The network for 'neuronal ion channel clustering' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuronal ion channel clustering

The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.

NameDescriptionProbabilityFunc Analog Organism
scn8aasodium channel, voltage-gated, type VIII, alpha a0.188
clrn1clarin 10.048
cdh23cadherin-like 230.037
sox10SRY-box containing gene 100.019
rc3rabconnectin 30.017
dpysl2bdihydropyrimidinase-like 2b0.015
cdh6cadherin 60.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Snap25Synapse protein 250.021
twstwins0.018
ogreoptic ganglion reduced0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
KCND2potassium voltage-gated channel, Shal-related subfamily, member 20.964
TGIF1TGFB-induced factor homeobox 10.919
EVLEnah/Vasp-like0.842
SPTBN1spectrin, beta, non-erythrocytic 10.631
KCNIP2Kv channel interacting protein 20.488
BAZ2Bbromodomain adjacent to zinc finger domain, 2B0.373
DDX24DEAD (Asp-Glu-Ala-Asp) box polypeptide 240.335
CD177CD177 molecule0.244
PTPRNprotein tyrosine phosphatase, receptor type, N0.186
FANCEFanconi anemia, complementation group E0.164
PTOV1prostate tumor overexpressed 10.150
FANCAFanconi anemia, complementation group A0.103
FANCCFanconi anemia, complementation group C0.095
KCNIP4Kv channel interacting protein 40.079
SOX13SRY (sex determining region Y)-box 130.072
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.058
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.048
CTBP1C-terminal binding protein 10.047
NRIP1nuclear receptor interacting protein 10.041
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.036
KCNIP1Kv channel interacting protein 10.025
AKTIPAKT interacting protein0.022
CCNHcyclin H0.020
DLG4discs, large homolog 4 (Drosophila)0.019
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.019
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.017
ZNF512Bzinc finger protein 512B0.016
TJP1tight junction protein 1 (zona occludens 1)0.015
TSSC4tumor suppressing subtransferable candidate 40.015
PROX1prospero homeobox 10.012
FANCFFanconi anemia, complementation group F0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ank1ankyrin 1, erythroid0.302
Hbb-b1hemoglobin, beta adult major chain0.094
Add2adducin 2 (beta)0.051
Dlg4discs, large homolog 4 (Drosophila)0.013
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.013
Hbb-b2hemoglobin, beta adult minor chain0.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sptbn1spectrin, beta, non-erythrocytic 10.324
Shank1SH3 and multiple ankyrin repeat domains 10.296
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.226
Dlgap1discs, large (Drosophila) homolog-associated protein 10.183
Dgkidiacylglycerol kinase, iota0.176
NsfN-ethylmaleimide-sensitive factor0.119
Grid2glutamate receptor, ionotropic, delta 20.072
Pi4kaphosphatidylinositol 4-kinase, catalytic, alpha0.070
Syn1synapsin I0.056
Unc5aunc-5 homolog A (C. elegans)0.051
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.047
Garnl1GTPase activating Rap/RanGAP domain-like 10.046
Appamyloid beta (A4) precursor protein0.046
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.045
Nckap1NCK-associated protein 10.045
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.044
Gria1glutamate receptor, ionotropic, AMPA 10.044
Spock1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 10.039
Mpripmyosin phosphatase Rho interacting protein0.039
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.038
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.035
Tmod2tropomodulin 20.035
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.034
Pja2praja 2, RING-H2 motif containing0.030
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.030
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.027
Nhlh1nescient helix loop helix 10.025
Wdr7WD repeat domain 70.024
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.023
Dync1h1dynein cytoplasmic 1 heavy chain 10.023
Rock2Rho-associated coiled-coil containing protein kinase 20.023
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.022
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.022
Synprsynaptoporin0.021
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.020
Syt11synaptotagmin XI0.020
Cnksr2connector enhancer of kinase suppressor of Ras 20.020
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.020
Pcsk2proprotein convertase subtilisin/kexin type 20.019
Cplx1complexin 10.019
Dlg4discs, large homolog 4 (Drosophila)0.019
Aqp4aquaporin 40.018
Pclopiccolo (presynaptic cytomatrix protein)0.018
Top1topoisomerase (DNA) I0.018
Nlgn1neuroligin 10.017
Syt9synaptotagmin IX0.017
Apcadenomatous polyposis coli0.017
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.016
LOC100361389hypothetical protein LOC1003613890.016
Nrxn1neurexin 10.016
Tacr3tachykinin receptor 30.016
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.016
ND4NADH dehydrogenase subunit 40.016
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.015
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.015
Dnm1ldynamin 1-like0.015
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.015
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.015
Glrbglycine receptor, beta0.015
Cyp2b21cytochrome P450, family 2, subfamily b, polypeptide 210.014
Maptmicrotubule-associated protein tau0.014
Gucy1a2guanylate cyclase 1, soluble, alpha 20.014
Gria2glutamate receptor, ionotropic, AMPA 20.014
Epha7Eph receptor A70.014
Sp4Sp4 transcription factor0.014
Sv2bsynaptic vesicle glycoprotein 2b0.013
Dlg2discs, large homolog 2 (Drosophila)0.013
Grip1glutamate receptor interacting protein 10.013
Atp1a3ATPase, Na+/K+ transporting, alpha 3 polypeptide0.013
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.013
Cttnbp2cortactin binding protein 20.013
Apbb3amyloid beta (A4) precursor protein-binding, family B, member 30.013
Taok1TAO kinase 10.013
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.013
LOC361188similar to WD repeat domain 170.013
Fgf14fibroblast growth factor 140.013
Cxxc4CXXC finger 40.012
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.012
Amphamphiphysin0.012
Rab3gap2RAB3 GTPase activating protein subunit 20.012
Gnazguanine nucleotide binding protein (G protein), alpha z polypeptide0.012
Plcd4phospholipase C, delta 40.012
Znf597zinc finger protein 5970.012
Kctd13potassium channel tetramerisation domain containing 130.012
Gdi1GDP dissociation inhibitor 10.012
Pex5lperoxisomal biogenesis factor 5-like0.012
Camk4calcium/calmodulin-dependent protein kinase IV0.012
Vitvitrin0.012
Akirin2akirin 20.012
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.012
Smc5structural maintenance of chromosomes 50.012
Map1amicrotubule-associated protein 1A0.011
Top2btopoisomerase (DNA) II beta0.011
Drd1adopamine receptor D1A0.011
Map2microtubule-associated protein 20.011
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.011
Plp1proteolipid protein 10.011
Mdm2Mdm2 p53 binding protein homolog (mouse)0.011
Cntn2contactin 2 (axonal)0.011
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism