The network for 'positive regulation of mitotic sister chromatid separation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mitotic sister chromatid separation

Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mcm-3Protein MCM-30.500
pcn-1Protein PCN-10.323
cyb-3Protein CYB-30.230
puf-6Protein PUF-60.185
rnr-1Protein RNR-10.167
hcp-2Protein HCP-20.151
F11E6.7Protein F11E6.70.117
mcm-7Protein MCM-70.091
T19H12.2Protein T19H12.20.091
zwl-1Protein ZWL-10.086
tpxl-1Protein TPXL-10.073
Y48G1C.7Protein Y48G1C.70.070
knl-1Protein KNL-10.069
puf-11Protein PUF-110.067
rod-1Protein ROD-10.061
bub-1Protein BUB-10.060
F56A6.4Protein F56A6.40.059
cdl-1Protein CDL-10.058
clec-87Protein CLEC-870.057
rpa-2Protein RPA-20.055
klp-19Protein KLP-190.054
rme-2Protein RME-20.051
zen-4Protein ZEN-40.050
wago-1Protein WAGO-10.049
mcm-5Protein MCM-50.048
crn-1Protein CRN-10.048
cyb-1Protein CYB-10.047
spd-1Protein SPD-10.045
zif-1Protein ZIF-10.045
ZC410.3Protein ZC410.30.045
lst-1Protein LST-10.044
mex-3Protein MEX-30.044
gln-6Protein GLN-60.042
F18A1.7Protein F18A1.70.042
mex-1Protein MEX-10.040
ZK328.4Protein ZK328.40.037
C44B9.3Protein C44B9.30.036
air-2Protein AIR-20.036
F39B2.1Protein F39B2.10.035
CELE_C24H12.5Protein C24H12.50.035
T22D1.5Protein T22D1.50.035
mcm-2Protein MCM-20.034
mcm-4Protein MCM-40.034
flh-1Protein FLH-10.034
dsh-2Protein DSH-20.033
spn-4Protein SPN-40.033
F58G11.3Protein F58G11.30.033
trcs-2Protein TRCS-20.031
npp-7Protein NPP-70.031
cyb-2.1Protein CYB-2.10.030
egg-1Protein EGG-10.028
CELE_C39E9.12Protein C39E9.120.028
mbk-1Protein MBK-10.028
cyk-4Protein CYK-40.028
cyb-2.2Protein CYB-2.20.027
sun-1Protein SUN-10.027
klp-18Protein KLP-180.027
ZK863.4Protein ZK863.40.027
ify-1Protein IFY-10.026
fbxa-215Protein FBXA-2150.026
fzy-1Protein FZY-10.026
F30F8.1Protein F30F8.10.026
CELE_W02F12.3Protein W02F12.30.025
pos-1Protein POS-10.025
hcp-6Protein HCP-60.025
clec-88Protein CLEC-880.025
T28D9.4Protein T28D9.40.025
puf-7Protein PUF-70.024
nasp-2Protein NASP-20.024
chaf-1Protein CHAF-10.024
F32D1.7Protein F32D1.70.023
spdl-1Protein SPDL-10.023
CELE_Y43F11A.1Protein Y43F11A.10.022
F55G1.6Protein F55G1.60.022
T09B4.1Protein T09B4.10.022
vps-33.2Protein VPS-33.20.021
ZK507.6Protein ZK507.60.021
ucr-2.3Protein UCR-2.30.021
mex-5Protein MEX-50.020
CELE_C08F8.3Protein C08F8.30.020
T10B11.8Protein T10B11.80.020
cpg-2Protein CPG-20.019
retr-1Protein RETR-10.019
air-1Protein AIR-10.019
hsr-9Protein HSR-90.019
CELE_Y14H12B.2Protein Y14H12B.20.018
icp-1Protein ICP-10.018
dpl-1Protein DPL-10.018
tag-296Protein TAG-2960.018
W05F2.6Protein W05F2.60.018
hcf-1Protein HCF-10.017
msh-2Protein MSH-20.017
hcp-1Protein HCP-10.017
Y42H9B.3Protein Y42H9B.30.017
knl-3Protein KNL-30.016
bmk-1Protein BMK-10.016
Y51F10.2Protein Y51F10.20.016
gla-3Protein GLA-30.016
B0432.8Protein B0432.80.016
xpc-1Protein XPC-10.015
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycACyclin A0.820
cmetCENP-meta0.803
pimpimples0.634
cavcaravaggio0.418
IncenpInner centromere protein0.325
idaimaginal discs arrested0.301
BubR1Bub1-related kinase0.298
Mcm10Sensitized chromosome inheritance modifier 190.272
dupdouble parked0.263
SseSeparase0.254
aspabnormal spindle0.233
stgstring0.209
Cenp-CCG31258 gene product from transcript CG31258-RA0.205
hpohippo0.201
MybMyb oncogene-like0.171
tefutelomere fusion0.130
dapdacapo0.123
gwlgreatwall0.123
ncdnon-claret disjunctional0.121
bratbrain tumor0.114
CycB3Cyclin B30.114
marsCG17064 gene product from transcript CG17064-RB0.111
CycBCyclin B0.106
CycECyclin E0.096
Psf2CG18013 gene product from transcript CG18013-RA0.095
Nuf2CG8902 gene product from transcript CG8902-RA0.093
Su(H)Suppressor of Hairless0.090
Vap-33-1CG5014 gene product from transcript CG5014-RB0.085
trolterribly reduced optic lobes0.077
Klp61FKinesin-like protein at 61F0.074
CG9772CG9772 gene product from transcript CG9772-RB0.067
l(1)dd4lethal (1) discs degenerate 40.067
Orc2Origin recognition complex subunit 20.063
vtdverthandi0.060
stisticky0.058
barrbarren0.054
Top1Topoisomerase 10.048
Mis12CG18156 gene product from transcript CG18156-RA0.043
aslasterless0.042
pblpebble0.041
Spc105RSpc105-related0.041
weeCG4488 gene product from transcript CG4488-RA0.040
pavpavarotti0.039
CG4680CG4680 gene product from transcript CG4680-RA0.038
Cks30ACyclin-dependent kinase subunit 30A0.038
Spc25CG7242 gene product from transcript CG7242-RA0.033
thrthree rows0.033
Nek2CG17256 gene product from transcript CG17256-RA0.032
poloCG12306 gene product from transcript CG12306-RA0.031
pashapartner of drosha0.030
pitaCG3941 gene product from transcript CG3941-RA0.029
Orc5Origin recognition complex subunit 50.028
IswiImitation SWI0.027
mus304mutagen-sensitive 3040.027
DrefDNA replication-related element factor0.027
Rca1Regulator of cyclin A10.026
Klp3AKinesin-like protein at 3A0.026
shtdshattered0.026
Klp10ACG1453 gene product from transcript CG1453-RA0.025
Su(var)2-10Suppressor of variegation 2-100.024
Cdc27CG8610 gene product from transcript CG8610-RA0.024
cidcentromere identifier0.023
DNApol-alpha60DNA polymerase alpha 60kD0.023
lkb1CG9374 gene product from transcript CG9374-RJ0.023
nbsCG6754 gene product from transcript CG6754-RC0.023
RbfRetinoblastoma-family protein0.020
Ndc80CG9938 gene product from transcript CG9938-RA0.020
slmbsupernumerary limbs0.020
Dhc64CDynein heavy chain 64C0.019
larpLa related protein0.018
PtenCG5671 gene product from transcript CG5671-RB0.017
Kmn1kinetochore Mis12-Ndc80 network component 10.017
Gem3Gemin30.017
Dap160Dynamin associated protein 1600.017
Cap-GCG34438 gene product from transcript CG34438-RF0.017
tumtumbleweed0.017
nmonemo0.016
rapretina aberrant in pattern0.016
Sgt1CG9617 gene product from transcript CG9617-RA0.016
Orc6Origin recognition complex subunit 60.016
swaswallow0.016
lqfRliquid facets-Related0.015
Dcr-1Dicer-10.015
trioCG18214 gene product from transcript CG18214-RA0.015
phopleiohomeotic0.014
ballballchen0.014
Nipped-ACG33554 gene product from transcript CG33554-RE0.014
Aats-metMethionyl-tRNA synthetase0.014
miminus0.013
CG4973CG4973 gene product from transcript CG4973-RA0.013
twetwine0.013
dmdiminutive0.012
nctnicastrin0.012
krzkurtz0.011
shgshotgun0.011
toctoucan0.011
mei-S332meiotic from via Salaria 3320.011
jumujumeau0.011
nxf2nuclear RNA export factor 20.010
piepineapple eye0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC27cell division cycle 27 homolog (S. cerevisiae)0.994
CDC20cell division cycle 20 homolog (S. cerevisiae)0.938
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.913
ANAPC4anaphase promoting complex subunit 40.657
PLK1polo-like kinase 10.480
ANAPC5anaphase promoting complex subunit 50.363
RBL1retinoblastoma-like 1 (p107)0.270
CCNA2cyclin A20.178
CLSPNclaspin0.176
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.148
PTTG1pituitary tumor-transforming 10.081
CDC23cell division cycle 23 homolog (S. cerevisiae)0.072
ANAPC7anaphase promoting complex subunit 70.062
CCNB1cyclin B10.055
RB1retinoblastoma 10.045
ANAPC11anaphase promoting complex subunit 110.041
CDC26cell division cycle 26 homolog (S. cerevisiae)0.039
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.038
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.037
ANAPC1anaphase promoting complex subunit 10.036
UBE2Cubiquitin-conjugating enzyme E2C0.035
E2F1E2F transcription factor 10.032
RBL2retinoblastoma-like 2 (p130)0.030
KIF20Akinesin family member 20A0.029
E2F4E2F transcription factor 4, p107/p130-binding0.028
NEK2NIMA (never in mitosis gene a)-related kinase 20.027
GTSE1G-2 and S-phase expressed 10.025
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.024
LIN54lin-54 homolog (C. elegans)0.020
MAKmale germ cell-associated kinase0.020
TTKTTK protein kinase0.019
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.018
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.017
RBBP8retinoblastoma binding protein 80.015
LIN9lin-9 homolog (C. elegans)0.015
AURKBaurora kinase B0.015
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis)0.015
E2F5E2F transcription factor 5, p130-binding0.015
SKA1spindle and kinetochore associated complex subunit 10.014
CDKN3cyclin-dependent kinase inhibitor 30.014
CDK2cyclin-dependent kinase 20.013
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.012
UHRF2ubiquitin-like with PHD and ring finger domains 20.011
SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Trp53transformation related protein 531.000
Ptenphosphatase and tensin homolog0.997
Apcadenomatosis polyposis coli0.989
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.968
Ccnb2cyclin B20.946
Ccna2cyclin A20.860
Cdk1cyclin-dependent kinase 10.859
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.839
Plk1polo-like kinase 1 (Drosophila)0.813
Ccnb1cyclin B10.769
Cdkn1bcyclin-dependent kinase inhibitor 1B0.734
Usp9xubiquitin specific peptidase 9, X chromosome0.676
H2afxH2A histone family, member X0.561
Rb1retinoblastoma 10.529
Atf2activating transcription factor 20.525
Kif22kinesin family member 220.502
Birc5baculoviral IAP repeat-containing 50.496
Cdca8cell division cycle associated 80.480
Psen1presenilin 10.469
Chd7chromodomain helicase DNA binding protein 70.465
Aurkbaurora kinase B0.438
Mki67antigen identified by monoclonal antibody Ki 670.406
Kitkit oncogene0.392
Prc1protein regulator of cytokinesis 10.389
Smad4MAD homolog 4 (Drosophila)0.373
Kif20akinesin family member 20A0.367
Ccnfcyclin F0.332
Axin1axin 10.274
Mdm2transformed mouse 3T3 cell double minute 20.271
Cdc25ccell division cycle 25 homolog C (S. pombe)0.271
Cdca5cell division cycle associated 50.270
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.252
Cenpacentromere protein A0.225
Ckap2cytoskeleton associated protein 20.222
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.203
Notch1Notch gene homolog 1 (Drosophila)0.177
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.167
Brca1breast cancer 10.166
Kif4kinesin family member 40.156
Spag5sperm associated antigen 50.149
Racgap1Rac GTPase-activating protein 10.137
Aurkaaurora kinase A0.136
Ythdf3YTH domain family 30.136
Lrp6low density lipoprotein receptor-related protein 60.133
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.132
BrafBraf transforming gene0.128
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.127
Hmmrhyaluronan mediated motility receptor (RHAMM)0.124
StilScl/Tal1 interrupting locus0.122
Lmnb1lamin B10.120
Bmi1Bmi1 polycomb ring finger oncogene0.119
Kif2ckinesin family member 2C0.117
Dlg1discs, large homolog 1 (Drosophila)0.114
Ube2cubiquitin-conjugating enzyme E2C0.113
Cdkn3cyclin-dependent kinase inhibitor 30.110
Ptch1patched homolog 10.110
Wdr26WD repeat domain 260.109
Nf2neurofibromatosis 20.107
E2f1E2F transcription factor 10.105
Ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.103
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.100
Ncapgnon-SMC condensin I complex, subunit G0.095
Hif1ahypoxia inducible factor 1, alpha subunit0.094
Kif23kinesin family member 230.092
Rrm2ribonucleotide reductase M20.091
Melkmaternal embryonic leucine zipper kinase0.091
Bmp4bone morphogenetic protein 40.086
Bmpr1abone morphogenetic protein receptor, type 1A0.085
Kif11kinesin family member 110.082
Dlgap5discs, large (Drosophila) homolog-associated protein 50.078
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.078
Rbl2retinoblastoma-like 20.076
Cenpncentromere protein N0.076
Ranbp9RAN binding protein 90.075
Tcf3transcription factor 30.069
Top2btopoisomerase (DNA) II beta0.069
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.065
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.062
Ncaphnon-SMC condensin I complex, subunit H0.059
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.057
Itgb1integrin beta 1 (fibronectin receptor beta)0.056
Ckap2lcytoskeleton associated protein 2-like0.056
Capn7calpain 70.055
Gtse1G two S phase expressed protein 10.054
Arid1aAT rich interactive domain 1A (SWI-like)0.053
Kitlkit ligand0.053
Espl1extra spindle poles-like 1 (S. cerevisiae)0.052
Fam64afamily with sequence similarity 64, member A0.051
Incenpinner centromere protein0.050
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.048
Ptpn11protein tyrosine phosphatase, non-receptor type 110.048
Zc3h14zinc finger CCCH type containing 140.048
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.047
Fam108afamily with sequence similarity 108, member A0.045
Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a0.044
Cul3cullin 30.043
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.042
BC018507cDNA sequence BC0185070.040
Shcbp1Shc SH2-domain binding protein 10.040
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC16Cdc16p0.021
CDC23Cdc23p0.018
CDC20Cdc20p0.018
CDC27Cdc27p0.016
CDC26Cdc26p0.011