The network for 'retinal ganglion cell axon guidance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retinal ganglion cell axon guidance

The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.

NameDescriptionProbabilityFunc Analog Organism
lhx2bLIM homeobox 2b1.000
shhasonic hedgehog a1.000
ndr2nodal-related 20.998
bocbrother of CDO0.998
ptch2patched 20.998
pax2apaired box gene 2a0.997
lamb1alaminin, beta 1a0.992
robo3roundabout homolog 30.988
gli2aGLI-Kruppel family member GLI2a0.987
cdh2cadherin 2, neuronal0.971
smosmoothened homolog (Drosophila)0.963
rx3retinal homeobox gene 30.956
disp1dispatched homolog 1 (Drosophila)0.954
tbx1T-box 10.952
lamc1laminin, gamma 10.946
robo2roundabout homolog 20.943
gli1GLI-Kruppel family member 10.942
tbx16T-box gene 160.926
extl3exostoses (multiple)-like 30.915
sox32SRY-box containing gene 320.913
cxcr4bchemokine (C-X-C motif), receptor 4b0.887
axin1axin 10.864
meis2.2myeloid ecotropic viral integration site 2.20.803
fn1fibronectin 10.801
mmp2matrix metalloproteinase 20.786
fgf8afibroblast growth factor 8 a0.721
dbx1adeveloping brain homeobox 1a0.713
slit3slit (Drosophila) homolog 30.677
fgfr4fibroblast growth factor receptor 40.641
metmet proto-oncogene (hepatocyte growth factor receptor)0.638
cdh23cadherin-like 230.635
lama1laminin, alpha 10.608
rarabretinoic acid receptor, alpha b0.589
efnb3bephrin B3b0.576
flhfloating head0.574
atoh7atonal homolog 70.569
wnt5bwingless-type MMTV integration site family, member 5b0.487
sox9aSRY-box containing gene 9a0.451
tfap2atranscription factor AP-2 alpha0.433
epha4aeph receptor A4a0.429
vangl2vang-like 2 (van gogh, Drosophila)0.418
cntn2contactin 20.412
jag2jagged 20.392
nrp2bneuropilin 2b0.389
pbx4pre-B-cell leukemia transcription factor 40.387
wnt8bwingless-type MMTV integration site family, member 8b0.377
dzip1DAZ interacting protein 10.340
wnt11wingless-type MMTV integration site family, member 110.337
edn1endothelin 10.336
bmp2bbone morphogenetic protein 2b0.318
irx4airoquois homeobox protein 4a0.308
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.302
dlx2adistal-less homeobox gene 2a0.294
ntn1anetrin 1a0.289
hoxa1ahomeo box A1a0.284
vax2ventral anterior homeobox 20.282
osr1odd-skipped related 1 (Drosophila)0.279
neo1neogenin 10.278
rargaretinoic acid receptor gamma a0.276
mibmind bomb0.274
prdm1aPR domain containing 1a, with ZNF domain0.268
nkx2.3NK2 transcription factor related 30.266
otx1aorthodenticle homolog 1a0.266
notch2notch homolog 20.261
gata2aGATA-binding protein 2a0.261
pax6apaired box gene 6a0.255
nog3noggin 30.255
hhiphedgehog interacting protein0.251
sall4sal-like 4 (Drosophila)0.250
robo1roundabout homolog 10.249
gbx2gastrulation brain homeo box 20.245
bmperBMP binding endothelial regulator0.244
jag1bjagged 1b0.243
evx1even-skipped homeobox 10.239
lmx1b.2LIM homeobox transcription factor 1, beta 20.237
notch3notch homolog 30.237
aldh1a2aldehyde dehydrogenase 1 family, member A20.232
pea3ETS-domain transcription factor pea30.231
foxd3forkhead box D30.230
tll1tolloid-like 10.226
tbx2bT-box 2b0.226
nrp2aneuropilin 2a0.225
gdf6agrowth differentiation factor 6a0.225
csnk1a1casein kinase 1, alpha 10.225
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.221
rereaarginine-glutamic acid dipeptide (RE) repeats a0.221
fgfr1bfibroblast growth factor receptor 1b0.219
efna5bephrin A5b0.213
hand2heart and neural crest derivatives expressed transcript 20.213
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.205
lama4laminin, alpha 40.201
fstl1bfollistatin-like 1b0.198
fezf2FEZ family zinc finger 20.198
pax7apaired box gene 7a0.197
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
robo3CG5423 gene product from transcript CG5423-RA0.982
trioCG18214 gene product from transcript CG18214-RA0.982
Sema-1aCG18405 gene product from transcript CG18405-RD0.967
Ptp69DProtein tyrosine phosphatase 69D0.937
Ext2CG8433 gene product from transcript CG8433-RA0.904
MadMothers against dpp0.902
cicubitus interruptus0.890
Sema-2aCG4700 gene product from transcript CG4700-RC0.806
stanstarry night0.783
unc-5CG8166 gene product from transcript CG8166-RA0.768
EphEph receptor tyrosine kinase0.763
botvbrother of tout-velu0.714
DscamDown syndrome cell adhesion molecule0.705
CapsCalcium activated protein for secretion0.663
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.617
gcmglial cells missing0.508
jingCG9397 gene product from transcript CG9397-RI0.439
plexAplexin A0.437
Fak56DFocal Adhesion Kinase0.429
spensplit ends0.393
emsempty spiracles0.377
Bre1CG10542 gene product from transcript CG10542-RA0.343
Wnt4Wnt oncogene analog 40.295
Wnt5Wnt oncogene analog 50.284
SmoxSmad on X0.227
Fas2Fasciclin 20.191
Lim3CG10699 gene product from transcript CG10699-RB0.167
rapretina aberrant in pattern0.157
CaMKIICalcium/calmodulin-dependent protein kinase II0.138
eyaeyes absent0.134
dallydivision abnormally delayed0.132
beat-Iabeaten path Ia0.113
plexBplexin B0.109
Trim9CG31721 gene product from transcript CG31721-RB0.109
EphrinCG1862 gene product from transcript CG1862-RA0.108
pod1CG4532 gene product from transcript CG4532-RF0.107
fz2frizzled 20.106
EgfrEpidermal growth factor receptor0.095
Pi3K92ECG4141 gene product from transcript CG4141-RB0.095
endoAendophilin A0.093
AblAbl tyrosine kinase0.092
reporeversed polarity0.087
LanALaminin A0.086
NotumCG13076 gene product from transcript CG13076-RB0.085
argosCG4531 gene product from transcript CG4531-RA0.081
HGTXCG13475 gene product from transcript CG13475-RB0.079
lolalongitudinals lacking0.079
gogogolden goal0.078
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.997
SMURF2SMAD specific E3 ubiquitin protein ligase 20.997
SMAD3SMAD family member 30.996
DVL3dishevelled, dsh homolog 3 (Drosophila)0.992
NRP1neuropilin 10.989
SMAD2SMAD family member 20.980
ZNF512Bzinc finger protein 512B0.950
DVL1dishevelled, dsh homolog 1 (Drosophila)0.915
AXIN1axin 10.901
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.892
SMAD5SMAD family member 50.860
VEGFAvascular endothelial growth factor A0.854
LAMB1laminin, beta 10.837
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.828
SUFUsuppressor of fused homolog (Drosophila)0.809
CSNK1Ecasein kinase 1, epsilon0.808
SMAD1SMAD family member 10.800
PGFplacental growth factor0.663
AGTPBP1ATP/GTP binding protein 10.623
PTCH1patched 10.621
SMAD7SMAD family member 70.596
CXXC5CXXC finger protein 50.571
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.527
ITSN1intersectin 1 (SH3 domain protein)0.525
TGFBR1transforming growth factor, beta receptor 10.518
TGFB1transforming growth factor, beta 10.494
GRB7growth factor receptor-bound protein 70.481
LRRK2leucine-rich repeat kinase 20.459
SKIv-ski sarcoma viral oncogene homolog (avian)0.416
CAV1caveolin 1, caveolae protein, 22kDa0.389
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.383
FYNFYN oncogene related to SRC, FGR, YES0.354
BCAR1breast cancer anti-estrogen resistance 10.347
SOX7SRY (sex determining region Y)-box 70.340
DNM1dynamin 10.323
COL2A1collagen, type II, alpha 10.310
SMAD6SMAD family member 60.300
WWP2WW domain containing E3 ubiquitin protein ligase 20.277
GRB10growth factor receptor-bound protein 100.270
SNAPINSNAP-associated protein0.261
CPEcarboxypeptidase E0.230
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.222
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.209
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.203
GDF5growth differentiation factor 50.201
EPHB3EPH receptor B30.182
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.180
DPP4dipeptidyl-peptidase 40.176
SKILSKI-like oncogene0.164
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.155
CEP164centrosomal protein 164kDa0.153
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.150
EPHB2EPH receptor B20.148
SHC2SHC (Src homology 2 domain containing) transforming protein 20.138
VHLvon Hippel-Lindau tumor suppressor0.131
LIMK1LIM domain kinase 10.126
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.121
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.118
NID1nidogen 10.114
FEZ1fasciculation and elongation protein zeta 1 (zygin I)0.114
HES1hairy and enhancer of split 1, (Drosophila)0.111
PTPN1protein tyrosine phosphatase, non-receptor type 10.106
FNDC3Bfibronectin type III domain containing 3B0.103
ATF7IPactivating transcription factor 7 interacting protein0.103
THBS1thrombospondin 10.100
MID1IP1MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))0.098
LRP6low density lipoprotein receptor-related protein 60.091
PTPRDprotein tyrosine phosphatase, receptor type, D0.091
MRC2mannose receptor, C type 20.090
CCR5chemokine (C-C motif) receptor 50.088
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.087
EPHA3EPH receptor A30.085
ARandrogen receptor0.085
PIAS4protein inhibitor of activated STAT, 40.084
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.081
FGD1FYVE, RhoGEF and PH domain containing 10.080
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.080
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.079
SMOsmoothened homolog (Drosophila)0.078
DDIT4DNA-damage-inducible transcript 40.078
MKL2MKL/myocardin-like 20.074
NLKnemo-like kinase0.074
TUBB2Atubulin, beta 2A0.072
CADM4cell adhesion molecule 40.070
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.069
ZMYM2zinc finger, MYM-type 20.069
JAG1jagged 10.068
GLI3GLI family zinc finger 30.068
PEX26peroxisomal biogenesis factor 260.067
PAX6paired box 60.067
TCF4transcription factor 40.066
SNAP25synaptosomal-associated protein, 25kDa0.066
NRP2neuropilin 20.065
BMP1bone morphogenetic protein 10.065
SOX13SRY (sex determining region Y)-box 130.064
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.062
EPAS1endothelial PAS domain protein 10.062
CHD3chromodomain helicase DNA binding protein 30.061
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 21.000
Gli3GLI-Kruppel family member GLI31.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Lhx1LIM homeobox protein 11.000
Fgf8fibroblast growth factor 81.000
Foxc1forkhead box C11.000
Pax3paired box gene 31.000
Sox2SRY-box containing gene 21.000
Efnb2ephrin B21.000
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Pax6paired box gene 60.999
Foxg1forkhead box G10.999
Eya1eyes absent 1 homolog (Drosophila)0.999
Emx2empty spiracles homolog 2 (Drosophila)0.998
Rargretinoic acid receptor, gamma0.998
Jag1jagged 10.998
Gbx2gastrulation brain homeobox 20.997
Robo1roundabout homolog 1 (Drosophila)0.997
Ctnnb1catenin (cadherin associated protein), beta 10.997
Isl1ISL1 transcription factor, LIM/homeodomain0.996
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.996
Hoxa1homeobox A10.995
Bmp4bone morphogenetic protein 40.995
Tbx1T-box 10.994
Foxc2forkhead box C20.993
Tgfb2transforming growth factor, beta 20.992
Ephb2Eph receptor B20.990
Pitx2paired-like homeodomain transcription factor 20.989
Dvl2dishevelled 2, dsh homolog (Drosophila)0.987
Lhx3LIM homeobox protein 30.980
Tgfbr2transforming growth factor, beta receptor II0.977
Chd7chromodomain helicase DNA binding protein 70.974
Otx1orthodenticle homolog 1 (Drosophila)0.963
Fgfr1fibroblast growth factor receptor 10.961
Dlx5distal-less homeobox 50.960
Fgf10fibroblast growth factor 100.950
Tcfap2atranscription factor AP-2, alpha0.949
Neurod1neurogenic differentiation 10.942
Sox9SRY-box containing gene 90.929
Epha4Eph receptor A40.926
Ntf3neurotrophin 30.921
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.920
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.916
Fgfr3fibroblast growth factor receptor 30.916
Lmx1aLIM homeobox transcription factor 1 alpha0.909
Gli2GLI-Kruppel family member GLI20.908
Emx1empty spiracles homolog 1 (Drosophila)0.907
Zeb1zinc finger E-box binding homeobox 10.906
Meox2mesenchyme homeobox 20.896
Rararetinoic acid receptor, alpha0.895
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.891
Smosmoothened homolog (Drosophila)0.870
Slit2slit homolog 2 (Drosophila)0.868
Sox11SRY-box containing gene 110.858
Hoxd13homeobox D130.852
Fbn1fibrillin 10.833
Pax8paired box gene 80.832
Apcadenomatosis polyposis coli0.813
Gdnfglial cell line derived neurotrophic factor0.812
Hes1hairy and enhancer of split 1 (Drosophila)0.805
Pbx1pre B-cell leukemia transcription factor 10.796
En1engrailed 10.793
Msx2homeobox, msh-like 20.786
Insm1insulinoma-associated 10.780
Zic2zinc finger protein of the cerebellum 20.775
Nr2f1nuclear receptor subfamily 2, group F, member 10.774
Hes5hairy and enhancer of split 5 (Drosophila)0.774
Ptenphosphatase and tensin homolog0.772
Ascl1achaete-scute complex homolog 1 (Drosophila)0.770
Retret proto-oncogene0.767
Acvr1activin A receptor, type 10.762
Gata4GATA binding protein 40.761
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.744
Pou3f3POU domain, class 3, transcription factor 30.740
Slit3slit homolog 3 (Drosophila)0.731
Ptch1patched homolog 10.715
Rarbretinoic acid receptor, beta0.711
Hmx3H6 homeobox 30.706
Smad7MAD homolog 7 (Drosophila)0.691
Efnb1ephrin B10.686
Ptk7PTK7 protein tyrosine kinase 70.675
Ednraendothelin receptor type A0.671
Wnt4wingless-related MMTV integration site 40.670
Flt4FMS-like tyrosine kinase 40.658
Smad4MAD homolog 4 (Drosophila)0.657
Wt1Wilms tumor 1 homolog0.652
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.639
Plxna1plexin A10.637
En2engrailed 20.625
Prrx1paired related homeobox 10.625
Hoxd11homeobox D110.624
Msx1homeobox, msh-like 10.622
Smad6MAD homolog 6 (Drosophila)0.621
Gdf11growth differentiation factor 110.612
Alx4aristaless-like homeobox 40.611
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grip1glutamate receptor interacting protein 10.127
Nfibnuclear factor I/B0.111
Gria2glutamate receptor, ionotropic, AMPA 20.100
Fgfr2fibroblast growth factor receptor 20.064
Pou2f2POU class 2 homeobox 20.056
Cngb1cyclic nucleotide gated channel beta 10.049
Cxxc4CXXC finger 40.047
Nfianuclear factor I/A0.042
Pxdnperoxidasin homolog (Drosophila)0.040
Ddr1discoidin domain receptor tyrosine kinase 10.039
Nxph1neurexophilin 10.038
Grip2glutamate receptor interacting protein 20.038
LOC100359879RIKEN cDNA A830041P22-like0.038
Pnmal2PNMA-like 20.037
Robo1roundabout homolog 1 (Drosophila)0.037
Lamc1laminin, gamma 10.034
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.033
Abca3ATP-binding cassette, subfamily A (ABC1), member 30.032
Fchsd2FCH and double SH3 domains 20.032
Pcdh8protocadherin 80.032
Itpr1inositol 1,4,5-triphosphate receptor, type 10.030
Gpr162G protein-coupled receptor 1620.029
Plcl1phospholipase C-like 10.029
Ageradvanced glycosylation end product-specific receptor0.028
Fam65afamily with sequence similarity 65, member A0.027
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.027
Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.027
Pecam1platelet/endothelial cell adhesion molecule 10.027
Daam1dishevelled associated activator of morphogenesis 10.027
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.027
Tnctenascin C0.026
Myh10myosin, heavy chain 10, non-muscle0.026
Nek9NIMA (never in mitosis gene a)- related kinase 90.026
Phka1phosphorylase kinase, alpha 10.025
Rcn1reticulocalbin 1, EF-hand calcium binding domain0.025
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.025
Lrch4leucine-rich repeats and calponin homology (CH) domain containing 40.025
Foxe3forkhead box E30.024
Gjd2gap junction protein, delta 20.024
Fam57bfamily with sequence similarity 57, member B0.024
Spdyaspeedy homolog A (Xenopus laevis)0.024
Slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.024
Zfp382zinc finger protein 3820.023
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.023
Ptprgprotein tyrosine phosphatase, receptor type, G0.023
Arnt2aryl hydrocarbon receptor nuclear translocator 20.023
Drd4dopamine receptor D40.022
Nrxn1neurexin 10.022
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.022
Alpk3alpha-kinase 30.022
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.022
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.022
Plcb1phospholipase C, beta 1 (phosphoinositide-specific)0.022
Ank2ankyrin 2, neuronal0.021
Ecel1endothelin converting enzyme-like 10.021
Trim2tripartite motif-containing 20.021
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.021
Ghrhgrowth hormone releasing hormone0.021
Lrp2low density lipoprotein-related protein 20.021
Ankrd43ankyrin repeat domain 430.020
Nlgn3neuroligin 30.020
Axin1axin 10.020
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.020
Ncam1neural cell adhesion molecule 10.019
Dnah1dynein, axonemal, heavy chain 10.019
Six3SIX homeobox 30.019
Axin2axin 20.019
Cnnm1cyclin M10.019
Fbxo16F-box protein 160.019
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.019
Enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.018
Myh9myosin, heavy chain 9, non-muscle0.018
Gzmmgranzyme M (lymphocyte met-ase 1)0.018
Rgrretinal G protein coupled receptor0.018
Clcn4-2chloride channel 4-20.018
Actr2ARP2 actin-related protein 2 homolog (yeast)0.018
Grm3glutamate receptor, metabotropic 30.018
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.018
Kcnk12potassium channel, subfamily K, member 120.018
Dixdc1DIX domain containing 10.018
Leneplens epithelial protein0.018
LOC302999similar to tripartite motif protein 320.018
Glg1golgi apparatus protein 10.018
Kcnt1potassium channel, subfamily T, member 10.018
Elk3ELK3, ETS-domain protein0.018
Cdh2cadherin 20.017
Pcdh1protocadherin 10.017
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.017
Fgf8fibroblast growth factor 80.017
Mdga1MAM domain containing glycosylphosphatidylinositol anchor 10.017
Angpt2angiopoietin 20.017
Oxtoxytocin, prepropeptide0.017
Tsga10testis specific 100.017
Lphn2latrophilin 20.017
RGD1560880similar to RIKEN cDNA 2310002J150.017
Znf76zinc finger protein 76 (expressed in testis)0.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism