The network for 'regulation of angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

NameDescriptionProbabilityFunc Analog Organism
plcg1phospholipase C, gamma 10.641
kdrlkinase insert domain receptor like0.602
notch3notch homolog 30.546
fbn2bfibrillin 2b0.428
dll4delta-like 4 (Drosophila)0.337
efnb2aephrin B2a0.263
cdh5cadherin 50.257
nrarpanotch-regulated ankyrin repeat protein a0.239
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.178
fn1fibronectin 10.176
nrp1aneuropilin 1a0.153
foxn4forkhead box N40.136
ephb4aeph receptor B4a0.121
cxcr4achemokine (C-X-C motif) receptor 4a0.121
ccm2cerebral cavernous malformation 20.118
vegfcvascular endothelial growth factor c0.117
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.097
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.095
sulf1sulfatase 10.092
tie2endothelium-specific receptor tyrosine kinase 20.089
agtr2angiotensin II receptor, type 20.086
etv2ets variant gene 20.082
plxnd1plexin D10.078
ilkintegrin linked kinase0.077
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.069
hey1hairy/enhancer-of-split related with YRPW motif 10.067
krit1KRIT1, ankyrin repeat containing0.067
jag2jagged 20.063
ptgs1prostaglandin-endoperoxide synthase 10.062
col5a2lcollagen, type V, alpha 2-like0.062
hs6st2heparan sulfate 6-O-sulfotransferase 20.061
lama5laminin, alpha 50.058
dnddead end0.056
epas1bendothelial PAS domain protein 1b0.053
hoxb5bhomeo box B5b0.052
calcrlacalcitonin receptor-like a0.048
antxr1anthrax toxin receptor 10.047
irx3airoquois homeobox protein 3a0.047
tal1T-cell acute lymphocytic leukemia 10.047
mcambmelanoma cell adhesion molecule b0.047
wnt11rwingless-type MMTV integration site family, member 11, related0.045
vegfaavascular endothelial growth factor Aa0.045
sox9aSRY-box containing gene 9a0.045
hey2hairy/enhancer-of-split related with YRPW motif 20.044
tcf12transcription factor 120.044
nf1aneurofibromin 1a0.044
fstafollistatin a0.043
sulf2sulfatase 20.043
selpselectin P0.041
bmp2bbone morphogenetic protein 2b0.041
pdgfrb2platelet derived growth factor receptor beta 20.040
neurod4neurogenic differentiation 40.040
edn1endothelin 10.040
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.039
col2a1acollagen type II, alpha-1a0.038
traf4atnf receptor-associated factor 4a0.038
gli2aGLI-Kruppel family member GLI2a0.038
hspa12bheat shock protein 12B0.037
olig2oligodendrocyte lineage transcription factor 20.036
nrp1bneuropilin 1b0.036
ankrd6ankyrin repeat domain 60.035
prdm16PR domain containing 160.035
pitx3paired-like homeodomain transcription factor 30.035
ntrk1neurotrophic tyrosine kinase, receptor, type 10.035
thbs1thrombospondin 10.034
pcdh18bprotocadherin 18b0.034
tbx20T-box 200.033
fras1Fraser syndrome 10.033
dlg2discs, large (Drosophila) homolog 20.032
nrp2aneuropilin 2a0.032
hlxb9lahomeo box HB9 like a0.032
atoh8atonal homolog 80.031
flt4fms-related tyrosine kinase 40.031
olig4oligodendrocyte transcription factor 40.031
hhexhematopoietically expressed homeobox0.031
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.031
acvrl1activin A receptor type II-like 10.031
pax8paired box gene 80.030
LOC796298isotocin receptor-like 10.030
LOC100003514protein kinase C alpha type-like0.030
tie1endothelium-specific receptor tyrosine kinase 10.029
cds2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 20.028
gja3gap junction protein, alpha 30.028
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.028
wt1bwilms tumor 1b0.028
igf1rainsulin-like growth factor 1a receptor0.028
ntn2netrin 20.028
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.028
wt1awilms tumor 1a0.027
eng1aengrailed 1a0.027
hoxb4ahomeo box B4a0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.999
FASFas (TNF receptor superfamily, member 6)0.986
FGFR2fibroblast growth factor receptor 20.957
TEKTEK tyrosine kinase, endothelial0.956
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.940
CCR5chemokine (C-C motif) receptor 50.936
VEGFAvascular endothelial growth factor A0.932
CAV1caveolin 1, caveolae protein, 22kDa0.925
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.914
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.911
FGFR1fibroblast growth factor receptor 10.856
IL8interleukin 80.835
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.830
LATlinker for activation of T cells0.829
PTPN1protein tyrosine phosphatase, non-receptor type 10.820
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.797
TAL1T-cell acute lymphocytic leukemia 10.793
PLAURplasminogen activator, urokinase receptor0.765
PLCG1phospholipase C, gamma 10.756
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.753
CXCL2chemokine (C-X-C motif) ligand 20.722
CALM1calmodulin 1 (phosphorylase kinase, delta)0.704
JAG1jagged 10.699
PECAM1platelet/endothelial cell adhesion molecule0.686
HOXB5homeobox B50.674
FGF1fibroblast growth factor 1 (acidic)0.654
METmet proto-oncogene (hepatocyte growth factor receptor)0.652
PLAUplasminogen activator, urokinase0.646
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.636
CDH5cadherin 5, type 2 (vascular endothelium)0.619
TIMP3TIMP metallopeptidase inhibitor 30.600
THBS1thrombospondin 10.580
NOTCH1notch 10.578
SKILSKI-like oncogene0.553
RUNX1runt-related transcription factor 10.534
CYR61cysteine-rich, angiogenic inducer, 610.527
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.517
DUSP1dual specificity phosphatase 10.508
IL2RBinterleukin 2 receptor, beta0.507
KLF4Kruppel-like factor 4 (gut)0.503
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.496
JUNjun proto-oncogene0.495
EGFRepidermal growth factor receptor0.493
PRKCAprotein kinase C, alpha0.490
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.474
CAV2caveolin 20.473
COL4A1collagen, type IV, alpha 10.458
COL4A2collagen, type IV, alpha 20.457
YAP1Yes-associated protein 10.448
IFNAR2interferon (alpha, beta and omega) receptor 20.442
DAXXdeath-domain associated protein0.418
STAT1signal transducer and activator of transcription 1, 91kDa0.400
CCL5chemokine (C-C motif) ligand 50.397
TGFB1transforming growth factor, beta 10.395
MEF2Cmyocyte enhancer factor 2C0.389
FGAfibrinogen alpha chain0.383
IL6interleukin 6 (interferon, beta 2)0.381
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.368
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.366
COL5A1collagen, type V, alpha 10.363
IL4Rinterleukin 4 receptor0.361
CREBBPCREB binding protein0.361
ANGPT2angiopoietin 20.350
ANXA5annexin A50.347
BCL6B-cell CLL/lymphoma 60.325
EP300E1A binding protein p3000.323
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.320
CXCL5chemokine (C-X-C motif) ligand 50.315
CCL20chemokine (C-C motif) ligand 200.306
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.298
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.295
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.286
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.273
STAB1stabilin 10.272
COL6A1collagen, type VI, alpha 10.264
TJP1tight junction protein 1 (zona occludens 1)0.264
PBX1pre-B-cell leukemia homeobox 10.262
CD34CD34 molecule0.260
CCL2chemokine (C-C motif) ligand 20.260
LMO2LIM domain only 2 (rhombotin-like 1)0.258
IFNGinterferon, gamma0.257
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.255
FOSFBJ murine osteosarcoma viral oncogene homolog0.250
CXCL3chemokine (C-X-C motif) ligand 30.249
NOTCH3notch 30.247
PDGFAplatelet-derived growth factor alpha polypeptide0.246
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.240
NRP1neuropilin 10.239
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.234
FGF10fibroblast growth factor 100.233
MEF2Amyocyte enhancer factor 2A0.219
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.216
HDAC7histone deacetylase 70.215
GRB10growth factor receptor-bound protein 100.215
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.214
RGS2regulator of G-protein signaling 2, 24kDa0.212
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 20.991
Rargretinoic acid receptor, gamma0.978
Ccr2chemokine (C-C motif) receptor 20.978
Col1a1collagen, type I, alpha 10.967
Kdrkinase insert domain protein receptor0.958
Csf1colony stimulating factor 1 (macrophage)0.949
Bmp4bone morphogenetic protein 40.949
Lhx1LIM homeobox protein 10.942
Vegfavascular endothelial growth factor A0.933
Wt1Wilms tumor 1 homolog0.910
Ccl2chemokine (C-C motif) ligand 20.900
Tcf21transcription factor 210.866
Foxc1forkhead box C10.846
Fgfr2fibroblast growth factor receptor 20.845
Gli3GLI-Kruppel family member GLI30.834
Nos3nitric oxide synthase 3, endothelial cell0.826
Nos2nitric oxide synthase 2, inducible0.802
Smad3MAD homolog 3 (Drosophila)0.795
Gata4GATA binding protein 40.768
Selpselectin, platelet0.757
Sox7SRY-box containing gene 70.755
Twist2twist homolog 2 (Drosophila)0.754
Leprleptin receptor0.735
Pbx1pre B-cell leukemia transcription factor 10.729
Apoeapolipoprotein E0.724
Bmp5bone morphogenetic protein 50.714
Trp53transformation related protein 530.701
Acvrl1activin A receptor, type II-like 10.701
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.697
Fzd1frizzled homolog 1 (Drosophila)0.694
Lyz2lysozyme 20.691
Epha4Eph receptor A40.688
Platplasminogen activator, tissue0.678
Adra2badrenergic receptor, alpha 2b0.675
Arntlaryl hydrocarbon receptor nuclear translocator-like0.671
Tgfbr2transforming growth factor, beta receptor II0.647
Flt1FMS-like tyrosine kinase 10.643
Ptenphosphatase and tensin homolog0.642
Shhsonic hedgehog0.637
Loxlysyl oxidase0.624
Cxcl13chemokine (C-X-C motif) ligand 130.613
Clockcircadian locomotor output cycles kaput0.609
Efnb2ephrin B20.598
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.597
Foxf1aforkhead box F1a0.583
Apcadenomatosis polyposis coli0.582
Emx2empty spiracles homolog 2 (Drosophila)0.569
Tgfb1i1transforming growth factor beta 1 induced transcript 10.557
Tgfbr3transforming growth factor, beta receptor III0.554
Hoxd13homeobox D130.537
Epas1endothelial PAS domain protein 10.533
Snai1snail homolog 1 (Drosophila)0.528
Pax3paired box gene 30.513
Ccr1chemokine (C-C motif) receptor 10.510
Ifnginterferon gamma0.507
Gata6GATA binding protein 60.504
Npr3natriuretic peptide receptor 30.501
Id3inhibitor of DNA binding 30.492
C3complement component 30.492
Myod1myogenic differentiation 10.485
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.480
Ddr2discoidin domain receptor family, member 20.464
Tgfb1transforming growth factor, beta 10.450
Ephb2Eph receptor B20.448
Cd7CD7 antigen0.448
Sox9SRY-box containing gene 90.446
Fgf10fibroblast growth factor 100.439
Prf1perforin 1 (pore forming protein)0.438
Htra3HtrA serine peptidase 30.438
Ccl3chemokine (C-C motif) ligand 30.433
Smad6MAD homolog 6 (Drosophila)0.432
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.431
Upk3buroplakin 3B0.421
Stat3signal transducer and activator of transcription 30.421
Gpc3glypican 30.419
Cdh5cadherin 50.415
Vhlvon Hippel-Lindau tumor suppressor0.414
Cyr61cysteine rich protein 610.409
Sox17SRY-box containing gene 170.407
Col4a3collagen, type IV, alpha 30.406
Islrimmunoglobulin superfamily containing leucine-rich repeat0.405
Ptprbprotein tyrosine phosphatase, receptor type, B0.404
Fzd4frizzled homolog 4 (Drosophila)0.403
Pthlhparathyroid hormone-like peptide0.401
Pcsk5proprotein convertase subtilisin/kexin type 50.396
Nrp1neuropilin 10.394
Cav1caveolin 1, caveolae protein0.392
Epha3Eph receptor A30.388
Adcy4adenylate cyclase 40.388
Flt4FMS-like tyrosine kinase 40.386
Ctnnb1catenin (cadherin associated protein), beta 10.382
Folr2folate receptor 2 (fetal)0.378
Id1inhibitor of DNA binding 10.372
Bnc1basonuclin 10.370
C3ar1complement component 3a receptor 10.369
Tlr2toll-like receptor 20.368
Pax6paired box gene 60.366
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl2chemokine (C-C motif) ligand 20.580
Csf1colony stimulating factor 1 (macrophage)0.476
Il1rl1interleukin 1 receptor-like 10.367
Fosl1fos-like antigen 10.331
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.309
Mmp3matrix metallopeptidase 30.284
MdficMyoD family inhibitor domain containing0.207
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.204
Cgaglycoprotein hormones, alpha polypeptide0.197
Il6interleukin 60.183
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.178
LOC60591calcium-activated potassium channel beta subunit0.176
Reg3gregenerating islet-derived 3 gamma0.170
Crisp1cysteine-rich secretory protein 10.167
Adora2aadenosine A2a receptor0.161
Il1binterleukin 1 beta0.158
Id3inhibitor of DNA binding 30.154
Gzmkgranzyme K0.153
Hspa1aheat shock 70kD protein 1A0.149
Fgfr2fibroblast growth factor receptor 20.145
Fgf2fibroblast growth factor 20.145
Ccl3chemokine (C-C motif) ligand 30.144
Cpb2carboxypeptidase B2 (plasma)0.142
Il8rbinterleukin 8 receptor, beta0.135
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.135
Edn1endothelin 10.134
Iappislet amyloid polypeptide0.130
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.120
Akr1c18aldo-keto reductase family 1, member C180.118
Tacr1tachykinin receptor 10.115
Selpselectin P0.113
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.107
RGD1564327similar to integrin alpha 80.105
Metmet proto-oncogene0.102
Cd4Cd4 molecule0.101
Cxcl2chemokine (C-X-C motif) ligand 20.098
Pgfplacental growth factor0.097
Igh-6immunoglobulin heavy chain 60.097
Map3k8mitogen-activated protein kinase kinase kinase 80.095
Mmp10matrix metallopeptidase 100.095
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.093
Mmp9matrix metallopeptidase 90.092
Col12a1collagen, type XII, alpha 10.092
Ccr5chemokine (C-C motif) receptor 50.090
Tpsab1tryptase alpha/beta 10.089
Sellselectin L0.089
Il4interleukin 40.089
Myo1dmyosin ID0.087
Il2rainterleukin 2 receptor, alpha0.084
Pld2phospholipase D20.083
Cd200r1CD200 receptor 10.083
Adam2ADAM metallopeptidase domain 20.081
Nfe2l2nuclear factor, erythroid derived 2, like 20.081
Galgalanin prepropeptide0.080
Il7interleukin 70.080
Cdh5cadherin 50.079
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.078
Cmklr1chemokine-like receptor 10.078
Slco2b1solute carrier organic anion transporter family, member 2b10.075
Cst8cystatin 8 (cystatin-related epididymal specific)0.073
Il9rinterleukin 9 receptor0.073
Sox7SRY (sex determining region Y)-box 70.072
Prok2prokineticin 20.071
Pmfbp1polyamine modulated factor 1 binding protein 10.071
Mmp13matrix metallopeptidase 130.070
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.069
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.068
Calcbcalcitonin-related polypeptide, beta0.068
Cxcr5chemokine (C-X-C motif) receptor 50.068
Prrx1paired related homeobox 10.067
Gna15guanine nucleotide binding protein, alpha 150.067
Nos3nitric oxide synthase 3, endothelial cell0.066
Cd80Cd80 molecule0.065
Gpr116G protein-coupled receptor 1160.065
Trim47tripartite motif-containing 470.064
Klf4Kruppel-like factor 4 (gut)0.064
Rup2urinary protein 20.063
Prkchprotein kinase C, eta0.063
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.063
LOC299282Serine protease inhibitor0.062
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.062
Bst1bone marrow stromal cell antigen 10.061
Stip1stress-induced phosphoprotein 10.061
Lamp2lysosomal-associated membrane protein 20.060
Arl5cADP-ribosylation factor-like 5C0.059
Ptpreprotein tyrosine phosphatase, receptor type, E0.059
Calcrlcalcitonin receptor-like0.059
Itih3inter-alpha trypsin inhibitor, heavy chain 30.059
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.058
Has2hyaluronan synthase 20.058
Orm1orosomucoid 10.057
Il1rninterleukin 1 receptor antagonist0.056
Pemtphosphatidylethanolamine N-methyltransferase0.055
Cfpcomplement factor properdin0.055
Smgbneonatal submandibular gland protein B0.054
Rgs1regulator of G-protein signaling 10.053
A1i3alpha-1-inhibitor III0.052
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism