The network for 'regulation of defense response to virus by host' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of defense response to virus by host

Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.

NameDescriptionProbabilityFunc Analog Organism
caspacaspase a0.807
nod1nucleotide-binding oligomerization domain containing 10.581
nod2nucleotide-binding oligomerization domain containing 20.325
pycardPYD and CARD domain containing0.311
s100a10bS100 calcium binding protein A10b0.200
tfe3btranscription factor binding to IGHM enhancer 3b0.132
adipor1badiponectin receptor 1b0.119
arhgdigRho GDP dissociation inhibitor (GDI) gamma0.100
LOC557722similar to transient receptor potential cation channel, subfamily M, member 50.087
cfl1cofilin 1 (non-muscle)0.069
acvr2aactivin receptor IIa0.069
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.059
LOC557072caspase recruitment domain-containing protein 11-like0.058
sass6spindle assembly 6 homolog (C. elegans)0.058
relv-rel reticuloendotheliosis viral oncogene homolog0.057
ikbkginhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.054
adipor1aadiponectin receptor 1a0.053
ripk2receptor-interacting serine-threonine kinase 20.051
rp2retinitis pigmentosa 2 (X-linked recessive)0.049
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.042
anxa2aannexin A2a0.041
slc14a2solute carrier family 14 (urea transporter), member 20.040
anxa1aannexin A1a0.037
tlr21toll-like receptor 210.036
LOC556160guanine nucleotide-binding protein subunit alpha-14-like0.036
LOC562403hypothetical LOC5624030.034
runx3runt-related transcription factor 30.032
tas1r2.2taste receptor, type 1, member 2.20.032
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.031
eif2ak3eukaryotic translation initiation factor 2-alpha kinase 30.030
LOC566020Gig2-like protein DreO0.026
mapkapk2amitogen-activated protein kinase-activated protein kinase 2a0.026
ef1aelongation factor 1-alpha0.023
unc5cunc-5 homolog C (C. elegans)0.022
nos2anitric oxide synthase 2a, inducible0.022
prkciprotein kinase C, iota0.022
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.022
mxamyxovirus (influenza) resistance A0.021
stc1lstanniocalcin 1, like0.021
sepw1selenoprotein W, 10.021
card9caspase recruitment domain family, member 90.020
caspbcaspase b and caspase b-like0.020
cx44.1connexin 44.10.020
tas2r200.2taste receptor, type 2, member 200.20.020
tas2r200.1taste receptor, type 2, member 200.10.020
rag1recombination activating gene 10.019
npy8brneuropeptide Y receptor Y8b0.019
tas1r2.1taste receptor, type 1, member 2.10.018
igf1insulin-like growth factor 10.018
per2period homolog 2 (Drosophila)0.017
plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.017
tial1TIA1 cytotoxic granule-associated RNA binding protein-like 10.017
socs3bsuppressor of cytokine signaling 3b0.017
irgq1immunity-related GTPase family, q10.016
styk1serine/threonine/tyrosine kinase 10.016
scdstearoyl-CoA desaturase (delta-9-desaturase)0.016
mapk14bmitogen-activated protein kinase 14b0.016
tas1r1taste receptor, type 1, member 10.016
plekha3pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 30.015
tas1r3taste receptor, type 1, member 30.015
plk3polo-like kinase 3 (Drosophila)0.015
nfe2l3nuclear factor (erythroid-derived 2)-like 30.015
cnppd1cyclin Pas1/PHO80 domain containing 10.014
cd40lgCD40 ligand0.014
ptk6aPTK6 protein tyrosine kinase 6a0.014
csnk1dacasein kinase 1, delta a0.014
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.014
fabp1afatty acid binding protein 1a, liver0.013
casp8caspase 8, apoptosis-related cysteine peptidase0.013
tbx21T-box 210.012
rag2recombination activating gene 20.012
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.012
vtg1vitellogenin 10.012
zfyve26zinc finger, FYVE domain containing 260.012
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.012
cotl1coactosin-like 1 (Dictyostelium)0.012
blnkB-cell linker0.011
gucy2fguanylate cyclase 2F, retinal0.011
stxbp2syntaxin binding protein 20.011
frylfurry homolog-like (Drosophila)0.011
pfn1profilin 10.011
satb2SATB homeobox 20.011
dnajb6bDnaJ (Hsp40) homolog, subfamily B, member 6b0.011
aktipakt interacting protein0.011
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.011
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.010
anxa1bannexin A1b0.010
vps37avacuolar protein sorting 37A0.010
pex13peroxisome biogenesis factor 130.010
nitr4anovel immune-type receptor 4a0.010
capns1acalpain, small subunit 1 a0.010
tsc22d2TSC22 domain family 2 and TSC22 domain family, member 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DreddDeath related ced-3/Nedd2-like protein0.991
ird5immune response deficient 50.958
BG4CG12297 gene product from transcript CG12297-RA0.957
Tak1TGF-beta activated kinase 10.899
AGO2Argonaute 20.743
Myd88CG2078 gene product from transcript CG2078-RA0.696
imdimmune deficiency0.658
Mpk2CG5475 gene product from transcript CG5475-RB0.653
PGRP-LCPeptidoglycan recognition protein LC0.618
ird1immune response deficient 10.423
r2d2CG7138 gene product from transcript CG7138-RB0.285
Vps16AVacuolar protein sorting 16A0.158
Adf1Adh transcription factor 10.101
Mekk1CG7717 gene product from transcript CG7717-RB0.091
PGRP-LEPeptidoglycan recognition protein LE0.090
HsfHeat shock factor0.078
CG16718CG16718 gene product from transcript CG16718-RA0.062
Atg18Autophagy-specific gene 180.062
TER94CG2331 gene product from transcript CG2331-RA0.056
Gcn2CG1609 gene product from transcript CG1609-RA0.051
Traf6TNF-receptor-associated factor 60.050
Tab2TAK1-associated binding protein 20.043
sqhspaghetti squash0.034
Sir2CG5216 gene product from transcript CG5216-RA0.031
Pi3K92ECG4141 gene product from transcript CG4141-RB0.030
p38bCG7393 gene product from transcript CG7393-RA0.027
StimStromal interaction molecule0.026
Rpd3CG7471 gene product from transcript CG7471-RA0.024
SaraSmad anchor for receptor activation0.023
grassGram-positive Specific Serine protease0.023
ari-2ariadne 20.023
pashapartner of drosha0.022
RbfRetinoblastoma-family protein0.021
SPESpatzle-Processing Enzyme0.020
cpacapping protein alpha0.020
Su(z)12CG8013 gene product from transcript CG8013-RA0.020
Hsp27Heat shock protein 270.017
AbiAbelson interacting protein0.015
Rab11Rab-protein 110.013
PargPoly(ADP-ribose) glycohydrolase0.013
DuoxDual oxidase0.012
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.012
Su(var)2-10Suppressor of variegation 2-100.011
CycACyclin A0.011
CG32185CG32185 gene product from transcript CG32185-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.984
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.982
IFIT1interferon-induced protein with tetratricopeptide repeats 10.977
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.935
IFIT3interferon-induced protein with tetratricopeptide repeats 30.879
IFIT5interferon-induced protein with tetratricopeptide repeats 50.852
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.841
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.798
IFIT2interferon-induced protein with tetratricopeptide repeats 20.797
STAT1signal transducer and activator of transcription 1, 91kDa0.775
NLRC4NLR family, CARD domain containing 40.739
CREBBPCREB binding protein0.713
IFI44Linterferon-induced protein 44-like0.683
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.682
NMIN-myc (and STAT) interactor0.603
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.601
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.582
MAVSmitochondrial antiviral signaling protein0.526
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.454
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.443
IL23Ainterleukin 23, alpha subunit p190.434
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.422
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.416
IFI44interferon-induced protein 440.411
PILRApaired immunoglobin-like type 2 receptor alpha0.402
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.400
IL4Rinterleukin 4 receptor0.363
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.334
TMEM173transmembrane protein 1730.327
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.299
DICER1dicer 1, ribonuclease type III0.298
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.267
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.254
XAF1XIAP associated factor 10.219
PTPN6protein tyrosine phosphatase, non-receptor type 60.208
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.197
HIPK2homeodomain interacting protein kinase 20.188
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.183
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.180
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.162
PTPN1protein tyrosine phosphatase, non-receptor type 10.145
HERC5hect domain and RLD 50.144
RABAC1Rab acceptor 1 (prenylated)0.141
SAMD9sterile alpha motif domain containing 90.139
SP110SP110 nuclear body protein0.138
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.129
ISG15ISG15 ubiquitin-like modifier0.126
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.119
SP100SP100 nuclear antigen0.117
RTP4receptor (chemosensory) transporter protein 40.106
SIGLEC7sialic acid binding Ig-like lectin 70.092
PLSCR1phospholipid scramblase 10.092
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.088
TYMPthymidine phosphorylase0.074
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.066
MEFVMediterranean fever0.062
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.062
INSRinsulin receptor0.061
DAXXdeath-domain associated protein0.059
TARBP2TAR (HIV-1) RNA binding protein 20.059
LGALS3lectin, galactoside-binding, soluble, 30.058
EIF2C2eukaryotic translation initiation factor 2C, 20.057
MAP3K14mitogen-activated protein kinase kinase kinase 140.053
USP18ubiquitin specific peptidase 180.051
OASL2'-5'-oligoadenylate synthetase-like0.050
NLRP3NLR family, pyrin domain containing 30.044
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.043
LAP3leucine aminopeptidase 30.041
PARP9poly (ADP-ribose) polymerase family, member 90.037
TRIM25tripartite motif containing 250.036
CYLDcylindromatosis (turban tumor syndrome)0.035
MBOAT7membrane bound O-acyltransferase domain containing 70.034
TDRD7tudor domain containing 70.034
CSKc-src tyrosine kinase0.033
BCL3B-cell CLL/lymphoma 30.033
RIPK2receptor-interacting serine-threonine kinase 20.033
IL15RAinterleukin 15 receptor, alpha0.032
TRIM22tripartite motif containing 220.030
STAP2signal transducing adaptor family member 20.030
TNIP2TNFAIP3 interacting protein 20.029
RSAD2radical S-adenosyl methionine domain containing 20.029
EPORerythropoietin receptor0.028
HK3hexokinase 3 (white cell)0.027
ZC3HAV1zinc finger CCCH-type, antiviral 10.027
ELF4E74-like factor 4 (ets domain transcription factor)0.025
TRIM21tripartite motif containing 210.025
MAP3K8mitogen-activated protein kinase kinase kinase 80.025
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.025
LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 30.024
BAXBCL2-associated X protein0.024
STX8syntaxin 80.023
PTAFRplatelet-activating factor receptor0.023
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.022
GBP1guanylate binding protein 1, interferon-inducible0.022
NOD2nucleotide-binding oligomerization domain containing 20.021
APOL6apolipoprotein L, 60.021
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.021
IFI16interferon, gamma-inducible protein 160.020
IL2RBinterleukin 2 receptor, beta0.020
CD33CD33 molecule0.019
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.998
Casp4caspase 4, apoptosis-related cysteine peptidase0.994
Gbp7guanylate binding protein 70.986
Stat1signal transducer and activator of transcription 10.979
Irgm1immunity-related GTPase family M member 10.976
Irgm2immunity-related GTPase family M member 20.945
Gbp3guanylate binding protein 30.945
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.937
Usp18ubiquitin specific peptidase 180.930
Gbp2guanylate binding protein 20.928
Trim21tripartite motif-containing 210.925
Tnftumor necrosis factor0.919
Ikbkginhibitor of kappaB kinase gamma0.900
Casp1caspase 10.896
Igtpinterferon gamma induced GTPase0.893
Ifit3interferon-induced protein with tetratricopeptide repeats 30.874
Irf1interferon regulatory factor 10.857
Ifih1interferon induced with helicase C domain 10.856
Trim30atripartite motif-containing 30A0.825
Stat5asignal transducer and activator of transcription 5A0.821
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.796
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.751
Gbp5guanylate binding protein 50.743
Irf9interferon regulatory factor 90.717
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.716
Uba7ubiquitin-like modifier activating enzyme 70.687
Stat3signal transducer and activator of transcription 30.672
Ifit1interferon-induced protein with tetratricopeptide repeats 10.655
Iigp1interferon inducible GTPase 10.646
Ifi47interferon gamma inducible protein 470.627
Lyz2lysozyme 20.555
Isg15ISG15 ubiquitin-like modifier0.554
Ikzf1IKAROS family zinc finger 10.469
Tgtp2T-cell specific GTPase 20.447
Oasl22'-5' oligoadenylate synthetase-like 20.419
Rtp4receptor transporter protein 40.416
Mndalmyeloid nuclear differentiation antigen like0.396
Trim25tripartite motif-containing 250.392
Parp14poly (ADP-ribose) polymerase family, member 140.363
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.342
PycardPYD and CARD domain containing0.323
Rsad2radical S-adenosyl methionine domain containing 20.317
AW112010expressed sequence AW1120100.315
Tor3atorsin family 3, member A0.309
Stat5bsignal transducer and activator of transcription 5B0.309
Ighimmunoglobulin heavy chain complex0.307
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.304
Sp100nuclear antigen Sp1000.301
Ikbkbinhibitor of kappaB kinase beta0.296
Irf7interferon regulatory factor 70.281
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.271
Zbp1Z-DNA binding protein 10.262
Aim2absent in melanoma 20.260
Ifit2interferon-induced protein with tetratricopeptide repeats 20.242
Myd88myeloid differentiation primary response gene 880.221
Parp9poly (ADP-ribose) polymerase family, member 90.207
Ifi35interferon-induced protein 350.194
Map3k14mitogen-activated protein kinase kinase kinase 140.158
Stat2signal transducer and activator of transcription 20.154
Cd40CD40 antigen0.139
Samd9lsterile alpha motif domain containing 9-like0.125
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.124
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.120
Psmb10proteasome (prosome, macropain) subunit, beta type 100.111
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.107
Il10interleukin 100.105
Trp53transformation related protein 530.104
NmiN-myc (and STAT) interactor0.093
Il15rainterleukin 15 receptor, alpha chain0.089
Unc93b1unc-93 homolog B1 (C. elegans)0.089
Mx1myxovirus (influenza virus) resistance 10.088
Mx2myxovirus (influenza virus) resistance 20.085
Ifi44interferon-induced protein 440.081
Cd19CD19 antigen0.080
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.077
Map3k8mitogen-activated protein kinase kinase kinase 80.076
TapbpTAP binding protein0.071
Ifnginterferon gamma0.070
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.068
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.065
Foxn1forkhead box N10.060
BC006779cDNA sequence BC0067790.059
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.058
Znfx1zinc finger, NFX1-type containing 10.056
Ifi203interferon activated gene 2030.055
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.051
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.051
FasFas (TNF receptor superfamily member 6)0.051
Parp10poly (ADP-ribose) polymerase family, member 100.046
Rnf31ring finger protein 310.045
Cxcl10chemokine (C-X-C motif) ligand 100.043
Plcg2phospholipase C, gamma 20.041
Ifnar2interferon (alpha and beta) receptor 20.041
Parp12poly (ADP-ribose) polymerase family, member 120.041
Map3k7mitogen-activated protein kinase kinase kinase 70.041
DaxxFas death domain-associated protein0.040
Il4rainterleukin 4 receptor, alpha0.040
Serpinb9serine (or cysteine) peptidase inhibitor, clade B, member 90.038
Dtx3ldeltex 3-like (Drosophila)0.038
Ticam1toll-like receptor adaptor molecule 10.036
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism