The network for 'positive regulation of stem cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of stem cell proliferation

Any process that activates or increases the frequency, rate or extent of stem cell proliferation.

NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.991
grem2gremlin 2, cysteine knot superfamily0.957
shhasonic hedgehog a0.926
dlx5adistal-less homeobox gene 5a0.922
bmp2bbone morphogenetic protein 2b0.894
ascl1aachaete-scute complex-like 1a (Drosophila)0.846
eya1eyes absent homolog 10.832
hey1hairy/enhancer-of-split related with YRPW motif 10.828
her6hairy-related 60.808
bmp4bone morphogenetic protein 40.800
wnt11wingless-type MMTV integration site family, member 110.735
fgf8afibroblast growth factor 8 a0.725
myf5myogenic factor 50.721
fgf3fibroblast growth factor 30.613
ptgs1prostaglandin-endoperoxide synthase 10.602
tbx16T-box gene 160.602
dlx3bdistal-less homeobox gene 3b0.563
tbx6T-box gene 60.544
msxemuscle segment homeobox E0.539
mmp15bmatrix metallopeptidase 15b0.535
ptch1patched 10.530
notch3notch homolog 30.512
otx2orthodenticle homolog 20.499
cdoncell adhesion molecule-related/down-regulated by oncogenes0.495
notch2notch homolog 20.491
nkx3.2NK3 homeobox 20.465
pea3ETS-domain transcription factor pea30.464
lef1lymphocyte enhancer binding factor 10.464
her15.1hairy and enhancer of split-related 15.10.461
pitx3paired-like homeodomain transcription factor 30.457
fgf10afibroblast growth factor 10a0.440
sox19aSRY-box containing gene 19a0.439
sox2SRY-box containing gene 20.421
hey2hairy/enhancer-of-split related with YRPW motif 20.413
nrarpanotch-regulated ankyrin repeat protein a0.412
fgfr4fibroblast growth factor receptor 40.399
bmp2abone morphogenetic protein 2a0.393
myod1myogenic differentiation 10.391
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.391
rad21RAD21 homolog (S. pombe)0.382
gli1GLI-Kruppel family member 10.378
sulf1sulfatase 10.369
foxn4forkhead box N40.369
foxc1aforkhead box C1a0.368
eng2bengrailed 2b0.354
tbx24T-box 240.352
col2a1acollagen type II, alpha-1a0.338
foxi1forkhead box I10.333
dlx2adistal-less homeobox gene 2a0.324
nr2e1nuclear receptor subfamily 2, group E, member 10.323
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.321
rargaretinoic acid receptor gamma a0.316
nkx2.3NK2 transcription factor related 30.308
jag1bjagged 1b0.308
gli2aGLI-Kruppel family member GLI2a0.289
sox1aSRY-box containing gene 1a0.286
bocbrother of CDO0.274
six4bsine oculis homeobox homolog 4b0.265
satb2SATB homeobox 20.261
foxg1aforkhead box G1a0.252
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.248
hoxc8ahomeo box C8a0.247
fli1afriend leukemia integration 1a0.241
mab21l2mab-21-like 20.239
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.239
six3asine oculis homeobox homolog 3a0.237
her7hairy and enhancer of split related-70.234
fzd7afrizzled homolog 7a0.231
tbx1T-box 10.226
otpborthopedia homolog b0.225
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.223
nkx2.5NK2 transcription factor related 50.219
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.216
axin2axin 2 (conductin, axil)0.215
bmp3bone morphogenetic protein 30.207
rx3retinal homeobox gene 30.206
six2asine oculis-related homeobox 2a0.204
fgf8bfibroblast growth factor 8 b0.202
col8a1acollagen, type VIII, alpha 1a0.201
hoxb1bhomeo box B1b0.201
her8ahairy-related 8a0.197
bmperBMP binding endothelial regulator0.193
gli3GLI-Kruppel family member GLI30.191
foxp2forkhead box P20.191
hoxa9ahomeo box A9a0.191
wlswntless homolog (Drosophila)0.186
mychmyelocytomatosis oncogene homolog0.181
msgn1mesogenin 10.177
ntlano tail a0.177
etv5bets variant 5b0.176
emx1empty spiracles homeobox 10.174
pax2apaired box gene 2a0.171
her1hairy-related 10.171
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.169
her3hairy-related 30.168
hoxc1ahomeo box C1a0.165
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.162
barx1BarH-like homeobox 10.158
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HLHmgammaE(spl) region transcript mgamma0.679
HLHm7E(spl) region transcript m70.474
HLHmdeltaE(spl) region transcript mdelta0.407
E(spl)Enhancer of split0.347
par-1CG8201 gene product from transcript CG8201-RA0.263
Fas2Fasciclin 20.093
HLHm5E(spl) region transcript m50.092
HLHmbetaE(spl) region transcript mbeta0.092
rapretina aberrant in pattern0.075
eyaeyes absent0.064
Su(H)Suppressor of Hairless0.063
Akt1CG4006 gene product from transcript CG4006-RA0.062
EgfrEpidermal growth factor receptor0.055
malphaE(spl) region transcript malpha0.048
InRInsulin-like receptor0.048
kibrakibra ortholog0.043
slp1sloppy paired 10.042
Trf2TATA box binding protein-related factor 20.032
DadDaughters against dpp0.032
HLHm3E(spl) region transcript m30.032
Dhc64CDynein heavy chain 64C0.032
Dcp-1Death caspase-10.026
tefutelomere fusion0.024
sosine oculis0.021
m2E(spl) region transcript m20.017
NotumCG13076 gene product from transcript CG13076-RB0.015
Src64BSrc oncogene at 64B0.014
RbfRetinoblastoma-family protein0.014
Eps-15Epidermal growth factor receptor pathway substrate clone 150.013
foxoforkhead box, sub-group O0.013
TBPHCG10327 gene product from transcript CG10327-RC0.012
Pk61CProtein kinase 61C0.012
TomTwin of m40.012
Pka-C1cAMP-dependent protein kinase 10.012
Pvf2PDGF- and VEGF-related factor 20.012
katanin-60katanin 600.011
CG3563CG3563 gene product from transcript CG3563-RA0.011
chicoCG5686 gene product from transcript CG5686-RB0.010
HphHIF prolyl hydroxylase0.010
Ras85DRas oncogene at 85D0.010
Wnt4Wnt oncogene analog 40.010
bratbrain tumor0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.483
BMP2bone morphogenetic protein 20.295
ATN1atrophin 10.260
FBLN1fibulin 10.237
CXCL3chemokine (C-X-C motif) ligand 30.217
INSRinsulin receptor0.204
FBLN5fibulin 50.181
PAX3paired box 30.162
CXCL2chemokine (C-X-C motif) ligand 20.161
IL8interleukin 80.159
POU3F2POU class 3 homeobox 20.153
JAG1jagged 10.095
LTBP4latent transforming growth factor beta binding protein 40.095
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.094
NRP1neuropilin 10.092
FGF1fibroblast growth factor 1 (acidic)0.082
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.081
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.073
GRB10growth factor receptor-bound protein 100.073
NOTCH3notch 30.054
SIRT1sirtuin 10.052
EGFRepidermal growth factor receptor0.052
FBN1fibrillin 10.052
IRS1insulin receptor substrate 10.046
JAG2jagged 20.046
RB1retinoblastoma 10.044
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.043
IGF1Rinsulin-like growth factor 1 receptor0.039
SMAD7SMAD family member 70.038
DNM1dynamin 10.038
SMAD3SMAD family member 30.037
PLCG1phospholipase C, gamma 10.036
COL6A1collagen, type VI, alpha 10.034
LTBP2latent transforming growth factor beta binding protein 20.034
HSPG2heparan sulfate proteoglycan 20.034
CDH5cadherin 5, type 2 (vascular endothelium)0.030
LOXlysyl oxidase0.027
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.027
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.026
HOXD9homeobox D90.025
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.024
AXIN1axin 10.024
ESR1estrogen receptor 10.024
NFYCnuclear transcription factor Y, gamma0.023
PTPN1protein tyrosine phosphatase, non-receptor type 10.022
BMP1bone morphogenetic protein 10.022
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.021
NR4A1nuclear receptor subfamily 4, group A, member 10.021
SYKspleen tyrosine kinase0.020
TP53tumor protein p530.020
FBLN2fibulin 20.020
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.020
REREarginine-glutamic acid dipeptide (RE) repeats0.020
LENG8leukocyte receptor cluster (LRC) member 80.020
CYFIP2cytoplasmic FMR1 interacting protein 20.020
PRMT6protein arginine methyltransferase 60.020
WWP2WW domain containing E3 ubiquitin protein ligase 20.020
PDGFCplatelet derived growth factor C0.019
POU5F1POU class 5 homeobox 10.019
IRS2insulin receptor substrate 20.018
FGF2fibroblast growth factor 2 (basic)0.018
FGFR2fibroblast growth factor receptor 20.018
FOXD3forkhead box D30.018
COL6A2collagen, type VI, alpha 20.017
CTGFconnective tissue growth factor0.017
LOXL1lysyl oxidase-like 10.017
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.017
ADORA2Aadenosine A2a receptor0.017
SOS1son of sevenless homolog 1 (Drosophila)0.016
TGFB3transforming growth factor, beta 30.016
MAP1Amicrotubule-associated protein 1A0.016
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.016
GABARAPGABA(A) receptor-associated protein0.015
ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix protein0.015
NFYBnuclear transcription factor Y, beta0.015
FN1fibronectin 10.015
IGFBP5insulin-like growth factor binding protein 50.014
RUNX1runt-related transcription factor 10.014
EP300E1A binding protein p3000.014
FSTL1follistatin-like 10.014
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.014
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.013
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
FGF10fibroblast growth factor 100.013
ACTN2actinin, alpha 20.013
DVL2dishevelled, dsh homolog 2 (Drosophila)0.013
NCOR1nuclear receptor corepressor 10.013
BMP4bone morphogenetic protein 40.013
LAMB2laminin, beta 2 (laminin S)0.012
SP1Sp1 transcription factor0.012
MDFIMyoD family inhibitor0.012
SOX11SRY (sex determining region Y)-box 110.012
PTPN11protein tyrosine phosphatase, non-receptor type 110.012
DKK1dickkopf homolog 1 (Xenopus laevis)0.012
AESamino-terminal enhancer of split0.012
MFAP5microfibrillar associated protein 50.012
FGF7fibroblast growth factor 70.012
IL6interleukin 6 (interferon, beta 2)0.012
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 20.999
Gli3GLI-Kruppel family member GLI30.999
Pax6paired box gene 60.999
Pax3paired box gene 30.999
Bmp4bone morphogenetic protein 40.997
Fgf10fibroblast growth factor 100.997
Prrx1paired related homeobox 10.997
Gli2GLI-Kruppel family member GLI20.997
Hand1heart and neural crest derivatives expressed transcript 10.995
Foxc1forkhead box C10.995
Pitx2paired-like homeodomain transcription factor 20.994
Otx2orthodenticle homolog 2 (Drosophila)0.993
Dlx5distal-less homeobox 50.991
Pax2paired box gene 20.991
Msx2homeobox, msh-like 20.987
Sox9SRY-box containing gene 90.986
Tgfb2transforming growth factor, beta 20.983
Fgf8fibroblast growth factor 80.982
Sox2SRY-box containing gene 20.982
Fgfr1fibroblast growth factor receptor 10.975
Tbx3T-box 30.973
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.972
Pitx1paired-like homeodomain transcription factor 10.970
Tcfap2atranscription factor AP-2, alpha0.963
Ror2receptor tyrosine kinase-like orphan receptor 20.958
Msx1homeobox, msh-like 10.955
Hand2heart and neural crest derivatives expressed transcript 20.953
Runx2runt related transcription factor 20.953
Ptenphosphatase and tensin homolog0.946
Eya1eyes absent 1 homolog (Drosophila)0.943
Emx1empty spiracles homolog 1 (Drosophila)0.938
Apcadenomatosis polyposis coli0.938
Meox2mesenchyme homeobox 20.930
Pax8paired box gene 80.919
Bmp7bone morphogenetic protein 70.919
Hes1hairy and enhancer of split 1 (Drosophila)0.911
Twist2twist homolog 2 (Drosophila)0.898
Zeb1zinc finger E-box binding homeobox 10.889
Prrx2paired related homeobox 20.887
Hoxa1homeobox A10.884
Tbx15T-box 150.870
Gscgoosecoid homeobox0.862
Pax9paired box gene 90.848
Fgfr3fibroblast growth factor receptor 30.842
Tgfbr2transforming growth factor, beta receptor II0.836
Wnt3awingless-related MMTV integration site 3A0.830
Rargretinoic acid receptor, gamma0.828
Dkk1dickkopf homolog 1 (Xenopus laevis)0.821
Smad6MAD homolog 6 (Drosophila)0.819
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.817
Hoxa2homeobox A20.816
Fzd8frizzled homolog 8 (Drosophila)0.802
Otx1orthodenticle homolog 1 (Drosophila)0.788
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.787
Alx4aristaless-like homeobox 40.783
Nkx2-1NK2 homeobox 10.782
Lhx3LIM homeobox protein 30.781
Myod1myogenic differentiation 10.773
Foxc2forkhead box C20.764
Vegfavascular endothelial growth factor A0.763
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.761
Ascl1achaete-scute complex homolog 1 (Drosophila)0.750
Foxg1forkhead box G10.718
Ctnnb1catenin (cadherin associated protein), beta 10.696
Smosmoothened homolog (Drosophila)0.679
Ptpn11protein tyrosine phosphatase, non-receptor type 110.669
Acvr1activin A receptor, type 10.665
Rarbretinoic acid receptor, beta0.657
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.655
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.649
Nos3nitric oxide synthase 3, endothelial cell0.648
Isl1ISL1 transcription factor, LIM/homeodomain0.638
Tbx1T-box 10.636
Foxa2forkhead box A20.623
Igf2bp1insulin-like growth factor 2 mRNA binding protein 10.620
Chd7chromodomain helicase DNA binding protein 70.615
Csf1colony stimulating factor 1 (macrophage)0.612
Gbx2gastrulation brain homeobox 20.611
Pou5f1POU domain, class 5, transcription factor 10.572
Hmx3H6 homeobox 30.568
Wt1Wilms tumor 1 homolog0.555
Snai1snail homolog 1 (Drosophila)0.546
Tbx2T-box 20.536
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.534
Alx3aristaless-like homeobox 30.529
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.520
Fgf15fibroblast growth factor 150.509
Sall3sal-like 3 (Drosophila)0.497
Gata6GATA binding protein 60.490
Pbx1pre B-cell leukemia transcription factor 10.489
Phox2bpaired-like homeobox 2b0.487
Lhx5LIM homeobox protein 50.485
Tcf21transcription factor 210.472
Ror1receptor tyrosine kinase-like orphan receptor 10.450
Hoxb6homeobox B60.445
Ghrgrowth hormone receptor0.438
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd4Cd4 molecule0.119
Lamc1laminin, gamma 10.046
Fgfr2fibroblast growth factor receptor 20.040
Nek9NIMA (never in mitosis gene a)- related kinase 90.039
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.037
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.034
Unc5bunc-5 homolog B (C. elegans)0.027
Bex4brain expressed, X-linked 40.024
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.022
Notch2Notch homolog 2 (Drosophila)0.022
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.017
Timp3TIMP metallopeptidase inhibitor 30.016
Itpr2inositol 1,4,5-triphosphate receptor, type 20.015
Jak1Janus kinase 10.015
Myo1cmyosin IC0.015
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.015
Pde5aphosphodiesterase 5A, cGMP-specific0.014
Sirpasignal-regulatory protein alpha0.014
Acvr1activin A receptor, type I0.013
GperG protein-coupled estrogen receptor 10.013
Irs1insulin receptor substrate 10.013
Gna15guanine nucleotide binding protein, alpha 150.013
Anpepalanyl (membrane) aminopeptidase0.012
Ngfrap1nerve growth factor receptor (TNFRSF16) associated protein 10.012
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.012
Rararetinoic acid receptor, alpha0.012
Foxs1forkhead box S10.012
Adora2aadenosine A2a receptor0.012
Arhgap23Rho GTPase activating protein 230.011
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.011
Rnf213ring finger protein 2130.010
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.010
Smad1SMAD family member 10.010
Ephb3Eph receptor B30.010
C3ar1complement component 3a receptor 10.010
Ddr1discoidin domain receptor tyrosine kinase 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism