The network for 'neuron fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.

NameDescriptionProbabilityFunc Analog Organism
pax2apaired box gene 2a0.995
lhx1aLIM homeobox 1a0.991
tbx1T-box 10.990
fezf2FEZ family zinc finger 20.976
bmp4bone morphogenetic protein 40.975
eng2aengrailed 2a0.965
otpborthopedia homolog b0.964
shhasonic hedgehog a0.951
lhx5LIM homeobox 50.943
sox3SRY-box containing gene 30.937
nr2e1nuclear receptor subfamily 2, group E, member 10.935
prdm1aPR domain containing 1a, with ZNF domain0.916
ndr2nodal-related 20.895
dlx2adistal-less homeobox gene 2a0.885
nkx2.2aNK2 transcription factor related 2a0.865
olig2oligodendrocyte lineage transcription factor 20.849
notch1anotch homolog 1a0.846
pax6apaired box gene 6a0.834
evx1even-skipped homeobox 10.834
mibmind bomb0.829
irx3airoquois homeobox protein 3a0.822
insm1binsulinoma-associated 1b0.810
neurodneurogenic differentiation0.797
pitx3paired-like homeodomain transcription factor 30.788
ascl1aachaete-scute complex-like 1a (Drosophila)0.780
tbx2bT-box 2b0.779
otx2orthodenticle homolog 20.776
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.773
barhl2BarH-like 20.759
mnx1motor neuron and pancreas homeobox 10.753
dlx1adistal-less homeobox gene 1a0.753
zic1zic family member 1 (odd-paired homolog, Drosophila)0.741
nkx2.2bNK2 transcription factor related 2b0.716
tfap2atranscription factor AP-2 alpha0.707
fgf8afibroblast growth factor 8 a0.703
six3bsine oculis homeobox homolog 3b0.701
foxg1aforkhead box G1a0.693
six3asine oculis homeobox homolog 3a0.682
gli1GLI-Kruppel family member 10.668
dlx5adistal-less homeobox gene 5a0.661
olig4oligodendrocyte transcription factor 40.658
pitx2paired-like homeodomain transcription factor 20.654
dlx2bdistal-less homeobox gene 2b0.607
nkx2.1aNK2 homeobox 1a0.603
atoh1aatonal homolog 1a0.602
bhlhe22basic helix-loop-helix family, member e220.558
hlxb9lahomeo box HB9 like a0.556
gli2aGLI-Kruppel family member GLI2a0.526
neurog1neurogenin 10.525
hmx3homeo box (H6 family) 30.506
sox1aSRY-box containing gene 1a0.498
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.476
otx1borthodenticle homolog 1b0.463
tal1T-cell acute lymphocytic leukemia 10.451
zic4zic family member 40.445
ptf1apancreas specific transcription factor, 1a0.445
foxd3forkhead box D30.425
lhx2bLIM homeobox 2b0.413
wnt11wingless-type MMTV integration site family, member 110.412
cdh2cadherin 2, neuronal0.406
lef1lymphocyte enhancer binding factor 10.406
rx3retinal homeobox gene 30.405
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.403
pax6bpaired box gene 6b0.402
myod1myogenic differentiation 10.393
msxcmuscle segment homeobox C0.387
olig3oligodendrocyte transcription factor 30.373
wnt8bwingless-type MMTV integration site family, member 8b0.370
eng2bengrailed 2b0.353
hhiphedgehog interacting protein0.333
phox2apaired-like homeobox 2a0.325
dccdeleted in colorectal carcinoma0.324
sox4bSRY-box containing gene 4b0.322
zic5zic family member 5 (odd-paired homolog, Drosophila)0.317
nkx2.1bNK2 homeobox 1b0.315
gbx2gastrulation brain homeo box 20.314
eomesaeomesodermin homolog a0.307
hnf1baHNF1 homeobox Ba0.307
sox19aSRY-box containing gene 19a0.292
meis3myeloid ecotropic viral integration site 30.291
otpaorthopedia homolog a0.279
nadl1.1neural adhesion molecule L1.10.274
sox2SRY-box containing gene 20.273
vsx1visual system homeobox 1 homolog, chx10-like0.270
six4bsine oculis homeobox homolog 4b0.259
nr2e3nuclear receptor subfamily 2, group E, member 30.256
flhfloating head0.251
pcdh18bprotocadherin 18b0.250
tcf7transcription factor 7 (T-cell specific, HMG-box)0.241
tgfb3transforming growth factor, beta 30.241
dbx1adeveloping brain homeobox 1a0.239
ncs1aneuronal calcium sensor 1a0.235
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.745
elt-6Protein ELT-60.607
egl-18Protein EGL-180.475
nhr-67Protein NHR-670.290
unc-42Protein UNC-420.157
ceh-27Protein CEH-270.120
rig-6Protein RIG-60.116
hnd-1Protein HND-10.111
cnd-1Protein CND-10.098
lin-11Protein LIN-110.071
lin-17Protein LIN-170.070
fkh-2Protein FKH-20.068
hlh-2Protein HLH-20.067
egl-46Protein EGL-460.063
unc-62Protein UNC-620.055
egl-5Protein EGL-50.053
cki-1Protein CKI-10.051
lin-29Protein LIN-290.050
sem-5Protein SEM-50.040
bar-1Protein BAR-10.039
vab-3Protein VAB-30.038
hbl-1Protein HBL-10.033
hlh-14Protein HLH-140.032
hlh-1Protein HLH-10.030
pop-1Protein POP-10.030
sel-12Protein SEL-120.027
sdz-28Protein SDZ-280.027
lin-12Protein LIN-120.027
lsy-2Protein LSY-20.024
let-60Protein LET-600.023
zip-7Protein ZIP-70.023
unc-86Protein UNC-860.023
ast-1Protein AST-10.022
ten-1Protein TEN-10.022
elc-1Protein ELC-10.021
ceh-36Protein CEH-360.020
lgc-55Protein LGC-550.015
tbx-8Protein TBX-80.015
mls-2Protein MLS-20.015
sel-7Protein SEL-70.015
pes-1Protein PES-10.015
sfrp-1Protein SFRP-10.015
insc-1Protein INSC-10.015
cam-1Protein CAM-10.014
dma-1Protein DMA-10.013
sos-1Protein SOS-10.013
irx-1Protein IRX-10.013
nhr-25Protein NHR-250.012
clec-180Protein CLEC-1800.012
ceh-48Protein CEH-480.012
zig-10Protein ZIG-100.011
ham-2Protein HAM-20.011
dyf-7Protein DYF-70.011
ceh-20Protein CEH-200.011
fmi-1Protein FMI-10.011
ref-2Protein REF-20.011
mrck-1Protein MRCK-10.011
rig-5Protein RIG-50.010
tbc-12Protein TBC-120.010
CELE_Y113G7B.11Protein Y113G7B.110.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
nkdnaked cuticle0.906
E(spl)Enhancer of split0.882
HLHm7E(spl) region transcript m70.791
EgfrEpidermal growth factor receptor0.766
emsempty spiracles0.727
rapretina aberrant in pattern0.604
HLHmdeltaE(spl) region transcript mdelta0.547
HGTXCG13475 gene product from transcript CG13475-RB0.542
phlpole hole0.537
sogshort gastrulation0.510
gcmglial cells missing0.491
cnkconnector enhancer of ksr0.467
Wnt4Wnt oncogene analog 40.463
sosine oculis0.459
aopanterior open0.457
lblladybird late0.452
Gap1GTPase-activating protein 10.440
Nedd4CG42279 gene product from transcript CG42279-RJ0.424
eveeven skipped0.390
HLHmbetaE(spl) region transcript mbeta0.389
argosCG4531 gene product from transcript CG4531-RA0.371
slp1sloppy paired 10.340
vvlventral veins lacking0.297
HLHm5E(spl) region transcript m50.294
svpseven up0.282
HLHmgammaE(spl) region transcript mgamma0.280
HLHm3E(spl) region transcript m30.274
unc-5CG8166 gene product from transcript CG8166-RA0.272
trioCG18214 gene product from transcript CG18214-RA0.230
Ras85DRas oncogene at 85D0.227
Taf4TBP-associated factor 40.217
slp2sloppy paired 20.213
InRInsulin-like receptor0.212
amosabsent MD neurons and olfactory sensilla0.210
fz2frizzled 20.208
Taf1TBP-associated factor 10.202
eyaeyes absent0.193
emcextra macrochaetae0.192
cdicenter divider0.192
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.184
pdm2POU domain protein 20.178
nabCG33545 gene product from transcript CG33545-RC0.176
ash2absent, small, or homeotic discs 20.174
Lim1CG11354 gene product from transcript CG11354-RA0.173
TolloCG6890 gene product from transcript CG6890-RA0.168
bowlbrother of odd with entrails limited0.166
cicubitus interruptus0.158
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)1.000
NOTCH1notch 11.000
TAL1T-cell acute lymphocytic leukemia 11.000
NOTCH3notch 31.000
JAG1jagged 11.000
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein1.000
SMAD4SMAD family member 40.999
MYOD1myogenic differentiation 10.997
SUFUsuppressor of fused homolog (Drosophila)0.996
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.996
FOXD3forkhead box D30.990
NKX2-1NK2 homeobox 10.988
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.988
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.986
PDX1pancreatic and duodenal homeobox 10.983
CDK2cyclin-dependent kinase 20.981
PAX8paired box 80.980
C2orf65chromosome 2 open reading frame 650.979
SKIv-ski sarcoma viral oncogene homolog (avian)0.977
SKILSKI-like oncogene0.977
POU3F2POU class 3 homeobox 20.974
SOX10SRY (sex determining region Y)-box 100.970
TCF12transcription factor 120.968
GFI1Bgrowth factor independent 1B transcription repressor0.955
LMX1ALIM homeobox transcription factor 1, alpha0.953
FOXA2forkhead box A20.947
LBX1ladybird homeobox 10.946
MEOX2mesenchyme homeobox 20.946
ZFYVE9zinc finger, FYVE domain containing 90.930
GLI1GLI family zinc finger 10.922
SMAD2SMAD family member 20.920
SMAD9SMAD family member 90.916
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein0.914
RCN3reticulocalbin 3, EF-hand calcium binding domain0.911
SMAD7SMAD family member 70.911
RAXretina and anterior neural fold homeobox0.886
STK36serine/threonine kinase 360.881
PTCH1patched 10.879
PAX6paired box 60.873
MAML1mastermind-like 1 (Drosophila)0.872
OLIG2oligodendrocyte lineage transcription factor 20.860
RUNX1runt-related transcription factor 10.843
FGF3fibroblast growth factor 30.840
PAX2paired box 20.826
HOXD12homeobox D120.819
SIX3SIX homeobox 30.807
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.805
LHX1LIM homeobox 10.795
TRIM33tripartite motif containing 330.792
SMAD3SMAD family member 30.791
SOX11SRY (sex determining region Y)-box 110.778
CDX2caudal type homeobox 20.776
CCNE1cyclin E10.771
NOTCH2notch 20.755
SFRP5secreted frizzled-related protein 50.748
NCOR1nuclear receptor corepressor 10.744
BHLHE23basic helix-loop-helix family, member e230.740
NKX2-2NK2 homeobox 20.734
FEVFEV (ETS oncogene family)0.732
SOX1SRY (sex determining region Y)-box 10.730
CDK6cyclin-dependent kinase 60.702
SMURF2SMAD specific E3 ubiquitin protein ligase 20.698
LHX5LIM homeobox 50.697
SOX2SRY (sex determining region Y)-box 20.692
MNX1motor neuron and pancreas homeobox 10.685
HOXC8homeobox C80.683
HOXB9homeobox B90.678
TP73tumor protein p730.664
HOXB13homeobox B130.660
GBX2gastrulation brain homeobox 20.642
ARandrogen receptor0.641
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.623
GSCgoosecoid homeobox0.620
RBPMSRNA binding protein with multiple splicing0.619
C1QL1complement component 1, q subcomponent-like 10.614
TCF4transcription factor 40.608
WNT1wingless-type MMTV integration site family, member 10.602
HOXD9homeobox D90.599
ALX4ALX homeobox 40.598
TGFB1transforming growth factor, beta 10.597
SIM2single-minded homolog 2 (Drosophila)0.596
FOXB1forkhead box B10.594
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.593
FOXE1forkhead box E1 (thyroid transcription factor 2)0.593
OTPorthopedia homeobox0.585
PAX7paired box 70.584
MSX1msh homeobox 10.577
PYYpeptide YY0.576
HES2hairy and enhancer of split 2 (Drosophila)0.573
UHRF2ubiquitin-like with PHD and ring finger domains 20.573
POU4F1POU class 4 homeobox 10.568
WNT10Awingless-type MMTV integration site family, member 10A0.567
POU4F2POU class 4 homeobox 20.559
VAX2ventral anterior homeobox 20.555
DLL3delta-like 3 (Drosophila)0.553
HOXD13homeobox D130.541
DLL1delta-like 1 (Drosophila)0.529
COL2A1collagen, type II, alpha 10.521
HOXD11homeobox D110.518
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.516
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Id3inhibitor of DNA binding 30.347
Id1inhibitor of DNA binding 10.132
Unc5bunc-5 homolog B (C. elegans)0.101
NrarpNotch-regulated ankyrin repeat protein0.080
Cep78centrosomal protein 780.065
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.062
Klf2Kruppel-like factor 2 (lung)0.061
Giprgastric inhibitory polypeptide receptor0.058
Gpr20G protein-coupled receptor 200.056
Znf76zinc finger protein 76 (expressed in testis)0.055
Sult5a1sulfotransferase family 5A, member 10.052
Barhl2BarH-like homeobox 20.049
Pou2f3POU class 2 homeobox 30.049
Foxs1forkhead box S10.048
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.048
Dchs1dachsous 1 (Drosophila)0.048
Nek9NIMA (never in mitosis gene a)- related kinase 90.047
Oxtoxytocin, prepropeptide0.047
Adam10ADAM metallopeptidase domain 100.047
Gdf11growth differentiation factor 110.046
Smad7SMAD family member 70.040
Tcp11t-complex protein 110.039
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.039
Bbxbobby sox homolog (Drosophila)0.038
Lef1lymphoid enhancer binding factor 10.038
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.038
Tgfbr2transforming growth factor, beta receptor II0.038
Abcc1ATP-binding cassette, subfamily C (CFTR/MRP), member 10.037
Foxd3forkhead box D30.037
Teddm1transmembrane epididymal protein 10.036
Sox10SRY (sex determining region Y)-box 100.036
Nr2f2nuclear receptor subfamily 2, group F, member 20.036
Twist1twist homolog 1 (Drosophila)0.036
Brca1breast cancer 10.034
Ednrbendothelin receptor type B0.034
Kcnh6potassium voltage-gated channel, subfamily H (eag-related), member 60.034
Ptgirprostaglandin I2 (prostacyclin) receptor (IP)0.033
Ckmcreatine kinase, muscle0.033
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.033
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.033
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.033
Tmod2tropomodulin 20.032
Gabregamma-aminobutyric acid (GABA) A receptor, epsilon0.032
Foxm1forkhead box M10.031
Isl2ISL LIM homeobox 20.031
Gstp1glutathione S-transferase pi 10.030
Epha8Eph receptor A80.029
Sept8septin 80.029
Flt1FMS-related tyrosine kinase 10.028
Phox2apaired-like homeobox 2a0.028
Itpr3inositol 1,4,5-triphosphate receptor, type 30.028
Six3SIX homeobox 30.028
Notch1Notch homolog 1, translocation-associated (Drosophila)0.028
Grip2glutamate receptor interacting protein 20.027
Alpk3alpha-kinase 30.027
Calcrcalcitonin receptor0.027
Itpr2inositol 1,4,5-triphosphate receptor, type 20.027
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.027
Mcammelanoma cell adhesion molecule0.027
Mpp4membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)0.027
Cd9CD9 molecule0.026
Nlgn2neuroligin 20.026
Tulp1tubby like protein 10.026
Kctd15potassium channel tetramerisation domain containing 150.026
Nxph4neurexophilin 40.026
Ecel1endothelin converting enzyme-like 10.025
Pde4cphosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)0.025
Robo1roundabout homolog 1 (Drosophila)0.025
Cdk2cyclin dependent kinase 20.025
Cyth3cytohesin 30.025
Hspb2heat shock protein beta 20.025
Cdk7cyclin-dependent kinase 70.025
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.025
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.024
Igfbp5insulin-like growth factor binding protein 50.024
Tcf4transcription factor 40.024
Hapln1hyaluronan and proteoglycan link protein 10.024
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.024
Egfl7EGF-like-domain, multiple 70.024
Ddr1discoidin domain receptor tyrosine kinase 10.024
Stc1stanniocalcin 10.023
Tnrtenascin R0.023
Jtbjumping translocation breakpoint0.023
Mxd4Max dimerization protein 40.023
Hoxb8homeo box B80.023
Dlg4discs, large homolog 4 (Drosophila)0.023
Nrmnurim (nuclear envelope membrane protein)0.022
Dpf1D4, zinc and double PHD fingers family 10.022
Olr825olfactory receptor 8250.022
Hist1h1ahistone cluster 1, H1a0.022
Add3adducin 3 (gamma)0.022
Brca2breast cancer 20.021
Nptxrneuronal pentraxin receptor0.021
Brunol5bruno-like 5, RNA binding protein (Drosophila)0.021
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.021
Zfp706zinc finger protein 7060.021
Ncam1neural cell adhesion molecule 10.021
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism