The network for 'heart development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 11.000
tbx5aT-box 5a1.000
bmp2bbone morphogenetic protein 2b0.999
kdrlkinase insert domain receptor like0.999
ttnatitin a0.997
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.997
bmp4bone morphogenetic protein 40.996
tmem2transmembrane protein 20.994
fn1fibronectin 10.994
notch1bnotch homolog 1b0.993
tal1T-cell acute lymphocytic leukemia 10.993
aldh1a2aldehyde dehydrogenase 1 family, member A20.993
pcdh8protocadherin 80.990
wnt11rwingless-type MMTV integration site family, member 11, related0.987
bmp2abone morphogenetic protein 2a0.986
wnt5bwingless-type MMTV integration site family, member 5b0.985
tbx20T-box 200.983
isl1islet10.983
myod1myogenic differentiation 10.980
wnt11wingless-type MMTV integration site family, member 110.978
gata3GATA-binding protein 30.978
tbx16T-box gene 160.977
acvr1lactivin A receptor, type I like0.977
fgf8afibroblast growth factor 8 a0.976
vmhcventricular myosin heavy chain0.975
fgf10afibroblast growth factor 10a0.973
tnni1btroponin I, skeletal, slow b0.970
myl7myosin, light polypeptide 7, regulatory0.968
prkciprotein kinase C, iota0.967
wt1awilms tumor 1a0.960
tbx2bT-box 2b0.960
foxi1forkhead box I10.959
tnnc1btroponin C type 1b (slow)0.959
tbx18T-box 180.958
ccm2cerebral cavernous malformation 20.953
tpm4tropomyosin 40.950
actc1aactin, alpha, cardiac muscle 1a0.950
lef1lymphocyte enhancer binding factor 10.945
hnf1baHNF1 homeobox Ba0.943
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.942
six4bsine oculis homeobox homolog 4b0.941
fzd7bfrizzled homolog 7b0.937
tnnt2atroponin T2a, cardiac0.936
fgfr1bfibroblast growth factor receptor 1b0.934
pdlim7PDZ and LIM domain 70.933
crip2cysteine-rich protein 20.933
fbn2bfibrillin 2b0.932
fgfr2fibroblast growth factor receptor 20.926
crabp2acellular retinoic acid binding protein 2, a0.925
oepone-eyed pinhead0.925
vcanaversican a0.923
gapdhglyceraldehyde-3-phosphate dehydrogenase0.922
shhasonic hedgehog a0.922
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.921
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.919
lrrc6leucine rich repeat containing 60.918
twist1atwist1a0.907
pkd2polycystic kidney disease 20.906
hey2hairy/enhancer-of-split related with YRPW motif 20.905
eya1eyes absent homolog 10.901
tbx2aT-box gene 2a0.898
hoxb5ahomeo box B5a0.894
neo1neogenin 10.891
hspb7heat shock protein family, alpha-crystallin-related, b70.891
fzd10frizzled homolog 100.888
ephb4beph receptor B4b0.883
unc45bunc-45 homolog B (C. elegans)0.879
synpo2lbsynaptopodin 2-like b0.876
notch2notch homolog 20.873
hspb1heat shock protein, alpha-crystallin-related, 10.872
cacnb4acalcium channel, voltage-dependent, beta 4a subunit0.872
tgfb3transforming growth factor, beta 30.872
spns2spinster homolog 2 (Drosophila)0.868
notch3notch homolog 30.868
itgavintegrin, alpha V0.864
prdm16PR domain containing 160.859
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.856
etv2ets variant gene 20.854
fzd7afrizzled homolog 7a0.849
rargaretinoic acid receptor gamma a0.848
foxn4forkhead box N40.842
fgf3fibroblast growth factor 30.839
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.832
tp53tumor protein p530.831
sulf1sulfatase 10.829
gro1groucho 10.829
her3hairy-related 30.825
actn3bactinin alpha 3b0.821
ntlano tail a0.810
yap1Yes-associated protein 10.807
lama4laminin, alpha 40.802
sall4sal-like 4 (Drosophila)0.801
egr2bearly growth response 2b0.800
actn2actinin, alpha 20.796
epas1bendothelial PAS domain protein 1b0.794
smad5MAD homolog 5 (Drosophila)0.789
gli2aGLI-Kruppel family member GLI2a0.788
prrx1apaired related homeobox 1a0.788
wnt9awingless-type MMTV integration site family, member 9A0.787
hoxc8ahomeo box C8a0.784
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor1.000
MadMothers against dpp0.999
wgwingless0.997
enengrailed0.992
kuzkuzbanian0.988
emcextra macrochaetae0.973
tintinman0.971
twitwist0.967
dallydivision abnormally delayed0.967
LanALaminin A0.959
MrtfMyocardin-related transcription factor0.956
slmbsupernumerary limbs0.953
dppdecapentaplegic0.951
roboroundabout0.941
slp1sloppy paired 10.934
MhcMyosin heavy chain0.933
LanB1CG7123 gene product from transcript CG7123-RA0.930
stumpsCG31317 gene product from transcript CG31317-RC0.929
cicubitus interruptus0.927
shnschnurri0.925
NrgNeuroglian0.925
Ras85DRas oncogene at 85D0.921
htlheartless0.906
LanB2Laminin B20.897
Rac1CG2248 gene product from transcript CG2248-RA0.897
Ggamma1G protein gamma 10.892
sdscalloped0.873
armarmadillo0.870
binbiniou0.864
hipkhomeodomain interacting protein kinase0.852
vgvestigial0.846
dmdiminutive0.844
Atg1Autophagy-specific gene 10.843
knknot0.835
zfh1Zn finger homeodomain 10.820
srpserpent0.818
AtpalphaNa pump alpha subunit0.808
hthhomothorax0.802
dadaughterless0.797
abd-Aabdominal A0.787
eveeven skipped0.783
nrv2nervana 20.781
DllDistal-less0.775
putpunt0.752
smosmoothened0.747
HLH54FCG5005 gene product from transcript CG5005-RA0.743
mammastermind0.741
gsbgooseberry0.738
ushu-shaped0.738
hpohippo0.737
mysmyospheroid0.720
G-oalpha47AG protein oalpha 47A0.709
hkbhuckebein0.698
midmidline0.693
nocno ocelli0.685
giggigas0.683
tlltailless0.672
DlDelta0.672
HandCG18144 gene product from transcript CG18144-RA0.648
zipzipper0.645
lealeak0.635
kluklumpfuss0.633
pntpointed0.603
Wnt2Wnt oncogene analog 20.602
wupAwings up A0.576
InRInsulin-like receptor0.572
KrKruppel0.557
UbxUltrabithorax0.550
Akt1CG4006 gene product from transcript CG4006-RA0.545
SmoxSmad on X0.537
eyaeyes absent0.534
spdosanpodo0.529
pyrpyramus0.525
tshteashirt0.520
fngfringe0.511
sogshort gastrulation0.506
howheld out wings0.495
bab2CG9102 gene product from transcript CG9102-RA0.491
Doc2Dorsocross20.482
pnrpannier0.474
coroCG9446 gene product from transcript CG9446-RC0.466
svpseven up0.466
kniknirps0.463
Sema-1aCG18405 gene product from transcript CG18405-RD0.457
mewmultiple edematous wings0.456
Dhc64CDynein heavy chain 64C0.434
MoeMoesin0.432
gcmglial cells missing0.431
slp2sloppy paired 20.428
CG9894CG9894 gene product from transcript CG9894-RB0.422
Gap1GTPase-activating protein 10.413
nejnejire0.400
fzfrizzled0.399
Hsc70-4Heat shock protein cognate 40.396
rapretina aberrant in pattern0.396
pdm2POU domain protein 20.395
rhorhomboid0.369
exexpanded0.366
SosSon of sevenless0.364
vkgviking0.358
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
SMAD3SMAD family member 30.997
EGFRepidermal growth factor receptor0.993
TRIM63tripartite motif containing 630.993
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.988
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.982
NOTCH1notch 10.976
RXRAretinoid X receptor, alpha0.974
TTNtitin0.973
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.971
EP300E1A binding protein p3000.963
RARAretinoic acid receptor, alpha0.961
SP1Sp1 transcription factor0.958
XIAPX-linked inhibitor of apoptosis0.954
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.944
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.929
CAV1caveolin 1, caveolae protein, 22kDa0.928
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.924
SMAD4SMAD family member 40.884
NR4A1nuclear receptor subfamily 4, group A, member 10.872
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.872
MAPK14mitogen-activated protein kinase 140.867
RB1retinoblastoma 10.849
SMAD2SMAD family member 20.833
CREBBPCREB binding protein0.828
TNNI1troponin I type 1 (skeletal, slow)0.827
FGFR2fibroblast growth factor receptor 20.824
TNNC1troponin C type 1 (slow)0.811
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.803
NCOR1nuclear receptor corepressor 10.801
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.771
VEGFAvascular endothelial growth factor A0.760
FLNAfilamin A, alpha0.760
ATF2activating transcription factor 20.750
NCOR2nuclear receptor corepressor 20.744
JAG1jagged 10.737
PBX1pre-B-cell leukemia homeobox 10.732
MYOD1myogenic differentiation 10.725
SRFserum response factor (c-fos serum response element-binding transcription factor)0.712
GSK3Bglycogen synthase kinase 3 beta0.694
PTPN11protein tyrosine phosphatase, non-receptor type 110.685
ATN1atrophin 10.676
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.664
DSPdesmoplakin0.658
COL4A1collagen, type IV, alpha 10.656
COL3A1collagen, type III, alpha 10.648
AXIN1axin 10.648
CTGFconnective tissue growth factor0.631
PABPC1poly(A) binding protein, cytoplasmic 10.625
NCOA3nuclear receptor coactivator 30.616
POU3F2POU class 3 homeobox 20.614
NOTCH3notch 30.605
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.605
NRP1neuropilin 10.575
GRB2growth factor receptor-bound protein 20.575
SMAD7SMAD family member 70.573
PAX3paired box 30.564
YY1YY1 transcription factor0.558
EPAS1endothelial PAS domain protein 10.551
GATA4GATA binding protein 40.544
FGF1fibroblast growth factor 1 (acidic)0.543
TPM1tropomyosin 1 (alpha)0.532
HDAC4histone deacetylase 40.530
ARandrogen receptor0.530
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.529
NCOA1nuclear receptor coactivator 10.516
MDFIMyoD family inhibitor0.506
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.492
MSX1msh homeobox 10.492
ZFYVE9zinc finger, FYVE domain containing 90.485
BMP2bone morphogenetic protein 20.479
ACTN2actinin, alpha 20.474
FKBP1AFK506 binding protein 1A, 12kDa0.470
TAL1T-cell acute lymphocytic leukemia 10.468
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.444
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.425
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.422
FLNCfilamin C, gamma0.418
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.415
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.404
TCAPtitin-cap (telethonin)0.404
SOX2SRY (sex determining region Y)-box 20.400
ACTA1actin, alpha 1, skeletal muscle0.395
STK3serine/threonine kinase 30.393
SMAD6SMAD family member 60.367
CALD1caldesmon 10.366
PKD2polycystic kidney disease 2 (autosomal dominant)0.365
YBX1Y box binding protein 10.361
MYOZ1myozenin 10.360
PMLpromyelocytic leukemia0.355
SIRT1sirtuin 10.351
COL5A1collagen, type V, alpha 10.349
COL1A2collagen, type I, alpha 20.349
FOXD3forkhead box D30.343
RANBP9RAN binding protein 90.340
MED25mediator complex subunit 250.337
SMYD1SET and MYND domain containing 10.336
TNNT3troponin T type 3 (skeletal, fast)0.332
TCF4transcription factor 40.330
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.328
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Smad3SMAD family member 30.304
Casq2calsequestrin 2 (cardiac muscle)0.271
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.239
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.220
Notch3Notch homolog 3 (Drosophila)0.212
Robo1roundabout homolog 1 (Drosophila)0.209
Syt8synaptotagmin VIII0.193
Hand2heart and neural crest derivatives expressed 20.182
Strnstriatin, calmodulin binding protein0.176
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.170
Dchs1dachsous 1 (Drosophila)0.169
Taglntransgelin0.162
Scn5asodium channel, voltage-gated, type V, alpha subunit0.158
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.148
Rararetinoic acid receptor, alpha0.142
Tgfbr2transforming growth factor, beta receptor II0.140
Plb1phospholipase B10.137
Ptgfrprostaglandin F receptor0.135
Actc1actin, alpha, cardiac muscle 10.131
Tpm3tropomyosin 3, gamma0.129
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.127
LOC100362824caveolin 2-like0.126
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.122
Asphaspartate-beta-hydroxylase0.122
Emp1epithelial membrane protein 10.119
Obp2bodorant binding protein 2B0.113
Nos3nitric oxide synthase 3, endothelial cell0.112
Ppardperoxisome proliferator-activated receptor delta0.112
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.106
Tnni1troponin I type 1 (skeletal, slow)0.104
Pfn1profilin 10.103
Dccdeleted in colorectal carcinoma0.103
Cela2achymotrypsin-like elastase family, member 2A0.095
Oprm1opioid receptor, mu 10.095
Hspa1lheat shock protein 1-like0.095
Gata6GATA binding protein 60.094
Cntn5contactin 50.091
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.091
Olr1867olfactory receptor 18670.091
Galr2galanin receptor 20.088
Nfianuclear factor I/A0.087
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.087
Akt1v-akt murine thymoma viral oncogene homolog 10.086
Nos1nitric oxide synthase 1, neuronal0.082
Cav1caveolin 1, caveolae protein0.081
Foxd3forkhead box D30.081
Hspb2heat shock protein beta 20.081
Gja1gap junction protein, alpha 10.079
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.079
Dmddystrophin0.077
Sox17SRY (sex determining region Y)-box 170.075
Id3inhibitor of DNA binding 30.075
Fgfr2fibroblast growth factor receptor 20.075
Cd9CD9 molecule0.075
Fgf7fibroblast growth factor 70.075
Slc22a6solute carrier family 22 (organic anion transporter), member 60.075
Tpm4tropomyosin 40.073
Vegfavascular endothelial growth factor A0.072
Prrx1paired related homeobox 10.072
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.072
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.071
Adrb1adrenergic, beta-1-, receptor0.069
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.068
LOC494499LOC494499 protein0.068
Ly6blymphocyte antigen 6 complex, locus B0.068
Tcfe2atranscription factor E2a0.067
Efnb1ephrin B10.067
Sstr5somatostatin receptor 50.066
MrgprfMAS-related GPR, member F0.066
Marcksmyristoylated alanine rich protein kinase C substrate0.066
RT1-BaRT1 class II, locus Ba0.065
Agtr1aangiotensin II receptor, type 1a0.065
Selpselectin P0.065
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.065
Cnga1cyclic nucleotide gated channel alpha 10.065
Eef2eukaryotic translation elongation factor 20.064
Bmp6bone morphogenetic protein 60.064
Hoxc4homeo box C40.063
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.063
Itpr1inositol 1,4,5-triphosphate receptor, type 10.063
Kcnn1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 10.062
Arpc2actin related protein 2/3 complex, subunit 20.062
Acta1actin, alpha 1, skeletal muscle0.062
Irs1insulin receptor substrate 10.061
Kcnv2potassium channel, subfamily V, member 20.061
Mc4rmelanocortin 4 receptor0.060
Myl7myosin, light chain 7, regulatory0.060
Il1r1interleukin 1 receptor, type I0.060
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.060
Col10a1collagen, type X, alpha 10.059
Mmp10matrix metallopeptidase 100.059
Dpysl3dihydropyrimidinase-like 30.057
Hnf1bHNF1 homeobox B0.057
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.057
Nfibnuclear factor I/B0.057
Tagln2transgelin 20.056
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.056
Klk1c10T-kininogenase0.056
Gja5gap junction protein, alpha 50.055
Mapre1microtubule-associated protein, RP/EB family, member 10.055
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism