The network for 'regulation of sarcomere organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of sarcomere organization

Any process that modulates the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

NameDescriptionProbabilityFunc Analog Organism
smyd1bSET and MYND domain containing 1b0.999
mef2cbmyocyte enhancer factor 2cb0.994
mef2camyocyte enhancer factor 2ca0.991
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.989
myhz2myosin, heavy polypeptide 2, fast muscle specific0.960
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.954
tnnc1btroponin C type 1b (slow)0.889
smyhc1slow myosin heavy chain 10.885
unc45bunc-45 homolog B (C. elegans)0.762
myod1myogenic differentiation 10.711
fabp11afatty acid binding protein 11a0.693
actn3aactinin alpha 3a0.522
myhc4myosin heavy chain 40.449
ryr3ryanodine receptor 30.408
tnni1btroponin I, skeletal, slow b0.340
pdlim7PDZ and LIM domain 70.282
smyd2aSET and MYND domain containing 2a0.268
ttnatitin a0.263
ryr1bryanodine receptor 1b (skeletal)0.242
ckmacreatine kinase, muscle a0.207
tbx5aT-box 5a0.203
mstnamyostatin a0.198
smyd1aSET and MYND domain containing 1a0.187
popdc2popeye domain containing 20.184
hsp90a.1heat shock protein 90-alpha 10.169
mylz2myosin, light polypeptide 2, skeletal muscle0.163
stac3SH3 and cysteine rich domain 30.159
pikfyvephosphoinositide kinase, FYVE finger containing0.140
xirp1xin actin-binding repeat containing 10.119
vgll2bvestigial like 2b0.102
ndrg4N-myc downstream regulated gene 40.097
lama2laminin, alpha 20.094
tgfb3transforming growth factor, beta 30.092
flncbfilamin C, gamma b (actin binding protein 280)0.092
hspb1heat shock protein, alpha-crystallin-related, 10.084
fabp3fatty acid binding protein 3, muscle and heart0.072
xirp2axin actin-binding repeat containing 2a0.065
leprleptin receptor0.064
fhlafour and a half LIM domains a0.061
rnasel1ribonuclease like 10.056
hspd1heat shock 60kD protein 1 (chaperonin)0.047
rbm24aRNA binding motif protein 24a0.046
vmhcventricular myosin heavy chain0.045
lbx2ladybird homeobox homolog 2 (Drosophila)0.045
dmrt2bdoublesex and mab-3 related transcription factor 2b0.042
actn2actinin, alpha 20.039
lamb2laminin, beta 2 (laminin S)0.039
six1bsine oculis homeobox homolog 1b0.037
tbx20T-box 200.037
rnf41ring finger protein 410.036
apobec2aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a0.035
desmadesmin a0.033
actn3bactinin alpha 3b0.032
tnnt1troponin T1, skeletal, slow0.031
LOC557072caspase recruitment domain-containing protein 11-like0.027
tnni1altroponin I, skeletal, slow like0.027
col2a1acollagen type II, alpha-1a0.026
map1lc3bmicrotubule-associated protein 1 light chain 3 beta0.025
park7parkinson disease (autosomal recessive, early onset) 70.024
flot1flotillin 10.024
synpo2lbsynaptopodin 2-like b0.023
sec61bSec61 beta subunit0.023
myf5myogenic factor 50.023
jam2ajunctional adhesion molecule 2a0.023
mecomMDS1 and EVI1 complex locus0.022
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.021
acta1aactin, alpha 1a, skeletal muscle0.021
tfr1atransferrin receptor 1a0.020
gfergrowth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)0.019
me2malic enzyme 2, NAD(+)-dependent, mitochondrial0.018
nsd1bnuclear receptor binding SET domain protein 1b0.017
nexnnexilin (F actin binding protein)0.017
mylipamyosin regulatory light chain interacting protein a0.017
mef2dmyocyte enhancer factor 2d0.017
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.017
mbnl2muscleblind-like 2 (Drosophila)0.017
myl1myosin, light chain 1, alkali; skeletal, fast0.016
scinlascinderin like a0.016
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.016
tbx5bT-box 5b0.015
smyd2bSET and MYND domain containing 2b0.015
lgi1bleucine-rich, glioma inactivated 1b0.015
stmn2bstathmin-like 2b0.014
eporerythropoietin receptor0.014
actn1actinin, alpha 10.014
ckmt2creatine kinase, mitochondrial 2 (sarcomeric)0.014
slc39a1solute carrier family 39 (zinc transporter), member 10.014
mybpc3myosin binding protein C, cardiac0.014
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.014
vegfaavascular endothelial growth factor Aa0.014
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.013
scn4absodium channel, voltage-gated, type IV, alpha, b0.013
alcamaactivated leukocyte cell adhesion molecule a0.013
ryr1aryanodine receptor 1a (skeletal)0.012
LOC566969similar to MOX-2 protein0.012
eng1aengrailed 1a0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wupAwings up A0.027
Actnalpha actinin0.024
Zasp52Z band alternatively spliced PDZ-motif protein 520.021
Tm2Tropomyosin 20.018
Mlc2Myosin light chain 20.017
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 11.000
FNBP1Lformin binding protein 1-like0.561
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.373
BMPR1Bbone morphogenetic protein receptor, type IB0.254
SIN3ASIN3 homolog A, transcription regulator (yeast)0.200
HDAC4histone deacetylase 40.150
HNF4Ahepatocyte nuclear factor 4, alpha0.103
GATAD2BGATA zinc finger domain containing 2B0.091
HDAC9histone deacetylase 90.062
RBBP7retinoblastoma binding protein 70.057
RCOR1REST corepressor 10.055
CDK2AP1cyclin-dependent kinase 2 associated protein 10.046
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.035
RBBP4retinoblastoma binding protein 40.033
MEF2Amyocyte enhancer factor 2A0.032
SPTBN1spectrin, beta, non-erythrocytic 10.028
AHRaryl hydrocarbon receptor0.028
MBD2methyl-CpG binding domain protein 20.027
SAP30Sin3A-associated protein, 30kDa0.026
NR5A2nuclear receptor subfamily 5, group A, member 20.024
TCF4transcription factor 40.024
DNTTIP1deoxynucleotidyltransferase, terminal, interacting protein 10.024
BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)0.023
RASSF1Ras association (RalGDS/AF-6) domain family member 10.020
NR2E3nuclear receptor subfamily 2, group E, member 30.020
AKAP11A kinase (PRKA) anchor protein 110.019
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.019
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.018
TRIP10thyroid hormone receptor interactor 100.018
MAPK14mitogen-activated protein kinase 140.017
GATAD2AGATA zinc finger domain containing 2A0.017
CHD4chromodomain helicase DNA binding protein 40.017
C16orf87chromosome 16 open reading frame 870.016
YY1YY1 transcription factor0.016
MTA3metastasis associated 1 family, member 30.016
CTBP2C-terminal binding protein 20.016
BCL6B-cell CLL/lymphoma 60.015
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.015
E2F2E2F transcription factor 20.015
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.014
COL2A1collagen, type II, alpha 10.013
BMP2bone morphogenetic protein 20.013
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.013
HDAC3histone deacetylase 30.012
CDYLchromodomain protein, Y-like0.012
DVL1dishevelled, dsh homolog 1 (Drosophila)0.012
KDM1Alysine (K)-specific demethylase 1A0.012
BMP4bone morphogenetic protein 40.011
C5orf4chromosome 5 open reading frame 40.011
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.011
APPL2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.011
SCRT1scratch homolog 1, zinc finger protein (Drosophila)0.011
SUDS3suppressor of defective silencing 3 homolog (S. cerevisiae)0.011
PITX2paired-like homeodomain 20.011
SAMD3sterile alpha motif domain containing 30.011
CUX1cut-like homeobox 10.011
NKAPNFKB activating protein0.010
CASQ2calsequestrin 2 (cardiac muscle)0.010
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.010
MSH6mutS homolog 6 (E. coli)0.010
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.010
IL1RAPL2interleukin 1 receptor accessory protein-like 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hdac4histone deacetylase 40.790
Sin3atranscriptional regulator, SIN3A (yeast)0.653
Hdac5histone deacetylase 50.615
Mef2cmyocyte enhancer factor 2C0.582
Hrchistidine rich calcium binding protein0.443
Arid1aAT rich interactive domain 1A (SWI-like)0.242
Actn2actinin alpha 20.211
Myl3myosin, light polypeptide 30.208
Nr2f2nuclear receptor subfamily 2, group F, member 20.206
Ldb3LIM domain binding 30.205
Sox2SRY-box containing gene 20.185
Zfp932zinc finger protein 9320.172
Myom2myomesin 20.159
Csrp3cysteine and glycine-rich protein 30.157
Tnnc2troponin C2, fast0.140
Mta2metastasis-associated gene family, member 20.139
Myl1myosin, light polypeptide 10.128
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.126
Cox8bcytochrome c oxidase, subunit VIIIb0.117
Myoz1myozenin 10.115
Mef2dmyocyte enhancer factor 2D0.115
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.114
Myom1myomesin 10.110
Tnnt3troponin T3, skeletal, fast0.108
Ckmcreatine kinase, muscle0.102
Tnni2troponin I, skeletal, fast 20.098
Nrapnebulin-related anchoring protein0.095
Suv39h1suppressor of variegation 3-9 homolog 1 (Drosophila)0.091
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.090
Ednrbendothelin receptor type B0.081
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.078
Pgam2phosphoglycerate mutase 20.076
Tcf4transcription factor 40.074
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.074
Art1ADP-ribosyltransferase 10.073
Mybphmyosin binding protein H0.072
Ebf2early B-cell factor 20.071
Ednraendothelin receptor type A0.070
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.065
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.064
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.062
Zeb2zinc finger E-box binding homeobox 20.062
Actc1actin, alpha, cardiac muscle 10.062
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.060
Spnb2spectrin beta 20.060
Kif1bkinesin family member 1B0.058
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.056
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.055
Gucy1b3guanylate cyclase 1, soluble, beta 30.055
Prkceprotein kinase C, epsilon0.054
Casq2calsequestrin 20.053
Hdac7histone deacetylase 70.053
SnrkSNF related kinase0.052
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.051
Ckmt2creatine kinase, mitochondrial 20.049
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.049
Kdm5blysine (K)-specific demethylase 5B0.049
Hdac9histone deacetylase 90.048
Txlnbtaxilin beta0.047
Myf6myogenic factor 60.047
Tgfb2transforming growth factor, beta 20.045
Myoz2myozenin 20.045
Rbbp7retinoblastoma binding protein 70.042
Ctbp1C-terminal binding protein 10.042
Fbxo32F-box protein 320.041
Lmod2leiomodin 2 (cardiac)0.039
Srpk3serine/arginine-rich protein specific kinase 30.038
Ryr1ryanodine receptor 1, skeletal muscle0.037
Xirp1xin actin-binding repeat containing 10.036
Ezh2enhancer of zeste homolog 2 (Drosophila)0.035
Foxc1forkhead box C10.035
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.035
Anp32aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A0.034
Phkg1phosphorylase kinase gamma 10.033
Parp1poly (ADP-ribose) polymerase family, member 10.033
Plxna2plexin A20.032
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.032
Myl7myosin, light polypeptide 7, regulatory0.031
Tcfcp2l1transcription factor CP2-like 10.030
Casq1calsequestrin 10.030
Acta1actin, alpha 1, skeletal muscle0.028
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.028
Myh2myosin, heavy polypeptide 2, skeletal muscle, adult0.028
Tnnc1troponin C, cardiac/slow skeletal0.026
Trim54tripartite motif-containing 540.026
Vldlrvery low density lipoprotein receptor0.026
Eya1eyes absent 1 homolog (Drosophila)0.026
Neurod1neurogenic differentiation 10.026
Smpxsmall muscle protein, X-linked0.026
Scn10asodium channel, voltage-gated, type X, alpha0.025
Hivep2human immunodeficiency virus type I enhancer binding protein 20.025
Sall4sal-like 4 (Drosophila)0.024
Zbtb20zinc finger and BTB domain containing 200.024
Tnnt2troponin T2, cardiac0.024
Gata6GATA binding protein 60.023
FynFyn proto-oncogene0.023
Cav3caveolin 30.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Myl1myosin, light chain 10.281
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.212
Mybphmyosin binding protein H0.154
Mybpc2myosin binding protein C, fast-type0.098
Tnni2troponin I type 2 (skeletal, fast)0.068
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.063
Myf6myogenic factor 60.045
Tnnt3troponin T type 3 (skeletal, fast)0.044
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.043
Tnni1troponin I type 1 (skeletal, slow)0.040
Tnnc2troponin C type 2 (fast)0.039
Myh2myosin, heavy chain 2, skeletal muscle, adult0.033
Falzfetal Alzheimer antigen0.026
Actc1actin, alpha, cardiac muscle 10.025
Myh7myosin, heavy chain 7, cardiac muscle, beta0.023
Il6interleukin 60.022
Ncor1nuclear receptor co-repressor 10.015
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.013
Mybpc1myosin binding protein C, slow type0.013
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.012
Vom2r44vomeronasal 2 receptor 440.011
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.011
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism