The network for 'negative regulation of protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

NameDescriptionProbabilityFunc Analog Organism
lef1lymphocyte enhancer binding factor 10.318
nf1aneurofibromin 1a0.311
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.171
tcf7transcription factor 7 (T-cell specific, HMG-box)0.166
cdc20cell division cycle 20 homolog0.131
igf1rbinsulin-like growth factor 1b receptor0.110
plk1polo-like kinase 1 (Drosophila)0.107
ptgs1prostaglandin-endoperoxide synthase 10.106
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.106
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.097
insrbinsulin receptor b0.096
trpv4transient receptor potential cation channel, subfamily V, member 40.094
mapk3mitogen-activated protein kinase 30.093
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.088
acvr1bactivin A receptor, type IB0.088
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.079
cdh1cadherin 1, epithelial0.075
kpna2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.071
capns1acalpain, small subunit 1 a0.069
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.068
nrg1neuregulin 10.068
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.068
thraathyroid hormone receptor alpha a0.066
ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.064
flhfloating head0.063
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.061
tp53bp2tumor protein p53 binding protein, 20.058
extl3exostoses (multiple)-like 30.057
gdf6agrowth differentiation factor 6a0.056
warstryptophanyl-tRNA synthetase0.056
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.053
akt2v-akt murine thymoma viral oncogene homolog 20.052
ptgesprostaglandin E synthase0.051
nf1bneurofibromin 1b0.051
wlswntless homolog (Drosophila)0.050
mcl1amyeloid cell leukemia sequence 1a0.049
ptpraprotein tyrosine phosphatase, receptor type, A0.048
fbn2bfibrillin 2b0.048
rnf128aring finger protein 128a0.046
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.046
cyp51cytochrome P450, family 510.046
ppp2r5dprotein phosphatase 2, regulatory subunit B', delta0.046
furinbfurin (paired basic amino acid cleaving enzyme) b0.044
pppde1PPPDE peptidase domain containing 10.043
ccr6achemokine (C-C motif) receptor 6a0.042
scn1labsodium channel, voltage-gated, type I like, alpha b0.041
mapk6mitogen-activated protein kinase 60.041
pld1aphospholipase D1a0.041
clk4aCDC-like kinase 4a0.040
nuf2NUF2, NDC80 kinetochore complex component, homolog0.040
rargaretinoic acid receptor gamma a0.039
birc5abaculoviral IAP repeat-containing 5a0.038
tmem161btransmembrane protein 161B0.038
jag2jagged 20.038
ntn2netrin 20.037
gro2groucho 20.037
mcl1bmyeloid cell leukemia sequence 1b0.037
lppLIM domain containing preferred translocation partner in lipoma0.036
klhl11kelch-like 11 (Drosophila)0.036
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.035
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.035
uspl1ubiquitin specific peptidase like 10.034
lsm1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.034
zbtb4zinc finger and BTB domain containing 40.033
vgll4lvestigial like 4 like0.033
ankrd13cankyrin repeat domain 13C0.033
bmpr1abbone morphogenetic protein receptor, type 1ab0.032
col7a1lcollagen type VII alpha 1-like0.032
ptpn11bprotein tyrosine phosphatase, non-receptor type 11, b0.032
grem1agremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)0.031
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.031
litaflipopolysaccharide-induced TNF factor0.031
tk2thymidine kinase 2, mitochondrial0.030
ip6k2inositol hexaphosphate kinase 20.030
trpm7transient receptor potential cation channel, subfamily M, member 70.030
mapk12mitogen-activated protein kinase 120.029
anxa13annexin A130.029
ptk2.1protein tyrosine kinase 2a0.029
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.029
pdcd6ipprogrammed cell death 6 interacting protein0.029
LOC793701growth arrest-specific protein 7-like0.029
sec24cSEC24 family, member C (S. cerevisiae)0.029
cishcytokine inducible SH2-containing protein0.029
cyp1acytochrome P450, family 1, subfamily A0.028
mkln1muskelin 1, intracellular mediator containing kelch motifs0.028
mycbp2MYC binding protein 20.028
smc4structural maintenance of chromosomes 40.028
atp2b4ATPase, Ca++ transporting, plasma membrane 40.028
gins2GINS complex subunit 20.028
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.028
aplnraapelin receptor a0.028
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.022
Akt1CG4006 gene product from transcript CG4006-RA0.015
l(2)gllethal (2) giant larvae0.013
mubmushroom-body expressed0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.942
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.907
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.848
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.730
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.613
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.600
GSK3Bglycogen synthase kinase 3 beta0.547
BTRCbeta-transducin repeat containing0.451
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.451
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.394
FASFas (TNF receptor superfamily, member 6)0.348
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.333
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.275
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.268
FBXW11F-box and WD repeat domain containing 110.229
CHUKconserved helix-loop-helix ubiquitous kinase0.227
FADDFas (TNFRSF6)-associated via death domain0.196
AXIN1axin 10.176
DTX3Ldeltex 3-like (Drosophila)0.142
CASP8caspase 8, apoptosis-related cysteine peptidase0.140
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.130
SKP1S-phase kinase-associated protein 10.123
MAP3K8mitogen-activated protein kinase kinase kinase 80.111
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.108
MDM2Mdm2 p53 binding protein homolog (mouse)0.105
CREBBPCREB binding protein0.103
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.102
PKD2polycystic kidney disease 2 (autosomal dominant)0.100
PARP14poly (ADP-ribose) polymerase family, member 140.089
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.087
PMLpromyelocytic leukemia0.081
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.078
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.077
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.076
HIPK3homeodomain interacting protein kinase 30.074
CFLARCASP8 and FADD-like apoptosis regulator0.070
PKD1polycystic kidney disease 1 (autosomal dominant)0.062
CUL1cullin 10.061
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.060
ERBB2IPerbb2 interacting protein0.060
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.056
IGF1Rinsulin-like growth factor 1 receptor0.054
PARP9poly (ADP-ribose) polymerase family, member 90.050
PROX1prospero homeobox 10.048
MAP2K5mitogen-activated protein kinase kinase 50.047
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.047
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.044
RARAretinoic acid receptor, alpha0.044
MAP3K3mitogen-activated protein kinase kinase kinase 30.042
CKAP5cytoskeleton associated protein 50.041
AXLAXL receptor tyrosine kinase0.040
TEKTEK tyrosine kinase, endothelial0.040
RANBP3RAN binding protein 30.037
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.036
MAPK3mitogen-activated protein kinase 30.036
CASP10caspase 10, apoptosis-related cysteine peptidase0.035
STRN3striatin, calmodulin binding protein 30.034
TCF4transcription factor 40.031
BCL3B-cell CLL/lymphoma 30.031
IRS1insulin receptor substrate 10.030
RCN3reticulocalbin 3, EF-hand calcium binding domain0.030
CALD1caldesmon 10.030
GLIS2GLIS family zinc finger 20.030
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)0.029
DYRK4dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 40.029
RPTORregulatory associated protein of MTOR, complex 10.028
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.027
DDAH2dimethylarginine dimethylaminohydrolase 20.027
SNAI1snail homolog 1 (Drosophila)0.026
YAP1Yes-associated protein 10.025
IRS2insulin receptor substrate 20.025
DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 20.024
PRKCZprotein kinase C, zeta0.024
LMO4LIM domain only 40.024
SOCS1suppressor of cytokine signaling 10.023
INSRinsulin receptor0.022
C3orf15chromosome 3 open reading frame 150.022
BBS10Bardet-Biedl syndrome 100.022
ZNF260zinc finger protein 2600.021
GLI1GLI family zinc finger 10.020
PSEN2presenilin 2 (Alzheimer disease 4)0.020
JUBjub, ajuba homolog (Xenopus laevis)0.020
ZNF84zinc finger protein 840.020
GRB10growth factor receptor-bound protein 100.020
MAPK14mitogen-activated protein kinase 140.020
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.020
C19orf46chromosome 19 open reading frame 460.020
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.019
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.019
PEX26peroxisomal biogenesis factor 260.019
TJP2tight junction protein 2 (zona occludens 2)0.019
APCadenomatous polyposis coli0.018
AMOTL1angiomotin like 10.018
SETD7SET domain containing (lysine methyltransferase) 70.018
AMOTL2angiomotin like 20.018
PRKCAprotein kinase C, alpha0.018
LZTS2leucine zipper, putative tumor suppressor 20.018
SMAD3SMAD family member 30.018
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.957
Trp53transformation related protein 530.953
Ptenphosphatase and tensin homolog0.716
Apcadenomatosis polyposis coli0.684
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.627
Gli3GLI-Kruppel family member GLI30.448
Fgfr2fibroblast growth factor receptor 20.382
Trp63transformation related protein 630.381
Casp4caspase 4, apoptosis-related cysteine peptidase0.352
Grb10growth factor receptor bound protein 100.286
Rararetinoic acid receptor, alpha0.280
Fgfr1fibroblast growth factor receptor 10.272
Casp1caspase 10.270
Gopcgolgi associated PDZ and coiled-coil motif containing0.253
Smad3MAD homolog 3 (Drosophila)0.152
Yap1yes-associated protein 10.147
Pbx1pre B-cell leukemia transcription factor 10.127
Bcl2B-cell leukemia/lymphoma 20.124
Iigp1interferon inducible GTPase 10.121
PycardPYD and CARD domain containing0.108
Gli2GLI-Kruppel family member GLI20.100
Aim2absent in melanoma 20.079
Smosmoothened homolog (Drosophila)0.077
Rxraretinoid X receptor alpha0.076
Pax8paired box gene 80.064
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.054
Gbp2guanylate binding protein 20.051
Wnt5awingless-related MMTV integration site 5A0.051
Ghrgrowth hormone receptor0.050
Ifit2interferon-induced protein with tetratricopeptide repeats 20.049
Gbp3guanylate binding protein 30.049
Fzd1frizzled homolog 1 (Drosophila)0.048
Sox9SRY-box containing gene 90.046
Irgm2immunity-related GTPase family M member 20.044
Sap18Sin3-associated polypeptide 180.044
Meox2mesenchyme homeobox 20.043
Prrx1paired related homeobox 10.041
Axin1axin 10.040
Stat6signal transducer and activator of transcription 60.040
Il6stinterleukin 6 signal transducer0.039
Rnh1ribonuclease/angiogenin inhibitor 10.039
Ptk7PTK7 protein tyrosine kinase 70.039
Serpinb9serine (or cysteine) peptidase inhibitor, clade B, member 90.038
Rb1retinoblastoma 10.035
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.034
Per2period homolog 2 (Drosophila)0.034
Bmp4bone morphogenetic protein 40.034
Bmpr1abone morphogenetic protein receptor, type 1A0.034
Fzd8frizzled homolog 8 (Drosophila)0.033
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.033
Ncoa3nuclear receptor coactivator 30.033
Notch2Notch gene homolog 2 (Drosophila)0.031
Kitlkit ligand0.030
Hoxa2homeobox A20.030
F2rcoagulation factor II (thrombin) receptor0.030
Shhsonic hedgehog0.029
Dlg2discs, large homolog 2 (Drosophila)0.028
Rargretinoic acid receptor, gamma0.028
Ikbkbinhibitor of kappaB kinase beta0.027
Bicc1bicaudal C homolog 1 (Drosophila)0.027
Tefthyrotroph embryonic factor0.026
Casp12caspase 120.026
Bcl3B-cell leukemia/lymphoma 30.026
Ifi203interferon activated gene 2030.025
Rnf115ring finger protein 1150.025
Bmp5bone morphogenetic protein 50.024
Dlg4discs, large homolog 4 (Drosophila)0.024
Eya1eyes absent 1 homolog (Drosophila)0.024
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.024
Arandrogen receptor0.024
Mapkap1mitogen-activated protein kinase associated protein 10.024
Tbx3T-box 30.024
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.023
Mdm2transformed mouse 3T3 cell double minute 20.023
Phldb2pleckstrin homology-like domain, family B, member 20.023
Nr1d2nuclear receptor subfamily 1, group D, member 20.023
Dvl3dishevelled 3, dsh homolog (Drosophila)0.023
Btbd3BTB (POZ) domain containing 30.022
Ptch1patched homolog 10.022
Rptorregulatory associated protein of MTOR, complex 10.022
Gbp7guanylate binding protein 70.022
Pax2paired box gene 20.022
Leprleptin receptor0.022
Hoxb3homeobox B30.021
Gbp6guanylate binding protein 60.021
Tsc1tuberous sclerosis 10.021
Per1period homolog 1 (Drosophila)0.021
Mpdzmultiple PDZ domain protein0.020
Arntlaryl hydrocarbon receptor nuclear translocator-like0.020
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.020
Oasl22'-5' oligoadenylate synthetase-like 20.020
Per3period homolog 3 (Drosophila)0.020
Igbp1immunoglobulin (CD79A) binding protein 10.020
Zfp358zinc finger protein 3580.020
Col4a5collagen, type IV, alpha 50.020
Vhlvon Hippel-Lindau tumor suppressor0.020
Rhoqras homolog gene family, member Q0.020
Wnt9bwingless-type MMTV integration site 9B0.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RragaRas-related GTP binding A0.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism