The network for 'histone demethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone demethylation

The modification of histones by removal of methyl groups.

NameDescriptionProbabilityFunc Analog Organism
kdm4blysine (K)-specific demethylase 4B0.351
LOC100536021spectrin beta chain, brain 1-like0.282
ankrd12ankyrin repeat domain 120.202
gpatch8G patch domain containing 80.180
ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.126
brapBRCA1 associated protein0.108
smurf2SMAD specific E3 ubiquitin protein ligase 20.092
fbxl5F-box and leucine-rich repeat protein 50.086
phf2PHD finger protein 20.079
btg1B-cell translocation gene 10.071
npeppsaminopeptidase puromycin sensitive0.063
ralgapa1Ral GTPase activating protein, alpha subunit 1 (catalytic)0.062
phrf1PHD and ring finger domains 10.059
lmbrd2bLMBR1 domain containing 2b0.056
tecpr2tectonin beta-propeller repeat containing 20.053
skianuclear oncoprotein skia0.047
rpap2RNA polymerase II associated protein 20.041
oxsr1aoxidative-stress responsive 1a0.041
actr8ARP8 actin-related protein 8 homolog (yeast)0.040
fcho2FCH domain only 20.038
supt6hsuppressor of Ty 6 homolog0.037
nsun5NOP2/Sun domain family, member 50.037
tyw3tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)0.035
nvlnuclear VCP-like0.035
fxr2fragile X mental retardation, autosomal homolog 20.035
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.033
ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.033
ptenaphosphatase and tensin homolog A0.032
nrp2bneuropilin 2b0.032
trmt5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)0.032
fam192afamily with sequence similarity 192, member A0.032
kidins220bkinase D-interacting substrate of 220b0.030
ints1integrator complex subunit 10.029
mbnl2muscleblind-like 2 (Drosophila)0.028
pcmtd1protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 10.027
tsc1tuberous sclerosis 10.026
utp23UTP23, small subunit (SSU) processome component, homolog (yeast)0.026
ppp3ccaprotein phosphatase 3, catalytic subunit, gamma isozyme, a0.026
kdm5balysine (K)-specific demethylase 5Ba0.026
rnf41ring finger protein 410.025
peli1bpellino homolog 1b (Drosophila)0.024
exoc7exocyst complex component 70.024
nova2neuro-oncological ventral antigen 20.023
LOC100331141ATP synthase subunit s-like protein-like0.023
ikbkaplinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein like0.023
ep300bE1A binding protein p300 b0.023
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.023
atp2b4ATPase, Ca++ transporting, plasma membrane 40.022
mical3flavoprotein oxidoreductase MICAL30.022
strn3striatin, calmodulin binding protein 30.022
apcadenomatosis polyposis coli0.021
kdm1alysine (K)-specific demethylase 1a0.021
wwp2WW domain containing E3 ubiquitin protein ligase 20.021
cltcaclathrin, heavy polypeptide a (Hc)0.020
pdcd4bprogrammed cell death 4b0.020
abca3ATP-binding cassette, sub-family A (ABC1), member 30.020
dohhdeoxyhypusine hydroxylase/monooxygenase0.020
abca5ATP-binding cassette, sub-family A (ABC1), member 50.020
med18mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)0.020
clstn1calsyntenin 10.020
elf2aE74-like factor 2a (ets domain transcription factor)0.019
nfianuclear factor I/A0.019
exosc2exosome component 20.019
rnf146ring finger protein 1460.019
caskcalcium/calmodulin-dependent serine protein kinase0.019
smn1survival motor neuron 10.019
tiprlTIP41, TOR signaling pathway regulator-like (S. cerevisiae)0.018
macf1microtubule-actin crosslinking factor 10.018
spna2spectrin alpha 20.018
mpped2metallophosphoesterase domain containing 20.017
brd3bbromodomain containing 3b0.017
otud5aOTU domain containing 5a0.017
myef2myelin expression factor 20.017
LOC555713hypothetical LOC5557130.017
znf148zinc finger protein 1480.016
fam203afamily with sequence similarity 203, member A0.016
eef2kelongation factor-2 kinase0.016
mapk3mitogen-activated protein kinase 30.016
brd8bromodomain containing 80.016
c1orf109c1orf109 homolog (H. sapiens)0.015
nt5dc25'-nucleotidase domain containing 20.015
golgb1golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 10.015
tsc22d2TSC22 domain family 2 and TSC22 domain family, member 20.015
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EIF1AYeukaryotic translation initiation factor 1A, Y-linked0.744
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.566
BCORBCL6 corepressor0.554
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.406
ZFXzinc finger protein, X-linked0.392
ZCCHC17zinc finger, CCHC domain containing 170.318
DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.269
ESR1estrogen receptor 10.253
ZNF512Bzinc finger protein 512B0.226
KDM5Blysine (K)-specific demethylase 5B0.208
HBP1HMG-box transcription factor 10.178
USP9Yubiquitin specific peptidase 9, Y-linked0.153
BRD4bromodomain containing 40.131
CCNL1cyclin L10.113
RCOR1REST corepressor 10.112
ZNF148zinc finger protein 1480.108
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.108
MKRN1makorin ring finger protein 10.104
KLHL24kelch-like 24 (Drosophila)0.100
CEP350centrosomal protein 350kDa0.097
CYorf15Achromosome Y open reading frame 15A0.096
ZNF217zinc finger protein 2170.089
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.087
RLFrearranged L-myc fusion0.085
UBR2ubiquitin protein ligase E3 component n-recognin 20.078
HELZhelicase with zinc finger0.075
NCOA6nuclear receptor coactivator 60.067
ZNF292zinc finger protein 2920.066
UBXN7UBX domain protein 70.058
RXRAretinoid X receptor, alpha0.057
GPBP1L1GC-rich promoter binding protein 1-like 10.056
MTA3metastasis associated 1 family, member 30.055
HIST1H3Bhistone cluster 1, H3b0.051
UBR1ubiquitin protein ligase E3 component n-recognin 10.050
ANKRD12ankyrin repeat domain 120.050
ZFYzinc finger protein, Y-linked0.044
RPS4Y1ribosomal protein S4, Y-linked 10.041
MLL3myeloid/lymphoid or mixed-lineage leukemia 30.041
CHD8chromodomain helicase DNA binding protein 80.040
ARandrogen receptor0.038
MTA1metastasis associated 10.037
SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)0.036
HIST1H4Fhistone cluster 1, H4f0.036
CCNG2cyclin G20.035
PUM1pumilio homolog 1 (Drosophila)0.035
RICTORRPTOR independent companion of MTOR, complex 20.035
CUX1cut-like homeobox 10.034
RCOR3REST corepressor 30.032
U2AF1U2 small nuclear RNA auxiliary factor 10.032
BRD1bromodomain containing 10.031
PRMT6protein arginine methyltransferase 60.031
NCOR1nuclear receptor corepressor 10.030
SETD2SET domain containing 20.030
UBR5ubiquitin protein ligase E3 component n-recognin 50.030
CHD4chromodomain helicase DNA binding protein 40.030
SIN3ASIN3 homolog A, transcription regulator (yeast)0.028
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.027
CLK4CDC-like kinase 40.027
WDR48WD repeat domain 480.027
PCGF1polycomb group ring finger 10.027
PHF21APHD finger protein 21A0.026
MTA2metastasis associated 1 family, member 20.025
USP9Xubiquitin specific peptidase 9, X-linked0.024
UTYubiquitously transcribed tetratricopeptide repeat gene, Y-linked0.024
JUNDjun D proto-oncogene0.023
RIOK3RIO kinase 3 (yeast)0.023
MED13Lmediator complex subunit 13-like0.023
ARID4AAT rich interactive domain 4A (RBP1-like)0.023
SMAD7SMAD family member 70.021
SPENspen homolog, transcriptional regulator (Drosophila)0.021
ATAD2BATPase family, AAA domain containing 2B0.021
SAMD3sterile alpha motif domain containing 30.020
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.020
ULK1unc-51-like kinase 1 (C. elegans)0.020
NCOA2nuclear receptor coactivator 20.018
KDM5Dlysine (K)-specific demethylase 5D0.018
KDM3Alysine (K)-specific demethylase 3A0.018
JARID2jumonji, AT rich interactive domain 20.018
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.018
MAML1mastermind-like 1 (Drosophila)0.017
WDR26WD repeat domain 260.017
MXI1MAX interactor 10.016
NCOR2nuclear receptor corepressor 20.015
PELP1proline, glutamate and leucine rich protein 10.015
KDM6Blysine (K)-specific demethylase 6B0.014
PHF1PHD finger protein 10.014
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.014
SNAI1snail homolog 1 (Drosophila)0.014
FAM9Afamily with sequence similarity 9, member A0.014
KDM2Alysine (K)-specific demethylase 2A0.014
PPARDperoxisome proliferator-activated receptor delta0.013
CSRNP1cysteine-serine-rich nuclear protein 10.013
RBBP5retinoblastoma binding protein 50.013
BRD2bromodomain containing 20.013
GOLGB1golgin B10.012
BAZ2Abromodomain adjacent to zinc finger domain, 2A0.012
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.996
Kdm1alysine (K)-specific demethylase 1A0.707
Sin3atranscriptional regulator, SIN3A (yeast)0.451
Kdm2blysine (K)-specific demethylase 2B0.387
Csnk2a1casein kinase 2, alpha 1 polypeptide0.219
Cbx8chromobox homolog 8 (Drosophila Pc class)0.184
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.178
Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.140
Men1multiple endocrine neoplasia 10.091
Zfp292zinc finger protein 2920.089
Ctbp1C-terminal binding protein 10.077
Clk1CDC-like kinase 10.056
Csnk2a2casein kinase 2, alpha prime polypeptide0.050
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.047
Arid1bAT rich interactive domain 1B (SWI-like)0.045
Jarid2jumonji, AT rich interactive domain 20.045
Kdm5dlysine (K)-specific demethylase 5D0.035
Lin28alin-28 homolog A (C. elegans)0.034
Sp1trans-acting transcription factor 10.031
Cul9cullin 90.031
Clk3CDC-like kinase 30.028
Arid1aAT rich interactive domain 1A (SWI-like)0.028
Utyubiquitously transcribed tetratricopeptide repeat gene, Y chromosome0.028
Eif4a2eukaryotic translation initiation factor 4A20.027
Dbx1developing brain homeobox 10.027
Clk4CDC like kinase 40.027
Thap11THAP domain containing 110.025
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.022
MgaMAX gene associated0.022
BcorBCL6 interacting corepressor0.021
Fbxo38F-box protein 380.020
Xrn15'-3' exoribonuclease 10.020
Yaf2YY1 associated factor 20.019
Ring1ring finger protein 10.019
Dvl3dishevelled 3, dsh homolog (Drosophila)0.019
Arid4bAT rich interactive domain 4B (RBP1-like)0.019
Morf4l1mortality factor 4 like 10.018
Eif1beukaryotic translation initiation factor 1B0.018
Kdm4clysine (K)-specific demethylase 4C0.017
Lin28blin-28 homolog B (C. elegans)0.016
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.015
Ino80eINO80 complex subunit E0.015
Rbm22RNA binding motif protein 220.015
Prmt5protein arginine N-methyltransferase 50.015
Maml1mastermind like 1 (Drosophila)0.014
RybpRING1 and YY1 binding protein0.014
Epc1enhancer of polycomb homolog 1 (Drosophila)0.014
Upf2UPF2 regulator of nonsense transcripts homolog (yeast)0.014
A930001N09RikRIKEN cDNA A930001N09 gene0.014
Zfp654zinc finger protein 6540.013
Ruvbl2RuvB-like protein 20.013
Fbxl3F-box and leucine-rich repeat protein 30.013
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.012
Rlfrearranged L-myc fusion sequence0.012
Phrf1PHD and ring finger domains 10.012
Pcgf2polycomb group ring finger 20.012
RestRE1-silencing transcription factor0.012
Siah1aseven in absentia 1A0.012
Sp4trans-acting transcription factor 40.012
Eif2s3yeukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked0.012
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.012
BanpBTG3 associated nuclear protein0.012
Brwd3bromodomain and WD repeat domain containing 30.011
Atf7ipactivating transcription factor 7 interacting protein0.011
Baz2abromodomain adjacent to zinc finger domain, 2A0.011
Zfp598zinc finger protein 5980.011
Alkbh1alkB, alkylation repair homolog 1 (E. coli)0.011
Chd4chromodomain helicase DNA binding protein 40.011
Whsc2Wolf-Hirschhorn syndrome candidate 2 (human)0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Arid4aAT rich interactive domain 4A (Rbp1 like)0.016
Phf12PHD finger protein 120.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism