The network for 'calcium ion dependent exocytosis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

calcium ion dependent exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions.

NameDescriptionProbabilityFunc Analog Organism
nr2f6anuclear receptor subfamily 2, group F, member 6a0.285
arnt2aryl hydrocarbon receptor nuclear translocator 20.153
wu:fi38e01wu:fi38e010.129
LOC100535118l-rhamnose-binding lectin CSL3-like0.113
zgc:171779zgc:1717790.110
zp3bzona pellucida glycoprotein 3b0.109
zpcxzona pellucida protein C0.108
LOC100333772zona pellucida sperm-binding protein 4-like0.092
zgc:111868zgc:1118680.088
zgc:171818zgc:1718180.088
or107-1odorant receptor, family D, subfamily 107, member 10.085
or102-1odorant receptor, family C, subfamily 102, member 10.084
esyt3extended synaptotagmin-like protein 30.083
trpc1transient receptor potential cation channel, subfamily C, member 10.080
zp3a.2zona pellucida glycoprotein 3a.20.078
wu:fi42e03wu:fi42e030.078
zp3a.1zona pellucida glycoprotein 3a.10.074
zp2.2zona pellucida glycoprotein 2.20.072
LOC100332822hypothetical protein LOC1003328220.071
zgc:165518zgc:1655180.070
crb2acrumbs homolog 2a0.067
retsatlretinol saturase (all-trans-retinol 13,14-reductase) like0.066
acsbg2acyl-CoA synthetase bubblegum family member 20.064
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.063
si:ch211-14a17.7si:ch211-14a17.70.061
LOC795984hypothetical LOC7959840.061
si:dkeyp-98a7.10si:dkeyp-98a7.100.059
zgc:91835zgc:918350.057
stat3signal transduction and activation of transcription 30.056
mibmind bomb0.055
slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.051
asphaspartate beta-hydroxylase0.050
islr2immunoglobulin superfamily containing leucine-rich repeat 20.050
zp3.1zona pellucida glycoprotein 3.10.050
zgc:122991zgc:1229910.048
npm2nucleoplasmin 20.048
lamb2laminin, beta 2 (laminin S)0.047
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.046
wu:fi34b01wu:fi34b010.045
sept2septin 20.044
acheacetylcholinesterase0.043
pobpartial optokinetic response b0.042
atp1a3aATPase, Na+/K+ transporting, alpha 3a polypeptide0.042
ilkintegrin linked kinase0.042
arpc5aactin related protein 2/3 complex, subunit 5A0.042
wu:fk73a07wu:fk73a070.041
eno2enolase 20.041
si:dkey-229d11.5si:dkey-229d11.50.040
si:dkey-46g23.5si:dkey-46g23.50.039
rab2aRAB2A, member RAS oncogene family0.039
LOC100008344hypothetical protein LOC1000083440.039
avplarginine vasopressin-like0.038
sox4aSRY-box containing gene 4a0.038
trpv4transient receptor potential cation channel, subfamily V, member 40.038
chatcholine acetyltransferase0.038
wu:fc18f06wu:fc18f060.037
zgc:171474zgc:1714740.037
nudt9nudix (nucleoside diphosphate linked moiety X)-type motif 90.036
yrkYes-related kinase0.036
LOC567452G protein-coupled receptor kinase 5-like0.036
dzip1DAZ interacting protein 10.035
wu:fb50h02wu:fb50h020.035
gh1growth hormone 10.034
ripk2receptor-interacting serine-threonine kinase 20.033
LOC100332505hypothetical protein LOC1003325050.033
valopavertebrate ancient long opsin a0.032
notch3notch homolog 30.032
calm1bcalmodulin 1b0.031
zgc:64040zgc:640400.031
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.031
wu:fi34e01wu:fi34e010.031
si:dkey-90l23.1si:dkey-90l23.10.031
elf2bE74-like factor 2b (ets domain transcription factor)0.031
gtf3abgeneral transcription factor IIIA, b0.030
sept6septin 60.030
clockclock0.030
ptpraprotein tyrosine phosphatase, receptor type, A0.029
zgc:171446zgc:1714460.029
ewsr1aEwing sarcoma breakpoint region 1a0.029
ttc39ctetratricopeptide repeat domain 39C0.028
LOC100534739hypothetical protein LOC1005347390.027
rab11bbRAB11B, member RAS oncogene family, b0.027
gnao1aguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a0.026
wnt8-2wnt8-like protein 20.026
syne1aspectrin repeat containing, nuclear envelope 1a0.026
vwfvon Willebrand factor0.026
psen1presenilin 10.025
klf7lKruppel-like factor 7 (ubiquitous), like0.025
zgc:165539zgc:1655390.025
si:ch73-90k17.1si:ch73-90k17.10.025
prkczprotein kinase C, zeta0.025
tgfb1atransforming growth factor, beta 1a0.024
grk5G protein-coupled receptor kinase 50.024
rad21RAD21 homolog (S. pombe)0.024
stx1bsyntaxin 1B0.024
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.024
rtcd1RNA terminal phosphate cyclase domain 10.024
ptpn11bprotein tyrosine phosphatase, non-receptor type 11, b0.024
ntrk2bneurotrophic tyrosine kinase, receptor, type 2b0.024
her12hairy-related 120.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SNAP25synaptosomal-associated protein, 25kDa0.589
OCRLoculocerebrorenal syndrome of Lowe0.368
SNAP23synaptosomal-associated protein, 23kDa0.165
WWP2WW domain containing E3 ubiquitin protein ligase 20.059
FOXD3forkhead box D30.050
JAG1jagged 10.027
SOX2SRY (sex determining region Y)-box 20.025
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.023
NOTCH3notch 30.021
STX4syntaxin 40.018
RAB11FIP1RAB11 family interacting protein 1 (class I)0.017
IRF2interferon regulatory factor 20.016
HMGA1high mobility group AT-hook 10.016
ANKRD27ankyrin repeat domain 27 (VPS9 domain)0.015
ANXA7annexin A70.014
PICALMphosphatidylinositol binding clathrin assembly protein0.011
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.011
LPHN1latrophilin 10.011
BSNbassoon (presynaptic cytomatrix protein)0.011
SYT1synaptotagmin I0.010
SRRM4serine/arginine repetitive matrix 40.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.961
Gabrb2gamma-aminobutyric acid (GABA) A receptor, subunit beta 20.928
Stx1asyntaxin 1A (brain)0.822
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.785
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.729
Snap25synaptosomal-associated protein 250.694
Syt2synaptotagmin II0.519
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.518
Grid1glutamate receptor, ionotropic, delta 10.516
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.419
Bsnbassoon0.415
Thrbthyroid hormone receptor beta0.380
Syt6synaptotagmin VI0.370
Pax3paired box gene 30.365
Drd2dopamine receptor D20.364
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.350
Raver2ribonucleoprotein, PTB-binding 20.340
Sypsynaptophysin0.300
Gabrg2gamma-aminobutyric acid (GABA) A receptor, subunit gamma 20.293
Gad2glutamic acid decarboxylase 20.272
Kifc2kinesin family member C20.247
Scn8asodium channel, voltage-gated, type VIII, alpha0.234
Slc12a5solute carrier family 12, member 50.226
Grm1glutamate receptor, metabotropic 10.216
Rab3aRAB3A, member RAS oncogene family0.212
Gabra1gamma-aminobutyric acid (GABA) A receptor, subunit alpha 10.209
Htthuntingtin0.196
Sh3gl2SH3-domain GRB2-like 20.195
Cdh23cadherin 23 (otocadherin)0.193
Ush1gUsher syndrome 1G homolog (human)0.189
Pcsk2proprotein convertase subtilisin/kexin type 20.181
Gabra5gamma-aminobutyric acid (GABA) A receptor, subunit alpha 50.180
Cnr1cannabinoid receptor 1 (brain)0.177
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.170
Rhorhodopsin0.161
Psen2presenilin 20.157
Syn2synapsin II0.154
Stx7syntaxin 70.146
Kif1akinesin family member 1A0.142
Crhr1corticotropin releasing hormone receptor 10.135
Prkccprotein kinase C, gamma0.135
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.135
Rasgrf2RAS protein-specific guanine nucleotide-releasing factor 20.134
Fgf13fibroblast growth factor 130.133
Pcsk1proprotein convertase subtilisin/kexin type 10.130
Syt10synaptotagmin X0.130
Zfpm2zinc finger protein, multitype 20.129
Dll1delta-like 1 (Drosophila)0.126
Syt1synaptotagmin I0.125
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.124
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.122
Cux2cut-like homeobox 20.121
Gpr3G-protein coupled receptor 30.117
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.116
Egfl7EGF-like domain 70.115
Syt7synaptotagmin VII0.108
Sult4a1sulfotransferase family 4A, member 10.107
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.105
SrcRous sarcoma oncogene0.105
Grm8glutamate receptor, metabotropic 80.102
Fgf12fibroblast growth factor 120.102
Sdcbpsyndecan binding protein0.101
Neurod1neurogenic differentiation 10.099
Rims2regulating synaptic membrane exocytosis 20.098
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.098
Stxbp5syntaxin binding protein 5 (tomosyn)0.097
Cbln1cerebellin 1 precursor protein0.097
Vamp4vesicle-associated membrane protein 40.095
Npas1neuronal PAS domain protein 10.093
AI118078expressed sequence AI1180780.093
Pgrprogesterone receptor0.092
Insm1insulinoma-associated 10.090
Cacna2d3calcium channel, voltage-dependent, alpha2/delta subunit 30.089
B3galt1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 10.089
Hrh1histamine receptor H10.088
Gabrg1gamma-aminobutyric acid (GABA) A receptor, subunit gamma 10.084
Homer1homer homolog 1 (Drosophila)0.084
L1camL1 cell adhesion molecule0.083
Capza2capping protein (actin filament) muscle Z-line, alpha 20.082
Elavl2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.082
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.081
Stx1bsyntaxin 1B0.080
Nrg3neuregulin 30.080
Htr75-hydroxytryptamine (serotonin) receptor 70.079
Dynlt1bdynein light chain Tctex-type 1D0.079
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.079
Map3k5mitogen-activated protein kinase kinase kinase 50.079
Rab27aRAB27A, member RAS oncogene family0.078
Dll4delta-like 4 (Drosophila)0.076
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.076
Atoh1atonal homolog 1 (Drosophila)0.076
Elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.075
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.074
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.074
Gjd2gap junction protein, delta 20.073
Rapgef4Rap guanine nucleotide exchange factor (GEF) 40.073
Otx2orthodenticle homolog 2 (Drosophila)0.073
Mtmr6myotubularin related protein 60.072
Dmrtc2doublesex and mab-3 related transcription factor like family C20.072
Gpr98G protein-coupled receptor 980.069
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.168
Snap25synaptosomal-associated protein 250.088
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.072
Unc5aunc-5 homolog A (C. elegans)0.064
Stx1asyntaxin 1A (brain)0.058
Gucy1b3guanylate cyclase 1, soluble, beta 30.049
Rab3aRAB3A, member RAS oncogene family0.046
Dlg4discs, large homolog 4 (Drosophila)0.044
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.040
Itgb1integrin, beta 10.032
Grm2glutamate receptor, metabotropic 20.032
Neurod2neurogenic differentiation 20.031
Pdx1pancreatic and duodenal homeobox 10.029
Sstr3somatostatin receptor 30.029
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.029
Hpcal4hippocalcin-like 40.028
Cplx1complexin 10.027
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.025
Rims1regulating synaptic membrane exocytosis 10.024
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.023
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.023
Camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.022
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.021
Gnazguanine nucleotide binding protein (G protein), alpha z polypeptide0.020
Tnrtenascin R0.020
Cspg5chondroitin sulfate proteoglycan 50.020
Oprl1opiate receptor-like 10.019
Pnckpregnancy upregulated non-ubiquitously expressed CaM kinase0.019
Ccbp2chemokine binding protein 20.018
Lrrc7leucine rich repeat containing 70.018
Nell1NEL-like 1 (chicken)0.017
Syn1synapsin I0.017
Gucy2fguanylate cyclase 2F0.017
Freqfrequenin homolog (Drosophila)0.015
Syt11synaptotagmin XI0.015
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.015
CartptCART prepropeptide0.014
Gckglucokinase0.014
Prps1phosphoribosyl pyrophosphate synthetase 10.014
Adra2cadrenergic, alpha-2C-, receptor0.014
Sez6l2seizure related 6 homolog (mouse)-like 20.014
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.014
Faim2Fas apoptotic inhibitory molecule 20.013
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.013
Pcsk2proprotein convertase subtilisin/kexin type 20.013
Sstsomatostatin0.013
Grid2glutamate receptor, ionotropic, delta 20.013
Cntfrciliary neurotrophic factor receptor0.013
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.012
Tspyl1TSPY-like 10.012
Nlgn3neuroligin 30.012
Rbm3RNA binding motif (RNP1, RRM) protein 30.012
Magi1membrane associated guanylate kinase, WW and PDZ domain containing 10.012
Mcf2lMCF.2 cell line derived transforming sequence-like0.012
Crhbpcorticotropin releasing hormone binding protein0.012
St18suppression of tumorigenicity 180.012
Adap1ArfGAP with dual PH domains 10.012
Odf4outer dense fiber of sperm tails 40.012
Ptch1patched homolog 1 (Drosophila)0.011
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.011
Syt7synaptotagmin VII0.011
Accn2amiloride-sensitive cation channel 2, neuronal0.011
Grm1glutamate receptor, metabotropic 10.011
Sstr2somatostatin receptor 20.011
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.011
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.011
RGD1562618similar to RIKEN cDNA 6030419C18 gene0.010
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.010
Elk3ELK3, ETS-domain protein0.010
Cryba2crystallin, beta A20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism