The network for 'response to hormone' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

NameDescriptionProbabilityFunc Analog Organism
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.911
fabp11afatty acid binding protein 11a0.849
egr2bearly growth response 2b0.800
notch1anotch homolog 1a0.772
prox1prospero-related homeobox gene 10.760
per2period homolog 2 (Drosophila)0.727
rbp1aretinol binding protein 1a, cellular0.525
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.505
sparcsecreted acidic cysteine rich glycoprotein0.503
crabp2acellular retinoic acid binding protein 2, a0.466
sox9aSRY-box containing gene 9a0.450
notch1bnotch homolog 1b0.421
gapdhglyceraldehyde-3-phosphate dehydrogenase0.392
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.374
gnrh3gonadotropin-releasing hormone 30.373
igf1insulin-like growth factor 10.347
tal1T-cell acute lymphocytic leukemia 10.341
igf2binsulin-like growth factor 2b0.275
vtg3vitellogenin 3, phosvitinless0.269
vasavasa homolog0.269
wlswntless homolog (Drosophila)0.264
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.258
pomcaproopiomelanocortin a0.256
kdrlkinase insert domain receptor like0.235
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.232
apoebapolipoprotein Eb0.228
ca2carbonic anhydrase II0.221
angpt2angiopoietin 20.218
cldnhclaudin h0.210
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.207
pcnaproliferating cell nuclear antigen0.203
adipor2adiponectin receptor 20.202
cry3cryptochrome 30.199
mef2dmyocyte enhancer factor 2d0.195
wnt10awingless-type MMTV integration site family, member 10a0.194
sox9bSRY-box containing gene 9b0.194
rdh10aretinol dehydrogenase 10a0.194
esr1estrogen receptor 10.186
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.185
inhainhibin, alpha0.185
sox5SRY-box containing gene 50.183
epas1bendothelial PAS domain protein 1b0.182
id1inhibitor of DNA binding 10.179
gdnfglial cell derived neurotrophic factor0.178
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.177
fabp10afatty acid binding protein 10a, liver basic0.174
lhcgrluteinizing hormone/choriogonadotropin receptor0.174
esr2aestrogen receptor 2a0.171
gnrh2gonadotropin-releasing hormone 20.170
foxc1aforkhead box C1a0.167
ptgs1prostaglandin-endoperoxide synthase 10.165
fgf3fibroblast growth factor 30.163
plcg1phospholipase C, gamma 10.158
rc3rabconnectin 30.157
otpaorthopedia homolog a0.155
igf2ainsulin-like growth factor 2a0.152
sema3dsemaphorin 3d0.150
otx5orthodenticle homolog 50.148
efnb2aephrin B2a0.146
crygn2crystallin, gamma N20.137
fshbfollicle stimulating hormone, beta polypeptide0.136
ptgs2aprostaglandin-endoperoxide synthase 2a0.136
tnfatumor necrosis factor a (TNF superfamily, member 2)0.136
thrabthyroid hormone receptor alpha b0.131
nr5a2nuclear receptor subfamily 5, group A, member 20.129
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.129
gperG protein-coupled estrogen receptor 10.128
sat1aspermidine/spermine N1-acetyltransferase 1a0.128
socs3asuppressor of cytokine signaling 3a0.125
avplarginine vasopressin-like0.125
rorcbRAR-related orphan receptor C b0.124
sec24cSEC24 family, member C (S. cerevisiae)0.124
duoxdual oxidase0.123
notch3notch homolog 30.123
idh1isocitrate dehydrogenase 1 (NADP+), soluble0.120
prox2prospero homeobox 20.120
gpiaglucose phosphate isomerase a0.119
mycamyelocytomatosis oncogene a0.117
vcanaversican a0.116
dlx5adistal-less homeobox gene 5a0.116
wnt5bwingless-type MMTV integration site family, member 5b0.115
mfn2mitofusin 20.114
serpinc1serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 10.112
tnnt2atroponin T2a, cardiac0.108
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.103
acox1acyl-Coenzyme A oxidase 1, palmitoyl0.100
col5a1procollagen, type V, alpha 10.100
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.100
tie1endothelium-specific receptor tyrosine kinase 10.099
crygm3crystallin, gamma M30.096
mstnbmyostatin b0.095
alcamaactivated leukocyte cell adhesion molecule a0.094
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.648
cicubitus interruptus0.496
Pi3K92ECG4141 gene product from transcript CG4141-RB0.440
Akt1CG4006 gene product from transcript CG4006-RA0.391
InRInsulin-like receptor0.231
Ugt35aUDP-glycosyltransferase 35a0.214
ftz-f1ftz transcription factor 10.189
EgfrEpidermal growth factor receptor0.188
rapretina aberrant in pattern0.132
S6kRPS6-p70-protein kinase0.125
Ilp5Insulin-like peptide 50.125
Cdc42CG12530 gene product from transcript CG12530-RA0.102
sinaseven in absentia0.084
cwoclockwork orange0.083
CG7998CG7998 gene product from transcript CG7998-RA0.079
osaCG7467 gene product from transcript CG7467-RD0.079
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.075
BRWD3CG31132 gene product from transcript CG31132-RA0.074
TequilaCG4821 gene product from transcript CG4821-RE0.073
drkdownstream of receptor kinase0.072
FhosCG42610 gene product from transcript CG42610-RC0.070
McrMacroglobulin complement-related0.068
CG6283CG6283 gene product from transcript CG6283-RA0.066
argosCG4531 gene product from transcript CG4531-RA0.066
Ilp2Insulin-like peptide 20.064
Cyp12a4CG6042 gene product from transcript CG6042-RA0.063
kibrakibra ortholog0.058
foxoforkhead box, sub-group O0.058
CG13253CG13253 gene product from transcript CG13253-RB0.057
Stat92ESignal-transducer and activator of transcription protein at 92E0.055
Cyp9f2CG11466 gene product from transcript CG11466-RB0.054
SosSon of sevenless0.054
CycGCyclin G0.053
LanB2Laminin B20.052
CG13310CG13310 gene product from transcript CG13310-RA0.049
ElfEf1alpha-like factor0.048
TorTarget of rapamycin0.048
jebjelly belly0.048
ThorCG8846 gene product from transcript CG8846-RA0.047
Cyp12e1CG14680 gene product from transcript CG14680-RC0.047
fz2frizzled 20.046
bowlbrother of odd with entrails limited0.045
norpAno receptor potential A0.045
HcfHost cell factor0.044
chicoCG5686 gene product from transcript CG5686-RB0.044
MadMothers against dpp0.043
Gyc76CGuanylyl cyclase at 76C0.042
NPFR1neuropeptide F receptor0.042
CycDCyclin D0.042
HopHsp70/Hsp90 organizing protein homolog0.042
LamCLamin C0.042
rdgAretinal degeneration A0.042
SmoxSmad on X0.041
IndyI'm not dead yet0.041
SelDSelenide,water dikinase0.041
Hsp26Heat shock protein 260.040
G-oalpha47AG protein oalpha 47A0.040
Fas2Fasciclin 20.040
SsdpSequence-specific single-stranded DNA-binding protein0.039
Ada2bCG9638 gene product from transcript CG9638-RA0.039
Sox14Sox box protein 140.039
HDAC6CG6170 gene product from transcript CG6170-RA0.039
Cyp6d5CG3050 gene product from transcript CG3050-RA0.039
bossbride of sevenless0.038
Gp150CG5820 gene product from transcript CG5820-RA0.036
Pkc98EProtein C kinase 98E0.036
CG14837CG14837 gene product from transcript CG14837-RC0.036
sNPF-Rshort neuropeptide F receptor0.036
CG13510CG13510 gene product from transcript CG13510-RA0.036
sxcsuper sex combs0.036
EcREcdysone receptor0.035
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
PTPN1protein tyrosine phosphatase, non-receptor type 11.000
CREBBPCREB binding protein1.000
EGFRepidermal growth factor receptor1.000
ARandrogen receptor1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.999
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.999
CAV1caveolin 1, caveolae protein, 22kDa0.998
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.996
GRB2growth factor receptor-bound protein 20.996
NCOA1nuclear receptor coactivator 10.995
GSK3Bglycogen synthase kinase 3 beta0.994
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.985
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.985
EP300E1A binding protein p3000.979
INSRinsulin receptor0.975
NCOR2nuclear receptor corepressor 20.973
NCOA6nuclear receptor coactivator 60.972
STAT5Asignal transducer and activator of transcription 5A0.970
PTK2PTK2 protein tyrosine kinase 20.966
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.952
NCOA2nuclear receptor coactivator 20.951
BCAR1breast cancer anti-estrogen resistance 10.949
TP53tumor protein p530.939
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.931
HDAC1histone deacetylase 10.928
HNF4Ahepatocyte nuclear factor 4, alpha0.923
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.920
JAK2Janus kinase 20.912
RXRAretinoid X receptor, alpha0.905
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.901
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.880
BRCA1breast cancer 1, early onset0.876
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.874
RARAretinoic acid receptor, alpha0.859
GSTM1glutathione S-transferase mu 10.850
PTPN11protein tyrosine phosphatase, non-receptor type 110.833
CASP3caspase 3, apoptosis-related cysteine peptidase0.832
HDAC3histone deacetylase 30.828
GRB10growth factor receptor-bound protein 100.784
MDM2Mdm2 p53 binding protein homolog (mouse)0.784
BCL2B-cell CLL/lymphoma 20.783
SKILSKI-like oncogene0.779
SOCS1suppressor of cytokine signaling 10.779
SP1Sp1 transcription factor0.766
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.742
IL8interleukin 80.733
RUNX1runt-related transcription factor 10.728
FN1fibronectin 10.724
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.712
NR4A1nuclear receptor subfamily 4, group A, member 10.689
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.685
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.672
IL6interleukin 6 (interferon, beta 2)0.670
SKP1S-phase kinase-associated protein 10.666
EPORerythropoietin receptor0.657
NCOA3nuclear receptor coactivator 30.654
GSTM2glutathione S-transferase mu 2 (muscle)0.654
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.647
RBBP4retinoblastoma binding protein 40.640
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.640
FHL2four and a half LIM domains 20.637
NRP1neuropilin 10.619
STAT1signal transducer and activator of transcription 1, 91kDa0.617
MAP3K11mitogen-activated protein kinase kinase kinase 110.607
ARRB1arrestin, beta 10.603
DUSP1dual specificity phosphatase 10.594
IL4Rinterleukin 4 receptor0.587
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.587
JAG1jagged 10.581
DAXXdeath-domain associated protein0.576
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.571
FOXO1forkhead box O10.566
TIMP1TIMP metallopeptidase inhibitor 10.563
EPAS1endothelial PAS domain protein 10.561
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.556
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.555
PLAURplasminogen activator, urokinase receptor0.554
TAL1T-cell acute lymphocytic leukemia 10.551
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.545
MAPK3mitogen-activated protein kinase 30.536
NCOR1nuclear receptor corepressor 10.536
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.533
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.521
PTPRBprotein tyrosine phosphatase, receptor type, B0.514
WDR5WD repeat domain 50.514
MAPTmicrotubule-associated protein tau0.514
XIAPX-linked inhibitor of apoptosis0.509
ANXA1annexin A10.502
GABARAPL1GABA(A) receptor-associated protein like 10.492
PPARAperoxisome proliferator-activated receptor alpha0.492
RASA1RAS p21 protein activator (GTPase activating protein) 10.489
NR4A3nuclear receptor subfamily 4, group A, member 30.489
HDAC4histone deacetylase 40.488
TGFB1transforming growth factor, beta 10.486
VEGFAvascular endothelial growth factor A0.483
TOB1transducer of ERBB2, 10.481
CFLARCASP8 and FADD-like apoptosis regulator0.481
IFNAR1interferon (alpha, beta and omega) receptor 10.481
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism