The network for 'somite development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somite development

The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

NameDescriptionProbabilityFunc Analog Organism
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.996
myf5myogenic factor 50.987
tbx1T-box 10.980
aldh1a2aldehyde dehydrogenase 1 family, member A20.973
gli1GLI-Kruppel family member 10.967
wnt11wingless-type MMTV integration site family, member 110.958
wnt3awingless-type MMTV integration site family, member 3A0.943
wnt1wingless-type MMTV integration site family, member 10.942
wnt4awingless-type MMTV integration site family, member 4a0.928
wnt5bwingless-type MMTV integration site family, member 5b0.919
dkk1bdickkopf 1b0.903
bmp2bbone morphogenetic protein 2b0.897
smyhc1slow myosin heavy chain 10.895
hnf1baHNF1 homeobox Ba0.894
foxd5forkhead box D50.892
mespamesoderm posterior a0.886
her7hairy and enhancer of split related-70.874
notch1anotch homolog 1a0.867
cdh2cadherin 2, neuronal0.856
bmp4bone morphogenetic protein 40.853
tbx16T-box gene 160.850
hes6hairy and enhancer of split 6 (Drosophila)0.835
tbx24T-box 240.806
cdx4caudal type homeo box transcription factor 40.804
gli2aGLI-Kruppel family member GLI2a0.790
bocbrother of CDO0.786
her1hairy-related 10.781
pdlim3aPDZ and LIM domain 3a0.759
mef2cbmyocyte enhancer factor 2cb0.759
dag1dystroglycan 10.754
has2hyaluronan synthase 20.754
hspb1heat shock protein, alpha-crystallin-related, 10.733
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.717
sema3aasemaphorin 3aa0.712
hey1hairy/enhancer-of-split related with YRPW motif 10.709
prickle1aprickle-like 1 (Drosophila) a0.703
myod1myogenic differentiation 10.697
her5hairy-related 50.659
lef1lymphocyte enhancer binding factor 10.651
pdlim3bPDZ and LIM domain 3b0.628
hhiphedgehog interacting protein0.618
fbn2bfibrillin 2b0.614
ntlano tail a0.610
ndr2nodal-related 20.607
fn1fibronectin 10.602
myhz2myosin, heavy polypeptide 2, fast muscle specific0.591
lama5laminin, alpha 50.588
col2a1acollagen type II, alpha-1a0.577
msgn1mesogenin 10.573
her15.1hairy and enhancer of split-related 15.10.569
wnt9awingless-type MMTV integration site family, member 9A0.567
fezf2FEZ family zinc finger 20.562
lamb1alaminin, beta 1a0.549
nrarpanotch-regulated ankyrin repeat protein a0.536
gata5GATA-binding protein 50.534
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.529
hand2heart and neural crest derivatives expressed transcript 20.527
sox17SRY-box containing gene 170.523
snai1bsnail homolog 1b (Drosophila)0.495
scube2signal peptide, CUB domain, EGF-like 20.493
tll1tolloid-like 10.486
osr2odd-skipped related 2 (Drosophila)0.480
fgf3fibroblast growth factor 30.480
her3hairy-related 30.478
tp63tumor protein p630.473
ptch1patched 10.469
sp5lSp5 transcription factor-like0.463
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.455
frem3Fras1 related extracellular matrix 30.453
fgfr1bfibroblast growth factor receptor 1b0.442
fgf19fibroblast growth factor 190.437
tnni1altroponin I, skeletal, slow like0.435
pdlim7PDZ and LIM domain 70.434
spry4sprouty (Drosophila) homolog 40.422
fgf17fibroblast growth factor 170.410
jag2jagged 20.406
msxbmuscle segment homeobox B0.403
traf4atnf receptor-associated factor 4a0.400
shhasonic hedgehog a0.397
dmrt2adoublesex and mab-3 related transcription factor 2a0.397
chrnb3acholinergic receptor, nicotinic, beta polypeptide 3a0.396
zbtb4zinc finger and BTB domain containing 40.394
sulf1sulfatase 10.393
lhx1aLIM homeobox 1a0.391
pax2apaired box gene 2a0.388
eng2aengrailed 2a0.385
foxi1forkhead box I10.382
emx3empty spiracles homeobox 30.381
gdnfglial cell derived neurotrophic factor0.380
notch2notch homolog 20.376
desmadesmin a0.376
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.373
apobec2aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a0.369
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.368
flhfloating head0.364
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BMP2bone morphogenetic protein 20.580
MEOX2mesenchyme homeobox 20.574
SMAD3SMAD family member 30.524
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.495
SRPK2SRSF protein kinase 20.339
JAG1jagged 10.291
MAPK8mitogen-activated protein kinase 80.210
PSEN1presenilin 10.192
PAX1paired box 10.164
MEOX1mesenchyme homeobox 10.120
PAX3paired box 30.107
NOTCH3notch 30.104
EXOC7exocyst complex component 70.099
CTGFconnective tissue growth factor0.098
BBS10Bardet-Biedl syndrome 100.077
NOTCH1notch 10.077
FZD1frizzled homolog 1 (Drosophila)0.074
SMOsmoothened homolog (Drosophila)0.068
TRRAPtransformation/transcription domain-associated protein0.064
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.061
SOX10SRY (sex determining region Y)-box 100.061
ZFYVE9zinc finger, FYVE domain containing 90.052
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.047
PGK1phosphoglycerate kinase 10.045
SMAD2SMAD family member 20.042
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.041
BBS2Bardet-Biedl syndrome 20.040
ZFXzinc finger protein, X-linked0.033
TRIM63tripartite motif containing 630.028
ATXN7ataxin 70.028
SKIv-ski sarcoma viral oncogene homolog (avian)0.027
ITGB1BP3integrin beta 1 binding protein 30.026
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.025
SPDEFSAM pointed domain containing ets transcription factor0.025
MED24mediator complex subunit 240.023
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.023
TCF4transcription factor 40.023
PCM1pericentriolar material 10.023
BMP1bone morphogenetic protein 10.023
LRP6low density lipoprotein receptor-related protein 60.022
XIAPX-linked inhibitor of apoptosis0.021
ERBB2IPerbb2 interacting protein0.021
WNT1wingless-type MMTV integration site family, member 10.021
MAML1mastermind-like 1 (Drosophila)0.021
HDAC4histone deacetylase 40.020
CSNK1Ecasein kinase 1, epsilon0.019
TBK1TANK-binding kinase 10.019
CYR61cysteine-rich, angiogenic inducer, 610.019
SFRP1secreted frizzled-related protein 10.019
MDFIMyoD family inhibitor0.018
GPIglucose-6-phosphate isomerase0.018
BMP7bone morphogenetic protein 70.017
FGF18fibroblast growth factor 180.017
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.017
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.016
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.016
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.016
BBS9Bardet-Biedl syndrome 90.016
AZI25-azacytidine induced 20.016
LDHAlactate dehydrogenase A0.015
NCK2NCK adaptor protein 20.015
FOXF2forkhead box F20.015
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.014
BMP4bone morphogenetic protein 40.014
IGF2Rinsulin-like growth factor 2 receptor0.014
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.014
USP9Xubiquitin specific peptidase 9, X-linked0.014
MED15mediator complex subunit 150.014
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.013
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.013
HIPK2homeodomain interacting protein kinase 20.013
BCAT2branched chain amino-acid transaminase 2, mitochondrial0.013
GSK3Bglycogen synthase kinase 3 beta0.012
FERMT2fermitin family member 20.012
FZD7frizzled homolog 7 (Drosophila)0.011
NOTCH2notch 20.011
ZMYND11zinc finger, MYND-type containing 110.011
FBLN1fibulin 10.010
PTENphosphatase and tensin homolog0.010
MED12mediator complex subunit 120.010
NAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.010
DVL3dishevelled, dsh homolog 3 (Drosophila)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI30.999
Otx2orthodenticle homolog 2 (Drosophila)0.997
Pitx2paired-like homeodomain transcription factor 20.997
Foxc1forkhead box C10.997
Pax3paired box gene 30.995
Notch1Notch gene homolog 1 (Drosophila)0.992
Ctnnb1catenin (cadherin associated protein), beta 10.992
Wnt3awingless-related MMTV integration site 3A0.991
Fgf8fibroblast growth factor 80.990
Hes1hairy and enhancer of split 1 (Drosophila)0.989
Pax6paired box gene 60.984
Dlx5distal-less homeobox 50.977
Tbx3T-box 30.973
Shhsonic hedgehog0.972
Rb1retinoblastoma 10.972
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.965
Fgfr2fibroblast growth factor receptor 20.964
Psen1presenilin 10.962
Hoxa1homeobox A10.938
Lef1lymphoid enhancer binding factor 10.931
Rargretinoic acid receptor, gamma0.929
Fgfr1fibroblast growth factor receptor 10.925
Sox2SRY-box containing gene 20.916
Eya1eyes absent 1 homolog (Drosophila)0.916
Msx1homeobox, msh-like 10.913
Smad6MAD homolog 6 (Drosophila)0.910
Meox2mesenchyme homeobox 20.909
Prrx1paired related homeobox 10.904
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.901
Hoxa2homeobox A20.898
Emx1empty spiracles homolog 1 (Drosophila)0.889
Gata4GATA binding protein 40.882
Ptch1patched homolog 10.881
Tbx1T-box 10.879
Hand1heart and neural crest derivatives expressed transcript 10.878
Cdkn1bcyclin-dependent kinase inhibitor 1B0.873
Ptenphosphatase and tensin homolog0.872
Dll4delta-like 4 (Drosophila)0.862
Otx1orthodenticle homolog 1 (Drosophila)0.860
En1engrailed 10.845
Smad3MAD homolog 3 (Drosophila)0.835
Lmx1aLIM homeobox transcription factor 1 alpha0.819
Fgf10fibroblast growth factor 100.801
Tgfb2transforming growth factor, beta 20.800
Gdnfglial cell line derived neurotrophic factor0.799
Foxc2forkhead box C20.788
Emx2empty spiracles homolog 2 (Drosophila)0.779
Pax9paired box gene 90.775
Lrp6low density lipoprotein receptor-related protein 60.737
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.729
Hand2heart and neural crest derivatives expressed transcript 20.721
Dll1delta-like 1 (Drosophila)0.720
Snai1snail homolog 1 (Drosophila)0.717
Bmp7bone morphogenetic protein 70.717
Grb10growth factor receptor bound protein 100.716
Pax7paired box gene 70.713
Ascl1achaete-scute complex homolog 1 (Drosophila)0.699
Zic3zinc finger protein of the cerebellum 30.697
Smad4MAD homolog 4 (Drosophila)0.689
Zeb1zinc finger E-box binding homeobox 10.682
Sox3SRY-box containing gene 30.679
Foxd1forkhead box D10.670
Foxh1forkhead box H10.669
Tbx2T-box 20.665
Pax2paired box gene 20.639
Ror2receptor tyrosine kinase-like orphan receptor 20.599
Smad1MAD homolog 1 (Drosophila)0.593
Vegfavascular endothelial growth factor A0.587
Sox11SRY-box containing gene 110.578
Msx2homeobox, msh-like 20.572
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.570
Acvr1activin A receptor, type 10.568
Notch3Notch gene homolog 3 (Drosophila)0.561
Ece1endothelin converting enzyme 10.551
Notch2Notch gene homolog 2 (Drosophila)0.547
Bmp4bone morphogenetic protein 40.539
Fzd1frizzled homolog 1 (Drosophila)0.538
Ntf3neurotrophin 30.507
Neurog2neurogenin 20.506
Wt1Wilms tumor 1 homolog0.502
Tcf15transcription factor 150.493
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.493
Smosmoothened homolog (Drosophila)0.486
Pbx1pre B-cell leukemia transcription factor 10.482
Fzd8frizzled homolog 8 (Drosophila)0.478
Apcadenomatosis polyposis coli0.478
Pitx1paired-like homeodomain transcription factor 10.476
Nf1neurofibromatosis 10.475
Bnc1basonuclin 10.466
Tcfap2atranscription factor AP-2, alpha0.462
Rxraretinoid X receptor alpha0.462
Twist2twist homolog 2 (Drosophila)0.461
Hoxc8homeobox C80.451
Chd7chromodomain helicase DNA binding protein 70.449
Hoxb6homeobox B60.446
Wnt1wingless-related MMTV integration site 10.435
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism