The network for 'adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

NameDescriptionProbabilityFunc Analog Organism
grnagranulin a0.306
nod1nucleotide-binding oligomerization domain containing 10.247
c1qccomplement component 1, q subcomponent, C chain0.231
tlr3toll-like receptor 30.225
adipoql2adiponectin, C1Q and collagen domain containing, like 20.178
tlr9toll-like receptor 90.164
irak4interleukin-1 receptor-associated kinase 40.154
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.143
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.138
dlg2discs, large (Drosophila) homolog 20.109
jag1bjagged 1b0.107
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.107
cd247lCD247 antigen like0.106
dlg4discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)0.104
adipoqladiponectin, C1Q and collagen domain containing, like0.102
il7rinterleukin 7 receptor0.090
LOC100000934hypothetical protein LOC1000009340.089
grn1granulin 10.081
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.078
mybl2myeloblastosis oncogene-like 20.076
rpe65bretinal pigment epithelium-specific protein 65b0.076
eomesbeomesodermin homolog b0.075
stat1bsignal transducer and activator of transcription 1b0.075
illr1immune-related, lectin-like receptor 10.071
pcsk2proprotein convertase subtilisin/kexin type 20.070
oprd1bopioid receptor, delta 1b0.069
coro1acoronin, actin binding protein, 1A0.068
tbx21T-box 210.068
irf11interferon regulatory factor 110.068
vdrbvitamin D receptor b0.067
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.066
isg15ISG15 ubiquitin-like modifier0.066
tmprss4btransmembrane protease, serine 4b0.065
tlr21toll-like receptor 210.065
hhiphedgehog interacting protein0.065
cxcr3.2chemokine (C-X-C motif) receptor 3.20.064
tnfatumor necrosis factor a (TNF superfamily, member 2)0.063
mef2camyocyte enhancer factor 2ca0.062
foxp3aforkhead box P3a0.062
eya2eyes absent homolog 2 (Drosophila)0.061
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.060
crfa31.2IL-4RA-like protein 20.059
tlr2toll-like receptor 20.059
adipor2adiponectin receptor 20.059
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.059
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.059
mef2cbmyocyte enhancer factor 2cb0.058
cd40lgCD40 ligand0.058
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.057
tnfsf10l4tumor necrosis factor (ligand) superfamily, member 10 like 40.057
cd247CD247 antigen0.057
lndc1ly6/neurotoxin domain containing 10.056
cxc46CXC chemokine 460.056
olig1oligodendrocyte lineage transcription factor 10.056
mef2amyocyte enhancer factor 2a0.055
nitr13novel immune-type receptor 130.055
hirip3HIRA interacting protein 30.053
s100a10aS100 calcium binding protein A10a0.051
mbtps1membrane-bound transcription factor protease, site 10.051
LOC100534776toll-like receptor 7-like0.051
calcrcalcitonin receptor0.051
kitlgakit ligand a0.050
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.050
lrrc33leucine rich repeat containing 330.050
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.047
adaadenosine deaminase0.047
adipor1aadiponectin receptor 1a0.046
scpep1serine carboxypeptidase 10.046
tsc22d1TSC22 domain family, member 10.046
tbx5bT-box 5b0.045
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.045
angptl1angiopoietin-like 10.045
tfectranscription factor EC0.045
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.044
il22interleukin 220.044
lmx1b.1LIM homeobox transcription factor 1, beta 10.044
ifng1-2interferon, gamma 1-20.043
ptk6aPTK6 protein tyrosine kinase 6a0.043
ikbkginhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.043
nfycnuclear transcription factor Y, gamma0.043
vcanbversican b0.042
rorcaRAR-related orphan receptor C a0.042
crfb7cytokine receptor family member b70.042
acsl1acyl-CoA synthetase long-chain family member 10.042
rhogbras homolog gene family, member Gb0.042
itkIL2-inducible T-cell kinase0.042
cftrcystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)0.041
g6pdglucose-6-phosphate dehydrogenase0.041
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.041
prkchaprotein kinase C, eta, a0.041
LOC100332193growth hormone secretagogue receptor type 1-like0.041
LOC566708FL cytokine receptor-like0.041
otcornithine carbamoyltransferase0.041
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IL4Rinterleukin 4 receptor0.966
PTPN6protein tyrosine phosphatase, non-receptor type 60.951
CASP8caspase 8, apoptosis-related cysteine peptidase0.880
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.877
NOTCH1notch 10.773
TRAF1TNF receptor-associated factor 10.722
HLA-Amajor histocompatibility complex, class I, A0.716
HLA-Cmajor histocompatibility complex, class I, C0.666
CD80CD80 molecule0.595
HLA-DMBmajor histocompatibility complex, class II, DM beta0.574
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.564
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.563
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.563
IL2RGinterleukin 2 receptor, gamma0.540
TRAF6TNF receptor-associated factor 60.531
CCL5chemokine (C-C motif) ligand 50.512
BTN3A2butyrophilin, subfamily 3, member A20.493
HLA-Gmajor histocompatibility complex, class I, G0.476
CCR5chemokine (C-C motif) receptor 50.475
CD40CD40 molecule, TNF receptor superfamily member 50.474
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.446
LTAlymphotoxin alpha (TNF superfamily, member 1)0.442
CCL4chemokine (C-C motif) ligand 40.428
LAPTM5lysosomal protein transmembrane 50.425
C1QAcomplement component 1, q subcomponent, A chain0.415
BTN3A1butyrophilin, subfamily 3, member A10.405
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.402
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.381
HLA-Bmajor histocompatibility complex, class I, B0.362
LCKlymphocyte-specific protein tyrosine kinase0.352
HLA-Fmajor histocompatibility complex, class I, F0.346
HLA-Emajor histocompatibility complex, class I, E0.342
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.328
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.308
BIRC3baculoviral IAP repeat containing 30.290
NR0B1nuclear receptor subfamily 0, group B, member 10.272
CALCOCO2calcium binding and coiled-coil domain 20.270
CXCL9chemokine (C-X-C motif) ligand 90.256
TNFtumor necrosis factor0.255
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.229
APLFaprataxin and PNKP like factor0.220
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.220
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.211
NRP1neuropilin 10.211
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.202
CCR7chemokine (C-C motif) receptor 70.199
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.197
CCL8chemokine (C-C motif) ligand 80.196
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.185
BTN3A3butyrophilin, subfamily 3, member A30.183
IL2RBinterleukin 2 receptor, beta0.179
IL4interleukin 40.177
DLG1discs, large homolog 1 (Drosophila)0.172
IRF4interferon regulatory factor 40.172
CD2CD2 molecule0.171
BCL3B-cell CLL/lymphoma 30.170
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.167
GRAP2GRB2-related adaptor protein 20.165
CD48CD48 molecule0.160
BRCA1breast cancer 1, early onset0.153
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.153
SMURF1SMAD specific E3 ubiquitin protein ligase 10.151
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.150
FASLGFas ligand (TNF superfamily, member 6)0.146
C1QCcomplement component 1, q subcomponent, C chain0.137
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.129
CTLA4cytotoxic T-lymphocyte-associated protein 40.126
ICAM1intercellular adhesion molecule 10.124
CD86CD86 molecule0.123
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.122
SOCS3suppressor of cytokine signaling 30.112
TRAF2TNF receptor-associated factor 20.106
MDC1mediator of DNA-damage checkpoint 10.104
IL8interleukin 80.099
TNFRSF9tumor necrosis factor receptor superfamily, member 90.098
SH2D2ASH2 domain containing 2A0.096
CD22CD22 molecule0.095
CCR1chemokine (C-C motif) receptor 10.094
CARD11caspase recruitment domain family, member 110.093
SIGLEC7sialic acid binding Ig-like lectin 70.092
CASP10caspase 10, apoptosis-related cysteine peptidase0.090
IFNGinterferon, gamma0.086
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.085
HDAC9histone deacetylase 90.083
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.083
IL6Rinterleukin 6 receptor0.082
SLC15A3solute carrier family 15, member 30.081
PILRApaired immunoglobin-like type 2 receptor alpha0.079
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.079
TAPBPTAP binding protein (tapasin)0.079
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.079
SYKspleen tyrosine kinase0.077
IRAK1interleukin-1 receptor-associated kinase 10.077
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.076
IL10interleukin 100.076
VAMP4vesicle-associated membrane protein 40.075
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.074
ZBP1Z-DNA binding protein 10.073
NOTCH3notch 30.072
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Ifnginterferon gamma1.000
Lyz2lysozyme 21.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a1.000
Ighimmunoglobulin heavy chain complex0.999
Cd40CD40 antigen0.999
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.998
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.997
Prf1perforin 1 (pore forming protein)0.997
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.997
Il10interleukin 100.987
Cd44CD44 antigen0.986
Il1r1interleukin 1 receptor, type I0.984
Il2rginterleukin 2 receptor, gamma chain0.983
Stat3signal transducer and activator of transcription 30.981
Ccl2chemokine (C-C motif) ligand 20.978
Il4interleukin 40.975
FaslFas ligand (TNF superfamily, member 6)0.974
Cd19CD19 antigen0.973
Foxp3forkhead box P30.973
Socs1suppressor of cytokine signaling 10.971
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.970
Ccr1chemokine (C-C motif) receptor 10.969
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.963
Ccr2chemokine (C-C motif) receptor 20.957
FasFas (TNF receptor superfamily member 6)0.954
Ptprcprotein tyrosine phosphatase, receptor type, C0.947
Klrk1killer cell lectin-like receptor subfamily K, member 10.943
Il6interleukin 60.942
Leprleptin receptor0.941
Zeb1zinc finger E-box binding homeobox 10.932
Itgb2integrin beta 20.930
C3complement component 30.924
H2-Eb1histocompatibility 2, class II antigen E beta0.923
Tnfaip3tumor necrosis factor, alpha-induced protein 30.923
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.921
H2-Ab1histocompatibility 2, class II antigen A, beta 10.909
Ccr7chemokine (C-C motif) receptor 70.903
Pax2paired box gene 20.890
Ifngr1interferon gamma receptor 10.889
Prdm1PR domain containing 1, with ZNF domain0.887
Fcgr2bFc receptor, IgG, low affinity IIb0.880
Casp4caspase 4, apoptosis-related cysteine peptidase0.860
Apoeapolipoprotein E0.859
Mmp9matrix metallopeptidase 90.847
Sfpi1SFFV proviral integration 10.847
H2-Aahistocompatibility 2, class II antigen A, alpha0.847
H2-K1histocompatibility 2, K1, K region0.840
Stat6signal transducer and activator of transcription 60.836
Jak2Janus kinase 20.835
Ccl3chemokine (C-C motif) ligand 30.834
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.831
Ccl8chemokine (C-C motif) ligand 80.827
Il27rainterleukin 27 receptor, alpha0.823
Map3k14mitogen-activated protein kinase kinase kinase 140.821
Ccl5chemokine (C-C motif) ligand 50.816
Il1binterleukin 1 beta0.798
Stat5asignal transducer and activator of transcription 5A0.787
B2mbeta-2 microglobulin0.780
Batfbasic leucine zipper transcription factor, ATF-like0.779
Rab27aRAB27A, member RAS oncogene family0.778
Ptenphosphatase and tensin homolog0.773
Cxcl13chemokine (C-X-C motif) ligand 130.771
Selpselectin, platelet0.770
Irf1interferon regulatory factor 10.770
Atmataxia telangiectasia mutated homolog (human)0.769
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.765
Bcl2B-cell leukemia/lymphoma 20.757
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.754
Clec4dC-type lectin domain family 4, member d0.749
Ccl22chemokine (C-C motif) ligand 220.748
Nos2nitric oxide synthase 2, inducible0.746
C1qbcomplement component 1, q subcomponent, beta polypeptide0.738
Il6stinterleukin 6 signal transducer0.726
Il1rl1interleukin 1 receptor-like 10.723
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.720
BtkBruton agammaglobulinemia tyrosine kinase0.718
Itgaxintegrin alpha X0.711
Tlr2toll-like receptor 20.710
Itgalintegrin alpha L0.707
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.700
Icosinducible T-cell co-stimulator0.699
Map3k7mitogen-activated protein kinase kinase kinase 70.692
Il10rainterleukin 10 receptor, alpha0.687
Inpp5dinositol polyphosphate-5-phosphatase D0.681
Card11caspase recruitment domain family, member 110.678
Cd86CD86 antigen0.677
Il1r2interleukin 1 receptor, type II0.677
Sh2d2aSH2 domain protein 2A0.676
Cd4CD4 antigen0.675
Pdcd1programmed cell death 10.666
Cishcytokine inducible SH2-containing protein0.653
Casp8caspase 80.653
Pax5paired box gene 50.641
Ptgirprostaglandin I receptor (IP)0.637
Cxcl9chemokine (C-X-C motif) ligand 90.635
Rc3h1RING CCCH (C3H) domains 10.635
Lag3lymphocyte-activation gene 30.635
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.631
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.072
RT1-DaRT1 class II, locus Da0.061
Cd37CD37 molecule0.045
RT1-BaRT1 class II, locus Ba0.045
RT1-Db1RT1 class II, locus Db10.039
Gbp2guanylate binding protein 20.029
Il1binterleukin 1 beta0.026
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.026
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.025
Irf1interferon regulatory factor 10.025
Casp1caspase 10.024
Hckhemopoietic cell kinase0.021
Hsph1heat shock 105/110 protein 10.020
Cxcl10chemokine (C-X-C motif) ligand 100.019
Aif1allograft inflammatory factor 10.019
Anpepalanyl (membrane) aminopeptidase0.018
Plcg2phospholipase C, gamma 20.017
RT1-DMbRT1 class II, locus DMb0.017
Hspb1heat shock protein 10.015
Fggfibrinogen gamma chain0.015
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.015
Slfn2schlafen 20.015
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.014
RT1-EC2RT1 class Ib, locus EC20.014
C1qbcomplement component 1, q subcomponent, B chain0.014
Apol3apolipoprotein L, 30.013
Il2rbinterleukin 2 receptor, beta0.013
LOC100364265ribosomal protein L19-like0.013
Tcf21transcription factor 210.012
Cd53Cd53 molecule0.012
Fth1ferritin, heavy polypeptide 10.011
Tpt1tumor protein, translationally-controlled 10.011
Il1r1interleukin 1 receptor, type I0.011
Mapk1mitogen activated protein kinase 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism