The network for 'positive regulation of mesenchymal cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mesenchymal cell proliferation

The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.

NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.910
bocbrother of CDO0.910
ptch1patched 10.875
tbx1T-box 10.803
smosmoothened homolog (Drosophila)0.774
gli1GLI-Kruppel family member 10.710
ptch2patched 20.677
ihhaIndian hedgehog homolog a0.634
rereaarginine-glutamic acid dipeptide (RE) repeats a0.597
hoxd4ahomeo box D4a0.574
sulf1sulfatase 10.569
dlx5adistal-less homeobox gene 5a0.452
bmp4bone morphogenetic protein 40.440
prrx1apaired related homeobox 1a0.411
grem2gremlin 2, cysteine knot superfamily0.409
ndr2nodal-related 20.394
gli2aGLI-Kruppel family member GLI2a0.372
bmp2bbone morphogenetic protein 2b0.368
sema3aasemaphorin 3aa0.366
dlx3bdistal-less homeobox gene 3b0.338
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.305
flhfloating head0.302
fn1fibronectin 10.291
atoh1aatonal homolog 1a0.286
jag1bjagged 1b0.284
hoxb5bhomeo box B5b0.277
wif1wnt inhibitory factor 10.276
eya1eyes absent homolog 10.270
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.269
foxa1forkhead box A10.259
col8a1acollagen, type VIII, alpha 1a0.253
foxi1forkhead box I10.242
mibmind bomb0.235
fgf3fibroblast growth factor 30.221
edn1endothelin 10.217
alpialkaline phosphatase, intestinal0.214
notch3notch homolog 30.207
nkx3.2NK3 homeobox 20.206
plcg1phospholipase C, gamma 10.189
fgf10afibroblast growth factor 10a0.188
pitx3paired-like homeodomain transcription factor 30.182
barx1BarH-like homeobox 10.173
fgfr4fibroblast growth factor receptor 40.169
wnt8bwingless-type MMTV integration site family, member 8b0.155
cdoncell adhesion molecule-related/down-regulated by oncogenes0.155
hoxb6ahomeo box B6a0.150
rargaretinoic acid receptor gamma a0.149
lef1lymphocyte enhancer binding factor 10.147
pmp22aperipheral myelin protein 22a0.144
mab21l2mab-21-like 20.140
vangl2vang-like 2 (van gogh, Drosophila)0.139
hoxa5ahomeo box A5a0.137
dlx1adistal-less homeobox gene 1a0.134
nkx2.3NK2 transcription factor related 30.133
meis3myeloid ecotropic viral integration site 30.132
smad1MAD homolog 1 (Drosophila)0.127
myod1myogenic differentiation 10.121
hand2heart and neural crest derivatives expressed transcript 20.116
mychmyelocytomatosis oncogene homolog0.116
notch2notch homolog 20.113
six2asine oculis-related homeobox 2a0.113
wnt5bwingless-type MMTV integration site family, member 5b0.109
gpc4glypican 40.108
snai1bsnail homolog 1b (Drosophila)0.106
ptgs1prostaglandin-endoperoxide synthase 10.105
hoxc1ahomeo box C1a0.104
fli1afriend leukemia integration 1a0.104
hoxc4ahomeo box C4a0.100
hoxa9bhomeo box A9b0.100
tp73tumor protein p730.097
pcdh18aprotocadherin 18a0.095
notch1bnotch homolog 1b0.094
six4bsine oculis homeobox homolog 4b0.093
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.088
acvr1lactivin A receptor, type I like0.087
mef2camyocyte enhancer factor 2ca0.086
tnfsf10l3tumor necrosis factor (ligand) superfamily, member 10 like 30.085
satb2SATB homeobox 20.083
bmp2abone morphogenetic protein 2a0.082
wnt4awingless-type MMTV integration site family, member 4a0.082
irx5airoquois homeobox protein 5a0.081
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.080
hoxb4ahomeo box B4a0.080
nkx2.1aNK2 homeobox 1a0.079
hoxa13bhomeo box A13b0.079
sox1aSRY-box containing gene 1a0.076
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.076
prrx1bpaired related homeobox 1b0.076
hoxd11ahomeo box D11a0.076
mef2dmyocyte enhancer factor 2d0.074
mmp15bmatrix metallopeptidase 15b0.073
tbx18T-box 180.072
hoxa2bhomeo box A2b0.070
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
INSRinsulin receptor0.999
PLCG1phospholipase C, gamma 10.997
IGF1Rinsulin-like growth factor 1 receptor0.994
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.981
GRB10growth factor receptor-bound protein 100.978
BMP2bone morphogenetic protein 20.975
FGF1fibroblast growth factor 1 (acidic)0.967
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.945
SHC1SHC (Src homology 2 domain containing) transforming protein 10.812
SMURF2SMAD specific E3 ubiquitin protein ligase 20.785
APCadenomatous polyposis coli0.765
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.703
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.690
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.670
APPamyloid beta (A4) precursor protein0.665
MAXMYC associated factor X0.664
FGF10fibroblast growth factor 100.637
BMP1bone morphogenetic protein 10.618
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.615
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.599
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.598
VEGFAvascular endothelial growth factor A0.565
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.539
CDH5cadherin 5, type 2 (vascular endothelium)0.528
PDGFCplatelet derived growth factor C0.498
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.497
SATB2SATB homeobox 20.493
SMAD7SMAD family member 70.453
DKK1dickkopf homolog 1 (Xenopus laevis)0.433
NRP1neuropilin 10.424
CAV1caveolin 1, caveolae protein, 22kDa0.407
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.373
CAV2caveolin 20.360
FGFR2fibroblast growth factor receptor 20.353
FGF2fibroblast growth factor 2 (basic)0.320
PTPN11protein tyrosine phosphatase, non-receptor type 110.311
HOXD9homeobox D90.285
KRT5keratin 50.281
FGF7fibroblast growth factor 70.272
PSEN1presenilin 10.264
CTNND1catenin (cadherin-associated protein), delta 10.243
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.217
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.211
SHC2SHC (Src homology 2 domain containing) transforming protein 20.211
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.199
FSTL1follistatin-like 10.199
SMAD3SMAD family member 30.199
CAPRIN2caprin family member 20.190
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.186
PTPN1protein tyrosine phosphatase, non-receptor type 10.184
MDM2Mdm2 p53 binding protein homolog (mouse)0.165
FZD1frizzled homolog 1 (Drosophila)0.162
KRT6Ckeratin 6C0.154
BTRCbeta-transducin repeat containing0.154
GAB1GRB2-associated binding protein 10.148
TGFB3transforming growth factor, beta 30.147
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.146
PGFplacental growth factor0.145
ZMYND11zinc finger, MYND-type containing 110.144
FRS2fibroblast growth factor receptor substrate 20.139
SMAD2SMAD family member 20.138
AXIN1axin 10.135
GAB2GRB2-associated binding protein 20.126
YAP1Yes-associated protein 10.120
PRKCAprotein kinase C, alpha0.116
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.116
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.101
SMAD6SMAD family member 60.101
GSK3Bglycogen synthase kinase 3 beta0.099
LRRK2leucine-rich repeat kinase 20.096
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.091
EPAS1endothelial PAS domain protein 10.090
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.087
MDFIMyoD family inhibitor0.082
BIN1bridging integrator 10.082
NEDD4neural precursor cell expressed, developmentally down-regulated 40.078
RASA1RAS p21 protein activator (GTPase activating protein) 10.072
FGFR1fibroblast growth factor receptor 10.071
ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix protein0.069
WNT3Awingless-type MMTV integration site family, member 3A0.069
PID1phosphotyrosine interaction domain containing 10.067
MMP14matrix metallopeptidase 14 (membrane-inserted)0.067
JAG1jagged 10.066
FZD7frizzled homolog 7 (Drosophila)0.064
SH2B1SH2B adaptor protein 10.064
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.062
SIRT1sirtuin 10.062
SOCS5suppressor of cytokine signaling 50.061
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.061
TCF4transcription factor 40.061
EYA1eyes absent homolog 1 (Drosophila)0.060
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.059
SHBSrc homology 2 domain containing adaptor protein B0.058
TGFB1transforming growth factor, beta 10.058
BMP4bone morphogenetic protein 40.057
STAT5Bsignal transducer and activator of transcription 5B0.056
HSPG2heparan sulfate proteoglycan 20.055
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Bmp4bone morphogenetic protein 41.000
Pax3paired box gene 31.000
Gli3GLI-Kruppel family member GLI31.000
Pitx2paired-like homeodomain transcription factor 20.999
Fgf10fibroblast growth factor 100.999
Tbx3T-box 30.998
Sox9SRY-box containing gene 90.998
Gli2GLI-Kruppel family member GLI20.997
Fgf8fibroblast growth factor 80.996
Foxc1forkhead box C10.995
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.992
Meox2mesenchyme homeobox 20.988
Otx2orthodenticle homolog 2 (Drosophila)0.985
Tgfb2transforming growth factor, beta 20.984
Nos3nitric oxide synthase 3, endothelial cell0.984
Zeb1zinc finger E-box binding homeobox 10.973
Pax2paired box gene 20.972
Prrx1paired related homeobox 10.969
Fgfr1fibroblast growth factor receptor 10.967
Rargretinoic acid receptor, gamma0.964
Wnt3awingless-related MMTV integration site 3A0.959
Trp53transformation related protein 530.947
Tgfbr2transforming growth factor, beta receptor II0.947
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.943
Sox7SRY-box containing gene 70.923
Foxc2forkhead box C20.923
Ptenphosphatase and tensin homolog0.907
Twist2twist homolog 2 (Drosophila)0.899
Hoxa1homeobox A10.899
Pitx1paired-like homeodomain transcription factor 10.888
Ctnnb1catenin (cadherin associated protein), beta 10.880
Isl1ISL1 transcription factor, LIM/homeodomain0.860
Prrx2paired related homeobox 20.855
Tbx1T-box 10.829
Sox2SRY-box containing gene 20.824
Vegfavascular endothelial growth factor A0.822
Msx1homeobox, msh-like 10.817
Wt1Wilms tumor 1 homolog0.810
Apcadenomatosis polyposis coli0.809
Dlx5distal-less homeobox 50.794
Pax6paired box gene 60.793
Smad6MAD homolog 6 (Drosophila)0.788
Col1a1collagen, type I, alpha 10.766
Ror2receptor tyrosine kinase-like orphan receptor 20.763
Msx2homeobox, msh-like 20.751
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.739
Retret proto-oncogene0.738
Bmp7bone morphogenetic protein 70.727
Alx4aristaless-like homeobox 40.719
Acvr1activin A receptor, type 10.715
Hand1heart and neural crest derivatives expressed transcript 10.696
Smosmoothened homolog (Drosophila)0.684
Foxf1aforkhead box F1a0.679
Eya1eyes absent 1 homolog (Drosophila)0.675
Lrp6low density lipoprotein receptor-related protein 60.670
Wnt4wingless-related MMTV integration site 40.656
Tcfap2atranscription factor AP-2, alpha0.652
Gata4GATA binding protein 40.645
Gscgoosecoid homeobox0.602
Ptpn11protein tyrosine phosphatase, non-receptor type 110.592
Sox11SRY-box containing gene 110.583
Pou3f3POU domain, class 3, transcription factor 30.573
Zic3zinc finger protein of the cerebellum 30.563
Ptprbprotein tyrosine phosphatase, receptor type, B0.563
Hspg2perlecan (heparan sulfate proteoglycan 2)0.562
Runx2runt related transcription factor 20.556
Flt4FMS-like tyrosine kinase 40.553
Gdnfglial cell line derived neurotrophic factor0.550
Gata6GATA binding protein 60.547
Snai1snail homolog 1 (Drosophila)0.543
Dkk1dickkopf homolog 1 (Xenopus laevis)0.541
Tbx15T-box 150.528
Tbx2T-box 20.515
Rarbretinoic acid receptor, beta0.505
Egfrepidermal growth factor receptor0.499
Hand2heart and neural crest derivatives expressed transcript 20.496
Ror1receptor tyrosine kinase-like orphan receptor 10.490
Pkd1polycystic kidney disease 1 homolog0.488
Kdrkinase insert domain protein receptor0.482
Sox18SRY-box containing gene 180.478
Bmpr1abone morphogenetic protein receptor, type 1A0.462
Hoxd11homeobox D110.458
Pax7paired box gene 70.457
Hoxa13homeobox A130.438
Rararetinoic acid receptor, alpha0.415
Lef1lymphoid enhancer binding factor 10.405
Lhx1LIM homeobox protein 10.402
Foxb1forkhead box B10.393
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.391
Wnt11wingless-related MMTV integration site 110.381
Ptch1patched homolog 10.379
Ntf3neurotrophin 30.370
Bdnfbrain derived neurotrophic factor0.359
Trp63transformation related protein 630.348
Shesrc homology 2 domain-containing transforming protein E0.344
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nek9NIMA (never in mitosis gene a)- related kinase 90.599
Myh9myosin, heavy chain 9, non-muscle0.541
Myo1cmyosin IC0.533
Unc5bunc-5 homolog B (C. elegans)0.517
Akt2v-akt murine thymoma viral oncogene homolog 20.353
Socs3suppressor of cytokine signaling 30.341
Igfbp5insulin-like growth factor binding protein 50.254
Tgfbr2transforming growth factor, beta receptor II0.252
Gna12guanine nucleotide binding protein (G protein) alpha 120.229
Prrx1paired related homeobox 10.220
Rxraretinoid X receptor alpha0.210
Acvr1activin A receptor, type I0.201
Clic4chloride intracellular channel 40.200
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.192
Efnb1ephrin B10.188
Rnf213ring finger protein 2130.185
Metmet proto-oncogene0.180
Arntaryl hydrocarbon receptor nuclear translocator0.178
Smad1SMAD family member 10.177
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.176
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.165
Smad7SMAD family member 70.165
Timp3TIMP metallopeptidase inhibitor 30.148
Notch2Notch homolog 2 (Drosophila)0.147
Map3k3mitogen activated protein kinase kinase kinase 30.143
LOC100362108poly (ADP-ribose) polymerase family, member 100.136
Nab1Ngfi-A binding protein 10.136
Sirpasignal-regulatory protein alpha0.129
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.109
Lamc1laminin, gamma 10.109
Fgfr1Fibroblast growth factor receptor 10.100
Flt1FMS-related tyrosine kinase 10.099
Zfp36zinc finger protein 360.096
Glg1golgi apparatus protein 10.096
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.084
Irs1insulin receptor substrate 10.083
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.083
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.081
Myo1dmyosin ID0.080
Olfml2bolfactomedin-like 2B0.076
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.076
Scarf2scavenger receptor class F, member 20.075
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.073
Soat1sterol O-acyltransferase 10.072
Cmklr1chemokine-like receptor 10.072
Junbjun B proto-oncogene0.070
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.068
Elf1E74-like factor 10.066
Tcfe2atranscription factor E2a0.064
Hdac7histone deacetylase 70.062
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.061
Calcrlcalcitonin receptor-like0.061
Lims1LIM and senescent cell antigen-like domains 10.061
Ptmaprothymosin alpha0.059
Ifi35interferon-induced protein 350.059
Nos3nitric oxide synthase 3, endothelial cell0.057
Itpr2inositol 1,4,5-triphosphate receptor, type 20.056
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.055
Icam1intercellular adhesion molecule 10.055
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.055
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.055
Fnbp1formin binding protein 10.054
Anpepalanyl (membrane) aminopeptidase0.054
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.052
Rararetinoic acid receptor, alpha0.052
Il6stinterleukin 6 signal transducer0.052
Ece1endothelin converting enzyme 10.051
Smosmoothened homolog (Drosophila)0.050
Ptger4prostaglandin E receptor 4 (subtype EP4)0.049
Igf2insulin-like growth factor 20.049
Stat1signal transducer and activator of transcription 10.049
Runx1runt-related transcription factor 10.048
Ptpn1protein tyrosine phosphatase, non-receptor type 10.046
Pcnaproliferating cell nuclear antigen0.046
Itga6integrin, alpha 60.046
Gdf11growth differentiation factor 110.045
Sellselectin L0.045
Itgb4integrin, beta 40.044
Litaflipopolysaccharide-induced TNF factor0.044
Rassf9Ras association (RalGDS/AF-6) domain family (N-terminal) member 90.043
Sp110SP110 nuclear body protein0.042
Abcc9ATP-binding cassette, subfamily C (CFTR/MRP), member 90.042
Trim25tripartite motif-containing 250.042
Frmd4bFERM domain containing 4B0.042
Pcdhgc3protocadherin gamma subfamily C, 30.042
S1pr2sphingosine-1-phosphate receptor 20.041
Galr2galanin receptor 20.040
Irf1interferon regulatory factor 10.039
Zfp94zinc finger protein 940.039
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.038
Tceb3transcription elongation factor B (SIII), polypeptide 30.038
Vipr1vasoactive intestinal peptide receptor 10.037
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.037
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.037
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism