The network for 'eye development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye development

The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.

NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal1.000
pax2apaired box gene 2a0.999
gdf6agrowth differentiation factor 6a0.997
shhasonic hedgehog a0.996
pvrl1apoliovirus receptor-related 1a0.995
flhfloating head0.995
fgf3fibroblast growth factor 30.992
pax6bpaired box gene 6b0.991
rx1retinal homeobox gene 10.991
atoh7atonal homolog 70.990
lmx1b.1LIM homeobox transcription factor 1, beta 10.988
foxg1aforkhead box G1a0.987
ift88intraflagellar transport 88 homolog0.986
lef1lymphocyte enhancer binding factor 10.984
atoh1aatonal homolog 1a0.982
dctn1adynactin 1a0.982
epb41l5erythrocyte membrane protein band 4.1 like 50.977
pax6apaired box gene 6a0.976
foxd3forkhead box D30.975
irx1airoquois homeobox protein 1, a0.974
aldh1a3aldehyde dehydrogenase 1 family, member A30.972
tbx2bT-box 2b0.972
runx1runt-related transcription factor 10.970
tal1T-cell acute lymphocytic leukemia 10.969
rx2retinal homeobox gene 20.968
guca1cguanylate cyclase activator 1C0.967
kif17kinesin family member 170.961
fezf2FEZ family zinc finger 20.959
aldh1a2aldehyde dehydrogenase 1 family, member A20.958
znf703zinc finger protein 7030.955
sox3SRY-box containing gene 30.951
tfap2atranscription factor AP-2 alpha0.948
eya1eyes absent homolog 10.948
six3bsine oculis homeobox homolog 3b0.945
gbx2gastrulation brain homeo box 20.943
lhx1aLIM homeobox 1a0.938
gdnfglial cell derived neurotrophic factor0.933
alcamaactivated leukocyte cell adhesion molecule a0.932
hey1hairy/enhancer-of-split related with YRPW motif 10.929
otx2orthodenticle homolog 20.927
traf4atnf receptor-associated factor 4a0.926
cntn1acontactin 1a0.922
kdrlkinase insert domain receptor like0.917
ndr2nodal-related 20.916
barhl2BarH-like 20.916
six4bsine oculis homeobox homolog 4b0.915
sox2SRY-box containing gene 20.912
otpborthopedia homolog b0.911
kitakit receptor a0.909
neurodneurogenic differentiation0.907
pea3ETS-domain transcription factor pea30.901
wnt11rwingless-type MMTV integration site family, member 11, related0.900
sox1aSRY-box containing gene 1a0.900
nr2e3nuclear receptor subfamily 2, group E, member 30.898
cmybtranscription factor cmyb0.897
wnt5bwingless-type MMTV integration site family, member 5b0.897
gli1GLI-Kruppel family member 10.894
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.892
snai1bsnail homolog 1b (Drosophila)0.889
bmp2bbone morphogenetic protein 2b0.888
bmperBMP binding endothelial regulator0.887
hhiphedgehog interacting protein0.886
wnt10awingless-type MMTV integration site family, member 10a0.884
her1hairy-related 10.877
ahctf1AT hook containing transcription factor 10.874
fgf8afibroblast growth factor 8 a0.873
crb2acrumbs homolog 2a0.872
foxp2forkhead box P20.870
fgfr1afibroblast growth factor receptor 1a0.869
gli2aGLI-Kruppel family member GLI2a0.866
tp53tumor protein p530.864
vcanaversican a0.864
rx3retinal homeobox gene 30.862
shhbsonic hedgehog b0.861
notch2notch homolog 20.861
wnt11wingless-type MMTV integration site family, member 110.861
dlx4adistal-less homeobox gene 4a0.859
chd7chromodomain helicase DNA binding protein 70.859
dlx3bdistal-less homeobox gene 3b0.858
fzd8afrizzled homolog 8a0.857
ptpraprotein tyrosine phosphatase, receptor type, A0.852
gata4GATA-binding protein 40.852
foxa2forkhead box A20.852
notch3notch homolog 30.847
gata3GATA-binding protein 30.845
scinlascinderin like a0.841
lamb1alaminin, beta 1a0.840
lama1laminin, alpha 10.838
pmelapremelanosome protein a0.836
ptf1apancreas specific transcription factor, 1a0.834
tbx5aT-box 5a0.833
spry4sprouty (Drosophila) homolog 40.829
vax2ventral anterior homeobox 20.826
jag1bjagged 1b0.826
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
spensplit ends1.000
Ten-mTenascin major0.999
snssticks and stones0.998
argosCG4531 gene product from transcript CG4531-RA0.996
hipkhomeodomain interacting protein kinase0.993
E(spl)Enhancer of split0.986
fl(2)dfemale lethal d0.986
TomTwin of m40.979
eyaeyes absent0.972
sosine oculis0.956
ebiCG4063 gene product from transcript CG4063-RA0.954
PebProtein ejaculatory bulb0.948
Rac1CG2248 gene product from transcript CG2248-RA0.943
Kap-alpha3karyopherin alpha30.939
Dsor1Downstream of raf10.934
amosabsent MD neurons and olfactory sensilla0.933
VangVan Gogh0.926
G-salpha60AG protein salpha 60A0.926
HLHm7E(spl) region transcript m70.922
S6kIIRPS6-protein kinase-II0.919
phlpole hole0.919
C3GCG42328 gene product from transcript CG42328-RC0.918
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.915
HLHmdeltaE(spl) region transcript mdelta0.907
HopHsp70/Hsp90 organizing protein homolog0.898
piepineapple eye0.896
Mi-2CG8103 gene product from transcript CG8103-RA0.896
stanstarry night0.895
kirrekin of irre0.893
trioCG18214 gene product from transcript CG18214-RA0.892
nkdnaked cuticle0.888
frcfringe connection0.884
RalaRas-related protein0.883
cutletCG33122 gene product from transcript CG33122-RA0.878
Gef26CG9491 gene product from transcript CG9491-RB0.873
Rab11Rab-protein 110.862
SmoxSmad on X0.861
cicubitus interruptus0.846
cnkconnector enhancer of ksr0.844
maskmultiple ankyrin repeats single KH domain0.844
fz2frizzled 20.840
CtBPC-terminal Binding Protein0.839
lolalongitudinals lacking0.826
Mob2CG11711 gene product from transcript CG11711-RC0.824
elavembryonic lethal abnormal vision0.823
Traf4TNF-receptor-associated factor 40.823
PtenCG5671 gene product from transcript CG5671-RB0.821
lqfliquid facets0.820
cindrCIN85 and CD2AP orthologue0.812
CG11347CG11347 gene product from transcript CG11347-RE0.812
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 10.894
TP53tumor protein p530.832
EGFRepidermal growth factor receptor0.805
RB1retinoblastoma 10.779
SMAD4SMAD family member 40.647
CREBBPCREB binding protein0.570
HDAC1histone deacetylase 10.570
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.548
NCOR1nuclear receptor corepressor 10.472
COL1A1collagen, type I, alpha 10.432
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.412
SIN3ASIN3 homolog A, transcription regulator (yeast)0.410
PBX1pre-B-cell leukemia homeobox 10.400
CTBP1C-terminal binding protein 10.396
APCadenomatous polyposis coli0.395
MDM2Mdm2 p53 binding protein homolog (mouse)0.383
SP1Sp1 transcription factor0.374
NCOR2nuclear receptor corepressor 20.353
ATXN1ataxin 10.345
JUNjun proto-oncogene0.337
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.336
EP300E1A binding protein p3000.335
NOTCH3notch 30.327
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.319
FGFR1fibroblast growth factor receptor 10.303
MCM7minichromosome maintenance complex component 70.298
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.292
RBBP4retinoblastoma binding protein 40.290
MYOD1myogenic differentiation 10.278
SMAD3SMAD family member 30.269
COL4A1collagen, type IV, alpha 10.244
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.243
SKILSKI-like oncogene0.237
PTPN11protein tyrosine phosphatase, non-receptor type 110.229
PMLpromyelocytic leukemia0.219
PRMT1protein arginine methyltransferase 10.214
SMAD2SMAD family member 20.211
HIPK2homeodomain interacting protein kinase 20.205
COL4A2collagen, type IV, alpha 20.195
PTENphosphatase and tensin homolog0.191
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.185
MDFIMyoD family inhibitor0.182
POU3F2POU class 3 homeobox 20.178
RUNX1runt-related transcription factor 10.173
FUSfused in sarcoma0.168
NFYAnuclear transcription factor Y, alpha0.166
CSNK1Ecasein kinase 1, epsilon0.154
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.153
JAG1jagged 10.149
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.148
GRB2growth factor receptor-bound protein 20.139
CHAF1Achromatin assembly factor 1, subunit A (p150)0.135
NRP1neuropilin 10.132
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.130
CRYBB2crystallin, beta B20.127
APPamyloid beta (A4) precursor protein0.127
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.126
ANAPC7anaphase promoting complex subunit 70.125
TGIF1TGFB-induced factor homeobox 10.122
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.122
BMPR1Abone morphogenetic protein receptor, type IA0.122
MAPK8mitogen-activated protein kinase 80.122
CAV1caveolin 1, caveolae protein, 22kDa0.118
PPARAperoxisome proliferator-activated receptor alpha0.118
NOTCH1notch 10.111
LMO4LIM domain only 40.111
NCOA1nuclear receptor coactivator 10.110
JUNBjun B proto-oncogene0.109
CTSAcathepsin A0.106
SOX2SRY (sex determining region Y)-box 20.104
SMAD1SMAD family member 10.102
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.100
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.099
SOX11SRY (sex determining region Y)-box 110.098
VEGFAvascular endothelial growth factor A0.094
NOSTRINnitric oxide synthase trafficker0.092
FGF1fibroblast growth factor 1 (acidic)0.091
ZFYVE9zinc finger, FYVE domain containing 90.090
HIC1hypermethylated in cancer 10.087
CRYBB3crystallin, beta B30.086
SOX1SRY (sex determining region Y)-box 10.085
BBS4Bardet-Biedl syndrome 40.083
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.081
WNT3Awingless-type MMTV integration site family, member 3A0.078
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.076
UBCubiquitin C0.075
CTSDcathepsin D0.075
CBX4chromobox homolog 40.075
E2F1E2F transcription factor 10.074
PBRM1polybromo 10.074
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.074
MAPK1mitogen-activated protein kinase 10.074
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.074
SMAD7SMAD family member 70.074
RARAretinoic acid receptor, alpha0.073
INADLInaD-like (Drosophila)0.072
BMI1BMI1 polycomb ring finger oncogene0.069
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Actbactin, beta0.483
FosFBJ osteosarcoma oncogene0.455
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.384
Junbjun B proto-oncogene0.285
Mipmajor intrinsic protein of lens fiber0.243
Mgpmatrix Gla protein0.240
Tmsb4xthymosin beta 4, X-linked0.232
Foxd3forkhead box D30.231
Egr1early growth response 10.228
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.225
Flt1FMS-related tyrosine kinase 10.210
Casp3caspase 30.181
Adam17ADAM metallopeptidase domain 170.170
Pax4paired box 40.164
St18suppression of tumorigenicity 180.160
Cryba4crystallin, beta A40.147
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.146
Cltcclathrin, heavy chain (Hc)0.133
Neurod2neurogenic differentiation 20.132
Sp1Sp1 transcription factor0.127
Btg2BTG family, member 20.126
Aebp1AE binding protein 10.125
Crygbcrystallin, gamma B0.121
Tgfbr2transforming growth factor, beta receptor II0.120
Lim2lens intrinsic membrane protein 20.116
Foxe3forkhead box E30.110
Cryaacrystallin, alpha A0.110
Vom1r97vomeronasal 1 receptor 970.105
Grifingalectin-related inter-fiber protein0.104
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.103
Col1a2collagen, type I, alpha 20.103
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.102
Egr2early growth response 20.101
Amelxamelogenin X chromosome0.100
Shc3SHC (Src homology 2 domain containing) transforming protein 30.099
Nr4a3nuclear receptor subfamily 4, group A, member 30.094
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.088
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.087
Crybb3crystallin, beta B30.087
Atxn1ataxin 10.083
Dusp6dual specificity phosphatase 60.083
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.083
Col1a1collagen, type I, alpha 10.082
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.080
Bmp7bone morphogenetic protein 70.079
Dusp1dual specificity phosphatase 10.079
Col5a2collagen, type V, alpha 20.079
Fgfr2fibroblast growth factor receptor 20.077
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.076
Agtr1bangiotensin II receptor, type 1b0.075
Chgbchromogranin B0.074
Esr2estrogen receptor 2 (ER beta)0.074
Oprm1opioid receptor, mu 10.073
Cngb1cyclic nucleotide gated channel beta 10.072
Chrnb4cholinergic receptor, nicotinic, beta 40.072
Hoxc4homeo box C40.072
Mll5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)0.071
Col3a1collagen, type III, alpha 10.069
Galr3galanin receptor 30.067
Fgf11fibroblast growth factor 110.067
Ncam1neural cell adhesion molecule 10.067
Hist1h1dhistone cluster 1, H1d0.067
Dlg4discs, large homolog 4 (Drosophila)0.065
Eef2eukaryotic translation elongation factor 20.064
Gjd2gap junction protein, delta 20.064
Col8a1collagen, type VIII, alpha 10.063
Syt6synaptotagmin VI0.063
Bcl2B-cell CLL/lymphoma 20.063
Akap12A kinase (PRKA) anchor protein 120.062
Foxd1forkhead box D10.062
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.060
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.059
Adrb1adrenergic, beta-1-, receptor0.058
Sstr5somatostatin receptor 50.058
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.057
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.057
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.057
Edn1endothelin 10.057
Slc12a5solute carrier family 12 (potassium-chloride transporter), member 50.055
Dab2disabled homolog 2 (Drosophila)0.055
RGD1564560similar to RCK0.055
Ctsccathepsin C0.055
Stat5bsignal transducer and activator of transcription 5B0.055
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.054
Socs3suppressor of cytokine signaling 30.054
NrarpNotch-regulated ankyrin repeat protein0.054
Rin1Ras and Rab interactor 10.054
Ctskcathepsin K0.053
Vax2ventral anterior homeobox 20.052
LOC679931hypothetical protein LOC6799310.052
Aanatarylalkylamine N-acetyltransferase0.051
Rabac1Rab acceptor 1 (prenylated)0.050
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.050
Gpc1glypican 10.050
Barhl2BarH-like homeobox 20.049
Runx1runt-related transcription factor 10.049
Itgb1integrin, beta 10.047
Plxdc2plexin domain containing 20.047
Apoeapolipoprotein E0.046
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism