The network for 'negative regulation of protein complex assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein complex assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.

NameDescriptionProbabilityFunc Analog Organism
lft1lefty10.780
lft2lefty20.744
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.336
ptger2aprostaglandin E receptor 2a (subtype EP2)0.326
nanos3nanos homolog 30.224
oprm1opioid receptor, mu 10.203
nkx2.5NK2 transcription factor related 50.195
hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.184
gata5GATA-binding protein 50.178
hmgb1ahigh-mobility group box 1a0.175
arpc5bactin related protein 2/3 complex, subunit 5B0.172
has2hyaluronan synthase 20.163
lonp2lon peptidase 2, peroxisomal0.158
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.156
papolbpoly(A) polymerase beta (testis specific)0.155
fzd8bfrizzled homolog 8b0.154
zgc:85727zgc:857270.150
cotl1coactosin-like 1 (Dictyostelium)0.128
capzbcapping protein (actin filament) muscle Z-line, beta0.126
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.121
tuba1ltubulin, alpha 1, like0.117
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.116
mllt11myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 110.113
csrp1acysteine and glycine-rich protein 1a0.109
rab5cRAB5C, member RAS oncogene family0.108
dmrt3adoublesex and mab-3 related transcription factor 3a0.100
dlg2discs, large (Drosophila) homolog 20.098
gng3guanine nucleotide binding protein (G protein), gamma 30.091
nr5a1bnuclear receptor subfamily 5, group A, member 1b0.088
depdc1aDEP domain containing 1a0.088
zgc:91930zgc:919300.087
wu:fb39e12wu:fb39e120.086
jak1Janus kinase 10.083
esr2bestrogen receptor 2b0.082
og9xOG9 homeobox gene0.082
prkar2aaprotein kinase, cAMP-dependent, regulatory, type II, alpha A0.080
esamaendothelial cell adhesion molecule a0.079
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.079
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.078
wu:fq41a10wu:fq41a100.078
ldb3bLIM domain binding 3b0.077
fgf17fibroblast growth factor 170.075
vasavasa homolog0.075
avpr1barginine vasopressin receptor 1B0.073
actr3ARP3 actin-related protein 3 homolog (yeast)0.073
tubb5tubulin, beta 50.071
mapk8bmitogen-activated protein kinase 8b0.070
si:dkeyp-104h9.6si:dkeyp-104h9.60.070
hn1lhematological and neurological expressed 1-like0.069
itgb1b.1integrin, beta 1b.10.068
agtr2angiotensin II receptor, type 20.068
igfbp1ainsulin-like growth factor binding protein 1a0.068
si:ch211-175f11.2si:ch211-175f11.20.067
thraathyroid hormone receptor alpha a0.066
alas2aminolevulinate, delta-, synthetase 20.065
sox17SRY-box containing gene 170.064
zgc:63587zgc:635870.064
dnddead end0.064
nt5c2l15'-nucleotidase, cytosolic II, like 10.063
rbpms2RNA binding protein with multiple splicing 20.063
ppp1r14aaprotein phosphatase 1, regulatory (inhibitor) subunit 14Aa0.063
msnamoesin a0.062
zgc:55307zgc:553070.061
picalmphosphatidylinositol binding clathrin assembly protein0.061
smoxspermine oxidase0.060
zgc:153012zgc:1530120.060
amd1adenosylmethionine decarboxylase 10.059
dusp5dual specificity phosphatase 50.059
mtpnmyotrophin0.059
prc1bprotein regulator of cytokinesis 1b0.058
hey2hairy/enhancer-of-split related with YRPW motif 20.058
si:ch211-156j22.4si:ch211-156j22.40.058
si:ch211-278b8.3si:ch211-278b8.30.058
mtormechanistic target of rapamycin (serine/threonine kinase)0.058
ptplbprotein tyrosine phosphatase-like (proline instead of catalytic arginine), member b0.057
rps6ka1ribosomal protein S6 kinase a, polypeptide 10.057
rnf17ring finger protein 170.057
mllt10myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 100.057
zgc:56010zgc:560100.057
vsg1vessel-specific 10.056
ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.055
LOC100331639hypothetical protein LOC1003316390.055
npdc1neural proliferation, differentiation and control, 10.055
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.055
zgc:123307zgc:1233070.055
s100bS100 calcium binding protein, beta (neural)0.054
srsf1bserine/arginine-rich splicing factor 1b0.053
camk2g2calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 20.053
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.053
kdm5clysine (K)-specific demethylase 5C0.053
svilsupervillin0.052
oprd1bopioid receptor, delta 1b0.052
zgc:114140zgc:1141400.052
aplnrbapelin receptor b0.052
cisd1CDGSH iron sulfur domain 10.052
ube2i2ubiquitin-conjugating enzyme E2I20.051
pth2rparathyroid hormone 2 receptor0.051
tbx20T-box 200.051
dlx2bdistal-less homeobox gene 2b0.051
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.050
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.987
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.982
FYNFYN oncogene related to SRC, FGR, YES0.789
NCF1neutrophil cytosolic factor 10.665
IGF2Rinsulin-like growth factor 2 receptor0.636
SMAD9SMAD family member 90.558
NCF4neutrophil cytosolic factor 4, 40kDa0.551
ACTBactin, beta0.543
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.522
SMAD3SMAD family member 30.479
NCOA1nuclear receptor coactivator 10.423
SKILSKI-like oncogene0.352
RXRAretinoid X receptor, alpha0.341
GRB2growth factor receptor-bound protein 20.314
RPTORregulatory associated protein of MTOR, complex 10.309
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.287
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.277
SMAD2SMAD family member 20.258
SMAD7SMAD family member 70.249
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.233
BAIAP2BAI1-associated protein 20.224
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.220
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.192
SYKspleen tyrosine kinase0.182
CSNK1A1casein kinase 1, alpha 10.180
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.169
PEX14peroxisomal biogenesis factor 140.154
CLASP1cytoplasmic linker associated protein 10.148
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.144
PRMT6protein arginine methyltransferase 60.132
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.132
SMURF2SMAD specific E3 ubiquitin protein ligase 20.126
WIPF1WAS/WASL interacting protein family, member 10.126
PIAS4protein inhibitor of activated STAT, 40.122
ARL2ADP-ribosylation factor-like 20.119
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.117
NEK6NIMA (never in mitosis gene a)-related kinase 60.116
RFX1regulatory factor X, 1 (influences HLA class II expression)0.114
IQGAP1IQ motif containing GTPase activating protein 10.111
MAPK1mitogen-activated protein kinase 10.109
TTNtitin0.108
NCK1NCK adaptor protein 10.105
KIF5Bkinesin family member 5B0.105
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.103
PRKCBprotein kinase C, beta0.098
TEX11testis expressed 110.095
HCKhemopoietic cell kinase0.094
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.093
C3orf15chromosome 3 open reading frame 150.093
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.093
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.085
ZYXzyxin0.084
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.081
PEX5peroxisomal biogenesis factor 50.080
NOXA1NADPH oxidase activator 10.079
MAPTmicrotubule-associated protein tau0.072
NCOR1nuclear receptor corepressor 10.070
CXXC5CXXC finger protein 50.070
CORO1Ccoronin, actin binding protein, 1C0.068
ITKIL2-inducible T-cell kinase0.067
BLNKB-cell linker0.067
LCKlymphocyte-specific protein tyrosine kinase0.064
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.063
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.063
FAM162Afamily with sequence similarity 162, member A0.061
RANBP3RAN binding protein 30.061
MYPNmyopalladin0.057
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.057
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.056
ARRB1arrestin, beta 10.056
ACTG1actin, gamma 10.055
HMGB2high mobility group box 20.055
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.055
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.054
TPM4tropomyosin 40.052
SPRR2Asmall proline-rich protein 2A0.052
MAPRE2microtubule-associated protein, RP/EB family, member 20.050
CFL1cofilin 1 (non-muscle)0.050
TBXA2Rthromboxane A2 receptor0.050
ARL6IP1ADP-ribosylation factor-like 6 interacting protein 10.049
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.049
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.048
PEX13peroxisomal biogenesis factor 130.048
NRASneuroblastoma RAS viral (v-ras) oncogene homolog0.048
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.048
BZW1basic leucine zipper and W2 domains 10.047
PRKCAprotein kinase C, alpha0.046
MAPK14mitogen-activated protein kinase 140.045
PEX12peroxisomal biogenesis factor 120.044
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.044
VDAC1voltage-dependent anion channel 10.044
MSNmoesin0.043
RNF11ring finger protein 110.042
CSNK2Bcasein kinase 2, beta polypeptide0.042
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.042
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.041
RIPK3receptor-interacting serine-threonine kinase 30.041
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.041
CCDC85Acoiled-coil domain containing 85A0.041
MAP2K1mitogen-activated protein kinase kinase 10.041
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.323
Jag1jagged 10.319
Pitx1paired-like homeodomain transcription factor 10.255
Pitx2paired-like homeodomain transcription factor 20.241
Notch2Notch gene homolog 2 (Drosophila)0.202
Rac1RAS-related C3 botulinum substrate 10.178
Wdr1WD repeat domain 10.176
Notch1Notch gene homolog 1 (Drosophila)0.173
Ctnnb1catenin (cadherin associated protein), beta 10.139
Trim30dtripartite motif-containing 30D0.138
Efnb2ephrin B20.104
Ptenphosphatase and tensin homolog0.090
Ncstnnicastrin0.089
Itgb1integrin beta 1 (fibronectin receptor beta)0.083
Actr3ARP3 actin-related protein 3 homolog (yeast)0.079
Ldb3LIM domain binding 30.074
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.074
Trim30atripartite motif-containing 30A0.069
Lrp6low density lipoprotein receptor-related protein 60.066
Scn5asodium channel, voltage-gated, type V, alpha0.062
Hif1ahypoxia inducible factor 1, alpha subunit0.062
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.055
Hccsholocytochrome c synthetase0.053
Ptp4a2protein tyrosine phosphatase 4a20.050
Lrrk2leucine-rich repeat kinase 20.049
Psen1presenilin 10.048
Tal1T-cell acute lymphocytic leukemia 10.048
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.048
Arpc4actin related protein 2/3 complex, subunit 40.047
Stat1signal transducer and activator of transcription 10.045
Ptpn11protein tyrosine phosphatase, non-receptor type 110.042
Foxh1forkhead box H10.042
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.042
Arf1ADP-ribosylation factor 10.042
Axin1axin 10.039
Emx1empty spiracles homolog 1 (Drosophila)0.039
Vhlvon Hippel-Lindau tumor suppressor0.037
Pcdhgb1protocadherin gamma subfamily B, 10.035
Robo1roundabout homolog 1 (Drosophila)0.035
Zic3zinc finger protein of the cerebellum 30.034
Slit3slit homolog 3 (Drosophila)0.030
Actbactin, beta0.030
Foxc1forkhead box C10.029
Nodalnodal0.028
Dnm1dynamin 10.027
Pax2paired box gene 20.026
Wt1Wilms tumor 1 homolog0.025
Kif5bkinesin family member 5B0.024
Capza2capping protein (actin filament) muscle Z-line, alpha 20.024
Lhx1LIM homeobox protein 10.024
Ptk2PTK2 protein tyrosine kinase 20.024
Prkceprotein kinase C, epsilon0.023
Rap1bRAS related protein 1b0.023
Chukconserved helix-loop-helix ubiquitous kinase0.023
Msnmoesin0.023
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.023
Rxraretinoid X receptor alpha0.022
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.022
Foxc2forkhead box C20.022
Arhgap1Rho GTPase activating protein 10.022
Bdnfbrain derived neurotrophic factor0.022
Vangl2vang-like 2 (van gogh, Drosophila)0.021
Gata4GATA binding protein 40.021
Vegfavascular endothelial growth factor A0.021
Vaspvasodilator-stimulated phosphoprotein0.021
Lef1lymphoid enhancer binding factor 10.021
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.021
Robo2roundabout homolog 2 (Drosophila)0.021
Notonotochord homolog (Xenopus laevis)0.019
Abi1abl-interactor 10.019
Actr2ARP2 actin-related protein 2 homolog (yeast)0.019
Ikbkginhibitor of kappaB kinase gamma0.019
Smurf1SMAD specific E3 ubiquitin protein ligase 10.019
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.019
Hoxa1homeobox A10.018
Bmp5bone morphogenetic protein 50.018
Efna1ephrin A10.018
Gja1gap junction protein, alpha 10.018
Crb2crumbs homolog 2 (Drosophila)0.018
Cfc1cripto, FRL-1, cryptic family 10.018
Hprthypoxanthine guanine phosphoribosyl transferase0.017
Capzbcapping protein (actin filament) muscle Z-line, beta0.017
Dnahc11dynein, axonemal, heavy chain 110.017
Siah2seven in absentia 20.017
Apcadenomatosis polyposis coli0.016
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.016
Ifi203interferon activated gene 2030.016
Hey1hairy/enhancer-of-split related with YRPW motif 10.016
Diablodiablo homolog (Drosophila)0.016
Trim12atripartite motif-containing 12A0.016
Tbx4T-box 40.016
Chd7chromodomain helicase DNA binding protein 70.016
Ntf3neurotrophin 30.016
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.016
Cd274CD274 antigen0.015
Nphs2nephrosis 2 homolog, podocin (human)0.015
Tbx3T-box 30.015
Dll4delta-like 4 (Drosophila)0.015
Thrbthyroid hormone receptor beta0.015
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.015
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rpl18ribosomal protein L180.025
Rps26ribosomal protein S260.018
LOC301124hypothetical LOC3011240.016
Tomm6translocase of outer mitochondrial membrane 6 homolog (yeast)0.014
Psmb6proteasome (prosome, macropain) subunit, beta type 60.013
Mrpl23mitochondrial ribosomal protein L230.012
Timm13translocase of inner mitochondrial membrane 13 homolog (yeast)0.012
Tceb2transcription elongation factor B (SIII), polypeptide 20.012
Psmb1proteasome (prosome, macropain) subunit, beta type 10.011
RGD1306917similar to RIKEN cDNA 2900010M230.011
Rps10ribosomal protein S100.011
Rpl41ribosomal protein L410.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
BOI1Boi1p0.175
KAR9Kar9p0.105
MYO5Myo5p0.070
KIP2Kip2p0.067
BUD6Bud6p0.065
DYN1Dyn1p0.064
FPK1Fpk1p0.061
LAS17Las17p0.060
SRV2Srv2p0.046
PSP2Psp2p0.043
PEX17Pex17p0.041
ABP1Abp1p0.039
COF1Cof1p0.034
SEC15Sec15p0.033
BOI2Boi2p0.032
CDC55Cdc55p0.032
TIM44Tim44p0.029
TSC11Tsc11p0.028
SPA2Spa2p0.027
PAC11Pac11p0.026
CAP2Cap2p0.026
SEC2Sec2p0.026
MDS3Mds3p0.025
PFY1Pfy1p0.025
PEX13Pex13p0.024
EXO70Exo70p0.024
AVO1Avo1p0.023
GYL1Gyl1p0.022
PEX8Pex8p0.021
YCL042Whypothetical protein0.021
SAC7Sac7p0.020
GDS1Gds1p0.020
ARC40Arc40p0.018
PEX5Pex5p0.018
KIN1Kin1p0.018
SPR6Spr6p0.018
ZDS1Zds1p0.018
TIM23Tim23p0.018
SCP1Scp1p0.017
ARP10Arp10p0.017
SAC6Sac6p0.017
YER039C-Ahypothetical protein0.017
HKR1Hkr1p0.016
SRD1Srd1p0.016
YPL066Whypothetical protein0.015
YFR016Chypothetical protein0.015
SIP5Sip5p0.015
YOL087Chypothetical protein0.015
RIB4Rib4p0.015
YLR264C-Ahypothetical protein0.015
STE13Ste13p0.015
CYR1Cyr1p0.014
PRS2Prs2p0.014
YPR1Ypr1p0.014
AIM3Aim3p0.014
STE5Ste5p0.014
URA3Ura3p0.014
YGR016Whypothetical protein0.014
YOL038C-Ahypothetical protein0.014
ARE2Are2p0.014
LEU2Leu2p0.014
YLR162Whypothetical protein0.013
PRR2Prr2p0.013
BUD13Bud13p0.013
ARO10Aro10p0.013
YDR239Chypothetical protein0.013
HXT11Hxt11p0.013
PEX21Pex21p0.012
ARG8Arg8p0.012
HXT3Hxt3p0.012
PHO81Pho81p0.012
FAA2Faa2p0.012
FIR1Fir1p0.012
TAX4Tax4p0.012
YOL014Whypothetical protein0.012
YBR013Chypothetical protein0.012
YIR035Chypothetical protein0.012
ICS2Ics2p0.012
MER1Mer1p0.011
YAR068Whypothetical protein0.011
YEL043Whypothetical protein0.011
AIP1Aip1p0.011
YLR042Chypothetical protein0.011
CUP1-1Cup1-1p0.011
BRN1Brn1p0.011
YPL216Whypothetical protein0.011
YPL014Whypothetical protein0.011
PSF1Psf1p0.011
SPL2Spl2p0.011
DSE1Dse1p0.011
HPF1Hpf1p0.011
YJL107Chypothetical protein0.011
YJR012Chypothetical protein0.011
YPR157Whypothetical protein0.011
AUA1Aua1p0.011
ATP6Atp6p0.011
GIC2Gic2p0.011
YDL129Whypothetical protein0.011
YER134Chypothetical protein0.011
PAM16Pam16p0.011