The network for 'positive regulation of bmp signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of bmp signaling pathway

Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.

NameDescriptionProbabilityFunc Analog Organism
ventventral expressed homeobox0.257
bmp2bbone morphogenetic protein 2b0.214
jag1bjagged 1b0.133
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.075
tcf7transcription factor 7 (T-cell specific, HMG-box)0.069
lhx2bLIM homeobox 2b0.062
ihhaIndian hedgehog homolog a0.058
sesn1sestrin 10.048
satb2SATB homeobox 20.047
bmp4bone morphogenetic protein 40.044
gro1groucho 10.044
dusp6dual specificity phosphatase 60.042
evx1even-skipped homeobox 10.039
mmp2matrix metalloproteinase 20.038
gdf6bgrowth differentiation factor 6b0.038
rxrbbretinoid x receptor, beta b0.037
nkd1naked cuticle homolog 1 (Drosophila)0.033
unc5bunc-5 homolog B (C. elegans)0.032
wnt8awingless-type MMTV integration site family, member 8a0.032
hey1hairy/enhancer-of-split related with YRPW motif 10.032
fgfr1bfibroblast growth factor receptor 1b0.031
vsx2visual system homeobox 20.029
notch2notch homolog 20.028
acvr2aactivin receptor IIa0.026
edn1endothelin 10.025
tbx18T-box 180.024
tjp1tight junction protein 1 (zona occludens 1)0.023
ctsl1bcathepsin L, 1 b0.023
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.023
prdm5PR domain containing 50.021
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.021
ccm2cerebral cavernous malformation 20.021
fgfr4fibroblast growth factor receptor 40.021
nortnotch-regulated transcript0.020
barx2BarH-like homeobox 20.019
dlx2adistal-less homeobox gene 2a0.019
dlx5adistal-less homeobox gene 5a0.019
crabp2bcellular retinoic acid binding protein 2, b0.019
dccdeleted in colorectal carcinoma0.019
ahr2aryl hydrocarbon receptor 20.018
tbx2aT-box gene 2a0.018
fibinfin bud initiation factor0.018
rxrgaretinoid x receptor, gamma a0.017
fzd7afrizzled homolog 7a0.017
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.017
ephb4beph receptor B4b0.017
sulf1sulfatase 10.017
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.017
mcoln1mucolipin 10.016
fkbp5FK506 binding protein 50.016
fgf16fibroblast growth factor 160.015
mchr1bmelanin-concentrating hormone receptor 1b0.015
cpla2cytosolic phospholipase a20.015
prdm1aPR domain containing 1a, with ZNF domain0.015
cdoncell adhesion molecule-related/down-regulated by oncogenes0.014
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.014
iqgap1IQ motif containing GTPase activating protein 10.014
nkx2.5NK2 transcription factor related 50.014
phf21aPHD finger protein 21A0.013
atoh7atonal homolog 70.013
nr6a1anuclear receptor subfamily 6, group A, member 1a0.013
hoxd13ahomeo box D13a0.013
glceaglucuronyl C5-epimerase a0.013
fzd5frizzled homolog 50.013
chsy1chondroitin sulfate synthase 10.013
klf2aKruppel-like factor 2a0.013
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.012
hoxa11ahomeo box A11a0.012
lhx1bLIM homeobox 1b0.012
cpa1carboxypeptidase A1 (pancreatic)0.012
her6hairy-related 60.012
cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.012
mgaMAX gene associated0.012
six1bsine oculis homeobox homolog 1b0.012
igf1rbinsulin-like growth factor 1b receptor0.012
gli2aGLI-Kruppel family member GLI2a0.011
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.011
hapln3hyaluronan and proteoglycan link protein 30.011
hoxa13bhomeo box A13b0.011
tgfb2transforming growth factor, beta 20.011
lef1lymphocyte enhancer binding factor 10.011
chpfchondroitin polymerizing factor0.011
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.011
edarectodysplasin A receptor0.011
slc30a7solute carrier family 30 (zinc transporter), member 70.011
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.011
gbx2gastrulation brain homeo box 20.011
slc4a2asolute carrier family 4, anion exchanger, member 2a0.010
gna12guanine nucleotide binding protein (G protein) alpha 120.010
ctgfconnective tissue growth factor0.010
mtnr1bamelatonin receptor type 1B a0.010
tbx16T-box gene 160.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ten-1Protein TEN-10.082
egl-18Protein EGL-180.059
daf-4Protein DAF-40.055
daf-14Protein DAF-140.050
lag-2Protein LAG-20.045
sel-8Protein SEL-80.039
lmn-1Protein LMN-10.035
pha-4Protein PHA-40.034
let-60Protein LET-600.033
elt-6Protein ELT-60.033
daf-1Protein DAF-10.028
crm-1Protein CRM-10.027
aars-2Protein AARS-20.027
lrp-2Protein LRP-20.025
T21B6.3Protein T21B6.30.024
atgp-1Protein ATGP-10.023
clr-1Protein CLR-10.023
cam-1Protein CAM-10.023
nhr-67Protein NHR-670.022
C35C5.6Protein C35C5.60.020
egl-15Protein EGL-150.020
sma-6Protein SMA-60.019
pqn-71Protein PQN-710.019
F07A11.2Protein F07A11.20.018
dhhc-2Protein DHHC-20.018
CELE_Y57G11C.22Protein Y57G11C.220.018
cnd-1Protein CND-10.018
daf-11Protein DAF-110.018
skn-1Protein SKN-10.017
edc-3Protein EDC-30.017
hlh-30Protein HLH-300.015
sma-3Protein SMA-30.015
wdr-5.3Protein WDR-5.30.015
inx-3Protein INX-30.015
ulp-2Protein ULP-20.015
CELE_F25E5.1Protein F25E5.10.015
CELE_R09F10.3Protein R09F10.30.015
sulp-2Protein SULP-20.015
del-5Protein DEL-50.014
C44C1.1Protein C44C1.10.014
atg-16.1Protein ATG-16.10.014
lin-36Protein LIN-360.014
CELE_T04A8.7Protein T04A8.70.014
scrm-1Protein SCRM-10.014
vab-1Protein VAB-10.013
twk-25Protein TWK-250.013
bar-1Protein BAR-10.013
pvf-1Protein PVF-10.013
egl-46Protein EGL-460.013
gei-8Protein GEI-80.013
dis-3Protein DIS-30.013
nhr-14Protein NHR-140.012
H10E21.1Protein H10E21.10.012
trim-9Protein TRIM-90.011
flt-1Protein FLT-10.011
scd-1Protein SCD-10.011
lin-12Protein LIN-120.011
ced-5Protein CED-50.011
rsd-3Protein RSD-30.011
pop-1Protein POP-10.011
nhr-71Protein NHR-710.011
unc-43Protein UNC-430.011
ceh-13Protein CEH-130.011
npr-1Protein NPR-10.011
mth-2Protein MTH-20.011
daf-7Protein DAF-70.010
pac-1Protein PAC-10.010
perm-1Protein PERM-10.010
CELE_C27D8.3Protein C27D8.30.010
unc-73Protein UNC-730.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.995
HLHm7E(spl) region transcript m70.990
HLHmdeltaE(spl) region transcript mdelta0.981
HLHmbetaE(spl) region transcript mbeta0.976
HLHmgammaE(spl) region transcript mgamma0.959
HLHm5E(spl) region transcript m50.928
MadMothers against dpp0.894
DadDaughters against dpp0.888
malphaE(spl) region transcript malpha0.835
gbbglass bottom boat0.811
HLHm3E(spl) region transcript m30.484
cicubitus interruptus0.436
m4E(spl) region transcript m40.411
m2E(spl) region transcript m20.405
TomTwin of m40.166
SmoxSmad on X0.145
Su(H)Suppressor of Hairless0.136
emcextra macrochaetae0.082
dallydivision abnormally delayed0.068
EgfrEpidermal growth factor receptor0.049
Sema-1aCG18405 gene product from transcript CG18405-RD0.047
BobABrother of Bearded A0.047
beta-Specbeta Spectrin0.038
sogshort gastrulation0.037
bratbrain tumor0.035
SnooSno oncogene0.033
l(2)gllethal (2) giant larvae0.023
witwishful thinking0.021
nocno ocelli0.017
zpgzero population growth0.017
bibbig brain0.015
NotumCG13076 gene product from transcript CG13076-RB0.015
CG12424CG12424 gene product from transcript CG12424-RC0.015
taptarget of Poxn0.014
slp1sloppy paired 10.013
salmspalt major0.013
argosCG4531 gene product from transcript CG4531-RA0.013
myoglianinCG1838 gene product from transcript CG1838-RD0.013
CG3194CG3194 gene product from transcript CG3194-RB0.013
SaraSmad anchor for receptor activation0.012
CG32372CG32372 gene product from transcript CG32372-RA0.012
Taf1TBP-associated factor 10.011
CG31352CG31352 gene product from transcript CG31352-RA0.011
Myo31DFMyosin 31DF0.011
LamCLamin C0.010
slmbsupernumerary limbs0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD3SMAD family member 31.000
SMAD2SMAD family member 21.000
SMAD7SMAD family member 70.999
SMAD1SMAD family member 10.998
TGFB1transforming growth factor, beta 10.997
SMURF2SMAD specific E3 ubiquitin protein ligase 20.996
NOTCH1notch 10.966
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.966
FN1fibronectin 10.947
JAG1jagged 10.896
SMAD4SMAD family member 40.855
SMURF1SMAD specific E3 ubiquitin protein ligase 10.826
SMAD5SMAD family member 50.778
VEGFAvascular endothelial growth factor A0.569
NRP1neuropilin 10.564
FKBP1AFK506 binding protein 1A, 12kDa0.514
CTGFconnective tissue growth factor0.488
BMP2bone morphogenetic protein 20.403
NR4A1nuclear receptor subfamily 4, group A, member 10.329
SKILSKI-like oncogene0.325
CDH5cadherin 5, type 2 (vascular endothelium)0.269
FBLN1fibulin 10.253
ZFYVE9zinc finger, FYVE domain containing 90.251
CYR61cysteine-rich, angiogenic inducer, 610.209
TGFBR1transforming growth factor, beta receptor 10.203
CXXC5CXXC finger protein 50.168
WWP2WW domain containing E3 ubiquitin protein ligase 20.143
NOTCH3notch 30.135
SKIv-ski sarcoma viral oncogene homolog (avian)0.132
SMAD6SMAD family member 60.129
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.110
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.098
GDF5growth differentiation factor 50.093
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.089
SPG20spastic paraplegia 20 (Troyer syndrome)0.067
MAML1mastermind-like 1 (Drosophila)0.062
SHC2SHC (Src homology 2 domain containing) transforming protein 20.051
BMPR1Abone morphogenetic protein receptor, type IA0.051
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.044
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.043
NEDD9neural precursor cell expressed, developmentally down-regulated 90.039
PAPPApregnancy-associated plasma protein A, pappalysin 10.034
ATXN1Lataxin 1-like0.033
PARVAparvin, alpha0.032
PRKG1protein kinase, cGMP-dependent, type I0.030
DLL1delta-like 1 (Drosophila)0.029
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.029
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.028
ARandrogen receptor0.028
AMOTL2angiomotin like 20.027
NOTCH2NLnotch 2 N-terminal like0.026
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.023
TBX5T-box 50.023
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 20.023
HEY1hairy/enhancer-of-split related with YRPW motif 10.023
MSX2msh homeobox 20.022
FHL2four and a half LIM domains 20.022
ZEB2zinc finger E-box binding homeobox 20.022
PARVBparvin, beta0.021
FSTL1follistatin-like 10.021
NOTCH2notch 20.021
MSX1msh homeobox 10.021
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.019
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.019
FBXL15F-box and leucine-rich repeat protein 150.017
BMP4bone morphogenetic protein 40.017
SOX7SRY (sex determining region Y)-box 70.017
SNIP1Smad nuclear interacting protein 10.016
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 10.015
DDR2discoidin domain receptor tyrosine kinase 20.015
EPAS1endothelial PAS domain protein 10.014
SCARB2scavenger receptor class B, member 20.013
SPENspen homolog, transcriptional regulator (Drosophila)0.013
AXIN1axin 10.013
PAMpeptidylglycine alpha-amidating monooxygenase0.013
RXRAretinoid X receptor, alpha0.012
EBF1early B-cell factor 10.012
PDGFCplatelet derived growth factor C0.012
RNF11ring finger protein 110.012
MED25mediator complex subunit 250.012
TRAF4TNF receptor-associated factor 40.011
DSEdermatan sulfate epimerase0.011
ZNF331zinc finger protein 3310.011
BCL2B-cell CLL/lymphoma 20.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Ctnnb1catenin (cadherin associated protein), beta 10.999
Otx2orthodenticle homolog 2 (Drosophila)0.999
Bmp4bone morphogenetic protein 40.998
Tgfb2transforming growth factor, beta 20.998
Foxc1forkhead box C10.998
Ptenphosphatase and tensin homolog0.997
Sox2SRY-box containing gene 20.996
Eya1eyes absent 1 homolog (Drosophila)0.992
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.990
Itgb1integrin beta 1 (fibronectin receptor beta)0.989
Foxa2forkhead box A20.989
Fgf8fibroblast growth factor 80.985
Smad4MAD homolog 4 (Drosophila)0.984
Pax3paired box gene 30.984
Vegfavascular endothelial growth factor A0.984
Pax6paired box gene 60.983
Pax2paired box gene 20.981
Gli2GLI-Kruppel family member GLI20.981
Meox2mesenchyme homeobox 20.975
Hes1hairy and enhancer of split 1 (Drosophila)0.974
Nos3nitric oxide synthase 3, endothelial cell0.973
Gdnfglial cell line derived neurotrophic factor0.964
Pitx2paired-like homeodomain transcription factor 20.961
Fgfr1fibroblast growth factor receptor 10.959
Apcadenomatosis polyposis coli0.958
Wt1Wilms tumor 1 homolog0.956
Lmx1bLIM homeobox transcription factor 1 beta0.956
Fgfr3fibroblast growth factor receptor 30.954
Hand1heart and neural crest derivatives expressed transcript 10.939
Tgfbr2transforming growth factor, beta receptor II0.937
Crb2crumbs homolog 2 (Drosophila)0.930
Ptch1patched homolog 10.927
En1engrailed 10.920
Atoh7atonal homolog 7 (Drosophila)0.894
Bcl2B-cell leukemia/lymphoma 20.892
Alx4aristaless-like homeobox 40.886
Gata4GATA binding protein 40.872
Isl1ISL1 transcription factor, LIM/homeodomain0.857
Tcfap2atranscription factor AP-2, alpha0.852
Zic3zinc finger protein of the cerebellum 30.846
Cdkn1bcyclin-dependent kinase inhibitor 1B0.845
Sox11SRY-box containing gene 110.839
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.835
Kdrkinase insert domain protein receptor0.830
Smad3MAD homolog 3 (Drosophila)0.827
Foxc2forkhead box C20.827
Bmpr1abone morphogenetic protein receptor, type 1A0.801
Nkx2-1NK2 homeobox 10.796
Cdh5cadherin 50.784
Bmp7bone morphogenetic protein 70.746
Ror2receptor tyrosine kinase-like orphan receptor 20.738
Rb1retinoblastoma 10.734
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.714
Sox17SRY-box containing gene 170.710
Hspg2perlecan (heparan sulfate proteoglycan 2)0.688
Hand2heart and neural crest derivatives expressed transcript 20.685
Hoxd13homeobox D130.668
Ascl1achaete-scute complex homolog 1 (Drosophila)0.664
Foxh1forkhead box H10.660
Notch1Notch gene homolog 1 (Drosophila)0.650
Prrx1paired related homeobox 10.648
Gbx2gastrulation brain homeobox 20.647
Notch2Notch gene homolog 2 (Drosophila)0.624
Acvr1activin A receptor, type 10.617
Psen1presenilin 10.609
Jag1jagged 10.590
Smad6MAD homolog 6 (Drosophila)0.585
Otx1orthodenticle homolog 1 (Drosophila)0.584
En2engrailed 20.572
Sox7SRY-box containing gene 70.565
Twist2twist homolog 2 (Drosophila)0.552
Pbx1pre B-cell leukemia transcription factor 10.548
Gata6GATA binding protein 60.538
Runx2runt related transcription factor 20.529
Ptpn11protein tyrosine phosphatase, non-receptor type 110.509
Shesrc homology 2 domain-containing transforming protein E0.509
Retret proto-oncogene0.497
Msx1homeobox, msh-like 10.495
Emx1empty spiracles homolog 1 (Drosophila)0.482
Acvrl1activin A receptor, type II-like 10.482
Gas1growth arrest specific 10.480
Egfrepidermal growth factor receptor0.479
Fgf10fibroblast growth factor 100.477
Smosmoothened homolog (Drosophila)0.476
Fgf15fibroblast growth factor 150.470
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.468
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.466
Lhx1LIM homeobox protein 10.462
Lmx1aLIM homeobox transcription factor 1 alpha0.447
Ebf3early B-cell factor 30.446
Ptprbprotein tyrosine phosphatase, receptor type, B0.443
Pou5f1POU domain, class 5, transcription factor 10.436
Ednrbendothelin receptor type B0.407
Pou4f2POU domain, class 4, transcription factor 20.397
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism