The network for 'receptor internalization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.

NameDescriptionProbabilityFunc Analog Organism
gria2aglutamate receptor, ionotropic, AMPA 2a0.424
gria4bglutamate receptor, ionotropic, AMPA 4b0.316
gria3aglutamate receptor, ionotropic, AMPA 3a0.269
hoxa13ahomeo box A13a0.155
trpc1transient receptor potential cation channel, subfamily C, member 10.133
gria2bglutamate receptor, ionotropic, AMPA 2b0.111
gria4aglutamate receptor, ionotropic, AMPA 4a0.103
gria3bglutamate receptor, ionotrophic, AMPA 3b0.088
gria1aglutamate receptor, ionotropic, AMPA 1a0.081
dccdeleted in colorectal carcinoma0.077
kal1aKallmann syndrome 1a sequence0.074
dlg2discs, large (Drosophila) homolog 20.072
pink1PTEN induced putative kinase 10.069
ghrbgrowth hormone receptor b0.069
nbl1neuroblastoma, suppression of tumorigenicity 10.066
gria1bglutamate receptor, ionotropic, AMPA 1b0.064
thtyrosine hydroxylase0.063
flot1flotillin 10.062
ghragrowth hormone receptor a0.061
sema3hsemaphorin 3h0.061
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.060
olfm2olfactomedin 20.059
dlg1discs, large (Drosophila) homolog 10.055
arandrogen receptor0.053
cxcr4achemokine (C-X-C motif) receptor 4a0.051
angptl2angiopoietin-like 20.051
ntlano tail a0.049
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.048
hmgb3ahigh-mobility group box 3a0.047
spry2sprouty homolog 20.045
leprleptin receptor0.045
notch1anotch homolog 1a0.044
cdh6cadherin 60.043
per2period homolog 2 (Drosophila)0.042
dzip1DAZ interacting protein 10.041
osr2odd-skipped related 2 (Drosophila)0.040
grin1aglutamate receptor, ionotropic, N-methyl D-aspartate 1a0.040
traf4atnf receptor-associated factor 4a0.038
irx3biroquois homeobox protein 3b0.037
arnt2aryl hydrocarbon receptor nuclear translocator 20.037
nlgn4aneuroligin 4a0.036
amotl2aangiomotin like 2a0.034
kctd12.1potassium channel tetramerisation domain containing 12.10.034
fgf17fibroblast growth factor 170.032
sepp1aselenoprotein P, plasma, 1a0.031
LOC555504novel protocadherin protein0.031
oprk1opioid receptor, kappa 10.031
meis2.2myeloid ecotropic viral integration site 2.20.030
phox2bpaired-like homeobox 2b0.030
csnk1dacasein kinase 1, delta a0.030
gfra1bgdnf family receptor alpha 1b0.030
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.029
drd2adopamine receptor D2a0.028
enc1ectodermal-neural cortex (with BTB-like domain)0.028
drd2bdopamine receptor D2b0.027
wnt10awingless-type MMTV integration site family, member 10a0.025
mapk1mitogen-activated protein kinase 10.025
pkd2polycystic kidney disease 20.024
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.024
scube2signal peptide, CUB domain, EGF-like 20.024
camkvbCaM kinase-like vesicle-associated b0.024
zmynd11zinc finger, MYND domain containing 110.023
sim1asingle-minded homolog 1a (Drosophila)0.023
slc4a2asolute carrier family 4, anion exchanger, member 2a0.023
wtipWilms tumor 1 interacting protein0.022
cxcr4bchemokine (C-X-C motif), receptor 4b0.022
fbln4fibulin 40.022
fn1fibronectin 10.022
paqr8progestin and adipoQ receptor family member VIII0.021
dcst2DC-STAMP domain containing 20.021
tac1tachykinin 10.021
slc30a7solute carrier family 30 (zinc transporter), member 70.021
mapk12mitogen-activated protein kinase 120.021
il17rdinterleukin 17 receptor D0.021
igf2binsulin-like growth factor 2b0.021
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.021
kirrelbkin of IRRE like b0.020
arhgap29bRho GTPase activating protein 29b0.020
gap43growth associated protein 430.020
evx2even-skipped homeobox 20.020
pax2apaired box gene 2a0.020
oprd1bopioid receptor, delta 1b0.020
tob1atransducer of ERBB2, 1a0.020
spon1aspondin 1a0.020
il1rapl1binterleukin 1 receptor accessory protein-like 1b0.019
scrt1ascratch homolog 1, zinc finger protein a (Drosophila)0.019
card9caspase recruitment domain family, member 90.019
rcn1reticulocalbin 1, EF-hand calcium binding domain0.019
hsp90a.2heat shock protein 90-alpha 20.019
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.018
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.018
capn2bcalpain 2, (m/II) large subunit b0.018
adra2cadrenergic, alpha-2C-, receptor0.018
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.018
vps26blvacuolar protein sorting 26 homolog B, like0.018
pomcaproopiomelanocortin a0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Nrx-IVNeurexin IV0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CAV1caveolin 1, caveolae protein, 22kDa0.999
TEKTEK tyrosine kinase, endothelial0.996
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.988
SNX9sorting nexin 90.970
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.939
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.929
VEGFAvascular endothelial growth factor A0.904
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.901
NEDD4neural precursor cell expressed, developmentally down-regulated 40.897
CCR5chemokine (C-C motif) receptor 50.891
CXCL2chemokine (C-X-C motif) ligand 20.864
SH3GL2SH3-domain GRB2-like 20.857
PTPRBprotein tyrosine phosphatase, receptor type, B0.843
LRP6low density lipoprotein receptor-related protein 60.833
EEA1early endosome antigen 10.822
ARRB2arrestin, beta 20.812
CCR2chemokine (C-C motif) receptor 20.697
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.665
PTENphosphatase and tensin homolog0.652
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.637
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.622
CCL20chemokine (C-C motif) ligand 200.577
HDAC6histone deacetylase 60.577
CXCL3chemokine (C-X-C motif) ligand 30.575
IL6interleukin 6 (interferon, beta 2)0.565
ADRB1adrenergic, beta-1-, receptor0.559
CCL5chemokine (C-C motif) ligand 50.559
RHOAras homolog gene family, member A0.545
IFNGinterferon, gamma0.544
CXCL9chemokine (C-X-C motif) ligand 90.538
CALCRLcalcitonin receptor-like0.526
GRB2growth factor receptor-bound protein 20.518
FGAfibrinogen alpha chain0.508
PTPN23protein tyrosine phosphatase, non-receptor type 230.499
ZFYVE9zinc finger, FYVE domain containing 90.498
CXCL5chemokine (C-X-C motif) ligand 50.459
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.452
APPL2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.448
ITSN1intersectin 1 (SH3 domain protein)0.447
IL8interleukin 80.437
ZNF496zinc finger protein 4960.431
LRRK2leucine-rich repeat kinase 20.419
CCL2chemokine (C-C motif) ligand 20.391
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.373
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.361
RAB5ARAB5A, member RAS oncogene family0.359
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.356
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.342
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.326
CXCL11chemokine (C-X-C motif) ligand 110.323
SH3GL3SH3-domain GRB2-like 30.305
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.297
CXCR3chemokine (C-X-C motif) receptor 30.279
IL2RBinterleukin 2 receptor, beta0.278
CXCL10chemokine (C-X-C motif) ligand 100.274
PTPN1protein tyrosine phosphatase, non-receptor type 10.262
SESN2sestrin 20.253
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.252
BAI1brain-specific angiogenesis inhibitor 10.244
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.243
CFL1cofilin 1 (non-muscle)0.234
AP2A1adaptor-related protein complex 2, alpha 1 subunit0.231
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.218
NRP1neuropilin 10.201
NTRK2neurotrophic tyrosine kinase, receptor, type 20.200
LDLRlow density lipoprotein receptor0.199
IL1Binterleukin 1, beta0.189
EGFRepidermal growth factor receptor0.189
SYNJ1synaptojanin 10.187
CD28CD28 molecule0.181
RNF11ring finger protein 110.180
LCKlymphocyte-specific protein tyrosine kinase0.170
CRHcorticotropin releasing hormone0.169
CXCL13chemokine (C-X-C motif) ligand 130.160
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.158
CCL4chemokine (C-C motif) ligand 40.146
TNFAIP6tumor necrosis factor, alpha-induced protein 60.141
RAMP3receptor (G protein-coupled) activity modifying protein 30.136
ANGPT2angiopoietin 20.135
CCL8chemokine (C-C motif) ligand 80.135
ITKIL2-inducible T-cell kinase0.135
ARRB1arrestin, beta 10.135
SH3KBP1SH3-domain kinase binding protein 10.130
PGFplacental growth factor0.129
FGGfibrinogen gamma chain0.122
SNCAIPsynuclein, alpha interacting protein0.121
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.121
DNM1dynamin 10.121
GABARAPGABA(A) receptor-associated protein0.120
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.119
PCBP1poly(rC) binding protein 10.115
WASLWiskott-Aldrich syndrome-like0.109
HIP1huntingtin interacting protein 10.109
ADRB2adrenergic, beta-2-, receptor, surface0.106
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.106
TLR2toll-like receptor 20.104
CCR7chemokine (C-C motif) receptor 70.103
PRLHRprolactin releasing hormone receptor0.100
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Drd2dopamine receptor D20.699
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.568
Dlg4discs, large homolog 4 (Drosophila)0.481
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.331
Pnpla2patatin-like phospholipase domain containing 20.237
Ppargperoxisome proliferator activated receptor gamma0.187
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.161
Adrb1adrenergic receptor, beta 10.129
Arrb2arrestin, beta 20.127
Arrb1arrestin, beta 10.119
Rac1RAS-related C3 botulinum substrate 10.108
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.102
Pgrprogesterone receptor0.098
Psen1presenilin 10.098
Sh3kbp1SH3-domain kinase binding protein 10.090
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.089
Prnpprion protein0.080
Pdcd6ipprogrammed cell death 6 interacting protein0.075
Leprleptin receptor0.074
Adrb2adrenergic receptor, beta 20.074
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.070
Appamyloid beta (A4) precursor protein0.070
Sstr4somatostatin receptor 40.064
Akt1thymoma viral proto-oncogene 10.063
ND6NADH dehydrogenase subunit 60.063
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.062
Cd247CD247 antigen0.061
Calcrlcalcitonin receptor-like0.057
Rnf11ring finger protein 110.053
Lhcgrluteinizing hormone/choriogonadotropin receptor0.053
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.048
Tctn1tectonic family member 10.046
Npy2rneuropeptide Y receptor Y20.043
Ntsr1neurotensin receptor 10.042
Cnr1cannabinoid receptor 1 (brain)0.042
Atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.040
Chl1cell adhesion molecule with homology to L1CAM0.039
Shc1src homology 2 domain-containing transforming protein C10.038
Wdr1WD repeat domain 10.038
Cckbrcholecystokinin B receptor0.037
Chrm1cholinergic receptor, muscarinic 1, CNS0.037
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.035
Sstr1somatostatin receptor 10.035
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.035
Aplp2amyloid beta (A4) precursor-like protein 20.031
Grik1glutamate receptor, ionotropic, kainate 10.030
Col4a3collagen, type IV, alpha 30.030
Gabra1gamma-aminobutyric acid (GABA) A receptor, subunit alpha 10.029
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.029
Nos1nitric oxide synthase 1, neuronal0.028
Shc3src homology 2 domain-containing transforming protein C30.028
Cntn3contactin 30.028
Sparcl1SPARC-like 10.028
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.028
Odz1odd Oz/ten-m homolog 1 (Drosophila)0.027
Grin2dglutamate receptor, ionotropic, NMDA2D (epsilon 4)0.027
Cdh10cadherin 100.027
Neto1neuropilin (NRP) and tolloid (TLL)-like 10.026
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.025
Oprm1opioid receptor, mu 10.025
Clstn1calsyntenin 10.025
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.025
Mta1metastasis associated 10.024
Adrb3adrenergic receptor, beta 30.023
Edil3EGF-like repeats and discoidin I-like domains 30.023
Arandrogen receptor0.023
Capn1calpain 10.023
Eya4eyes absent 4 homolog (Drosophila)0.023
Lrp1low density lipoprotein receptor-related protein 10.022
Gypaglycophorin A0.022
Grb2growth factor receptor bound protein 20.022
Myh9myosin, heavy polypeptide 9, non-muscle0.022
Sqstm1sequestosome 10.022
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.021
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.020
Cyldcylindromatosis (turban tumor syndrome)0.020
Cacng2calcium channel, voltage-dependent, gamma subunit 20.019
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.019
Pcdh10protocadherin 100.019
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.019
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.018
Nxph1neurexophilin 10.018
Ptprqprotein tyrosine phosphatase, receptor type, Q0.018
Apoeapolipoprotein E0.018
Adcy2adenylate cyclase 20.017
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.017
Stat3signal transducer and activator of transcription 30.017
Rnf112ring finger protein 1120.016
Pou3f3POU domain, class 3, transcription factor 30.016
Dlx6distal-less homeobox 60.016
Numbnumb gene homolog (Drosophila)0.016
Stat6signal transducer and activator of transcription 60.016
Add1adducin 1 (alpha)0.016
Ctnnb1catenin (cadherin associated protein), beta 10.016
Oprk1opioid receptor, kappa 10.016
Dennd4cDENN/MADD domain containing 4C0.016
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.016
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gria2glutamate receptor, ionotropic, AMPA 20.923
Grip1glutamate receptor interacting protein 10.490
Dlg4discs, large homolog 4 (Drosophila)0.387
Shank1SH3 and multiple ankyrin repeat domains 10.121
Mmp13matrix metallopeptidase 130.107
Eif5aeukaryotic translation initiation factor 5A0.103
Cd80Cd80 molecule0.102
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.101
Efhd2EF-hand domain family, member D20.094
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.083
Baiap2BAI1-associated protein 20.077
Mmp9matrix metallopeptidase 90.046
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.046
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.043
Gakcyclin G associated kinase0.043
Eif4eeukaryotic translation initiation factor 4E0.040
Grid1glutamate receptor, ionotropic, delta 10.036
Pfn1profilin 10.036
Ap2a1adaptor-related protein complex 2, alpha 1 subunit0.035
Accn3amiloride-sensitive cation channel 30.034
Nlgn1neuroligin 10.034
Dgkzdiacylglycerol kinase zeta0.032
Aldh6a1aldehyde dehydrogenase 6 family, member A10.030
Mmp7matrix metallopeptidase 70.029
Ctsl1cathepsin L10.028
Rab1RAB1, member RAS oncogene family0.027
Il1rl1interleukin 1 receptor-like 10.026
Tmed2transmembrane emp24 domain trafficking protein 20.025
Gria4glutamate receptor, ionotrophic, AMPA 40.025
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.025
Tacr1tachykinin receptor 10.023
Grb2growth factor receptor bound protein 20.021
Itgamintegrin, alpha M0.021
Trpv1transient receptor potential cation channel, subfamily V, member 10.021
Smap2small ArfGAP20.020
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.020
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.020
Timp2TIMP metallopeptidase inhibitor 20.020
Adrbk1adrenergic, beta, receptor kinase 10.020
Prph2peripherin 20.019
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.019
Ap2b1adaptor-related protein complex 2, beta 1 subunit0.019
Trhrthyrotropin releasing hormone receptor0.019
Dgkidiacylglycerol kinase, iota0.019
Gdf10growth differentiation factor 100.019
Mybphmyosin binding protein H0.019
Papolapoly (A) polymerase alpha0.019
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.019
Il13interleukin 130.018
Klhl17kelch-like 17 (Drosophila)0.018
RorbRAR-related orphan receptor B0.018
Sdcbpsyndecan binding protein0.017
Agtr1aangiotensin II receptor, type 1a0.017
Dlgap3discs, large (Drosophila) homolog-associated protein 30.016
NsfN-ethylmaleimide-sensitive factor0.016
Itgb1integrin, beta 10.016
Map2microtubule-associated protein 20.015
Hpcal1hippocalcin-like 10.015
Jak1Janus kinase 10.015
Ppp1r9bprotein phosphatase 1, regulatory subunit 9B0.015
Csn3casein kappa0.015
RGD1311122similar to RIKEN cDNA 1110003E010.015
Lin7blin-7 homolog b (C. elegans)0.015
Grik1glutamate receptor, ionotropic, kainate 10.015
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.015
Jdp2Jun dimerization protein 20.015
Dlg1discs, large homolog 1 (Drosophila)0.015
Irs1insulin receptor substrate 10.014
Calcrcalcitonin receptor0.014
Egfrepidermal growth factor receptor0.014
Dnm3dynamin 30.014
Dnm1dynamin 10.014
Sdk2sidekick homolog 2 (chicken)0.014
Cstbcystatin B (stefin B)0.014
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.014
Samsn1SAM domain, SH3 domain and nuclear localization signals, 10.014
Celcarboxyl ester lipase0.014
MaddMAP-kinase activating death domain0.014
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.013
Scarb1scavenger receptor class B, member 10.013
C1qtnf6C1q and tumor necrosis factor related protein 60.013
Grm7glutamate receptor, metabotropic 70.013
Morf4l2mortality factor 4 like 20.013
Olfm1olfactomedin 10.013
Cacnb3calcium channel, voltage-dependent, beta 3 subunit0.013
Wdr1WD repeat domain 10.013
Spock1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 10.013
Galntl1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 10.013
Epha7Eph receptor A70.013
Tfectranscription factor EC0.013
Agap2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.013
C1qtnf5C1q and tumor necrosis factor related protein 50.013
Akt1v-akt murine thymoma viral oncogene homolog 10.013
Syt11synaptotagmin XI0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism