The network for 'regulation of macromolecule metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.992
tfap2atranscription factor AP-2 alpha0.992
gli1GLI-Kruppel family member 10.990
ntlano tail a0.990
shhasonic hedgehog a0.989
bmp4bone morphogenetic protein 40.984
fgf3fibroblast growth factor 30.982
snai1asnail homolog 1a (Drosophila)0.981
notch1anotch homolog 1a0.977
eya1eyes absent homolog 10.976
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.974
evx1even-skipped homeobox 10.972
foxi1forkhead box I10.970
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.967
gata5GATA-binding protein 50.965
dlx2adistal-less homeobox gene 2a0.960
foxh1forkhead box H10.955
robo3roundabout homolog 30.953
tll1tolloid-like 10.949
sox9aSRY-box containing gene 9a0.948
six4bsine oculis homeobox homolog 4b0.946
dusp6dual specificity phosphatase 60.946
bmp2abone morphogenetic protein 2a0.944
fgfr1afibroblast growth factor receptor 1a0.943
ndr2nodal-related 20.939
prkciprotein kinase C, iota0.939
gata3GATA-binding protein 30.938
lef1lymphocyte enhancer binding factor 10.935
otx2orthodenticle homolog 20.934
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.933
lhx1aLIM homeobox 1a0.926
cx43connexin 430.925
tp53tumor protein p530.924
hoxa9ahomeo box A9a0.924
cdh1cadherin 1, epithelial0.922
wnt11wingless-type MMTV integration site family, member 110.920
spry4sprouty (Drosophila) homolog 40.917
wnt2bbwingless-type MMTV integration site family, member 2Bb0.915
hnf1baHNF1 homeobox Ba0.915
meis3myeloid ecotropic viral integration site 30.912
efnb2aephrin B2a0.912
flhfloating head0.907
kdrlkinase insert domain receptor like0.901
mapk1mitogen-activated protein kinase 10.900
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.898
fgfr4fibroblast growth factor receptor 40.898
osr1odd-skipped related 1 (Drosophila)0.894
barx1BarH-like homeobox 10.894
mespamesoderm posterior a0.892
fzd8afrizzled homolog 8a0.885
dlx6adistal-less homeobox gene 6a0.882
pou3f1POU class 3 homeobox 10.882
pax8paired box gene 80.876
nanos3nanos homolog 30.875
mbnl2muscleblind-like 2 (Drosophila)0.874
crabp2acellular retinoic acid binding protein 2, a0.872
eng2aengrailed 2a0.866
pax6bpaired box gene 6b0.855
hhiphedgehog interacting protein0.855
pax2apaired box gene 2a0.851
nkx2.2aNK2 transcription factor related 2a0.850
prnprs3prion protein, related sequence 30.845
sall1asal-like 1a (Drosophila)0.845
prdm1aPR domain containing 1a, with ZNF domain0.843
irx1biroquois homeobox protein 1, b0.843
ptf1apancreas specific transcription factor, 1a0.842
irx4biroquois homeobox protein 4b0.839
runx2brunt-related transcription factor 2b0.838
gata6GATA-binding protein 60.838
pitx3paired-like homeodomain transcription factor 30.836
rarabretinoic acid receptor, alpha b0.835
six3bsine oculis homeobox homolog 3b0.834
bocbrother of CDO0.833
rad21RAD21 homolog (S. pombe)0.833
hoxb1bhomeo box B1b0.827
mecomMDS1 and EVI1 complex locus0.827
klf4aKruppel-like transcription factor 4a0.825
foxp2forkhead box P20.822
foxa3forkhead box A30.820
sema3aasemaphorin 3aa0.820
cdx4caudal type homeo box transcription factor 40.818
gyltl1bglycosyltransferase-like 1b0.817
ncor1nuclear receptor co-repressor 10.815
wnt10awingless-type MMTV integration site family, member 10a0.814
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.812
olfm2olfactomedin 20.809
lhx1bLIM homeobox 1b0.809
wnt3wingless-type MMTV integration site family, member 30.807
tgfb1atransforming growth factor, beta 1a0.804
oprm1opioid receptor, mu 10.804
egr1early growth response 10.799
six3asine oculis homeobox homolog 3a0.796
otpborthopedia homolog b0.791
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.984
pha-4Protein PHA-40.983
egl-18Protein EGL-180.972
atn-1Protein ATN-10.935
nhr-67Protein NHR-670.926
hlh-2Protein HLH-20.925
unc-37Protein UNC-370.913
elt-6Protein ELT-60.871
CELE_C25A1.4Protein C25A1.40.849
his-64Protein HIS-640.847
egl-15Protein EGL-150.839
mdf-2Protein MDF-20.832
dbr-1Protein DBR-10.827
csn-1Protein CSN-10.816
zyg-1Protein ZYG-10.807
lin-35Protein LIN-350.801
unc-62Protein UNC-620.797
mig-5Protein MIG-50.789
aly-3Protein ALY-30.783
ceh-20Protein CEH-200.779
egl-13Protein EGL-130.779
T26A5.5Protein T26A5.50.776
csn-4Protein CSN-40.773
hda-1Protein HDA-10.760
daf-1Protein DAF-10.758
zyg-9Protein ZYG-90.757
eftu-2Protein EFTU-20.748
gon-4Protein GON-40.746
aap-1Protein AAP-10.746
hcp-3Protein HCP-30.743
rnr-1Protein RNR-10.742
F33H1.4Protein F33H1.40.738
hbl-1Protein HBL-10.733
sli-1Protein SLI-10.732
cdk-9Protein CDK-90.732
nud-2Protein NUD-20.710
CELE_C17E4.6Protein C17E4.60.706
cacn-1Protein CACN-10.697
egl-46Protein EGL-460.689
emb-5Protein EMB-50.688
sas-5Protein SAS-50.683
pis-1Protein PIS-10.674
hlh-1Protein HLH-10.664
kle-2Protein KLE-20.661
cnd-1Protein CND-10.659
nhr-2Protein NHR-20.654
lin-36Protein LIN-360.648
R186.7Protein R186.70.641
skp-1Protein SKP-10.641
egl-27Protein EGL-270.639
npp-4Protein NPP-40.635
eya-1Protein EYA-10.633
rnp-6Protein RNP-60.630
pry-1Protein PRY-10.623
mei-2Protein MEI-20.623
F39B2.1Protein F39B2.10.621
fli-1Protein FLI-10.609
alp-1Protein ALP-10.605
unc-73Protein UNC-730.602
spr-5Protein SPR-50.602
ubq-1Protein UBQ-10.600
attf-2Protein ATTF-20.597
nhr-49Protein NHR-490.596
unc-40Protein UNC-400.595
hum-5Protein HUM-50.594
lag-1Protein LAG-10.591
F25H5.5Protein F25H5.50.590
W04D2.6Protein W04D2.60.585
B0261.1Protein B0261.10.584
dlk-1Protein DLK-10.580
F33E11.3Protein F33E11.30.574
his-31Protein HIS-310.570
CELE_C16C10.4Protein C16C10.40.559
F13E6.1Protein F13E6.10.558
his-5Protein HIS-50.556
klp-15Protein KLP-150.554
eor-1Protein EOR-10.554
sec-16Protein SEC-160.553
cpg-2Protein CPG-20.544
mex-5Protein MEX-50.540
Y87G2A.1Protein Y87G2A.10.536
F33D11.10Protein F33D11.100.535
his-1Protein HIS-10.533
skr-1Protein SKR-10.531
ulp-2Protein ULP-20.531
fkh-2Protein FKH-20.529
wrm-1Protein WRM-10.528
scc-1Protein SCC-10.525
ced-9Protein CED-90.524
H06I04.1Protein H06I04.10.523
pqn-59Protein PQN-590.522
T28D9.4Protein T28D9.40.520
R11A8.7Protein R11A8.70.518
ppfr-2Protein PPFR-20.512
pmk-1Protein PMK-10.509
bet-1Protein BET-10.508
par-5Protein PAR-50.505
aph-2Protein APH-20.505
CELE_Y41E3.11Protein Y41E3.110.501
mes-2Protein MES-20.497
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism