The network for 'negative regulation of jnk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of jnk cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.

NameDescriptionProbabilityFunc Analog Organism
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.083
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.075
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.060
cdc42cell division cycle 420.055
epha4aeph receptor A4a0.046
mapk3mitogen-activated protein kinase 30.044
wnt4awingless-type MMTV integration site family, member 4a0.042
dusp6dual specificity phosphatase 60.035
fgf3fibroblast growth factor 30.034
faf2Fas associated factor family member 20.034
ntn1bnetrin 1b0.030
spry4sprouty (Drosophila) homolog 40.029
wnt4bwingless-type MMTV integration site family, member 4b0.028
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.028
mapk1mitogen-activated protein kinase 10.025
rab22aRAB22A, member RAS oncogene family0.025
col5a2lcollagen, type V, alpha 2-like0.025
ldb3aLIM-domain binding factor 3a0.025
kal1bKallmann syndrome 1b sequence0.024
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.023
npepl1aminopeptidase-like 10.023
sfrp1asecreted frizzled-related protein 1a0.022
gyltl1bglycosyltransferase-like 1b0.022
phf23aPHD finger protein 23a0.022
mll4bmyeloid/lymphoid or mixed-lineage leukemia 4b0.022
ahsa1lAHA1, activator of heat shock protein ATPase homolog 1, like0.022
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.022
trim55atripartite motif-containing 55a0.021
gdf11growth differentiation factor 110.021
brd4bromodomain containing 40.020
porP450 (cytochrome) oxidoreductase0.019
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.019
oprd1bopioid receptor, delta 1b0.019
grem1agremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)0.019
rspo3R-spondin 3 homolog (Xenopus laevis)0.018
brd2bbromodomain containing 2b0.018
mesp2mesoderm posterior 2 homolog (mouse)0.018
tmem38atransmembrane protein 38A0.018
cav3caveolin 30.017
ppp6r3protein phosphatase 6, regulatory subunit 30.017
her15.1hairy and enhancer of split-related 15.10.016
pias4aprotein inhibitor of activated STAT, 4a0.016
fcho2FCH domain only 20.016
emx1empty spiracles homeobox 10.016
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.016
osr2odd-skipped related 2 (Drosophila)0.015
k23k23 gene0.015
zbtb4zinc finger and BTB domain containing 40.015
brd2abromodomain-containing 2a0.015
pacsin3protein kinase C and casein kinase substrate in neurons 30.015
dkk1bdickkopf 1b0.015
rykreceptor-like tyrosine kinase0.015
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.015
otud7bOTU domain containing 7B0.015
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.015
mapk14bmitogen-activated protein kinase 14b0.014
fgfr2fibroblast growth factor receptor 20.014
ppm1baprotein phosphatase, Mg2+/Mn2+ dependent, 1Ba0.014
ntn2netrin 20.014
b4galt5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 50.014
cdh6cadherin 60.014
ilkintegrin linked kinase0.014
oprd1aopioid receptor, delta 1a0.014
ip6k2inositol hexaphosphate kinase 20.013
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.013
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.013
fzd8afrizzled homolog 8a0.013
fzd5frizzled homolog 50.013
phf17PHD finger protein 170.013
irf2bp1interferon regulatory factor 2 binding protein 10.013
trim13tripartite motif-containing 130.013
lmnl3lamin L30.013
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.013
ergic2ERGIC and golgi 20.012
gng7guanine nucleotide binding protein (G protein), gamma 70.012
usp4ubiquitin specific protease 4 (proto-oncogene)0.012
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.012
six2asine oculis-related homeobox 2a0.012
bbs4Bardet-Biedl syndrome 40.012
gpibglucose phosphate isomerase b0.012
pgdphosphogluconate hydrogenase0.012
piguphosphatidylinositol glycan anchor biosynthesis, class U0.012
abl1c-abl oncogene 1, non-receptor tyrosine kinase0.012
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.012
cyb5r3cytochrome b5 reductase 30.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ZNF43zinc finger protein 430.990
MAP2K4mitogen-activated protein kinase kinase 40.948
MAPK8mitogen-activated protein kinase 80.904
ZNF253zinc finger protein 2530.859
ZNF273zinc finger protein 2730.832
GSK3Bglycogen synthase kinase 3 beta0.684
MAPK14mitogen-activated protein kinase 140.675
CALM1calmodulin 1 (phosphorylase kinase, delta)0.655
ZNF675zinc finger protein 6750.651
MAPK1mitogen-activated protein kinase 10.559
NCOR1nuclear receptor corepressor 10.458
MAP3K7mitogen-activated protein kinase kinase kinase 70.423
ZNF746zinc finger protein 7460.356
ILKintegrin-linked kinase0.315
MAP2K7mitogen-activated protein kinase kinase 70.293
CHUKconserved helix-loop-helix ubiquitous kinase0.275
ZNF430zinc finger protein 4300.252
ZNF91zinc finger protein 910.231
PPARAperoxisome proliferator-activated receptor alpha0.184
ZNF708zinc finger protein 7080.183
ZNF93zinc finger protein 930.180
ZNF117zinc finger protein 1170.173
AXIN1axin 10.170
ARRB2arrestin, beta 20.166
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.166
ZNF680zinc finger protein 6800.156
CSNK1Ecasein kinase 1, epsilon0.140
ZNF85zinc finger protein 850.139
ATF2activating transcription factor 20.135
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.117
ZNF254zinc finger protein 2540.117
SMAD2SMAD family member 20.114
CREBBPCREB binding protein0.114
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.097
CUL1cullin 10.090
JUNjun proto-oncogene0.084
AKT1v-akt murine thymoma viral oncogene homolog 10.074
CREB1cAMP responsive element binding protein 10.072
RALBP1ralA binding protein 10.072
WWOXWW domain containing oxidoreductase0.069
ZNF107zinc finger protein 1070.069
TOX4TOX high mobility group box family member 40.067
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.066
ARRB1arrestin, beta 10.057
HDAC3histone deacetylase 30.057
MAPK3mitogen-activated protein kinase 30.054
DUSP1dual specificity phosphatase 10.054
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.053
MAP3K1mitogen-activated protein kinase kinase kinase 10.051
RANBP3RAN binding protein 30.048
L3MBTL2l(3)mbt-like 2 (Drosophila)0.045
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.045
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.043
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme0.042
HSPA8heat shock 70kDa protein 80.041
ZNF92zinc finger protein 920.041
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.035
APCadenomatous polyposis coli0.034
MAPK9mitogen-activated protein kinase 90.032
RAB10RAB10, member RAS oncogene family0.031
CAV1caveolin 1, caveolae protein, 22kDa0.031
NCK2NCK adaptor protein 20.030
LIMD1LIM domains containing 10.030
ANXA7annexin A70.030
MAGEA2melanoma antigen family A, 20.027
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.027
ATF3activating transcription factor 30.026
TRAF5TNF receptor-associated factor 50.026
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.026
PKM2pyruvate kinase, muscle0.025
ZNF682zinc finger protein 6820.025
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.023
FBXW11F-box and WD repeat domain containing 110.023
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.022
CLIP1CAP-GLY domain containing linker protein 10.022
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.022
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.021
CHD3chromodomain helicase DNA binding protein 30.021
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.021
ZCCHC17zinc finger, CCHC domain containing 170.021
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.020
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.020
MAP2K3mitogen-activated protein kinase kinase 30.020
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.020
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.019
SIRT1sirtuin 10.018
SGK3serum/glucocorticoid regulated kinase family, member 30.017
SUGT1SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)0.017
MSH5mutS homolog 5 (E. coli)0.017
ZNF320zinc finger protein 3200.017
BTRCbeta-transducin repeat containing0.016
ATXN3ataxin 30.016
NCOR2nuclear receptor corepressor 20.016
PEA15phosphoprotein enriched in astrocytes 150.015
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.015
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.015
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.015
MDFIMyoD family inhibitor0.015
MTMR4myotubularin related protein 40.015
RAB21RAB21, member RAS oncogene family0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mdm2transformed mouse 3T3 cell double minute 20.707
Ptenphosphatase and tensin homolog0.432
Ctnnb1catenin (cadherin associated protein), beta 10.418
Per2period homolog 2 (Drosophila)0.352
Axin1axin 10.128
FosFBJ osteosarcoma oncogene0.119
Apcadenomatosis polyposis coli0.083
Ilkintegrin linked kinase0.071
Mapk14mitogen-activated protein kinase 140.069
Trp53transformation related protein 530.058
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.050
Sfrp2secreted frizzled-related protein 20.037
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.037
Rac1RAS-related C3 botulinum substrate 10.037
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.032
Sfrp1secreted frizzled-related protein 10.032
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.029
Ccnd1cyclin D10.027
Hspa8heat shock protein 80.023
JunJun oncogene0.019
Vangl2vang-like 2 (van gogh, Drosophila)0.019
Trp63transformation related protein 630.019
Rnf11ring finger protein 110.018
Mapk1mitogen-activated protein kinase 10.018
Dvl2dishevelled 2, dsh homolog (Drosophila)0.018
Cyldcylindromatosis (turban tumor syndrome)0.017
Klc1kinesin light chain 10.017
Atf2activating transcription factor 20.016
Smad6MAD homolog 6 (Drosophila)0.013
Ncoa1nuclear receptor coactivator 10.013
Smad7MAD homolog 7 (Drosophila)0.013
Tpm4tropomyosin 40.012
Dact3dapper homolog 3, antagonist of beta-catenin (xenopus)0.012
Rab10RAB10, member RAS oncogene family0.012
Cdkn1bcyclin-dependent kinase inhibitor 1B0.012
Arid1bAT rich interactive domain 1B (SWI-like)0.012
Trp73transformation related protein 730.012
Gsta4glutathione S-transferase, alpha 40.011
Rb1retinoblastoma 10.011
Csnk1ecasein kinase 1, epsilon0.010
Traf6TNF receptor-associated factor 60.010
Smad3MAD homolog 3 (Drosophila)0.010
Prdx6peroxiredoxin 60.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsph1heat shock 105/110 protein 10.036
Rab1bRAB1B, member RAS oncogene family0.031
Fgfr1Fibroblast growth factor receptor 10.030
Syt4synaptotagmin IV0.028
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.025
Ccnd3cyclin D30.023
Zfp91zinc finger protein 910.022
Gsrglutathione reductase0.022
Idsiduronate 2-sulfatase0.021
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.020
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.020
Serinc1serine incorporator 10.020
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.020
Eef2eukaryotic translation elongation factor 20.019
St13suppression of tumorigenicity 130.018
Epn1Epsin 10.018
Ptp4a2protein tyrosine phosphatase 4a20.018
Tspyl1TSPY-like 10.018
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.017
Usf2upstream transcription factor 2, c-fos interacting0.017
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.017
Map2microtubule-associated protein 20.016
Cltcclathrin, heavy chain (Hc)0.016
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.016
Cpxm2carboxypeptidase X (M14 family), member 20.016
Gna12guanine nucleotide binding protein (G protein) alpha 120.016
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.015
SnrkSNF related kinase0.015
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.015
Ccdc92coiled-coil domain containing 920.015
Sox4SRY (sex determining region Y)-box 40.015
Eif2c2eukaryotic translation initiation factor 2C, 20.014
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.014
Csnk1g2casein kinase 1, gamma 20.014
Tsc22d3TSC22 domain family, member 30.014
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.014
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.014
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.014
Ppardperoxisome proliferator-activated receptor delta0.014
Pim3pim-3 oncogene0.013
Hist1h1ahistone cluster 1, H1a0.013
Ptp4a1protein tyrosine phosphatase type IVA, member 10.013
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.013
Slc30a4solute carrier family 30 (zinc transporter), member 40.013
Klf9Kruppel-like factor 90.013
Trappc6btrafficking protein particle complex 6B0.013
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.013
Gria2glutamate receptor, ionotropic, AMPA 20.013
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.013
Sncasynuclein, alpha (non A4 component of amyloid precursor)0.012
JunJun oncogene0.012
Homer1homer homolog 1 (Drosophila)0.012
Vdac1voltage-dependent anion channel 10.012
Lrpap1low density lipoprotein receptor-related protein associated protein 10.012
Arl5aADP-ribosylation factor-like 5A0.012
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.012
Gprc5aG protein-coupled receptor, family C, group 5, member A0.011
Cyfip2cytoplasmic FMR1 interacting protein 20.011
Mapk3mitogen activated protein kinase 30.011
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.011
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.011
Gatad1GATA zinc finger domain containing 10.011
Acvr1activin A receptor, type I0.011
Itpr1inositol 1,4,5-triphosphate receptor, type 10.011
Mxd4Max dimerization protein 40.011
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.011
Mapre3microtubule-associated protein, RP/EB family, member 30.011
Ubl3ubiquitin-like 30.011
Cx3cl1chemokine (C-X3-C motif) ligand 10.011
Phka1phosphorylase kinase, alpha 10.010
Cd83CD83 molecule0.010
DbpD site of albumin promoter (albumin D-box) binding protein0.010
Sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.010
Nr1d2nuclear receptor subfamily 1, group D, member 20.010
Per2period homolog 2 (Drosophila)0.010
Pgrprogesterone receptor0.010
Syngr2synaptogyrin 20.010
Cntlncentlein, centrosomal protein0.010
Gstm1glutathione S-transferase mu 10.010
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.010
Akt1s1AKT1 substrate 1 (proline-rich)0.010
Oaz2ornithine decarboxylase antizyme 20.010
Uso1USO1 homolog, vesicle docking protein (yeast)0.010
Akap1A kinase (PRKA) anchor protein 10.010
Ckmt1creatine kinase, mitochondrial 10.010
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.010
Wdr73WD repeat domain 730.010
Bace1beta-site APP cleaving enzyme 10.010
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.010
Lrfn4leucine rich repeat and fibronectin type III domain containing 40.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism