6Protein Y47D3B.60.325
abl-1Protein ABL-10.321
abu-15Protein ABU-150.318
hsp-17Protein HSP-170.312
pdfr-1Protein PDFR-10.300
apc-2Protein APC-20.298
hnd-1Protein HND-10.298
pqn-54Protein PQN-540.291
hmr-1Protein HMR-10.291
F44E5.4Protein F44E5.40.285
abu-1Protein ABU-10.285
pkn-1Protein PKN-10.283
aak-2Protein AAK-20.280
ccch-1Protein CCCH-10.277
bar-1Protein BAR-10.276
wrn-1Protein WRN-10.276
W02B8.1Protein W02B8.10.273
lmn-1Protein LMN-10.271
mig-5Protein MIG-50.269
kin-3Protein KIN-30.265
pmt-1Protein PMT-10.257
sas-5Protein SAS-50.251
ahcy-1Protein AHCY-10.251
F53F10.2Protein F53F10.20.249
unc-86Protein UNC-860.249
che-2Protein CHE-20.245
unc-62Protein UNC-620.243
unc-104Protein UNC-1040.241
lin-25Protein LIN-250.239
C35C5.3Protein C35C5.30.238
daf-11Protein DAF-110.238
osm-6Protein OSM-60.234
sos-1Protein SOS-10.233
hum-5Protein HUM-50.229
unc-7Protein UNC-70.228
elt-6Protein ELT-60.227
itr-1Protein ITR-10.212
nhr-25Protein NHR-250.208
CELE_T05E11.3Protein T05E11.30.204
egl-15Protein EGL-150.204
ptr-14Protein PTR-140.203
sid-1Protein SID-10.198
vit-2Protein VIT-20.197
egl-8Protein EGL-80.197
unc-40Protein UNC-400.196
tax-6Protein TAX-60.193
gld-1Protein GLD-10.192
abu-14Protein ABU-140.189
oac-46Protein OAC-460.189
inx-1Protein INX-10.188
odr-3Protein ODR-30.188
sur-2Protein SUR-20.188
unc-32Protein UNC-320.186
dlk-1Protein DLK-10.184
cam-1Protein CAM-10.181
sel-7Protein SEL-70.179
jmjd-3.1Protein JMJD-3.10.178
cyp-35C1Protein CYP-35C10.177
daf-7Protein DAF-70.177
nhr-34Protein NHR-340.175
apr-1Protein APR-10.175
abu-11Protein ABU-110.174
chd-7Protein CHD-70.174
cat-2Protein CAT-20.167
CELE_C01G6.5Protein C01G6.50.166
inx-4Protein INX-40.165
lact-3Protein LACT-30.165
dsc-4Protein DSC-40.165
daf-2Protein DAF-20.164
atg-2Protein ATG-20.161
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EcREcdysone receptor0.997
S6kRPS6-p70-protein kinase0.995
Pi3K92ECG4141 gene product from transcript CG4141-RB0.995
EgfrEpidermal growth factor receptor0.994
Ras85DRas oncogene at 85D0.980
InRInsulin-like receptor0.974
Sir2CG5216 gene product from transcript CG5216-RA0.968
foxoforkhead box, sub-group O0.965
phlpole hole0.964
p53CG33336 gene product from transcript CG33336-RB0.950
rlrolled0.940
sinaseven in absentia0.937
cicubitus interruptus0.926
rutrutabaga0.903
Stat92ESignal-transducer and activator of transcription protein at 92E0.888
eveeven skipped0.886
RelRelish0.881
bowlbrother of odd with entrails limited0.879
chicoCG5686 gene product from transcript CG5686-RB0.874
hephemipterous0.872
miltmilton0.848
drkdownstream of receptor kinase0.847
Akt1CG4006 gene product from transcript CG4006-RA0.834
Pink1PTEN-induced putative kinase 10.832
G-salpha60AG protein salpha 60A0.823
Hsc70-4Heat shock protein cognate 40.819
bskbasket0.813
Fmr1CG6203 gene product from transcript CG6203-RC0.812
MadMothers against dpp0.812
SmoxSmad on X0.806
MerMerlin0.805
arrarrow0.801
CatCatalase0.801
dmdiminutive0.799
Lis-1Lissencephaly-10.794
Hsp68Heat shock protein 680.788
frufruitless0.780
emcextra macrochaetae0.776
loqsloquacious0.768
JraJun-related antigen0.753
Pka-C1cAMP-dependent protein kinase 10.753
panpangolin0.751
putpunt0.747
NFATNFAT homolog0.745
TpiTriose phosphate isomerase0.740
shnschnurri0.739
shishibire0.738
NNotch0.704
Hsp70AbHeat-shock-protein-70Ab0.698
dsxdoublesex0.686
UbqnUbiquilin0.682
Spn27ASerpin 27A0.675
CG7998CG7998 gene product from transcript CG7998-RA0.675
hthhomothorax0.668
nebnebbish0.661
nkdnaked cuticle0.660
cswcorkscrew0.660
sflsulfateless0.650
AdhAlcohol dehydrogenase0.631
Kr-h1Kruppel homolog 10.624
drlderailed0.620
scnyscrawny0.619
ttvtout-velu0.617
gcmglial cells missing0.615
ssspineless0.613
pntpointed0.609
RpII215RNA polymerase II 215kD subunit0.607
SodSuperoxide dismutase0.603
apapterous0.602
Nmdar1NMDA receptor 10.595
sevsevenless0.593
exexpanded0.588
discodisconnected0.587
amosabsent MD neurons and olfactory sensilla0.572
rapretina aberrant in pattern0.571
argosCG4531 gene product from transcript CG4531-RA0.564
UbxUltrabithorax0.560
TrhTryptophan hydroxylase0.553
dshdishevelled0.544
fufused0.543
E(spl)Enhancer of split0.537
DadDaughters against dpp0.531
CycGCyclin G0.513
benbendless0.511
CG8155CG8155 gene product from transcript CG8155-RA0.510
hhhedgehog0.508
Galpha49BG protein alpha49B0.503
Ugt35aUDP-glycosyltransferase 35a0.502
egreiger0.500
pumpumilio0.500
par-1CG8201 gene product from transcript CG8201-RA0.499
Cdc42CG12530 gene product from transcript CG12530-RA0.494
tarataranis0.492
sdscalloped0.491
lin19lin-19-like0.484
wtswarts0.482
mofmales absent on the first0.474
LnkCG17367 gene product from transcript CG17367-RC0.473
CapsCalcium activated protein for secretion0.471
CG17734CG17734 gene product from transcript CG17734-RA0.468
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
STE4Ste4p0.990
STE11Ste11p0.972
BEM1Bem1p0.964
HSP82Hsp82p0.959
SST2Sst2p0.955
FAR1Far1p0.938
SLT2Slt2p0.884
FUS3Fus3p0.877
AGA2Aga2p0.852
RHO1Rho1p0.845
STE5Ste5p0.825
HOG1Hog1p0.825
STE2Ste2p0.815
PPH21Pph21p0.815
CLA4Cla4p0.794
RTG3Rtg3p0.784
CDC48Cdc48p0.784
AGA1Aga1p0.751
CDC24Cdc24p0.740
STE7Ste7p0.689
RPN4Rpn4p0.681
MIG1Mig1p0.678
STE20Ste20p0.671
SHO1Sho1p0.670
CRZ1Crz1p0.663
TPK1Tpk1p0.659
HSP104Hsp104p0.650
GLN3Gln3p0.625
TOR1Tor1p0.614
SLG1Slg1p0.605
HXT7Hxt7p0.582
RAS2Ras2p0.581
GPA1Gpa1p0.571
FAR10Far10p0.552
PMT1Pmt1p0.533
KDX1Kdx1p0.526
SSK2Ssk2p0.522
KSS1Kss1p0.519
SSA1Ssa1p0.517
UBP15Ubp15p0.515
BMH1Bmh1p0.513
SGT2Sgt2p0.512
MFA1Mfa1p0.507
PTC1Ptc1p0.499
SGV1Sgv1p0.491
KSP1Ksp1p0.489
NPR1Npr1p0.481
FAR11Far11p0.481
FUS1Fus1p0.469
PPZ1Ppz1p0.467
HSP60Hsp60p0.462
STE18Ste18p0.449
STE50Ste50p0.428
LCB4Lcb4p0.426
PRC1Prc1p0.411
CLB6Clb6p0.390
TPO4Tpo4p0.385
CLB3Clb3p0.380
SWE1Swe1p0.380
LDB19Ldb19p0.379
AHA1Aha1p0.378
MKK1Mkk1p0.374
MSG5Msg5p0.373
RRI2Rri2p0.366
USA1Usa1p0.365
YPL150Whypothetical protein0.364
PST2Pst2p0.364
MKS1Mks1p0.358
RRI1Rri1p0.358
SUP35Sup35p0.354
FIG2Fig2p0.352
KCC4Kcc4p0.339
BAR1Bar1p0.336
AKR1Akr1p0.331
CMP2Cmp2p0.326
RHO5Rho5p0.324
PMT2Pmt2p0.318
ASG1Asg1p0.314
DIA2Dia2p0.314
FAR3Far3p0.312
FUS2Fus2p0.306
HSL7Hsl7p0.301
LYS5Lys5p0.299
PRK1Prk1p0.295
CSG2Csg2p0.295
ROG3Rog3p0.293
ATG32Atg32p0.293
BDF1Bdf1p0.292
YJL163Chypothetical protein0.289
SAP185Sap185p0.288
SSE2Sse2p0.284
PTR3Ptr3p0.283
HRK1Hrk1p0.282
GPR1Gpr1p0.282
AQY2Aqy2p0.277
HXT6Hxt6p0.277
CSN9Csn9p0.277
ESP1Esp1p0.275
MF(ALPHA)1Mf(alpha)1p0.270
MIG2Mig2p0.262