The network for 'negative regulation of peptidase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of peptidase activity

Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.

NameDescriptionProbabilityFunc Analog Organism
adipor2adiponectin receptor 20.168
ptf1apancreas specific transcription factor, 1a0.156
hhiphedgehog interacting protein0.155
ass1argininosuccinate synthetase 10.141
furinafurin (paired basic amino acid cleaving enzyme) a0.128
igf1rainsulin-like growth factor 1a receptor0.091
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.080
stc1lstanniocalcin 1, like0.076
pcsk5bproprotein convertase subtilisin/kexin type 5b0.066
bbc3BCL2 binding component 30.061
hbbe1.1hemoglobin beta embryonic-1.10.055
map2k4amitogen-activated protein kinase kinase 4a0.054
cdh4cadherin 4, retinal0.052
adipoqladiponectin, C1Q and collagen domain containing, like0.052
bcl2l1bcl2-like 10.050
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.049
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.048
calcrcalcitonin receptor0.047
adipoql2adiponectin, C1Q and collagen domain containing, like 20.047
bhmtbetaine-homocysteine methyltransferase0.046
furinbfurin (paired basic amino acid cleaving enzyme) b0.044
nf1aneurofibromin 1a0.041
rhagRhesus blood group-associated glycoprotein0.040
vwfvon Willebrand factor0.040
pcsk5aproprotein convertase subtilisin/kexin type 5a0.039
pcsk9proprotein convertase subtilisin/kexin type 90.038
itih2inter-alpha (globulin) inhibitor H20.036
s1pr3sphingosine-1-phosphate receptor 30.033
ldb1aLIM-domain binding factor 1a0.033
pcsk1proprotein convertase subtilisin/kexin type 10.033
sepp1bselenoprotein P, plasma, 1b0.032
nrg1neuregulin 10.029
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.029
ctsbacathepsin B, a0.029
pcsk7proprotein convertase subtilisin/kexin type 70.029
pcsk2proprotein convertase subtilisin/kexin type 20.029
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.028
ripk2receptor-interacting serine-threonine kinase 20.026
mcl1bmyeloid cell leukemia sequence 1b0.025
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.025
nrg2aneuregulin 2a0.024
tp53bp2tumor protein p53 binding protein, 20.022
zbtb4zinc finger and BTB domain containing 40.022
mbtps1membrane-bound transcription factor protease, site 10.022
insrbinsulin receptor b0.022
baxabcl2-associated X protein, a0.021
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.021
angptl2angiopoietin-like 20.021
bidaBH3 interacting domain death agonist0.020
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.020
per2period homolog 2 (Drosophila)0.019
LOC566708FL cytokine receptor-like0.019
wnt9bwingless-type MMTV integration site family, member 9B0.019
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.018
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.018
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.018
oc90otoconin 900.018
hgfbhepatocyte growth factor b0.018
LOC567131calcitonin gene-related peptide type 1 receptor-like0.018
sfrp1bsecreted frizzled-related protein 1b0.017
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.017
notum3notum 30.017
lcp1lymphocyte cytosolic plastin 10.017
trim13tripartite motif-containing 130.017
rspo1R-spondin homolog (Xenopus laevis)0.016
slc4a2asolute carrier family 4, anion exchanger, member 2a0.016
trpv6transient receptor potential cation channel, subfamily V, member 60.016
snap25asynaptosome-associated protein 25a0.016
hoxc13bhomeo box C13b0.016
pklrpyruvate kinase, liver and RBC0.015
mipamajor intrinsic protein of lens fiber a0.015
adipor1badiponectin receptor 1b0.014
nr5a1bnuclear receptor subfamily 5, group A, member 1b0.014
lhbluteinizing hormone, beta polypeptide0.014
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.014
igfbp1binsulin-like growth factor binding protein 1b0.014
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.014
cyp17a1cytochrome P450, family 17, subfamily A, polypeptide 10.014
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.014
inhbaainhibin, beta Aa0.014
usp5ubiquitin specific protease 50.014
rnasel1ribonuclease like 10.013
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.013
chmp5chromatin modifying protein 50.013
mcl1amyeloid cell leukemia sequence 1a0.013
ncoa2nuclear receptor coactivator 20.013
aqp12aquaporin 120.013
ghragrowth hormone receptor a0.013
ptgs1prostaglandin-endoperoxide synthase 10.013
numblnumb homolog (Drosophila)-like0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Akt1CG4006 gene product from transcript CG4006-RA0.263
Rac2CG8556 gene product from transcript CG8556-RA0.076
Hsp23Heat shock protein 230.037
CtBPC-terminal Binding Protein0.032
par-1CG8201 gene product from transcript CG8201-RA0.031
msopamale-specific opa containing gene0.030
kirrekin of irre0.029
inaDinactivation no afterpotential D0.024
Hsp68Heat shock protein 680.024
trptransient receptor potential0.020
Pi3K92ECG4141 gene product from transcript CG4141-RB0.020
Hsp27Heat shock protein 270.020
CG12766CG12766 gene product from transcript CG12766-RA0.019
norpAno receptor potential A0.017
foxoforkhead box, sub-group O0.017
dallydivision abnormally delayed0.017
Tbp-1Tat-binding protein-10.015
CG18284CG18284 gene product from transcript CG18284-RB0.015
CG3563CG3563 gene product from transcript CG3563-RA0.015
CG9572CG9572 gene product from transcript CG9572-RA0.015
ninaCneither inactivation nor afterpotential C0.014
Arr2Arrestin 20.014
RalaRas-related protein0.014
skpACG16983 gene product from transcript CG16983-RD0.013
GripGlutamate receptor binding protein0.013
granny-smithgranny smith0.012
Mst57DcMale-specific RNA 57Dc0.012
lunaCG33473 gene product from transcript CG33473-RB0.012
Hsp26Heat shock protein 260.012
Aplip1APP-like protein interacting protein 10.011
rdgCretinal degeneration C0.011
Rh3Rhodopsin 30.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
BCL2B-cell CLL/lymphoma 20.992
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.990
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.981
XIAPX-linked inhibitor of apoptosis0.961
CASP8caspase 8, apoptosis-related cysteine peptidase0.960
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.936
SH3RF1SH3 domain containing ring finger 10.912
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.909
CTSBcathepsin B0.908
PLAURplasminogen activator, urokinase receptor0.901
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.897
SMN1survival of motor neuron 1, telomeric0.887
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.864
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.844
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.839
HCKhemopoietic cell kinase0.786
UBQLN1ubiquilin 10.756
APPamyloid beta (A4) precursor protein0.744
MAPK14mitogen-activated protein kinase 140.741
FYNFYN oncogene related to SRC, FGR, YES0.728
PLATplasminogen activator, tissue0.708
RAD23BRAD23 homolog B (S. cerevisiae)0.677
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.665
MMP14matrix metallopeptidase 14 (membrane-inserted)0.663
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.657
BADBCL2-associated agonist of cell death0.649
MAP3K3mitogen-activated protein kinase kinase kinase 30.639
GSK3Bglycogen synthase kinase 3 beta0.623
FASFas (TNF receptor superfamily, member 6)0.621
MAPTmicrotubule-associated protein tau0.608
BCL2L1BCL2-like 10.575
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.573
CFLARCASP8 and FADD-like apoptosis regulator0.556
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.551
ANXA1annexin A10.519
RGS2regulator of G-protein signaling 2, 24kDa0.518
PLAUplasminogen activator, urokinase0.515
DUSP1dual specificity phosphatase 10.499
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.499
S100A10S100 calcium binding protein A100.488
SOD1superoxide dismutase 1, soluble0.474
SPRR2Asmall proline-rich protein 2A0.456
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.455
UBCubiquitin C0.445
NOXA1NADPH oxidase activator 10.443
RB1retinoblastoma 10.433
KLF4Kruppel-like factor 4 (gut)0.423
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.406
RIPK2receptor-interacting serine-threonine kinase 20.401
ANXA7annexin A70.397
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.394
CASP10caspase 10, apoptosis-related cysteine peptidase0.388
PSEN1presenilin 10.382
CASP3caspase 3, apoptosis-related cysteine peptidase0.376
MAPK1mitogen-activated protein kinase 10.373
GBP2guanylate binding protein 2, interferon-inducible0.361
TK1thymidine kinase 1, soluble0.359
IQGAP1IQ motif containing GTPase activating protein 10.358
KPNA1karyopherin alpha 1 (importin alpha 5)0.349
FADDFas (TNFRSF6)-associated via death domain0.336
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.327
CCND1cyclin D10.317
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.309
BIRC2baculoviral IAP repeat containing 20.295
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.287
IFITM3interferon induced transmembrane protein 3 (1-8U)0.279
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.277
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.272
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.267
FN1fibronectin 10.266
KAT2BK(lysine) acetyltransferase 2B0.260
CCND3cyclin D30.251
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.243
IL13RA1interleukin 13 receptor, alpha 10.241
SRFserum response factor (c-fos serum response element-binding transcription factor)0.236
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.234
RHOAras homolog gene family, member A0.233
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.230
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.230
SAT1spermidine/spermine N1-acetyltransferase 10.230
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.229
MEOX1mesenchyme homeobox 10.229
APOEapolipoprotein E0.228
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.214
APCadenomatous polyposis coli0.212
NRP1neuropilin 10.208
TGFBItransforming growth factor, beta-induced, 68kDa0.204
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.204
ATXN3ataxin 30.192
ANXA2annexin A20.190
LY6Elymphocyte antigen 6 complex, locus E0.189
CASP9caspase 9, apoptosis-related cysteine peptidase0.183
AXLAXL receptor tyrosine kinase0.180
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.179
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.178
BIDBH3 interacting domain death agonist0.174
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mndalmyeloid nuclear differentiation antigen like0.604
Shhsonic hedgehog0.589
Otx2orthodenticle homolog 2 (Drosophila)0.541
Fggfibrinogen gamma chain0.454
Hspa1aheat shock protein 1A0.423
S100a6S100 calcium binding protein A6 (calcyclin)0.415
Drd2dopamine receptor D20.382
Fgfr2fibroblast growth factor receptor 20.357
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.352
Arrb1arrestin, beta 10.348
Mndamyeloid cell nuclear differentiation antigen0.322
Chd7chromodomain helicase DNA binding protein 70.321
Anxa1annexin A10.303
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.298
Pax2paired box gene 20.287
AxlAXL receptor tyrosine kinase0.277
Dkk1dickkopf homolog 1 (Xenopus laevis)0.258
Tlr4toll-like receptor 40.248
Fgfr1fibroblast growth factor receptor 10.244
Apoa1apolipoprotein A-I0.238
Arrb2arrestin, beta 20.213
Fgafibrinogen alpha chain0.211
Prnpprion protein0.206
Tnfaip3tumor necrosis factor, alpha-induced protein 30.202
Osmroncostatin M receptor0.202
Emx2empty spiracles homolog 2 (Drosophila)0.197
Fgbfibrinogen beta chain0.189
Ptgs2prostaglandin-endoperoxide synthase 20.186
Krt14keratin 140.183
Prkceprotein kinase C, epsilon0.175
Egfrepidermal growth factor receptor0.172
Lhx1LIM homeobox protein 10.172
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.170
Rargretinoic acid receptor, gamma0.169
Lgals3lectin, galactose binding, soluble 30.163
Fgf8fibroblast growth factor 80.162
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.160
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.159
Emx1empty spiracles homolog 1 (Drosophila)0.158
Wnt4wingless-related MMTV integration site 40.158
Ifi203interferon activated gene 2030.155
Nbl1neuroblastoma, suppression of tumorigenicity 10.152
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.150
Trp63transformation related protein 630.141
Lyz2lysozyme 20.140
Bcl2B-cell leukemia/lymphoma 20.135
Apoeapolipoprotein E0.131
Ece1endothelin converting enzyme 10.127
Krt13keratin 130.124
Rararetinoic acid receptor, alpha0.119
Apomapolipoprotein M0.116
AI607873expressed sequence AI6078730.115
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.113
Muc5acmucin 5, subtypes A and C, tracheobronchial/gastric0.111
Rxraretinoid X receptor alpha0.110
Gli3GLI-Kruppel family member GLI30.109
Pax3paired box gene 30.102
Anxa3annexin A30.101
Pax8paired box gene 80.099
Itih4inter alpha-trypsin inhibitor, heavy chain 40.098
S100a11S100 calcium binding protein A11 (calgizzarin)0.098
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.097
Cdkn1bcyclin-dependent kinase inhibitor 1B0.097
FasFas (TNF receptor superfamily member 6)0.096
Wnt3awingless-related MMTV integration site 3A0.095
Ambpalpha 1 microglobulin/bikunin0.093
Serpina3mserine (or cysteine) peptidase inhibitor, clade A, member 3M0.090
Hmx3H6 homeobox 30.089
Krtdapkeratinocyte differentiation associated protein0.089
Ednraendothelin receptor type A0.088
Ctgfconnective tissue growth factor0.088
Gcgroup specific component0.084
Tcf7transcription factor 7, T-cell specific0.083
Retret proto-oncogene0.083
C9complement component 90.082
S100a10S100 calcium binding protein A10 (calpactin)0.081
TcraT-cell receptor alpha chain0.081
Dusp1dual specificity phosphatase 10.079
Pthlhparathyroid hormone-like peptide0.079
F2coagulation factor II0.078
Tcf21transcription factor 210.078
Klf4Kruppel-like factor 4 (gut)0.078
Anxa2annexin A20.076
Cficomplement component factor i0.076
Akr1c6aldo-keto reductase family 1, member C60.075
Gata3GATA binding protein 30.075
Foxc1forkhead box C10.074
F12coagulation factor XII (Hageman factor)0.073
Hoxd11homeobox D110.072
Tbx1T-box 10.071
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr1early growth response 10.203
Fggfibrinogen gamma chain0.162
Cd9CD9 molecule0.141
Procprotein C0.122
Taok1TAO kinase 10.096
Atf3activating transcription factor 30.092
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.088
Jak1Janus kinase 10.085
Nr4a3nuclear receptor subfamily 4, group A, member 30.085
Gcgroup specific component0.083
A1i3alpha-1-inhibitor III0.083
Gja1gap junction protein, alpha 10.083
Apohapolipoprotein H (beta-2-glycoprotein I)0.080
Dusp1dual specificity phosphatase 10.072
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.072
FosFBJ osteosarcoma oncogene0.068
Apoa2apolipoprotein A-II0.066
Azgp1alpha-2-glycoprotein 1, zinc-binding0.063
Timp2TIMP metallopeptidase inhibitor 20.062
Fgfr1Fibroblast growth factor receptor 10.060
Itih4inter alpha-trypsin inhibitor, heavy chain 40.059
Cpb2carboxypeptidase B2 (plasma)0.058
C9complement component 90.057
F2coagulation factor II (thrombin)0.056
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.056
Spp2secreted phosphoprotein 20.055
Lgals3lectin, galactoside-binding, soluble, 30.054
Apoa5apolipoprotein A-V0.053
Ifitm3interferon induced transmembrane protein 30.052
Fabp1fatty acid binding protein 1, liver0.050
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.050
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.047
Spink1serine peptidase inhibitor, Kazal type 10.041
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.040
Btg2BTG family, member 20.039
LOC299282Serine protease inhibitor0.038
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.038
Tdo2tryptophan 2,3-dioxygenase0.038
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.037
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.037
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.036
Aqp9aquaporin 90.036
LOC293989cytochrome P450-like0.036
C1rcomplement component 1, r subcomponent0.035
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.034
Orm1orosomucoid 10.033
Cd63Cd63 molecule0.033
Ptgs2prostaglandin-endoperoxide synthase 20.033
Junbjun B proto-oncogene0.033
Kng2kininogen 20.032
C1scomplement component 1, s subcomponent0.032
Pzppregnancy-zone protein0.031
Fgafibrinogen alpha chain0.031
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.031
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.031
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.031
Tcf12transcription factor 120.030
Agtr1aangiotensin II receptor, type 1a0.030
Gnrhrgonadotropin releasing hormone receptor0.029
Ccnd3cyclin D30.029
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.028
Chatcholine acetyltransferase0.028
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.028
Hsph1heat shock 105/110 protein 10.028
Fxyd4FXYD domain-containing ion transport regulator 40.027
Hspb1heat shock protein 10.027
Myo1bmyosin Ib0.026
Pea15aphosphoprotein enriched in astrocytes 15A0.026
Mapk3mitogen activated protein kinase 30.026
Cficomplement factor I0.026
Fn1fibronectin 10.026
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.026
Errfi1ERBB receptor feedback inhibitor 10.026
Ccl2chemokine (C-C motif) ligand 20.025
Csnk1g3casein kinase 1, gamma 30.025
JunJun oncogene0.025
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.025
C4bpbcomplement component 4 binding protein, beta0.025
Egr4early growth response 40.024
Apobapolipoprotein B0.024
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.024
C1qccomplement component 1, q subcomponent, C chain0.024
Jak2Janus kinase 20.024
Ptch1patched homolog 1 (Drosophila)0.024
Apoeapolipoprotein E0.023
Gna12guanine nucleotide binding protein (G protein) alpha 120.023
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.023
Ptprsprotein tyrosine phosphatase, receptor type, S0.023
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.023
Ubtfupstream binding transcription factor, RNA polymerase I0.023
Lbplipopolysaccharide binding protein0.023
Arpc1bactin related protein 2/3 complex, subunit 1B0.023
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism