The network for 'negative regulation of axon guidance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of axon guidance

Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance.

NameDescriptionProbabilityFunc Analog Organism
bocbrother of CDO0.996
lhx2bLIM homeobox 2b0.986
nrp1aneuropilin 1a0.972
slit3slit (Drosophila) homolog 30.958
wnt3wingless-type MMTV integration site family, member 30.874
nrp2bneuropilin 2b0.873
dzip1DAZ interacting protein 10.831
tbx1T-box 10.828
fgfr3fibroblast growth factor receptor 30.814
robo3roundabout homolog 30.780
twist1atwist1a0.774
sema3dsemaphorin 3d0.771
cdh2cadherin 2, neuronal0.737
slit2slit (Drosophila) homolog 20.661
efnb3bephrin B3b0.648
epha4aeph receptor A4a0.643
sema3aasemaphorin 3aa0.632
mecomMDS1 and EVI1 complex locus0.589
emx3empty spiracles homeobox 30.576
foxp2forkhead box P20.549
ntn1anetrin 1a0.515
slit1aslit homolog 1a (Drosophila)0.468
gli2aGLI-Kruppel family member GLI2a0.449
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.433
metmet proto-oncogene (hepatocyte growth factor receptor)0.418
arxaristaless related homeobox0.410
ebf3early B-cell factor 30.403
robo1roundabout homolog 10.399
fgf3fibroblast growth factor 30.381
fgf10afibroblast growth factor 10a0.377
skianuclear oncoprotein skia0.357
wnt4awingless-type MMTV integration site family, member 4a0.324
lef1lymphocyte enhancer binding factor 10.307
twist3twist30.292
foxa1forkhead box A10.290
neo1neogenin 10.283
tbx2bT-box 2b0.280
irx1airoquois homeobox protein 1, a0.273
igfbp3insulin-like growth factor binding protein 30.271
sox9aSRY-box containing gene 9a0.269
robo2roundabout homolog 20.266
shhasonic hedgehog a0.265
ephb4beph receptor B4b0.264
dladeltaA0.263
cntn2contactin 20.259
gli1GLI-Kruppel family member 10.228
dlx2adistal-less homeobox gene 2a0.219
bmp2abone morphogenetic protein 2a0.217
wnt7bawingless-type MMTV integration site family, member 7Ba0.209
tbx2aT-box gene 2a0.208
axin1axin 10.206
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.205
ntn1bnetrin 1b0.201
nova2neuro-oncological ventral antigen 20.194
tnctenascin C0.194
mef2dmyocyte enhancer factor 2d0.189
fzd9bfrizzled homolog 9b0.185
wu:fv91b12wu:fv91b120.185
flot1flotillin 10.182
ttnatitin a0.182
epb4.1l4erythrocyte protein band 4.1-like 40.178
fgfr2fibroblast growth factor receptor 20.177
irx5airoquois homeobox protein 5a0.166
emx1empty spiracles homeobox 10.164
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.155
nrp2aneuropilin 2a0.151
foxd3forkhead box D30.150
evx1even-skipped homeobox 10.143
esrrgaestrogen-related receptor gamma a0.139
efna2ephrin A20.134
sox2SRY-box containing gene 20.133
eya1eyes absent homolog 10.130
sfrp1asecreted frizzled-related protein 1a0.128
ptch2patched 20.122
isl2aislet2a0.118
plxna4plexin A40.116
hs3st3b1bheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b0.116
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.113
kal1aKallmann syndrome 1a sequence0.112
efnb2aephrin B2a0.111
myod1myogenic differentiation 10.110
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.108
smoc1SPARC related modular calcium binding 10.107
igf1rbinsulin-like growth factor 1b receptor0.107
hoxb3ahomeo box B3a0.107
smosmoothened homolog (Drosophila)0.104
msxcmuscle segment homeobox C0.102
tbx5aT-box 5a0.102
znf503zinc finger protein 5030.101
sulf1sulfatase 10.101
plxnb2aplexin b2a0.095
notch3notch homolog 30.094
irx2airoquois homeobox protein 2, a0.090
gli3GLI-Kruppel family member GLI30.089
disp1dispatched homolog 1 (Drosophila)0.088
nav3neuron navigator 30.086
slit1bslit homolog 1b (Drosophila)0.083
mibmind bomb0.083
sp8asp8 transcription factor a0.083
ret1receptor tyrosine kinase0.080
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
VEGFAvascular endothelial growth factor A1.000
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.973
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.891
FZD1frizzled homolog 1 (Drosophila)0.565
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.479
COL3A1collagen, type III, alpha 10.450
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.358
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.312
TGFB3transforming growth factor, beta 30.253
LRP6low density lipoprotein receptor-related protein 60.166
FAPfibroblast activation protein, alpha0.106
PGFplacental growth factor0.104
SLIT2slit homolog 2 (Drosophila)0.071
SFRP4secreted frizzled-related protein 40.062
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.061
CDH5cadherin 5, type 2 (vascular endothelium)0.058
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.054
TGFB1transforming growth factor, beta 10.052
DMPKdystrophia myotonica-protein kinase0.050
ATN1atrophin 10.049
COL5A1collagen, type V, alpha 10.044
RBMS3RNA binding motif, single stranded interacting protein 30.040
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.036
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.030
CRIP2cysteine-rich protein 20.029
COL14A1collagen, type XIV, alpha 10.028
NRP2neuropilin 20.028
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.027
RGS5regulator of G-protein signaling 50.026
HLA-DPB1major histocompatibility complex, class II, DP beta 10.026
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.025
BNC2basonuclin 20.025
TGFBR1transforming growth factor, beta receptor 10.025
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.024
LENG8leukocyte receptor cluster (LRC) member 80.024
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 30.023
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.023
POSTNperiostin, osteoblast specific factor0.023
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.022
FZD8frizzled homolog 8 (Drosophila)0.021
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.021
TGFB2transforming growth factor, beta 20.020
LUMlumican0.020
GLI3GLI family zinc finger 30.019
COL4A5collagen, type IV, alpha 50.019
KCNRGpotassium channel regulator0.019
PDGFCplatelet derived growth factor C0.019
LSM11LSM11, U7 small nuclear RNA associated0.018
LAMA4laminin, alpha 40.018
STC1stanniocalcin 10.018
PTGISprostaglandin I2 (prostacyclin) synthase0.018
JAG2jagged 20.018
FLRT2fibronectin leucine rich transmembrane protein 20.017
BMP4bone morphogenetic protein 40.016
TGFBR3transforming growth factor, beta receptor III0.016
RAI1retinoic acid induced 10.016
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.015
PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1B0.015
MAST2microtubule associated serine/threonine kinase 20.015
FBXL7F-box and leucine-rich repeat protein 70.015
PTNpleiotrophin0.014
AGAP1ArfGAP with GTPase domain, ankyrin repeat and PH domain 10.014
FZD2frizzled homolog 2 (Drosophila)0.014
ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)0.014
ELNelastin0.014
STC2stanniocalcin 20.014
MFAP4microfibrillar-associated protein 40.014
SNAI2snail homolog 2 (Drosophila)0.014
MAP3K5mitogen-activated protein kinase kinase kinase 50.013
GLT8D2glycosyltransferase 8 domain containing 20.013
BICC1bicaudal C homolog 1 (Drosophila)0.013
PCDH17protocadherin 170.013
FBLN1fibulin 10.013
FGD1FYVE, RhoGEF and PH domain containing 10.013
COL1A2collagen, type I, alpha 20.013
PTPRDprotein tyrosine phosphatase, receptor type, D0.013
PTPRGprotein tyrosine phosphatase, receptor type, G0.012
MPP1membrane protein, palmitoylated 1, 55kDa0.012
OLFM2olfactomedin 20.012
NR2F1nuclear receptor subfamily 2, group F, member 10.012
SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8)0.012
GPC1glypican 10.012
KLHL5kelch-like 5 (Drosophila)0.012
LAMB1laminin, beta 10.012
SEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.012
LTBP4latent transforming growth factor beta binding protein 40.011
JAG1jagged 10.011
NAV3neuron navigator 30.011
FBLN5fibulin 50.011
EDNRAendothelin receptor type A0.011
SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.011
NOVnephroblastoma overexpressed gene0.011
LDB2LIM domain binding 20.011
PARVAparvin, alpha0.011
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 10.011
BDKRB2bradykinin receptor B20.011
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 50.011
EFNB2ephrin-B20.010
SOCS5suppressor of cytokine signaling 50.010
OSTF1osteoclast stimulating factor 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A1.000
Robo1roundabout homolog 1 (Drosophila)0.998
Slit2slit homolog 2 (Drosophila)0.996
Rargretinoic acid receptor, gamma0.990
AxlAXL receptor tyrosine kinase0.989
Gli3GLI-Kruppel family member GLI30.987
Fgf8fibroblast growth factor 80.987
Plxna1plexin A10.987
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.985
Epha4Eph receptor A40.983
Ednraendothelin receptor type A0.977
Pax2paired box gene 20.975
Rarbretinoic acid receptor, beta0.973
Fzd1frizzled homolog 1 (Drosophila)0.943
Acvr1activin A receptor, type 10.936
Lhx1LIM homeobox protein 10.928
Chrdchordin0.918
Rararetinoic acid receptor, alpha0.893
Fgfr2fibroblast growth factor receptor 20.891
Wnt4wingless-related MMTV integration site 40.876
Shhsonic hedgehog0.863
Tbx1T-box 10.850
Pax3paired box gene 30.836
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.813
Slit3slit homolog 3 (Drosophila)0.811
Tyro3TYRO3 protein tyrosine kinase 30.799
Fgfr1fibroblast growth factor receptor 10.794
Dlg4discs, large homolog 4 (Drosophila)0.782
Nognoggin0.762
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.741
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.715
Retret proto-oncogene0.690
Foxc1forkhead box C10.689
Gdnfglial cell line derived neurotrophic factor0.656
Ror1receptor tyrosine kinase-like orphan receptor 10.638
Otx2orthodenticle homolog 2 (Drosophila)0.635
Vegfavascular endothelial growth factor A0.604
Nrp2neuropilin 20.572
Pax8paired box gene 80.563
Grb10growth factor receptor bound protein 100.558
Wnt3awingless-related MMTV integration site 3A0.552
Robo2roundabout homolog 2 (Drosophila)0.525
Pou3f3POU domain, class 3, transcription factor 30.497
Dkk1dickkopf homolog 1 (Xenopus laevis)0.470
Ddr2discoidin domain receptor family, member 20.462
Tspan9tetraspanin 90.458
Gli2GLI-Kruppel family member GLI20.453
Fgf18fibroblast growth factor 180.452
Gab1growth factor receptor bound protein 2-associated protein 10.451
Pbx1pre B-cell leukemia transcription factor 10.438
Sema3csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C0.433
Wnt6wingless-related MMTV integration site 60.407
Cdh6cadherin 60.385
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.355
Emx2empty spiracles homolog 2 (Drosophila)0.350
Fzd8frizzled homolog 8 (Drosophila)0.348
Ephb2Eph receptor B20.347
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.343
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.339
Hoxa3homeobox A30.339
Fgf10fibroblast growth factor 100.335
Ednrbendothelin receptor type B0.334
Mertkc-mer proto-oncogene tyrosine kinase0.331
Ece1endothelin converting enzyme 10.331
Gpr27G protein-coupled receptor 270.323
Mgat3mannoside acetylglucosaminyltransferase 30.298
Flt1FMS-like tyrosine kinase 10.296
Klklotho0.271
Sdc3syndecan 30.262
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.248
Bmp7bone morphogenetic protein 70.244
Pou3f2POU domain, class 3, transcription factor 20.244
Lama5laminin, alpha 50.240
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.234
Kcnd3potassium voltage-gated channel, Shal-related family, member 30.231
Plcg1phospholipase C, gamma 10.224
Wnt2bwingless related MMTV integration site 2b0.224
Wnt10bwingless related MMTV integration site 10b0.221
Hmx3H6 homeobox 30.216
Dlx5distal-less homeobox 50.213
Tead3TEA domain family member 30.210
Emp2epithelial membrane protein 20.206
Fgfr4fibroblast growth factor receptor 40.195
Prrx1paired related homeobox 10.189
Grin2dglutamate receptor, ionotropic, NMDA2D (epsilon 4)0.187
Efnb2ephrin B20.182
Adra2cadrenergic receptor, alpha 2c0.180
Cdk14cyclin-dependent kinase 140.176
Smad3MAD homolog 3 (Drosophila)0.174
Epha3Eph receptor A30.173
Arandrogen receptor0.171
Mid2midline 20.168
Esr1estrogen receptor 1 (alpha)0.165
Matn4matrilin 40.160
Mafavian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog0.160
Pcdh12protocadherin 120.160
Ltbp1latent transforming growth factor beta binding protein 10.158
Wnt7bwingless-related MMTV integration site 7B0.157
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.156
Hoxd11homeobox D110.148
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nfibnuclear factor I/B0.072
Pxdnperoxidasin homolog (Drosophila)0.066
Epha7Eph receptor A70.038
Robo2roundabout homolog 2 (Drosophila)0.038
Grm5glutamate receptor, metabotropic 50.034
Hrh1histamine receptor H 10.031
Robo1roundabout homolog 1 (Drosophila)0.029
Kctd13potassium channel tetramerisation domain containing 130.028
Cckarcholecystokinin A receptor0.023
Fgfr2fibroblast growth factor receptor 20.019
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.017
Matkmegakaryocyte-associated tyrosine kinase0.017
Efna5ephrin A50.017
Tcf4transcription factor 40.016
Gdf11growth differentiation factor 110.015
Akap4A kinase (PRKA) anchor protein 40.014
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.014
Ppp1r9aprotein phosphatase 1, regulatory (inhibitor) subunit 9A0.013
Sox17SRY (sex determining region Y)-box 170.013
Ltbp4latent transforming growth factor beta binding protein 40.013
Cntn1contactin 10.012
Sptbn1spectrin, beta, non-erythrocytic 10.012
Hoxc4homeo box C40.012
A3galt2alpha 1,3-galactosyltransferase 20.011
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.011
Mrasmuscle RAS oncogene homolog0.011
Zfp382zinc finger protein 3820.011
Ptk2bPTK2B protein tyrosine kinase 2 beta0.011
Slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.011
Tnrc6btrinucleotide repeat containing 6B0.011
Pdcphosducin0.011
KitlgKIT ligand0.011
Pmepa1prostate transmembrane protein, androgen induced 10.011
Klk1b3kallikrein 1-related peptidase b30.011
Muc3amucin 3A, cell surface associated0.010
Acppacid phosphatase, prostate0.010
Ctsdcathepsin D0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism