The network for 'b cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

b cell activation

The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb0.527
tbx1T-box 10.253
egr2bearly growth response 2b0.249
tp53tumor protein p530.222
edn1endothelin 10.221
rag1recombination activating gene 10.157
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.146
tgfb3transforming growth factor, beta 30.139
pcdh18bprotocadherin 18b0.135
restRE1-silencing transcription factor0.129
wnt9bwingless-type MMTV integration site family, member 9B0.128
il7rinterleukin 7 receptor0.122
mpxmyeloid-specific peroxidase0.120
kitakit receptor a0.119
mmp13amatrix metalloproteinase 13a0.115
rspo3R-spondin 3 homolog (Xenopus laevis)0.113
col7a1lcollagen type VII alpha 1-like0.103
hbae1hemoglobin alpha embryonic-10.099
ros1v-ros UR2 sarcoma virus oncogene homolog 1 (avian)0.092
srfserum response factor0.089
runx1runt-related transcription factor 10.088
larsleucyl-tRNA synthetase0.087
nrp1bneuropilin 1b0.080
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.078
hspa9heat shock protein 90.074
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.074
trim33tripartite motif-containing 330.073
vdrbvitamin D receptor b0.072
bmp2bbone morphogenetic protein 2b0.072
lfnglunatic fringe homolog0.071
eya2eyes absent homolog 2 (Drosophila)0.071
mitfamicrophthalmia-associated transcription factor a0.071
pdcd2programmed cell death 20.071
rhoabras homolog gene family, member Ab0.070
mycl1bv-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b0.069
mycamyelocytomatosis oncogene a0.069
jak1Janus kinase 10.068
mapk14amitogen-activated protein kinase 14a0.068
sema3aasemaphorin 3aa0.068
tshbthyroid stimulating hormone, beta subunit0.067
bcl2l1bcl2-like 10.067
ildr1bimmunoglobulin-like domain containing receptor 1b0.067
fgfr1bfibroblast growth factor receptor 1b0.066
f2rcoagulation factor II (thrombin) receptor0.064
mpllmyeloproliferative leukemia virus oncogene, like0.064
runx3runt-related transcription factor 30.064
coblcordon-bleu homolog (mouse)0.062
gmnngeminin, DNA replication inhibitor0.061
pou4f1POU domain, class 4, transcription factor 10.060
mep1a.1meprin A, alpha.10.060
hirip3HIRA interacting protein 30.059
lrrc33leucine rich repeat containing 330.058
hmgb1bhigh-mobility group box 1b0.058
rykreceptor-like tyrosine kinase0.058
mesp2mesoderm posterior 2 homolog (mouse)0.057
csnk1a1casein kinase 1, alpha 10.057
wnt3wingless-type MMTV integration site family, member 30.057
bcl2l10BCL2-like 10 (apoptosis facilitator)0.055
efna2ephrin A20.055
zfp36l1azinc finger protein 36, C3H type-like 1a0.055
csf1racolony stimulating factor 1 receptor, a0.055
cldn15aclaudin 15a0.054
dnmt4DNA (cytosine-5-)-methyltransferase 40.054
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.054
cdh17cadherin 17, LI cadherin (liver-intestine)0.053
rif1RAP1 interacting factor homolog (yeast)0.052
tgfb2transforming growth factor, beta 20.052
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.051
tfebtranscription factor EB0.051
tie1endothelium-specific receptor tyrosine kinase 10.051
dlx6adistal-less homeobox gene 6a0.051
mybl2myeloblastosis oncogene-like 20.051
tlr2toll-like receptor 20.051
cflarCASP8 and FADD-like apoptosis regulator0.051
foxe3forkhead box E30.051
ctr9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.050
tprbtranslocated promoter region b (to activated MET oncogene)0.050
alkanaplastic lymphoma kinase (Ki-1)0.050
gmpsguanine monphosphate synthetase0.049
mtmr8myotubularin related protein 80.049
wlswntless homolog (Drosophila)0.049
numblnumb homolog (Drosophila)-like0.049
stc1lstanniocalcin 1, like0.049
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.048
c1qacomplement component 1, q subcomponent, A chain0.048
jam2bjunctional adhesion molecule 2b0.048
dnm2dynamin 20.048
ddr2bdiscoidin domain receptor family, member 2b0.048
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.047
hbbe1.1hemoglobin beta embryonic-1.10.047
phf6PHD finger protein 60.047
mibmind bomb0.047
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN6protein tyrosine phosphatase, non-receptor type 60.964
SHC1SHC (Src homology 2 domain containing) transforming protein 10.939
IL4Rinterleukin 4 receptor0.918
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.907
SYKspleen tyrosine kinase0.891
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.869
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.845
INSRinsulin receptor0.707
BCL2B-cell CLL/lymphoma 20.607
BRCA1breast cancer 1, early onset0.574
LAPTM5lysosomal protein transmembrane 50.566
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.498
LATlinker for activation of T cells0.459
SH3KBP1SH3-domain kinase binding protein 10.426
IL2RGinterleukin 2 receptor, gamma0.395
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.366
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.356
TNFAIP3tumor necrosis factor, alpha-induced protein 30.349
IRAK1interleukin-1 receptor-associated kinase 10.345
RUNX1runt-related transcription factor 10.327
BCL2L1BCL2-like 10.311
CTLA4cytotoxic T-lymphocyte-associated protein 40.306
PTPN1protein tyrosine phosphatase, non-receptor type 10.276
APLFaprataxin and PNKP like factor0.261
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.259
SH3BP2SH3-domain binding protein 20.255
CD80CD80 molecule0.251
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.248
MAP3K8mitogen-activated protein kinase kinase kinase 80.215
TGIF1TGFB-induced factor homeobox 10.192
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.186
IRS1insulin receptor substrate 10.171
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.170
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.168
PARP1poly (ADP-ribose) polymerase 10.157
HDAC9histone deacetylase 90.152
BLNKB-cell linker0.140
GHRgrowth hormone receptor0.122
IL10RAinterleukin 10 receptor, alpha0.118
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.118
BRIP1BRCA1 interacting protein C-terminal helicase 10.118
APAF1apoptotic peptidase activating factor 10.112
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.111
MYD88myeloid differentiation primary response gene (88)0.108
TRAF6TNF receptor-associated factor 60.108
MS4A1membrane-spanning 4-domains, subfamily A, member 10.106
PMLpromyelocytic leukemia0.105
DDIT3DNA-damage-inducible transcript 30.104
PTK2BPTK2B protein tyrosine kinase 2 beta0.103
ATMataxia telangiectasia mutated0.103
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.102
JAK2Janus kinase 20.101
BCL10B-cell CLL/lymphoma 100.101
TNIP1TNFAIP3 interacting protein 10.097
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.095
TCF12transcription factor 120.093
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.092
NOTCH1notch 10.088
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.085
THOC4THO complex 40.084
GRB7growth factor receptor-bound protein 70.084
TP53BP1tumor protein p53 binding protein 10.083
LY96lymphocyte antigen 960.082
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.080
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.080
CARD11caspase recruitment domain family, member 110.080
MAL2mal, T-cell differentiation protein 2 (gene/pseudogene)0.079
MSH3mutS homolog 3 (E. coli)0.077
SIRT1sirtuin 10.077
BCL2L11BCL2-like 11 (apoptosis facilitator)0.077
IRF4interferon regulatory factor 40.076
GAS7growth arrest-specific 70.074
SOS1son of sevenless homolog 1 (Drosophila)0.074
IKZF3IKAROS family zinc finger 3 (Aiolos)0.073
PIK3CGphosphoinositide-3-kinase, catalytic, gamma polypeptide0.072
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.071
TAL1T-cell acute lymphocytic leukemia 10.070
EP300E1A binding protein p3000.069
CD86CD86 molecule0.068
IL2RBinterleukin 2 receptor, beta0.062
CDK6cyclin-dependent kinase 60.061
GRAP2GRB2-related adaptor protein 20.060
RBBP8retinoblastoma binding protein 80.060
SMC1Astructural maintenance of chromosomes 1A0.059
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.059
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.059
GRB10growth factor receptor-bound protein 100.058
EPORerythropoietin receptor0.057
NCOR2nuclear receptor corepressor 20.055
BLMBloom syndrome, RecQ helicase-like0.055
IQGAP1IQ motif containing GTPase activating protein 10.054
ICAM1intercellular adhesion molecule 10.051
CDK2cyclin-dependent kinase 20.051
IL4interleukin 40.051
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.051
BIDBH3 interacting domain death agonist0.051
UHRF2ubiquitin-like with PHD and ring finger domains 20.050
CALCOCO2calcium binding and coiled-coil domain 20.049
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ighimmunoglobulin heavy chain complex1.000
Ikzf1IKAROS family zinc finger 11.000
Ptenphosphatase and tensin homolog1.000
Cd19CD19 antigen0.999
BtkBruton agammaglobulinemia tyrosine kinase0.999
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.998
Trp53transformation related protein 530.997
Tlr4toll-like receptor 40.996
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.995
Cd40CD40 antigen0.992
Tnftumor necrosis factor0.989
FasFas (TNF receptor superfamily member 6)0.987
Myd88myeloid differentiation primary response gene 880.983
Socs1suppressor of cytokine signaling 10.977
Cd28CD28 antigen0.975
Sykbspleen tyrosine kinase0.955
Map3k14mitogen-activated protein kinase kinase kinase 140.950
Il10interleukin 100.941
Sfpi1SFFV proviral integration 10.938
Pax2paired box gene 20.937
Esr1estrogen receptor 1 (alpha)0.930
Nr5a1nuclear receptor subfamily 5, group A, member 10.929
FynFyn proto-oncogene0.928
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.924
Ltalymphotoxin A0.923
Stat3signal transducer and activator of transcription 30.922
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.921
Rag2recombination activating gene 20.920
Tcf3transcription factor 30.918
Rnf2ring finger protein 20.916
Lyz2lysozyme 20.913
Icosinducible T-cell co-stimulator0.912
Bcl2B-cell leukemia/lymphoma 20.911
Cd22CD22 antigen0.910
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.891
Pax8paired box gene 80.882
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.874
Il2rginterleukin 2 receptor, gamma chain0.867
Hand1heart and neural crest derivatives expressed transcript 10.849
Ptprcprotein tyrosine phosphatase, receptor type, C0.845
Bcl6B-cell leukemia/lymphoma 60.845
Pax5paired box gene 50.843
FaslFas ligand (TNF superfamily, member 6)0.840
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.840
Inpp5dinositol polyphosphate-5-phosphatase D0.830
Cd180CD180 antigen0.828
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.825
Zeb1zinc finger E-box binding homeobox 10.820
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.803
Foxp3forkhead box P30.790
Otx2orthodenticle homolog 2 (Drosophila)0.784
Nr3c1nuclear receptor subfamily 3, group C, member 10.773
Prf1perforin 1 (pore forming protein)0.765
RybpRING1 and YY1 binding protein0.760
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.759
Pitx1paired-like homeodomain transcription factor 10.754
TcrdT-cell receptor delta chain0.750
Runx1runt related transcription factor 10.749
Plcg2phospholipase C, gamma 20.744
Lhx3LIM homeobox protein 30.730
Ikzf3IKAROS family zinc finger 30.725
Irf8interferon regulatory factor 80.710
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.709
Casp1caspase 10.690
Onecut1one cut domain, family member 10.681
Tbx2T-box 20.677
Gli2GLI-Kruppel family member GLI20.676
Cdkn1bcyclin-dependent kinase inhibitor 1B0.672
Ptf1apancreas specific transcription factor, 1a0.670
Mdm2transformed mouse 3T3 cell double minute 20.666
H2-Aahistocompatibility 2, class II antigen A, alpha0.664
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.645
CblCasitas B-lineage lymphoma0.639
Casp4caspase 4, apoptosis-related cysteine peptidase0.618
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.606
2010106G01RikRIKEN cDNA 2010106G01 gene0.600
Csf1colony stimulating factor 1 (macrophage)0.598
Emx1empty spiracles homolog 1 (Drosophila)0.597
Rag1recombination activating gene 10.594
Itgalintegrin alpha L0.591
Ifnginterferon gamma0.586
Pou2af1POU domain, class 2, associating factor 10.580
Gdf3growth differentiation factor 30.573
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.557
Msx3homeobox, msh-like 30.550
Notch2Notch gene homolog 2 (Drosophila)0.545
Card11caspase recruitment domain family, member 110.545
Ascl1achaete-scute complex homolog 1 (Drosophila)0.540
Tgfb1transforming growth factor, beta 10.532
Ccr7chemokine (C-C motif) receptor 70.527
Atmataxia telangiectasia mutated homolog (human)0.526
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.523
Neurod1neurogenic differentiation 10.516
Jak2Janus kinase 20.514
Fgf5fibroblast growth factor 50.506
Ltblymphotoxin B0.500
Ptpn6protein tyrosine phosphatase, non-receptor type 60.495
Hic1hypermethylated in cancer 10.492
Mdm4transformed mouse 3T3 cell double minute 40.488
Lef1lymphoid enhancer binding factor 10.487
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.025
Hckhemopoietic cell kinase0.022
Cd37CD37 molecule0.015
Inpp5dinositol polyphosphate-5-phosphatase D0.012
Rassf5Ras association (RalGDS/AF-6) domain family member 50.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism