The network for 'ear morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ear morphogenesis

The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

NameDescriptionProbabilityFunc Analog Organism
eya1eyes absent homolog 10.999
bmp4bone morphogenetic protein 40.999
pax2apaired box gene 2a0.995
sox2SRY-box containing gene 20.988
hnf1baHNF1 homeobox Ba0.985
fgf8afibroblast growth factor 8 a0.970
fgf10afibroblast growth factor 10a0.964
fgf3fibroblast growth factor 30.962
gli2aGLI-Kruppel family member GLI2a0.960
fgfr1afibroblast growth factor receptor 1a0.944
dladeltaA0.939
osr1odd-skipped related 1 (Drosophila)0.939
dlx2adistal-less homeobox gene 2a0.937
chdchordin0.933
gpr126G protein-coupled receptor 1260.930
fgfr4fibroblast growth factor receptor 40.928
atoh1batonal homolog 1b0.918
gbx2gastrulation brain homeo box 20.912
foxi1forkhead box I10.911
bmp2bbone morphogenetic protein 2b0.911
gata3GATA-binding protein 30.902
msxcmuscle segment homeobox C0.895
tbx1T-box 10.895
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.855
flhfloating head0.852
wnt2bbwingless-type MMTV integration site family, member 2Bb0.846
lmx1b.1LIM homeobox transcription factor 1, beta 10.834
dlx3bdistal-less homeobox gene 3b0.824
atoh1aatonal homolog 1a0.813
lft1lefty10.799
six4bsine oculis homeobox homolog 4b0.785
hoxb3ahomeo box B3a0.776
tfap2atranscription factor AP-2 alpha0.762
foxc1aforkhead box C1a0.750
hand2heart and neural crest derivatives expressed transcript 20.746
bmp2abone morphogenetic protein 2a0.728
shhasonic hedgehog a0.716
dlx4adistal-less homeobox gene 4a0.713
lef1lymphocyte enhancer binding factor 10.676
hey1hairy/enhancer-of-split related with YRPW motif 10.665
neurog1neurogenin 10.663
fzd7afrizzled homolog 7a0.659
dlx4bdistal-less homeobox gene 4b0.634
dlcdeltaC0.631
gata2aGATA-binding protein 2a0.628
jag1bjagged 1b0.614
wnt1wingless-type MMTV integration site family, member 10.611
shhbsonic hedgehog b0.608
sfrp1asecreted frizzled-related protein 1a0.598
ncs1aneuronal calcium sensor 1a0.595
fgf8bfibroblast growth factor 8 b0.594
gbx1gastrulation brain homeobox 10.588
myo7aamyosin VIIAa0.584
hmx3homeo box (H6 family) 30.574
foxg1aforkhead box G1a0.562
pcdh8protocadherin 80.559
dkk1bdickkopf 1b0.559
twist3twist30.558
emx3empty spiracles homeobox 30.556
irx1biroquois homeobox protein 1, b0.555
igfbp3insulin-like growth factor binding protein 30.533
sox3SRY-box containing gene 30.528
snai1bsnail homolog 1b (Drosophila)0.525
jag2jagged 20.525
prdm1aPR domain containing 1a, with ZNF domain0.515
mibmind bomb0.501
dhrs3adehydrogenase/reductase (SDR family) member 3a0.495
dachadachshund a0.495
fgf17fibroblast growth factor 170.476
dlx2bdistal-less homeobox gene 2b0.472
lhx1aLIM homeobox 1a0.466
foxa2forkhead box A20.459
pcdh10bprotocadherin 10b0.452
dlx6adistal-less homeobox gene 6a0.439
fzd8afrizzled homolog 8a0.436
msxemuscle segment homeobox E0.430
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.417
six4asine oculis homeobox homolog 4a0.405
dlx5adistal-less homeobox gene 5a0.393
sox19aSRY-box containing gene 19a0.387
sox9aSRY-box containing gene 9a0.386
wif1wnt inhibitory factor 10.383
neurod4neurogenic differentiation 40.377
raraaretinoic acid receptor, alpha a0.371
smad1MAD homolog 1 (Drosophila)0.369
rxrbbretinoid x receptor, beta b0.366
has2hyaluronan synthase 20.357
tp63tumor protein p630.350
wnt5bwingless-type MMTV integration site family, member 5b0.333
vax1ventral anterior homeobox 10.332
aplnrbapelin receptor b0.330
tgfb2transforming growth factor, beta 20.330
notch2notch homolog 20.327
ncam1bneural cell adhesion molecule 1b0.322
pax9paired box gene 90.305
hapln1ahyaluronan and proteoglycan link protein 1a0.304
mmp2matrix metalloproteinase 20.302
fzd10frizzled homolog 100.301
nr2e1nuclear receptor subfamily 2, group E, member 10.300
si:dkeyp-7c9.1si:dkeyp-7c9.10.300
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.597
TAL1T-cell acute lymphocytic leukemia 10.369
COL1A1collagen, type I, alpha 10.305
NOTCH1notch 10.261
CHD7chromodomain helicase DNA binding protein 70.201
SMAD1SMAD family member 10.171
FSTL1follistatin-like 10.168
VEGFAvascular endothelial growth factor A0.152
DVL3dishevelled, dsh homolog 3 (Drosophila)0.149
CSNK1Ecasein kinase 1, epsilon0.138
EGFRepidermal growth factor receptor0.136
NOTCH3notch 30.136
CHD8chromodomain helicase DNA binding protein 80.129
PTCH1patched 10.122
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.120
SMAD3SMAD family member 30.118
TRIP6thyroid hormone receptor interactor 60.095
INSRinsulin receptor0.090
SEC23ASec23 homolog A (S. cerevisiae)0.088
BMPR1Abone morphogenetic protein receptor, type IA0.084
NKX2-1NK2 homeobox 10.080
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.074
PPARAperoxisome proliferator-activated receptor alpha0.065
MDFIMyoD family inhibitor0.062
SOX2SRY (sex determining region Y)-box 20.061
LATlinker for activation of T cells0.060
CALCAcalcitonin-related polypeptide alpha0.053
COL2A1collagen, type II, alpha 10.052
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.052
DVL1dishevelled, dsh homolog 1 (Drosophila)0.050
FGF10fibroblast growth factor 100.050
BMP7bone morphogenetic protein 70.049
BMP2bone morphogenetic protein 20.049
BBS10Bardet-Biedl syndrome 100.048
FOXA2forkhead box A20.046
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.046
WT1Wilms tumor 10.043
POU5F1POU class 5 homeobox 10.042
USHBP1Usher syndrome 1C binding protein 10.042
ZFYVE9zinc finger, FYVE domain containing 90.040
MSX2msh homeobox 20.040
BMP1bone morphogenetic protein 10.039
TTNtitin0.038
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.033
FGF2fibroblast growth factor 2 (basic)0.032
SH3BP4SH3-domain binding protein 40.031
AXIN1axin 10.028
NEDD4neural precursor cell expressed, developmentally down-regulated 40.027
DHCR77-dehydrocholesterol reductase0.024
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.024
IRS1insulin receptor substrate 10.024
SNIP1Smad nuclear interacting protein 10.020
SIX3SIX homeobox 30.019
HOXC8homeobox C80.019
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.019
KRTAP4-12keratin associated protein 4-120.019
ELF5E74-like factor 5 (ets domain transcription factor)0.018
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.017
IDI1isopentenyl-diphosphate delta isomerase 10.017
RSBN1round spermatid basic protein 10.016
FZD1frizzled homolog 1 (Drosophila)0.016
HOXA11homeobox A110.016
LRRK2leucine-rich repeat kinase 20.016
PAX2paired box 20.016
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.015
FGFR2fibroblast growth factor receptor 20.015
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.015
LRP6low density lipoprotein receptor-related protein 60.015
CEP164centrosomal protein 164kDa0.015
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.014
SMURF2SMAD specific E3 ubiquitin protein ligase 20.014
RETret proto-oncogene0.014
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.014
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.014
TBC1D10ATBC1 domain family, member 10A0.014
HOXA9homeobox A90.014
KCTD1potassium channel tetramerisation domain containing 10.013
DLX2distal-less homeobox 20.013
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.013
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.013
NGFRnerve growth factor receptor0.013
SIM2single-minded homolog 2 (Drosophila)0.013
ZFP28zinc finger protein 28 homolog (mouse)0.013
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.013
RUNX1runt-related transcription factor 10.013
RASA1RAS p21 protein activator (GTPase activating protein) 10.013
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.013
CAV1caveolin 1, caveolae protein, 22kDa0.012
COL1A2collagen, type I, alpha 20.012
SIX1SIX homeobox 10.012
HMGA2high mobility group AT-hook 20.012
PHF3PHD finger protein 30.012
FRS2fibroblast growth factor receptor substrate 20.012
YY1YY1 transcription factor0.012
SALL2sal-like 2 (Drosophila)0.012
FBLN1fibulin 10.011
SC4MOLsterol-C4-methyl oxidase-like0.011
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.011
GRB10growth factor receptor-bound protein 100.011
ZADH2zinc binding alcohol dehydrogenase domain containing 20.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Eya1eyes absent 1 homolog (Drosophila)1.000
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Pax2paired box gene 21.000
Foxc1forkhead box C11.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Foxc2forkhead box C21.000
Fgfr2fibroblast growth factor receptor 21.000
Gli2GLI-Kruppel family member GLI21.000
Pax3paired box gene 31.000
Chd7chromodomain helicase DNA binding protein 71.000
Sox2SRY-box containing gene 20.999
Pitx2paired-like homeodomain transcription factor 20.999
Prrx1paired related homeobox 10.999
Bmp4bone morphogenetic protein 40.999
Tbx3T-box 30.999
Fgf10fibroblast growth factor 100.999
Tbx1T-box 10.999
Foxg1forkhead box G10.998
Fgf8fibroblast growth factor 80.998
Dlx5distal-less homeobox 50.997
Tcfap2atranscription factor AP-2, alpha0.997
Otx2orthodenticle homolog 2 (Drosophila)0.996
Pax6paired box gene 60.996
Hoxa1homeobox A10.996
Hoxd13homeobox D130.994
Tgfb2transforming growth factor, beta 20.993
Cdh23cadherin 23 (otocadherin)0.993
Msx1homeobox, msh-like 10.993
Nognoggin0.993
Hand1heart and neural crest derivatives expressed transcript 10.993
Hand2heart and neural crest derivatives expressed transcript 20.992
Pax9paired box gene 90.992
Jag1jagged 10.988
Ptk7PTK7 protein tyrosine kinase 70.987
Ascl1achaete-scute complex homolog 1 (Drosophila)0.987
Rargretinoic acid receptor, gamma0.987
Ednraendothelin receptor type A0.986
Sall4sal-like 4 (Drosophila)0.986
Rarbretinoic acid receptor, beta0.984
Gscgoosecoid homeobox0.984
Sox9SRY-box containing gene 90.984
Pou4f3POU domain, class 4, transcription factor 30.984
Fgf3fibroblast growth factor 30.977
Ror2receptor tyrosine kinase-like orphan receptor 20.977
Gata3GATA binding protein 30.975
Lmx1bLIM homeobox transcription factor 1 beta0.975
Ush1gUsher syndrome 1G homolog (human)0.975
Fgfr1fibroblast growth factor receptor 10.973
Isl1ISL1 transcription factor, LIM/homeodomain0.973
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.972
Pou3f3POU domain, class 3, transcription factor 30.968
Pax8paired box gene 80.968
Neurod1neurogenic differentiation 10.966
Hoxa2homeobox A20.966
Hoxd3homeobox D30.965
Chrdchordin0.947
Pbx1pre B-cell leukemia transcription factor 10.946
Msx2homeobox, msh-like 20.945
Sox11SRY-box containing gene 110.943
Retret proto-oncogene0.936
Hoxa13homeobox A130.929
Rspo2R-spondin 2 homolog (Xenopus laevis)0.920
Hoxd11homeobox D110.920
Bmp7bone morphogenetic protein 70.918
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.913
Acvr1activin A receptor, type 10.910
Gbx2gastrulation brain homeobox 20.909
Hoxb1homeobox B10.909
Myo15myosin XV0.907
Lhx3LIM homeobox protein 30.902
Twist2twist homolog 2 (Drosophila)0.902
Smosmoothened homolog (Drosophila)0.901
Sall3sal-like 3 (Drosophila)0.900
Dvl3dishevelled 3, dsh homolog (Drosophila)0.898
Wnt5awingless-related MMTV integration site 5A0.894
Pitx1paired-like homeodomain transcription factor 10.892
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.890
Efnb2ephrin B20.882
Dvl2dishevelled 2, dsh homolog (Drosophila)0.881
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.881
Trp63transformation related protein 630.879
Zeb1zinc finger E-box binding homeobox 10.877
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.874
Neurog2neurogenin 20.873
Tbx15T-box 150.872
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.872
Col2a1collagen, type II, alpha 10.869
Dkk1dickkopf homolog 1 (Xenopus laevis)0.865
Hmx3H6 homeobox 30.864
Lhx1LIM homeobox protein 10.863
Grb10growth factor receptor bound protein 100.859
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.853
Wnt3awingless-related MMTV integration site 3A0.848
Lef1lymphoid enhancer binding factor 10.836
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.823
Alx4aristaless-like homeobox 40.821
Scn5asodium channel, voltage-gated, type V, alpha0.818
Tbx10T-box 100.818
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a2nuclear receptor subfamily 4, group A, member 20.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism