The network for 'hindbrain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hindbrain development

The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).

NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.998
egr2bearly growth response 2b0.998
crabp2acellular retinoic acid binding protein 2, a0.996
foxa2forkhead box A20.978
six3bsine oculis homeobox homolog 3b0.974
atoh1batonal homolog 1b0.939
foxa1forkhead box A10.932
ptf1apancreas specific transcription factor, 1a0.928
pax2apaired box gene 2a0.926
pax6bpaired box gene 6b0.921
raraaretinoic acid receptor, alpha a0.918
bmp2bbone morphogenetic protein 2b0.918
otpborthopedia homolog b0.909
hnf1baHNF1 homeobox Ba0.906
lfnglunatic fringe homolog0.903
neurod4neurogenic differentiation 40.893
gbx1gastrulation brain homeobox 10.886
pcdh19protocadherin 190.881
sox2SRY-box containing gene 20.877
lft1lefty10.877
zic1zic family member 1 (odd-paired homolog, Drosophila)0.875
sp5lSp5 transcription factor-like0.870
tal1T-cell acute lymphocytic leukemia 10.865
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.863
spry2sprouty homolog 20.857
msxemuscle segment homeobox E0.856
ephb3aeph receptor B3a0.852
sox1aSRY-box containing gene 1a0.828
fzd3afrizzled homolog 3a0.827
neurodneurogenic differentiation0.822
wnt4awingless-type MMTV integration site family, member 4a0.822
eng2bengrailed 2b0.810
pea3ETS-domain transcription factor pea30.799
sox9aSRY-box containing gene 9a0.792
hoxb1bhomeo box B1b0.790
sall4sal-like 4 (Drosophila)0.784
tp53tumor protein p530.783
shhasonic hedgehog a0.768
gata3GATA-binding protein 30.768
sema3aasemaphorin 3aa0.760
fgfr1afibroblast growth factor receptor 1a0.759
dlddeltaD0.755
otx5orthodenticle homolog 50.754
fgf8afibroblast growth factor 8 a0.746
irx4airoquois homeobox protein 4a0.742
mecomMDS1 and EVI1 complex locus0.732
irx7iroquois homeobox protein 70.729
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.728
atoh1aatonal homolog 1a0.727
pitx3paired-like homeodomain transcription factor 30.725
wnt8bwingless-type MMTV integration site family, member 8b0.720
otx2orthodenticle homolog 20.719
mnx1motor neuron and pancreas homeobox 10.711
lhx1aLIM homeobox 1a0.704
itgb1b.2integrin, beta 1b.20.688
gbx2gastrulation brain homeo box 20.685
egr1early growth response 10.679
fgf10afibroblast growth factor 10a0.678
ptch1patched 10.676
fn1fibronectin 10.662
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.660
dlcdeltaC0.646
meis2.1myeloid ecotropic viral integration site 2.10.644
fgfr4fibroblast growth factor receptor 40.624
sox3SRY-box containing gene 30.622
egr2aearly growth response 2a0.621
gata5GATA-binding protein 50.618
barhl2BarH-like 20.598
dkk1bdickkopf 1b0.592
fgfr2fibroblast growth factor receptor 20.591
tgfbitransforming growth factor, beta-induced0.589
gli2aGLI-Kruppel family member GLI2a0.588
pax6apaired box gene 6a0.584
foxd3forkhead box D30.583
irx1biroquois homeobox protein 1, b0.576
scribscribbled homolog (Drosophila)0.566
olig2oligodendrocyte lineage transcription factor 20.558
nkx1.2laNK1 transcription factor related 2-like,a0.556
efnb1ephrin B10.551
tbx1T-box 10.547
rx3retinal homeobox gene 30.547
wnt3wingless-type MMTV integration site family, member 30.539
zgc:101606zgc:1016060.528
ephb4beph receptor B4b0.526
map2k4amitogen-activated protein kinase kinase 4a0.523
tfap2atranscription factor AP-2 alpha0.520
hmx3homeo box (H6 family) 30.517
zic5zic family member 5 (odd-paired homolog, Drosophila)0.516
epha4beph receptor A4b0.510
rargaretinoic acid receptor gamma a0.502
odz4odd Oz/ten-m homolog 40.499
eya1eyes absent homolog 10.498
alcamaactivated leukocyte cell adhesion molecule a0.486
fzd7afrizzled homolog 7a0.485
ascl1aachaete-scute complex-like 1a (Drosophila)0.484
six4bsine oculis homeobox homolog 4b0.483
lhx2bLIM homeobox 2b0.481
wnt3awingless-type MMTV integration site family, member 3A0.478
hapln1ahyaluronan and proteoglycan link protein 1a0.477
pax3apaired box gene 3a0.473
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HLHm7E(spl) region transcript m70.957
spensplit ends0.939
MadMothers against dpp0.937
cicubitus interruptus0.893
E(spl)Enhancer of split0.884
trxtrithorax0.859
malphaE(spl) region transcript malpha0.714
sdscalloped0.701
HLHmbetaE(spl) region transcript mbeta0.677
shishibire0.665
hthhomothorax0.661
ococelliless0.633
ssspineless0.612
Sema-1aCG18405 gene product from transcript CG18405-RD0.581
Atg1Autophagy-specific gene 10.566
UbxUltrabithorax0.541
ash2absent, small, or homeotic discs 20.530
atoatonal0.517
HLHm5E(spl) region transcript m50.512
HLHmgammaE(spl) region transcript mgamma0.508
kluklumpfuss0.460
SoxNSoxNeuro0.450
Su(H)Suppressor of Hairless0.443
aopanterior open0.423
Syx1ASyntaxin 1A0.392
alaristaless0.387
VangVan Gogh0.377
wgwingless0.347
gekgenghis khan0.343
HLHmdeltaE(spl) region transcript mdelta0.309
ewgerect wing0.299
sbbscribbler0.277
eygeyegone0.272
giggigas0.264
HLHm3E(spl) region transcript m30.260
PebProtein ejaculatory bulb0.252
putpunt0.252
AntpAntennapedia0.248
emcextra macrochaetae0.247
scscute0.241
SerSerrate0.233
elavembryonic lethal abnormal vision0.231
norpAno receptor potential A0.226
opaodd paired0.223
esgescargot0.220
hydhyperplastic discs0.220
l(2)gllethal (2) giant larvae0.213
bratbrain tumor0.212
DAAMDishevelled Associated Activator of Morphogenesis0.211
lidlittle imaginal discs0.210
senssenseless0.208
bowlbrother of odd with entrails limited0.206
lzlozenge0.205
rorough0.201
tuptailup0.199
emsempty spiracles0.196
amosabsent MD neurons and olfactory sensilla0.196
hhhedgehog0.188
GugGrunge0.186
l(2)k16918lethal (2) k169180.185
kuzkuzbanian0.176
ftfat0.172
enengrailed0.166
RicRas which interacts with Calmodulin0.161
bskbasket0.161
ushu-shaped0.154
spispitz0.152
hipkhomeodomain interacting protein kinase0.150
Myo31DFMyosin 31DF0.149
vvlventral veins lacking0.148
Stat92ESignal-transducer and activator of transcription protein at 92E0.147
osaCG7467 gene product from transcript CG7467-RD0.146
Ca-alpha1DCa[2+]-channel protein alpha[[1]] subunit D0.145
ttktramtrack0.145
fzfrizzled0.143
snostrawberry notch0.142
cdicenter divider0.141
hpohippo0.137
MedMedea0.136
dydusky0.135
hephemipterous0.134
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.133
reporeversed polarity0.133
argosCG4531 gene product from transcript CG4531-RA0.130
TolloCG6890 gene product from transcript CG6890-RA0.130
scascabrous0.130
CG10631CG10631 gene product from transcript CG10631-RA0.129
stanstarry night0.127
dmdiminutive0.127
numbCG3779 gene product from transcript CG3779-RB0.127
DfdDeformed0.126
sevsevenless0.124
tlltailless0.123
vgvestigial0.123
AdarAdenosine deaminase acting on RNA0.122
sosine oculis0.121
Tsc1CG6147 gene product from transcript CG6147-RA0.121
CkIIalphaCasein kinase II alpha subunit0.121
slp1sloppy paired 10.118
dppdecapentaplegic0.117
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EP300E1A binding protein p3000.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.999
JAG1jagged 10.995
ESR1estrogen receptor 10.993
EGFRepidermal growth factor receptor0.993
ARandrogen receptor0.989
NCOA1nuclear receptor coactivator 10.977
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.973
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.970
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.967
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.954
SKIv-ski sarcoma viral oncogene homolog (avian)0.945
FGFR1fibroblast growth factor receptor 10.932
NR0B1nuclear receptor subfamily 0, group B, member 10.908
SETD8SET domain containing (lysine methyltransferase) 80.899
INADLInaD-like (Drosophila)0.897
HNF4Ahepatocyte nuclear factor 4, alpha0.848
APCadenomatous polyposis coli0.831
METmet proto-oncogene (hepatocyte growth factor receptor)0.828
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.811
PDZD11PDZ domain containing 110.810
GSK3Bglycogen synthase kinase 3 beta0.809
ATXN1ataxin 10.802
PDX1pancreatic and duodenal homeobox 10.784
RASA1RAS p21 protein activator (GTPase activating protein) 10.782
SMAD3SMAD family member 30.781
TAL1T-cell acute lymphocytic leukemia 10.756
MPDZmultiple PDZ domain protein0.737
NR4A1nuclear receptor subfamily 4, group A, member 10.732
TRRAPtransformation/transcription domain-associated protein0.717
COPB2coatomer protein complex, subunit beta 2 (beta prime)0.708
ARID1AAT rich interactive domain 1A (SWI-like)0.705
RPL18Aribosomal protein L18a0.703
TCF4transcription factor 40.698
TP53tumor protein p530.692
BCORBCL6 corepressor0.692
ASB2ankyrin repeat and SOCS box containing 20.688
MDM2Mdm2 p53 binding protein homolog (mouse)0.679
CHDHcholine dehydrogenase0.667
QKIquaking homolog, KH domain RNA binding (mouse)0.656
RBPMSRNA binding protein with multiple splicing0.644
GATA2GATA binding protein 20.642
RUNX1runt-related transcription factor 10.634
PBX1pre-B-cell leukemia homeobox 10.611
EGR1early growth response 10.605
ARID1BAT rich interactive domain 1B (SWI1-like)0.596
NCOR1nuclear receptor corepressor 10.582
PTCH1patched 10.581
GATA4GATA binding protein 40.581
SNTG2syntrophin, gamma 20.580
LMO4LIM domain only 40.564
TESK1testis-specific kinase 10.537
SH3KBP1SH3-domain kinase binding protein 10.536
SOX1SRY (sex determining region Y)-box 10.522
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.508
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.503
SOX11SRY (sex determining region Y)-box 110.478
SIX6SIX homeobox 60.467
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.467
SIRT1sirtuin 10.450
GRB7growth factor receptor-bound protein 70.449
SUFUsuppressor of fused homolog (Drosophila)0.447
HTThuntingtin0.442
EGR3early growth response 30.439
P4HBprolyl 4-hydroxylase, beta polypeptide0.439
ONECUT1one cut homeobox 10.423
ATN1atrophin 10.419
MYOD1myogenic differentiation 10.408
NEUROD1neurogenic differentiation 10.383
PAX6paired box 60.377
NRXN1neurexin 10.376
GLIS2GLIS family zinc finger 20.375
TRIP6thyroid hormone receptor interactor 60.373
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.366
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.366
FOXA2forkhead box A20.365
HNF1AHNF1 homeobox A0.363
CREBBPCREB binding protein0.359
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.356
FHL2four and a half LIM domains 20.351
RAXretina and anterior neural fold homeobox0.344
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.341
SP1Sp1 transcription factor0.340
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.336
SESN2sestrin 20.335
ERBB2IPerbb2 interacting protein0.326
SHC3SHC (Src homology 2 domain containing) transforming protein 30.323
POU4F2POU class 4 homeobox 20.323
RXRAretinoid X receptor, alpha0.321
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.320
DKK1dickkopf homolog 1 (Xenopus laevis)0.319
TUBB2Btubulin, beta 2B0.319
RIN1Ras and Rab interactor 10.318
BMP7bone morphogenetic protein 70.311
RANBP9RAN binding protein 90.311
APLP1amyloid beta (A4) precursor-like protein 10.310
HOXD12homeobox D120.309
UBR1ubiquitin protein ligase E3 component n-recognin 10.306
SIX3SIX homeobox 30.306
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.304
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Pax2paired box gene 21.000
Fgf8fibroblast growth factor 81.000
Tbx1T-box 11.000
Pitx2paired-like homeodomain transcription factor 21.000
Pax3paired box gene 30.999
Tbx3T-box 30.999
Rargretinoic acid receptor, gamma0.999
Fgfr1fibroblast growth factor receptor 10.998
Hoxa1homeobox A10.998
En1engrailed 10.998
Fgf10fibroblast growth factor 100.998
Dlx5distal-less homeobox 50.997
Emx2empty spiracles homolog 2 (Drosophila)0.996
Fgfr2fibroblast growth factor receptor 20.996
Foxc1forkhead box C10.996
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.995
Eya1eyes absent 1 homolog (Drosophila)0.995
Hand2heart and neural crest derivatives expressed transcript 20.995
Sox2SRY-box containing gene 20.994
Ctnnb1catenin (cadherin associated protein), beta 10.994
Smosmoothened homolog (Drosophila)0.994
Gli2GLI-Kruppel family member GLI20.994
Lmx1aLIM homeobox transcription factor 1 alpha0.993
Isl1ISL1 transcription factor, LIM/homeodomain0.993
Lef1lymphoid enhancer binding factor 10.992
Msx2homeobox, msh-like 20.989
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.988
Nognoggin0.988
Lhx1LIM homeobox protein 10.987
Emx1empty spiracles homolog 1 (Drosophila)0.986
Rararetinoic acid receptor, alpha0.985
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.984
Lhx3LIM homeobox protein 30.982
Chd7chromodomain helicase DNA binding protein 70.981
Hoxa2homeobox A20.981
Ptenphosphatase and tensin homolog0.979
Gbx2gastrulation brain homeobox 20.975
Sox9SRY-box containing gene 90.975
Foxc2forkhead box C20.970
Vegfavascular endothelial growth factor A0.966
Phox2bpaired-like homeobox 2b0.965
Ascl1achaete-scute complex homolog 1 (Drosophila)0.965
Lmx1bLIM homeobox transcription factor 1 beta0.964
Otx1orthodenticle homolog 1 (Drosophila)0.964
Gscgoosecoid homeobox0.964
Pax6paired box gene 60.959
Bmp4bone morphogenetic protein 40.959
Msx1homeobox, msh-like 10.957
Chrdchordin0.957
Wnt1wingless-related MMTV integration site 10.956
Hes1hairy and enhancer of split 1 (Drosophila)0.955
Prrx1paired related homeobox 10.950
Hmx3H6 homeobox 30.939
Gdnfglial cell line derived neurotrophic factor0.937
Rarbretinoic acid receptor, beta0.937
Trp63transformation related protein 630.936
Pax8paired box gene 80.930
Ednraendothelin receptor type A0.926
Zeb1zinc finger E-box binding homeobox 10.916
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.904
Smad6MAD homolog 6 (Drosophila)0.903
Kitkit oncogene0.900
Smad1MAD homolog 1 (Drosophila)0.899
Tgfb2transforming growth factor, beta 20.895
Vangl2vang-like 2 (van gogh, Drosophila)0.894
Prrx2paired related homeobox 20.887
Bdnfbrain derived neurotrophic factor0.886
Smad3MAD homolog 3 (Drosophila)0.884
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.882
Dkk1dickkopf homolog 1 (Xenopus laevis)0.875
Tlx3T-cell leukemia, homeobox 30.874
Lhx5LIM homeobox protein 50.870
Pou3f3POU domain, class 3, transcription factor 30.867
Hoxd3homeobox D30.866
Itgb1integrin beta 1 (fibronectin receptor beta)0.859
Wnt6wingless-related MMTV integration site 60.854
Leprleptin receptor0.852
Twist2twist homolog 2 (Drosophila)0.850
Tcfap2atranscription factor AP-2, alpha0.848
Neurod1neurogenic differentiation 10.846
Ptf1apancreas specific transcription factor, 1a0.845
Pitx1paired-like homeodomain transcription factor 10.839
Bcl2B-cell leukemia/lymphoma 20.830
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.828
Zic3zinc finger protein of the cerebellum 30.822
Fgf15fibroblast growth factor 150.819
Insm1insulinoma-associated 10.806
Nr5a1nuclear receptor subfamily 5, group A, member 10.805
Drd2dopamine receptor D20.798
Hoxd11homeobox D110.796
Gsk3bglycogen synthase kinase 3 beta0.796
Fzd7frizzled homolog 7 (Drosophila)0.789
Acvr1activin A receptor, type 10.784
Dll1delta-like 1 (Drosophila)0.783
Ror2receptor tyrosine kinase-like orphan receptor 20.782
MecomMDS1 and EVI1 complex locus0.776
Retret proto-oncogene0.775
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
ND1NADH dehydrogenase subunit 10.022
Bcl2B-cell CLL/lymphoma 20.019
CYTBcytochrome b0.019
ATP6ATPase subunit 60.015
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.015
Kcnk3potassium channel, subfamily K, member 30.014
Grid2glutamate receptor, ionotropic, delta 20.013
Ompolfactory marker protein0.013
Prlhrprolactin releasing hormone receptor0.012
Prph2peripherin 20.012
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.012
Eporerythropoietin receptor0.011
Adarb2adenosine deaminase, RNA-specific, B20.011
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.011
Accn2amiloride-sensitive cation channel 2, neuronal0.011
Galr3galanin receptor 30.011
Grm2glutamate receptor, metabotropic 20.011
Ncanneurocan0.011
Slc14a2solute carrier family 14 (urea transporter), member 20.011
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.011
Shox2short stature homeobox 20.011
Sdc3syndecan 30.011
Ascl1achaete-scute complex homolog 1 (Drosophila)0.011
Glra1glycine receptor, alpha 10.011
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.011
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.011
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.010
Gata6GATA binding protein 60.010
Tnrtenascin R0.010
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.010
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.010
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.010
Npy5rneuropeptide Y receptor Y50.010
Gad1glutamate decarboxylase 10.010
Fgfr2fibroblast growth factor receptor 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism