The network for 'syncytium formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

syncytium formation

The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.

NameDescriptionProbabilityFunc Analog Organism
myod1myogenic differentiation 10.768
dccdeleted in colorectal carcinoma0.766
mef2camyocyte enhancer factor 2ca0.457
jam2ajunctional adhesion molecule 2a0.451
gpiaglucose phosphate isomerase a0.421
kirrel3lkin of IRRE like 3 like0.355
btkBruton agammaglobulinemia tyrosine kinase0.262
jam3bjunctional adhesion molecule 3b0.255
hsp90a.1heat shock protein 90-alpha 10.246
frmd6FERM domain containing 60.176
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.161
aldocbaldolase C, fructose-bisphosphate, b0.151
dock1dedicator of cytokinesis 10.131
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.129
rogdirogdi homolog (Drosophila)0.122
mef2dmyocyte enhancer factor 2d0.114
atp6v1b2ATPase, H+ transporting, lysosomal V1 subunit B20.112
llgl2lethal giant larvae homolog 2 (Drosophila)0.110
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.099
wtipWilms tumor 1 interacting protein0.095
vegfabvascular endothelial growth factor Ab0.094
foxo3bforkhead box O3b0.091
hoxa11ahomeo box A11a0.090
flot1bflotillin 1b0.089
lrrc33leucine rich repeat containing 330.089
spry4sprouty (Drosophila) homolog 40.088
ndfip1Nedd4 family interacting protein 10.085
ckbbcreatine kinase, brain b0.084
pak2ap21 (CDKN1A)-activated kinase 2a0.080
ptk2.1protein tyrosine kinase 2a0.077
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.077
colec11collectin sub-family member 110.076
mmp9matrix metalloproteinase 90.076
jag2jagged 20.072
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.070
prrx1bpaired related homeobox 1b0.068
ttnatitin a0.068
wt1bwilms tumor 1b0.065
meox1mesenchyme homeobox 10.063
desmadesmin a0.060
LOC566969similar to MOX-2 protein0.059
bocbrother of CDO0.056
stac3SH3 and cysteine rich domain 30.054
insrbinsulin receptor b0.054
f11rF11 receptor0.052
efnb2aephrin B2a0.051
plxnb2aplexin b2a0.051
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.050
cxadrcoxsackie virus and adenovirus receptor0.048
laptm4blysosomal associated protein transmembrane 4 beta0.047
neurodneurogenic differentiation0.046
ldb1aLIM-domain binding factor 1a0.046
arfip2aADP-ribosylation factor interacting protein 2a0.045
pfn1profilin 10.044
lbx2ladybird homeobox homolog 2 (Drosophila)0.043
plce1phospholipase C, epsilon 10.043
mxi1max interacting protein0.042
vgll2bvestigial like 2b0.041
tpm4tropomyosin 40.041
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.040
csf3rcolony stimulating factor 3 receptor (granulocyte)0.039
cdh1cadherin 1, epithelial0.039
vegfaavascular endothelial growth factor Aa0.039
ptpraprotein tyrosine phosphatase, receptor type, A0.039
dock5dedicator of cytokinesis 50.038
ryr1bryanodine receptor 1b (skeletal)0.037
jupjunction plakoglobin0.037
spon1bspondin 1b0.036
mycamyelocytomatosis oncogene a0.035
tpm3tropomyosin 30.034
ldb2aLIM-domain binding factor 2a0.034
tcf12transcription factor 120.034
bmp4bone morphogenetic protein 40.033
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.032
zbtb4zinc finger and BTB domain containing 40.032
nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.031
coro1acoronin, actin binding protein, 1A0.031
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.030
calm1bcalmodulin 1b0.029
smyd1bSET and MYND domain containing 1b0.028
cyt1type I cytokeratin, enveloping layer0.028
efnb3bephrin B3b0.027
olig4oligodendrocyte transcription factor 40.026
rtn1areticulon 1a0.026
camk2d2calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 20.026
fmr1fragile X mental retardation 10.025
hhatlahedgehog acyltransferase-like, a0.025
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.025
gmfgglia maturation factor, gamma0.024
crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.024
lhx9LIM homeobox 90.024
flncbfilamin C, gamma b (actin binding protein 280)0.024
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.023
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vha-14Protein VHA-140.015
kin-4Protein KIN-40.013
sup-17Protein SUP-170.011
rskn-1Protein RSKN-10.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Vrp1Verprolin 11.000
mbcmyoblast city1.000
blowblown fuse0.995
snssticks and stones0.992
Arf51FADP ribosylation factor 51F0.991
lbeladybird early0.988
Mp20Muscle protein 200.987
rolsrolling pebbles0.981
foxoforkhead box, sub-group O0.966
Rac2CG8556 gene product from transcript CG8556-RA0.948
ThorCG8846 gene product from transcript CG8846-RA0.947
kirrekin of irre0.919
S6kRPS6-p70-protein kinase0.879
PyKPyruvate kinase0.871
Rac1CG2248 gene product from transcript CG2248-RA0.801
ImpL3Ecdysone-inducible gene L30.779
TpiTriose phosphate isomerase0.779
Arf79FADP ribosylation factor 79F0.753
lmdlame duck0.727
Mlp84BMuscle LIM protein at 84B0.695
Atg1Autophagy-specific gene 10.691
InRInsulin-like receptor0.617
eveeven skipped0.539
Mef2Myocyte enhancer factor 20.523
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 10.502
AcslAcyl-CoA synthetase long-chain0.501
LamCLamin C0.450
slp1sloppy paired 10.440
Rho1CG8416 gene product from transcript CG8416-RB0.420
WASpCG1520 gene product from transcript CG1520-RA0.372
AbiAbelson interacting protein0.364
Sra-1specifically Rac1-associated protein 10.312
RalaRas-related protein0.311
zfh1Zn finger homeodomain 10.295
aopanterior open0.270
X11LCG5675 gene product from transcript CG5675-RB0.253
Arp66BActin-related protein 66B0.240
PgkPhosphoglycerate kinase0.198
stumpsCG31317 gene product from transcript CG31317-RC0.191
singsingles bar0.189
bibbig brain0.186
p120ctnAdherens junction protein p1200.160
imdimmune deficiency0.157
GripGlutamate receptor binding protein0.152
ParpPoly-(ADP-ribose) polymerase0.148
LanB2Laminin B20.129
Akt1CG4006 gene product from transcript CG4006-RA0.118
ik2IkappaB kinase-like 20.116
beat-Iabeaten path Ia0.112
mib2mind bomb 20.112
vavCG7893 gene product from transcript CG7893-RB0.103
sosine oculis0.103
Cip4CG15015 gene product from transcript CG15015-RA0.098
CkIalphaCasein kinase Ialpha0.086
AlkCG8250 gene product from transcript CG8250-RA0.075
Act57BActin 57B0.075
Eip63EEcdysone-induced protein 63E0.062
LrtLeucine-rich tendon-specific protein0.062
drkdownstream of receptor kinase0.058
LanALaminin A0.057
HimHoles in muscle0.055
PoxmPox meso0.054
HLH54FCG5005 gene product from transcript CG5005-RA0.051
lqfliquid facets0.050
GlyPGlycogen phosphorylase0.049
reporeversed polarity0.046
eyaeyes absent0.046
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GRB2growth factor receptor-bound protein 20.866
EGFRepidermal growth factor receptor0.204
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.128
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.123
PTK2PTK2 protein tyrosine kinase 20.111
ABI2abl-interactor 20.106
IQGAP1IQ motif containing GTPase activating protein 10.064
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.045
CASP8caspase 8, apoptosis-related cysteine peptidase0.035
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.029
SHC1SHC (Src homology 2 domain containing) transforming protein 10.027
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.024
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.024
ALDOAaldolase A, fructose-bisphosphate0.022
SLC7A5solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.022
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.018
AKT1v-akt murine thymoma viral oncogene homolog 10.018
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.017
BCAR1breast cancer anti-estrogen resistance 10.016
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.015
HDAC4histone deacetylase 40.014
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.012
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.012
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E10.012
PTRFpolymerase I and transcript release factor0.011
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.943
Mapk14mitogen-activated protein kinase 140.871
Vav1vav 1 oncogene0.865
Grb10growth factor receptor bound protein 100.829
Map3k14mitogen-activated protein kinase kinase kinase 140.808
Ltblymphotoxin B0.735
Ccl2chemokine (C-C motif) ligand 20.719
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.715
Leprleptin receptor0.642
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.620
Efnb2ephrin B20.619
Stat5bsignal transducer and activator of transcription 5B0.575
Stat6signal transducer and activator of transcription 60.568
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.465
Stat5asignal transducer and activator of transcription 5A0.439
RictorRPTOR independent companion of MTOR, complex 20.429
Cd40CD40 antigen0.377
Irs1insulin receptor substrate 10.376
Pax7paired box gene 70.365
Casp4caspase 4, apoptosis-related cysteine peptidase0.347
Cxcr4chemokine (C-X-C motif) receptor 40.338
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.312
Il2interleukin 20.291
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.282
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.282
Il4rainterleukin 4 receptor, alpha0.277
Cxcl13chemokine (C-X-C motif) ligand 130.266
Csf1colony stimulating factor 1 (macrophage)0.255
Ccr1chemokine (C-C motif) receptor 10.254
Socs1suppressor of cytokine signaling 10.252
Jak2Janus kinase 20.252
Pitx1paired-like homeodomain transcription factor 10.250
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.248
Irf9interferon regulatory factor 90.233
Wnt10bwingless related MMTV integration site 10b0.228
Myo1cmyosin IC0.223
Bcl2B-cell leukemia/lymphoma 20.215
BtkBruton agammaglobulinemia tyrosine kinase0.213
Hif1ahypoxia inducible factor 1, alpha subunit0.207
Wnt1wingless-related MMTV integration site 10.203
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.199
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.197
Tbx4T-box 40.194
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.186
Il1binterleukin 1 beta0.185
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.176
Esx1extraembryonic, spermatogenesis, homeobox 10.163
Smad3MAD homolog 3 (Drosophila)0.160
Ptk2PTK2 protein tyrosine kinase 20.158
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.157
Tnftumor necrosis factor0.157
Timp1tissue inhibitor of metalloproteinase 10.157
Ltalymphotoxin A0.156
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.150
Gdnfglial cell line derived neurotrophic factor0.148
Cxcr5chemokine (C-X-C motif) receptor 50.148
Iigp1interferon inducible GTPase 10.144
En1engrailed 10.141
Ncoa3nuclear receptor coactivator 30.140
Mapkap1mitogen-activated protein kinase associated protein 10.140
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.134
Tpm4tropomyosin 40.133
Msx3homeobox, msh-like 30.133
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.131
Igtpinterferon gamma induced GTPase0.130
Akt1thymoma viral proto-oncogene 10.129
Hdac4histone deacetylase 40.128
Igf2insulin-like growth factor 20.128
Hdac7histone deacetylase 70.127
Prrx2paired related homeobox 20.127
Bcar1breast cancer anti-estrogen resistance 10.122
Ccl12chemokine (C-C motif) ligand 120.119
Rac1RAS-related C3 botulinum substrate 10.118
Nphs2nephrosis 2 homolog, podocin (human)0.118
Prkceprotein kinase C, epsilon0.114
Pgk1phosphoglycerate kinase 10.113
Stat3signal transducer and activator of transcription 30.113
Rhogras homolog gene family, member G0.113
Mapk11mitogen-activated protein kinase 110.111
Ptrfpolymerase I and transcript release factor0.111
Tgfb1transforming growth factor, beta 10.110
Dkk1dickkopf homolog 1 (Xenopus laevis)0.108
Wdr26WD repeat domain 260.107
Wdr1WD repeat domain 10.107
Gbp2guanylate binding protein 20.106
MgmtO-6-methylguanine-DNA methyltransferase0.105
Mapk8mitogen-activated protein kinase 80.104
Itgb1integrin beta 1 (fibronectin receptor beta)0.103
Sftpbsurfactant associated protein B0.098
Otx1orthodenticle homolog 1 (Drosophila)0.097
Disp1dispatched homolog 1 (Drosophila)0.097
Actr2ARP2 actin-related protein 2 homolog (yeast)0.096
Mapkapk2MAP kinase-activated protein kinase 20.095
Lmx1bLIM homeobox transcription factor 1 beta0.094
Chrndcholinergic receptor, nicotinic, delta polypeptide0.093
Hoxa2homeobox A20.093
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Casp1caspase 10.033
Emp1epithelial membrane protein 10.025
Col4a1collagen, type IV, alpha 10.024
Ccl2chemokine (C-C motif) ligand 20.021
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.020
Cd14CD14 molecule0.020
Rab1bRAB1B, member RAS oncogene family0.020
Ptbp1polypyrimidine tract binding protein 10.019
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.018
Ptprcprotein tyrosine phosphatase, receptor type, C0.017
Syngr2synaptogyrin 20.017
Mapre1microtubule-associated protein, RP/EB family, member 10.017
Lbrlamin B receptor0.017
Tgfbr2transforming growth factor, beta receptor II0.017
Pkm2pyruvate kinase, muscle0.016
Acta2smooth muscle alpha-actin0.016
S1pr2sphingosine-1-phosphate receptor 20.016
Socs3suppressor of cytokine signaling 30.016
Tpm4tropomyosin 40.016
Csnk1g2casein kinase 1, gamma 20.016
Smad1SMAD family member 10.015
Anxa1annexin A10.015
Adam17ADAM metallopeptidase domain 170.015
Aldoaaldolase A, fructose-bisphosphate0.015
Wdfy1WD repeat and FYVE domain containing 10.015
Myl1myosin, light chain 10.015
Eef2eukaryotic translation elongation factor 20.015
Ccnd3cyclin D30.015
Skap2src kinase associated phosphoprotein 20.015
Smad2SMAD family member 20.014
Fitm1fat storage-inducing transmembrane protein 10.014
Cdv3carnitine deficiency-associated gene expressed in ventricle 3 homolog (mouse)0.014
Magt1magnesium transporter 10.014
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.014
Alas2aminolevulinate, delta-, synthase 20.014
Ctsccathepsin C0.014
Tcf12transcription factor 120.014
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.014
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.014
Cd48Cd48 molecule0.014
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.014
Tgfb1transforming growth factor, beta 10.013
Acvr1activin A receptor, type I0.013
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.013
Stk17bserine/threonine kinase 17b0.013
Gbp2guanylate binding protein 20.013
Il18interleukin 180.013
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.013
Bnip2BCL2/adenovirus E1B interacting protein 20.013
Arl5aADP-ribosylation factor-like 5A0.013
Itpkcinositol 1,4,5-trisphosphate 3-kinase C0.013
Cngb1cyclic nucleotide gated channel beta 10.013
Adam10ADAM metallopeptidase domain 100.013
Actc1actin, alpha, cardiac muscle 10.013
Gsrglutathione reductase0.013
Cox8bcytochrome c oxidase, subunit VIIIb0.013
Cav3caveolin 30.013
Tp53tumor protein p530.013
Bnip3lBCL2/adenovirus E1B interacting protein 3-like0.013
Casq2calsequestrin 2 (cardiac muscle)0.012
Flnbfilamin, beta0.012
Irs1insulin receptor substrate 10.012
Il1binterleukin 1 beta0.012
Il1r2interleukin 1 receptor, type II0.012
Myo1bmyosin Ib0.012
Clic4chloride intracellular channel 40.012
Mpripmyosin phosphatase Rho interacting protein0.012
Cald1caldesmon 10.012
Stat6signal transducer and activator of transcription 60.012
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.012
Efna5ephrin A50.012
Tcp11l2t-complex 11 (mouse) like 20.012
Cxcl9chemokine (C-X-C motif) ligand 90.012
Hk2hexokinase 20.012
RGD1309414similar to KIAA0913 protein0.012
RT1-DaRT1 class II, locus Da0.012
Csnk1g3casein kinase 1, gamma 30.012
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.012
Map4microtubule-associated protein 40.012
Tpm1tropomyosin 1, alpha0.012
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.012
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.012
Cybbcytochrome b-245, beta polypeptide0.012
Stat3signal transducer and activator of transcription 30.012
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.012
Rhoaras homolog gene family, member A0.012
Usf2upstream transcription factor 2, c-fos interacting0.012
Cyb5bcytochrome b5 type B (outer mitochondrial membrane)0.012
MdficMyoD family inhibitor domain containing0.012
Scarb1scavenger receptor class B, member 10.012
Rnf4ring finger protein 40.012
Tjp1tight junction protein 10.012
Map3k1mitogen activated protein kinase kinase kinase 10.012
Lig3ligase III, DNA, ATP-dependent0.012
Fgfr1Fibroblast growth factor receptor 10.012
Snap23synaptosomal-associated protein 230.012
Rpl3lribosomal protein L3-like0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism