The network for 'isoprenoid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

isoprenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

NameDescriptionProbabilityFunc Analog Organism
gro1groucho 10.322
tbx1T-box 10.172
axin1axin 10.150
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.147
tp53tumor protein p530.100
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.062
srd5a2asteroid-5-alpha-reductase, alpha polypeptide 2a0.056
snai1asnail homolog 1a (Drosophila)0.053
ocrloculocerebrorenal syndrome of Lowe0.047
smad2MAD homolog 2 (Drosophila)0.039
tbpTATA box binding protein0.039
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.038
lef1lymphocyte enhancer binding factor 10.037
ahctf1AT hook containing transcription factor 10.036
tm4sf4transmembrane 4 L six family member 40.034
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.034
hprt1hypoxanthine phosphoribosyltransferase 10.029
dctdopachrome tautomerase0.029
wnt11wingless-type MMTV integration site family, member 110.028
m17IL-6 subfamily cytokine M170.027
myh11amyosin, heavy polypeptide 11, smooth muscle a0.026
tjp1tight junction protein 1 (zona occludens 1)0.026
hoxc8ahomeo box C8a0.025
hmx2H6 family homeobox 20.025
rgrbretinal G protein coupled receptor b0.024
wlswntless homolog (Drosophila)0.022
fabp2fatty acid binding protein 2, intestinal0.022
notch3notch homolog 30.022
gro2groucho 20.021
fzd7bfrizzled homolog 7b0.020
rorbRAR-related orphan receptor B0.020
foxp1bforkhead box P1b0.019
kdrlkinase insert domain receptor like0.019
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.018
meis2.1myeloid ecotropic viral integration site 2.10.018
mibmind bomb0.018
tbx5aT-box 5a0.018
faddFas (tnfrsf6)-associated via death domain0.017
agxtaalanine-glyoxylate aminotransferase a0.017
slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.017
gata5GATA-binding protein 50.017
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.016
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.016
ef1aelongation factor 1-alpha0.015
hgdhomogentisate 1,2-dioxygenase0.015
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.015
dachadachshund a0.015
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.014
olfm1aolfactomedin 1a0.014
dhrs3adehydrogenase/reductase (SDR family) member 3a0.014
eya4eyes absent homolog 4 (Drosophila)0.014
trpv6transient receptor potential cation channel, subfamily V, member 60.014
col9a2procollagen, type IX, alpha 20.014
epha7eph receptor A70.013
smosmoothened homolog (Drosophila)0.013
cyp4v2cytochrome P450, family 4, subfamily V, polypeptide 20.012
sox1aSRY-box containing gene 1a0.012
vwfvon Willebrand factor0.012
ephb4beph receptor B4b0.012
spry2sprouty homolog 20.011
pcdh18aprotocadherin 18a0.011
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.011
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.011
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.011
hnf1baHNF1 homeobox Ba0.011
chgachromogranin A0.011
gcgaglucagon a and glucagon a-like0.011
sulf1sulfatase 10.011
otx5orthodenticle homolog 50.011
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.011
nrg1neuregulin 10.010
dhrs9dehydrogenase/reductase (SDR family) member 90.010
olfm1bolfactomedin 1b0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG8386CG8386 gene product from transcript CG8386-RA0.012
CG3621CG3621 gene product from transcript CG3621-RA0.012
alpha-Catalpha Catenin0.012
RpS12Ribosomal protein S120.012
CG10083CG10083 gene product from transcript CG10083-RA0.011
RpL29Ribosomal protein L290.011
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 20.987
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.958
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.844
WWP2WW domain containing E3 ubiquitin protein ligase 20.637
ZFYVE9zinc finger, FYVE domain containing 90.444
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.427
SMURF1SMAD specific E3 ubiquitin protein ligase 10.263
SMAD4SMAD family member 40.238
NEDD4neural precursor cell expressed, developmentally down-regulated 40.232
WWP1WW domain containing E3 ubiquitin protein ligase 10.177
ANKRD13Aankyrin repeat domain 13A0.168
FBXL15F-box and leucine-rich repeat protein 150.149
SMAD5SMAD family member 50.078
SQLEsqualene epoxidase0.065
SMAD1SMAD family member 10.064
SMAD7SMAD family member 70.060
FGFR1fibroblast growth factor receptor 10.058
TRAF4TNF receptor-associated factor 40.049
LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.045
ALDH2aldehyde dehydrogenase 2 family (mitochondrial)0.041
ING2inhibitor of growth family, member 20.041
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.040
CXXC5CXXC finger protein 50.038
INSIG1insulin induced gene 10.037
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.028
RNF168ring finger protein 1680.024
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.020
ZFAND5zinc finger, AN1-type domain 50.018
SOX7SRY (sex determining region Y)-box 70.017
SGK3serum/glucocorticoid regulated kinase family, member 30.016
FDFT1farnesyl-diphosphate farnesyltransferase 10.016
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.016
SC4MOLsterol-C4-methyl oxidase-like0.015
DHCR77-dehydrocholesterol reductase0.014
NEDD9neural precursor cell expressed, developmentally down-regulated 90.014
PLEKHO1pleckstrin homology domain containing, family O member 10.013
SNX9sorting nexin 90.013
UBQLN2ubiquilin 20.013
MVDmevalonate (diphospho) decarboxylase0.011
KLF5Kruppel-like factor 5 (intestinal)0.011
MKL2MKL/myocardin-like 20.010
PDLIM7PDZ and LIM domain 7 (enigma)0.010
MFSD3major facilitator superfamily domain containing 30.010
SREBF2sterol regulatory element binding transcription factor 20.010
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cyp51cytochrome P450, family 510.902
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.899
Sqlesqualene epoxidase0.872
Sc4molsterol-C4-methyl oxidase-like0.626
Rarbretinoic acid receptor, beta0.543
Tcf7transcription factor 7, T-cell specific0.453
Foxc2forkhead box C20.386
Mvdmevalonate (diphospho) decarboxylase0.307
Cyldcylindromatosis (turban tumor syndrome)0.140
Dhcr77-dehydrocholesterol reductase0.108
Acat2acetyl-Coenzyme A acetyltransferase 20.095
Ednraendothelin receptor type A0.090
Fdpsfarnesyl diphosphate synthetase0.085
Sc5dsterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)0.084
Aacsacetoacetyl-CoA synthetase0.070
Sox4SRY-box containing gene 40.070
Nrp1neuropilin 10.062
Gsta3glutathione S-transferase, alpha 30.059
Mvkmevalonate kinase0.053
Ldlrlow density lipoprotein receptor0.053
Lratlecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)0.050
Rargretinoic acid receptor, gamma0.050
Dhcr2424-dehydrocholesterol reductase0.049
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.045
Lsslanosterol synthase0.045
Stard4StAR-related lipid transfer (START) domain containing 40.045
NsdhlNAD(P) dependent steroid dehydrogenase-like0.043
Nlrp6NLR family, pyrin domain containing 60.038
BC089597cDNA sequence BC0895970.037
Tmem64transmembrane protein 640.036
Aadacarylacetamide deacetylase (esterase)0.034
Ces2acarboxylesterase 2A0.031
Hsd17b7hydroxysteroid (17-beta) dehydrogenase 70.026
Pkhd1polycystic kidney and hepatic disease 10.026
Wnk4WNK lysine deficient protein kinase 40.025
Ces1ccarboxylesterase 1C0.024
Otx2orthodenticle homolog 2 (Drosophila)0.024
Slc17a1solute carrier family 17 (sodium phosphate), member 10.023
Pmvkphosphomevalonate kinase0.023
Grb10growth factor receptor bound protein 100.022
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.021
Nr1i2nuclear receptor subfamily 1, group I, member 20.021
Rdh11retinol dehydrogenase 110.021
Tm7sf2transmembrane 7 superfamily member 20.020
Ece1endothelin converting enzyme 10.018
Cyp2j5cytochrome P450, family 2, subfamily j, polypeptide 50.018
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.018
Procprotein C0.018
Prrg2proline-rich Gla (G-carboxyglutamic acid) polypeptide 20.018
Pdzk1PDZ domain containing 10.017
Hoxa3homeobox A30.017
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.017
Tbx3T-box 30.017
Rararetinoic acid receptor, alpha0.017
Rdh10retinol dehydrogenase 10 (all-trans)0.017
0610007P14RikRIKEN cDNA 0610007P14 gene0.016
Pla2g12bphospholipase A2, group XIIB0.016
AclyATP citrate lyase0.016
Ces2ecarboxylesterase 2E0.016
Iydiodotyrosine deiodinase0.016
Vegfavascular endothelial growth factor A0.015
Aldh8a1aldehyde dehydrogenase 8 family, member A10.015
Chd7chromodomain helicase DNA binding protein 70.015
Fgf8fibroblast growth factor 80.015
Prodh2proline dehydrogenase (oxidase) 20.014
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.014
MecomMDS1 and EVI1 complex locus0.014
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.013
Rxraretinoid X receptor alpha0.013
Sult1b1sulfotransferase family 1B, member 10.013
Cyp4f14cytochrome P450, family 4, subfamily f, polypeptide 140.013
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.013
Acot4acyl-CoA thioesterase 40.013
Ugt3a2UDP glycosyltransferases 3 family, polypeptide A20.013
Acox2acyl-Coenzyme A oxidase 2, branched chain0.012
Rdh9retinol dehydrogenase 90.012
Mep1bmeprin 1 beta0.012
Slco1b2solute carrier organic anion transporter family, member 1b20.012
Leap2liver-expressed antimicrobial peptide 20.012
Agmatagmatine ureohydrolase (agmatinase)0.012
Bmpr1abone morphogenetic protein receptor, type 1A0.012
Ovol1OVO homolog-like 1 (Drosophila)0.012
Defb1defensin beta 10.011
Sgk2serum/glucocorticoid regulated kinase 20.011
Mettl7bmethyltransferase like 7B0.011
Kif27kinesin family member 270.011
Cyp2c44cytochrome P450, family 2, subfamily c, polypeptide 440.010
Clec2hC-type lectin domain family 2, member h0.010
Ugt3a1UDP glycosyltransferases 3 family, polypeptide A10.010
Wnt5awingless-related MMTV integration site 5A0.010
C1qtnf5C1q and tumor necrosis factor related protein 50.010
Acnat2acyl-coenzyme A amino acid N-acyltransferase 20.010
CflarCASP8 and FADD-like apoptosis regulator0.010
Numbnumb gene homolog (Drosophila)0.010
Fgfr1fibroblast growth factor receptor 10.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.653
Sc4molsterol-C4-methyl oxidase-like0.371
Cyp51cytochrome P450, family 510.371
Idi1isopentenyl-diphosphate delta isomerase 10.341
Sqlesqualene epoxidase0.316
Acat3acetyl-Coenzyme A acetyltransferase 30.189
Fdft1farnesyl diphosphate farnesyl transferase 10.184
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.133
Insig1insulin induced gene 10.059
Fabp1fatty acid binding protein 1, liver0.038
Dhcr2424-dehydrocholesterol reductase0.032
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.027
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.022
Cd36CD36 molecule (thrombospondin receptor)0.021
Otcornithine carbamoyltransferase0.016
Mvdmevalonate (diphospho) decarboxylase0.014
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.011
Sc5dlsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.011
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.011
Apohapolipoprotein H (beta-2-glycoprotein I)0.011
Pmvkphosphomevalonate kinase0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism