The network for 'protein destabilization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein destabilization

Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

NameDescriptionProbabilityFunc Analog Organism
bmp4bone morphogenetic protein 40.780
bmp2bbone morphogenetic protein 2b0.539
tp53tumor protein p530.113
aurkbaurora kinase B0.077
apoebapolipoprotein Eb0.057
msxbmuscle segment homeobox B0.046
fgf24fibroblast growth factor 240.041
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.035
lama5laminin, alpha 50.030
bmp2abone morphogenetic protein 2a0.029
ccng1cyclin G10.027
sdc2syndecan 20.026
nap1l1nucleosome assembly protein 1, like 10.026
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.025
hspa5heat shock protein 50.024
fgf8afibroblast growth factor 8 a0.023
actn4actinin, alpha 40.022
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.021
ef1aelongation factor 1-alpha0.021
dlx3bdistal-less homeobox gene 3b0.021
igf1rbinsulin-like growth factor 1b receptor0.020
pcnaproliferating cell nuclear antigen0.020
ddx18DEAD (Asp-Glu-Ala-Asp) box polypeptide 180.019
ssbSjogren syndrome antigen B (autoantigen La)0.019
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.019
rbp4retinol binding protein 4, plasma0.017
bbc3BCL2 binding component 30.015
cx43connexin 430.014
runx1runt-related transcription factor 10.014
npm4nucleophosmin/nucleoplasmin, 40.014
xbp1X-box binding protein 10.013
ttkttk protein kinase0.013
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.013
mmp9matrix metalloproteinase 90.013
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.013
wdr43WD repeat domain 430.013
acvr1bactivin A receptor, type IB0.013
bcl2l1bcl2-like 10.012
hsp47heat shock protein 470.012
ccna2cyclin A20.012
ercc2excision repair cross-complementing rodent repair deficiency, complementation group 20.012
wacaWW domain containing adaptor with coiled-coil a0.012
ccnb1cyclin B10.011
dvl3dishevelled, dsh homolog 3 (Drosophila)0.011
gdf6agrowth differentiation factor 6a0.011
zcchc7zinc finger, CCHC domain containing 70.011
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.011
znf143zinc finger protein 1430.011
cxcr4achemokine (C-X-C motif) receptor 4a0.010
lppLIM domain containing preferred translocation partner in lipoma0.010
etv5bets variant 5b0.010
cpa5carboxypeptidase A50.010
spry4sprouty (Drosophila) homolog 40.010
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.010
crip2cysteine-rich protein 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG16817CG16817 gene product from transcript CG16817-RA0.083
CG2862CG2862 gene product from transcript CG2862-RA0.078
CG5515CG5515 gene product from transcript CG5515-RA0.067
Tom20Translocase of outer membrane 200.062
ftz-f1ftz transcription factor 10.050
CG13220CG13220 gene product from transcript CG13220-RA0.044
CG9797CG9797 gene product from transcript CG9797-RA0.042
CG9172CG9172 gene product from transcript CG9172-RA0.040
Pros29Proteasome 29kD subunit0.031
CG6459CG6459 gene product from transcript CG6459-RA0.030
CG11279CG11279 gene product from transcript CG11279-RA0.030
Cyp1Cyclophilin 10.029
mRpS18Amitochondrial ribosomal protein S18A0.028
Aos1CG12276 gene product from transcript CG12276-RA0.026
CG7603CG7603 gene product from transcript CG7603-RA0.026
Int6Int6 homologue0.024
CG3560CG3560 gene product from transcript CG3560-RA0.022
CG11920CG11920 gene product from transcript CG11920-RA0.021
Rpb10CG13628 gene product from transcript CG13628-RA0.020
FK506-bp2FK506-binding protein 20.020
eIF3-S10CG9805 gene product from transcript CG9805-RA0.020
lolalongitudinals lacking0.019
mRpS11mitochondrial ribosomal protein S110.019
mRpS18Bmitochondrial ribosomal protein S18B0.019
l(2)03709lethal (2) 037090.018
CG1307CG1307 gene product from transcript CG1307-RB0.018
OscpOligomycin sensitivity-conferring protein0.018
eIF-3p66Eukaryotic initiation factor 3 p66 subunit0.018
CG4646CG4646 gene product from transcript CG4646-RA0.017
Arf102FADP ribosylation factor 102F0.017
Sec61betaCG10130 gene product from transcript CG10130-RA0.017
CG7033CG7033 gene product from transcript CG7033-RC0.016
CG8386CG8386 gene product from transcript CG8386-RA0.016
RpII140RNA polymerase II 140kD subunit0.016
AtpalphaNa pump alpha subunit0.016
Prosbeta5Proteasome beta5 subunit0.016
CG12304CG12304 gene product from transcript CG12304-RA0.015
Cbp20cap binding protein 200.015
ublubiquitin like0.015
RpL34bRibosomal protein L34b0.015
CG2263CG2263 gene product from transcript CG2263-RA0.015
CG17202CG17202 gene product from transcript CG17202-RA0.014
mRpL49mitochondrial ribosomal protein L490.014
CG13993CG13993 gene product from transcript CG13993-RA0.014
chbchromosome bows0.014
eIF-3p40Eukaryotic initiation factor 3 p40 subunit0.014
CG12079CG12079 gene product from transcript CG12079-RA0.014
CG5986CG5986 gene product from transcript CG5986-RA0.014
CG9140CG9140 gene product from transcript CG9140-RA0.014
Sra-1specifically Rac1-associated protein 10.013
e(r)enhancer of rudimentary0.013
His3.3AHistone H3.3A0.013
LSm7CG13277 gene product from transcript CG13277-RA0.013
SetCG4299 gene product from transcript CG4299-RA0.013
shotshort stop0.013
CG6180CG6180 gene product from transcript CG6180-RA0.013
CG6370CG6370 gene product from transcript CG6370-RA0.013
CG17259CG17259 gene product from transcript CG17259-RA0.013
HopHsp70/Hsp90 organizing protein homolog0.013
CG7845CG7845 gene product from transcript CG7845-RB0.013
Moca-cypCG1866 gene product from transcript CG1866-RA0.012
CG6719CG6719 gene product from transcript CG6719-RA0.012
Nurf-38Nucleosome remodeling factor - 38kD0.012
TorTarget of rapamycin0.012
l(3)01239lethal (3) 012390.012
CG8801CG8801 gene product from transcript CG8801-RA0.012
awdabnormal wing discs0.012
eIF-2betaEukaryotic initiation factor 2beta0.012
Prosalpha5Proteasome alpha5 subunit0.012
mRpL33mitochondrial ribosomal protein L330.012
RpL4Ribosomal protein L40.012
CG7911CG7911 gene product from transcript CG7911-RA0.011
CG6610CG6610 gene product from transcript CG6610-RA0.011
levyCG17280 gene product from transcript CG17280-RA0.011
CG11266CG11266 gene product from transcript CG11266-RD0.011
CG9107CG9107 gene product from transcript CG9107-RA0.011
ATPsyn-bATP synthase, subunit b0.011
CG3887CG3887 gene product from transcript CG3887-RA0.011
CG10664CG10664 gene product from transcript CG10664-RB0.011
Fmr1CG6203 gene product from transcript CG6203-RC0.011
CG5706CG5706 gene product from transcript CG5706-RA0.011
eIF4AIIICG7483 gene product from transcript CG7483-RA0.011
Exp6Exportin 60.011
Neb-cGPCG15304 gene product from transcript CG15304-RA0.011
mRpL46mitochondrial ribosomal protein L460.011
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MDM2Mdm2 p53 binding protein homolog (mouse)0.973
BTRCbeta-transducin repeat containing0.587
FBXW11F-box and WD repeat domain containing 110.533
DAXXdeath-domain associated protein0.392
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.365
BMPR1Abone morphogenetic protein receptor, type IA0.286
PAX3paired box 30.277
RB1retinoblastoma 10.158
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.139
HIPK2homeodomain interacting protein kinase 20.121
PMLpromyelocytic leukemia0.120
TRIM5tripartite motif containing 50.097
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.096
ZNF263zinc finger protein 2630.090
POU3F2POU class 3 homeobox 20.082
TP53tumor protein p530.073
SKP1S-phase kinase-associated protein 10.070
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.059
CUL1cullin 10.055
TRIM21tripartite motif containing 210.052
TRIM39tripartite motif containing 390.044
SMAD7SMAD family member 70.044
MED1mediator complex subunit 10.035
ZNRF1zinc and ring finger 10.033
GORABgolgin, RAB6-interacting0.031
RNF126ring finger protein 1260.031
XIAPX-linked inhibitor of apoptosis0.029
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.026
PRNPprion protein0.025
UBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)0.024
CHEK2CHK2 checkpoint homolog (S. pombe)0.023
IRF2interferon regulatory factor 20.021
SNCAIPsynuclein, alpha interacting protein0.020
ZNF473zinc finger protein 4730.019
MED13mediator complex subunit 130.019
MED29mediator complex subunit 290.017
TRIM34tripartite motif containing 340.017
TRIM17tripartite motif containing 170.016
MARCKSL1MARCKS-like 10.015
TRIM26tripartite motif containing 260.015
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.014
SOCS1suppressor of cytokine signaling 10.014
SP100SP100 nuclear antigen0.013
MED26mediator complex subunit 260.013
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.012
PDK2pyruvate dehydrogenase kinase, isozyme 20.012
FASFas (TNF receptor superfamily, member 6)0.012
TRIM35tripartite motif containing 350.012
COMMD3COMM domain containing 30.012
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.012
CDK6cyclin-dependent kinase 60.012
CSNK1A1casein kinase 1, alpha 10.012
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.012
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.012
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.012
MTAPmethylthioadenosine phosphorylase0.012
MAPK8mitogen-activated protein kinase 80.011
CDC25Ccell division cycle 25 homolog C (S. pombe)0.011
ARIH2ariadne homolog 2 (Drosophila)0.011
MED10mediator complex subunit 100.011
APCadenomatous polyposis coli0.011
BFARbifunctional apoptosis regulator0.011
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.010
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.010
RNF38ring finger protein 380.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Id3inhibitor of DNA binding 30.180
Id1inhibitor of DNA binding 10.147
Trp53transformation related protein 530.069
Fgfr2fibroblast growth factor receptor 20.065
Msx1homeobox, msh-like 10.049
Ptenphosphatase and tensin homolog0.045
Shhsonic hedgehog0.037
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.032
Mdm4transformed mouse 3T3 cell double minute 40.030
Tcf3transcription factor 30.029
Hes1hairy and enhancer of split 1 (Drosophila)0.025
Ptch1patched homolog 10.024
Tgfb2transforming growth factor, beta 20.023
Ctnnb1catenin (cadherin associated protein), beta 10.022
Sox9SRY-box containing gene 90.019
Apcadenomatosis polyposis coli0.018
Per2period homolog 2 (Drosophila)0.017
Stat1signal transducer and activator of transcription 10.017
Fgfr3fibroblast growth factor receptor 30.016
Foxc1forkhead box C10.013
Cry2cryptochrome 2 (photolyase-like)0.013
FasFas (TNF receptor superfamily member 6)0.012
Gli3GLI-Kruppel family member GLI30.012
Bmp7bone morphogenetic protein 70.012
Zfp830zinc finger protein 8300.012
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.011
Zic3zinc finger protein of the cerebellum 30.011
Cdkn1bcyclin-dependent kinase inhibitor 1B0.011
Arntlaryl hydrocarbon receptor nuclear translocator-like0.010
Fgfr1fibroblast growth factor receptor 10.010
Ighimmunoglobulin heavy chain complex0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism