The network for 'positive regulation of signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of signaling

Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.952
dharmadharma0.864
bmp2abone morphogenetic protein 2a0.858
plcg1phospholipase C, gamma 10.805
dkk1bdickkopf 1b0.777
wnt2bbwingless-type MMTV integration site family, member 2Bb0.711
ndr2nodal-related 20.677
evx1even-skipped homeobox 10.640
fgf3fibroblast growth factor 30.609
chdchordin0.600
fn1fibronectin 10.562
shhasonic hedgehog a0.546
klf4Kruppel-like factor 40.532
sulf1sulfatase 10.493
tbx16T-box gene 160.492
gli1GLI-Kruppel family member 10.455
tbx1T-box 10.447
fgf8afibroblast growth factor 8 a0.429
efnb2aephrin B2a0.425
acvr1bactivin A receptor, type IB0.417
ascl1aachaete-scute complex-like 1a (Drosophila)0.411
sox9aSRY-box containing gene 9a0.408
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.406
ntlano tail a0.394
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.389
tnfrsfatumor necrosis factor receptor superfamily, member a0.386
sox32SRY-box containing gene 320.384
ptch1patched 10.367
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.336
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.335
neurog1neurogenin 10.324
rag1recombination activating gene 10.309
sparcsecreted acidic cysteine rich glycoprotein0.306
cdx4caudal type homeo box transcription factor 40.296
nrg1neuregulin 10.281
pkd2polycystic kidney disease 20.279
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.272
nadl1.2neural adhesion molecule L1.20.267
foxa2forkhead box A20.266
gli2aGLI-Kruppel family member GLI2a0.265
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.261
eve1even-skipped-like10.258
bmp7abone morphogenetic protein 7a0.256
bbc3BCL2 binding component 30.251
fzd7afrizzled homolog 7a0.251
tbx6T-box gene 60.247
wnt4awingless-type MMTV integration site family, member 4a0.246
eya1eyes absent homolog 10.237
wnt10awingless-type MMTV integration site family, member 10a0.234
appbamyloid beta (A4) precursor protein b0.231
cdoncell adhesion molecule-related/down-regulated by oncogenes0.227
acvr2aactivin receptor IIa0.213
disp1dispatched homolog 1 (Drosophila)0.212
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.212
klf4aKruppel-like transcription factor 4a0.211
rarabretinoic acid receptor, alpha b0.209
trim3atripartite motif-containing 3a0.199
cd63Cd63 antigen0.197
zbtb4zinc finger and BTB domain containing 40.196
dync1h1dynein, cytoplasmic 1, heavy chain 10.193
lft1lefty10.192
robo3roundabout homolog 30.188
brd4bromodomain containing 40.188
yap1Yes-associated protein 10.178
ahr2aryl hydrocarbon receptor 20.176
mespbmesoderm posterior b0.175
cdh2cadherin 2, neuronal0.175
rykreceptor-like tyrosine kinase0.175
igf1insulin-like growth factor 10.174
dusp6dual specificity phosphatase 60.172
angptl2angiopoietin-like 20.172
ihhaIndian hedgehog homolog a0.169
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.168
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.166
spry4sprouty (Drosophila) homolog 40.163
fgfr1bfibroblast growth factor receptor 1b0.162
jag1bjagged 1b0.162
bocbrother of CDO0.161
map3k4mitogen activated protein kinase kinase kinase 40.161
mgaMAX gene associated0.160
frem3Fras1 related extracellular matrix 30.156
spry2sprouty homolog 20.155
robo2roundabout homolog 20.155
dlx5adistal-less homeobox gene 5a0.153
psen1presenilin 10.152
fgfr1afibroblast growth factor receptor 1a0.152
ldb1aLIM-domain binding factor 1a0.151
hmx1H6 homeo box 10.151
flt4fms-related tyrosine kinase 40.150
fezf2FEZ family zinc finger 20.148
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.147
itgb1aintegrin, beta 1a0.145
trpm7transient receptor potential cation channel, subfamily M, member 70.145
fzd7bfrizzled homolog 7b0.145
col1a1acollagen, type I, alpha 1a0.143
nog1noggin 10.142
ext2exostoses (multiple) 20.142
ventventral expressed homeobox0.139
egr2bearly growth response 2b0.139
runx2brunt-related transcription factor 2b0.139
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.877
lmn-1Protein LMN-10.768
let-60Protein LET-600.764
daf-11Protein DAF-110.714
unc-9Protein UNC-90.665
osm-5Protein OSM-50.564
sem-5Protein SEM-50.513
jnk-1Protein JNK-10.422
abl-1Protein ABL-10.403
osm-3Protein OSM-30.387
msp-78Protein MSP-780.371
let-756Protein LET-7560.335
eor-1Protein EOR-10.323
unc-10Protein UNC-100.315
ten-1Protein TEN-10.283
unc-43Protein UNC-430.274
ist-1Protein IST-10.272
egl-15Protein EGL-150.271
pha-4Protein PHA-40.270
pry-1Protein PRY-10.267
plc-1Protein PLC-10.259
lin-25Protein LIN-250.243
bar-1Protein BAR-10.238
afd-1Protein AFD-10.235
spc-1Protein SPC-10.234
lag-1Protein LAG-10.232
par-5Protein PAR-50.224
svh-2Protein SVH-20.220
let-23Protein LET-230.217
itr-1Protein ITR-10.213
msp-152Protein MSP-1520.210
eya-1Protein EYA-10.205
nhr-34Protein NHR-340.204
sma-6Protein SMA-60.200
mat-3Protein MAT-30.186
goa-1Protein GOA-10.186
sad-1Protein SAD-10.180
gpb-1Protein GPB-10.168
msp-36Protein MSP-360.167
imb-2Protein IMB-20.164
lin-45Protein LIN-450.162
sol-1Protein SOL-10.162
msp-55Protein MSP-550.159
sys-1Protein SYS-10.156
cdc-42Protein CDC-420.156
unc-37Protein UNC-370.155
nhr-67Protein NHR-670.153
lin-11Protein LIN-110.152
msp-77Protein MSP-770.151
tag-262Protein TAG-2620.151
swan-2Protein SWAN-20.150
pak-1Protein PAK-10.150
che-13Protein CHE-130.147
daf-2Protein DAF-20.146
sel-8Protein SEL-80.146
rab-1Protein RAB-10.144
his-72Protein HIS-720.142
sel-12Protein SEL-120.142
pal-1Protein PAL-10.142
msp-40Protein MSP-400.142
syd-2Protein SYD-20.137
F46H5.2Protein F46H5.20.134
gei-18Protein GEI-180.133
scd-1Protein SCD-10.133
pat-3Protein PAT-30.132
unc-32Protein UNC-320.130
sel-10Protein SEL-100.129
sax-3Protein SAX-30.128
trim-9Protein TRIM-90.126
unc-40Protein UNC-400.122
msp-64Protein MSP-640.122
cyp-35C1Protein CYP-35C10.122
mod-1Protein MOD-10.122
rpm-1Protein RPM-10.121
zer-1Protein ZER-10.119
ida-1Protein IDA-10.116
msp-76Protein MSP-760.116
lin-9Protein LIN-90.115
ugt-22Protein UGT-220.115
ccf-1Protein CCF-10.114
cey-1Protein CEY-10.114
pkg-1Protein PKG-10.113
msp-142Protein MSP-1420.113
T19D12.2Protein T19D12.20.111
pop-1Protein POP-10.109
CELE_F53C11.4Protein F53C11.40.108
exc-7Protein EXC-70.108
pqn-55Protein PQN-550.107
vha-15Protein VHA-150.106
htz-1Protein HTZ-10.105
hmg-1.2Protein HMG-1.20.102
sur-2Protein SUR-20.102
cyp-35A3Protein CYP-35A30.102
msp-33Protein MSP-330.101
atg-18Protein ATG-180.101
soc-2Protein SOC-20.101
K10D6.4Protein K10D6.40.097
sma-1Protein SMA-10.097
zoo-1Protein ZOO-10.097
hnd-1Protein HND-10.096
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Akt1CG4006 gene product from transcript CG4006-RA0.968
kaykayak0.912
Atg1Autophagy-specific gene 10.905
CaMKIICalcium/calmodulin-dependent protein kinase II0.890
maskmultiple ankyrin repeats single KH domain0.848
wlswntless0.840
wgwingless0.831
Ras85DRas oncogene at 85D0.776
Pi3K92ECG4141 gene product from transcript CG4141-RB0.767
phlpole hole0.729
dmdiminutive0.720
domedomeless0.710
bratbrain tumor0.703
rlrolled0.668
Stat92ESignal-transducer and activator of transcription protein at 92E0.666
eIF-4EEukaryotic initiation factor 4E0.646
Rab5Rab-protein 50.643
O-fut1O-fucosyltransferase 10.642
shnschnurri0.636
EgfrEpidermal growth factor receptor0.628
cicubitus interruptus0.625
putpunt0.619
ewgerect wing0.612
lealeak0.606
hbshibris0.598
SmoxSmad on X0.592
fzfrizzled0.585
spasspastin0.584
MadMothers against dpp0.565
Lis-1Lissencephaly-10.564
GluRIIAGlutamate receptor IIA0.546
Rac2CG8556 gene product from transcript CG8556-RA0.540
Smg1CG32743 gene product from transcript CG32743-RA0.530
sdscalloped0.523
gbbglass bottom boat0.522
InRInsulin-like receptor0.510
CblCG7037 gene product from transcript CG7037-RB0.501
bskbasket0.494
Pp2B-14DProtein phosphatase 2B at 14D0.489
DabDisabled0.481
TlToll0.476
unc-104CG8566 gene product from transcript CG8566-RB0.474
EcREcdysone receptor0.474
rstroughest0.471
Jon99CiiiJonah 99Ciii0.470
p53CG33336 gene product from transcript CG33336-RB0.463
AblAbl tyrosine kinase0.451
DadDaughters against dpp0.446
miltmilton0.439
jebjelly belly0.434
ecdecdysoneless0.433
fz2frizzled 20.427
wocwithout children0.416
UbxUltrabithorax0.412
MAN1CG3167 gene product from transcript CG3167-RA0.406
Nrx-IVNeurexin IV0.404
dncdunce0.391
trioCG18214 gene product from transcript CG18214-RA0.387
Dsor1Downstream of raf10.382
HsfHeat shock factor0.379
amosabsent MD neurons and olfactory sensilla0.376
hephemipterous0.375
Nup153Nucleoporin 1530.371
PliPellino0.368
Gap1GTPase-activating protein 10.366
CadNCadherin-N0.366
mbcmyoblast city0.364
HLHmgammaE(spl) region transcript mgamma0.362
shishibire0.347
emcextra macrochaetae0.345
CG31146CG31146 gene product from transcript CG31146-RD0.344
mtmmyotubularin0.342
Arp66BActin-related protein 66B0.342
sflsulfateless0.334
myoglianinCG1838 gene product from transcript CG1838-RD0.330
KhcKinesin heavy chain0.327
inx2innexin 20.327
spispitz0.323
babobaboon0.314
unc-13CG2999 gene product from transcript CG2999-RA0.309
Ets97DEts at 97D0.309
atoatonal0.308
Ced-12CG5336 gene product from transcript CG5336-RA0.307
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.305
Fmr1CG6203 gene product from transcript CG6203-RC0.304
JraJun-related antigen0.301
dcodiscs overgrown0.299
esnespinas0.297
ushu-shaped0.296
laplike-AP1800.295
mttmangetout0.291
CycDCyclin D0.288
aopanterior open0.285
CG12424CG12424 gene product from transcript CG12424-RC0.285
FsFollistatin0.285
dlg1discs large 10.284
cv-ccrossveinless c0.283
ttvtout-velu0.283
Aos1CG12276 gene product from transcript CG12276-RA0.278
betaTrybetaTrypsin0.278
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ghsrgrowth hormone secretagogue receptor0.796
Ptafrplatelet-activating factor receptor0.747
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.746
Ccl4chemokine (C-C motif) ligand 40.672
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.664
Prrx1paired related homeobox 10.644
Jak2Janus kinase 20.638
FevFEV (ETS oncogene family)0.623
Fgf7fibroblast growth factor 70.621
Gna12guanine nucleotide binding protein (G protein) alpha 120.618
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.613
Notch3Notch homolog 3 (Drosophila)0.598
Gng7guanine nucleotide binding protein (G protein), gamma 70.596
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.593
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.583
Lgals5lectin, galactose binding, soluble 50.571
Grm7glutamate receptor, metabotropic 70.570
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.566
Rararetinoic acid receptor, alpha0.565
Capgcapping protein (actin filament), gelsolin-like0.559
Pde3aphosphodiesterase 3A, cGMP inhibited0.555
Runx1runt-related transcription factor 10.540
Cxcl2chemokine (C-X-C motif) ligand 20.539
Csf1colony stimulating factor 1 (macrophage)0.538
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.535
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.529
Gria2glutamate receptor, ionotropic, AMPA 20.520
Tnftumor necrosis factor (TNF superfamily, member 2)0.519
Itgamintegrin, alpha M0.515
Prkcgprotein kinase C, gamma0.514
Utrnutrophin0.514
Gja1gap junction protein, alpha 10.512
Gna15guanine nucleotide binding protein, alpha 150.510
Htr75-hydroxytryptamine (serotonin) receptor 70.508
Ednrbendothelin receptor type B0.502
Calcrlcalcitonin receptor-like0.499
Syt8synaptotagmin VIII0.483
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.479
Vegp2von Ebners gland protein 20.470
Cd14CD14 molecule0.469
Adora2aadenosine A2a receptor0.450
Ush1cUsher syndrome 1C homolog (human)0.446
Cd4Cd4 molecule0.444
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.437
Nlgn3neuroligin 30.432
Ddr1discoidin domain receptor tyrosine kinase 10.432
Gpr6G protein-coupled receptor 60.425
C5ar1complement component 5a receptor 10.425
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.421
Olr1654olfactory receptor 16540.420
Smad3SMAD family member 30.419
Ugt2b7UDP glucuronosyltransferase 2 family, polypeptide B70.418
Bcanbrevican0.418
Irs1insulin receptor substrate 10.414
Gfapglial fibrillary acidic protein0.409
Gja6gap junction protein, alpha 60.407
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.401
Phox2apaired-like homeobox 2a0.397
Fgfr1Fibroblast growth factor receptor 10.395
Jak1Janus kinase 10.395
Mapk9mitogen-activated protein kinase 90.394
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.392
Rbp2retinol binding protein 2, cellular0.392
Mapk1mitogen activated protein kinase 10.387
Acsl4acyl-CoA synthetase long-chain family member 40.386
Agtr1aangiotensin II receptor, type 1a0.382
Vamp2vesicle-associated membrane protein 20.381
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.376
Glg1golgi apparatus protein 10.373
Cd44Cd44 molecule0.371
Prkcaprotein kinase C, alpha0.369
Edn1endothelin 10.366
Nek9NIMA (never in mitosis gene a)- related kinase 90.363
Syt4synaptotagmin IV0.361
Itpr2inositol 1,4,5-triphosphate receptor, type 20.358
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.357
Dab2disabled homolog 2 (Drosophila)0.356
Elk3ELK3, ETS-domain protein0.356
Ncr1natural cytotoxicity triggering receptor 10.355
Ptger2prostaglandin E receptor 2 (subtype EP2)0.354
Pou3f2POU class 3 homeobox 20.351
Fgf5fibroblast growth factor 50.351
Myl7myosin, light chain 7, regulatory0.350
Nfascneurofascin0.350
Ncanneurocan0.348
Pnlippancreatic lipase0.348
Efnb1ephrin B10.347
Mapk8mitogen-activated protein kinase 80.347
Nrg1neuregulin 10.346
Fam70bfamily with sequence similarity 70, member B0.345
Magmyelin-associated glycoprotein0.345
Hckhemopoietic cell kinase0.343
Nrxn1neurexin 10.343
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.342
Cgaglycoprotein hormones, alpha polypeptide0.341
S100a8S100 calcium binding protein A80.339
Rab3il1RAB3A interacting protein (rabin3)-like 10.338
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.337
Il2rginterleukin 2 receptor, gamma0.337
Fgfr2fibroblast growth factor receptor 20.334
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
NBP2Nbp2p0.607
SSK2Ssk2p0.598
PBS2Pbs2p0.442
ENA5Ena5p0.399
ERP4Erp4p0.372
PRK1Prk1p0.298
ROM2Rom2p0.278
CPR1Cpr1p0.237
AKL1Akl1p0.232
TPK1Tpk1p0.121
TOR1Tor1p0.121
CKA2Cka2p0.115
HOS4Hos4p0.114
PTC1Ptc1p0.104
RTG3Rtg3p0.092
CLA4Cla4p0.089
SSK22Ssk22p0.070
BMH2Bmh2p0.064
ARC35Arc35p0.062
BMH1Bmh1p0.061
AQR1Aqr1p0.059
TPO4Tpo4p0.055
DNM1Dnm1p0.055
FAR11Far11p0.054
SSK1Ssk1p0.053
YAK1Yak1p0.053
CDC34Cdc34p0.052
RGD1Rgd1p0.052
ERP5Erp5p0.052
PRD1Prd1p0.050
PAN1Pan1p0.050
CKB2Ckb2p0.050
AKR2Akr2p0.047
SLM2Slm2p0.044
STE5Ste5p0.044
ERP2Erp2p0.041
GLO3Glo3p0.041
OSH2Osh2p0.040
RPS0ARps0ap0.037
KOG1Kog1p0.037
AHP1Ahp1p0.037
APP1App1p0.036
SLA2Sla2p0.036
STE23Ste23p0.035
ERV25Erv25p0.034
OSH6Osh6p0.032
LCB4Lcb4p0.032
ENA2Ena2p0.031
SAP4Sap4p0.031
ERP3Erp3p0.029
HHT1Hht1p0.029
FUS3Fus3p0.029
CMP2Cmp2p0.027
SRO7Sro7p0.026
LAS17Las17p0.025
OLE1Ole1p0.025
RSC8Rsc8p0.025
SIF2Sif2p0.025
VRP1Vrp1p0.025
HSP60Hsp60p0.024
STE7Ste7p0.024
RIM15Rim15p0.023
TCO89Tco89p0.023
SDS22Sds22p0.022
UGP1Ugp1p0.022
BOP2Bop2p0.022
PST2Pst2p0.022
DGR2Dgr2p0.021
POL5Pol5p0.021
CRR1Crr1p0.021
RTT106Rtt106p0.020
BNI1Bni1p0.020
STE12Ste12p0.020
SSO1Sso1p0.019
GPB2Gpb2p0.019
IZH4Izh4p0.019
KAR5Kar5p0.019
CNS1Cns1p0.019
TOR2Tor2p0.019
MEH1Meh1p0.019
RRP7Rrp7p0.019
TRA1Tra1p0.019
BEM3Bem3p0.019
PMT3Pmt3p0.019
MIG1Mig1p0.019
FUS1Fus1p0.019
RIO2Rio2p0.019
CMK1Cmk1p0.018
MSI1Msi1p0.018
MKK1Mkk1p0.018
DML1Dml1p0.018
ARR3Arr3p0.018
ERP6Erp6p0.017
EPL1Epl1p0.017
IPI1Ipi1p0.017
HST1Hst1p0.017
YCL042Whypothetical protein0.017
SMF1Smf1p0.017
SET3Set3p0.016
FPS1Fps1p0.016