The network for 'ectoderm development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ectoderm development

The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.

NameDescriptionProbabilityFunc Analog Organism
hnf1baHNF1 homeobox Ba0.995
wnt1wingless-type MMTV integration site family, member 10.952
cdh1cadherin 1, epithelial0.942
wnt4awingless-type MMTV integration site family, member 4a0.855
bmp4bone morphogenetic protein 40.621
wnt2wingless-type MMTV integration site family member 20.574
foxa2forkhead box A20.551
wnt10awingless-type MMTV integration site family, member 10a0.542
wnt8bwingless-type MMTV integration site family, member 8b0.474
wnt9awingless-type MMTV integration site family, member 9A0.417
cntn2contactin 20.405
lmx1b.1LIM homeobox transcription factor 1, beta 10.297
wnt9bwingless-type MMTV integration site family, member 9B0.286
wnt2bbwingless-type MMTV integration site family, member 2Bb0.285
tbx1T-box 10.198
wnt11wingless-type MMTV integration site family, member 110.182
btg2B-cell translocation gene 20.182
perpPERP, TP53 apoptosis effector0.181
oepone-eyed pinhead0.177
bmpr1aabone morphogenetic protein receptor, type 1aa0.174
wnt16wingless-type MMTV integration site family, member 160.160
spry2sprouty homolog 20.158
egr2bearly growth response 2b0.156
prlprolactin0.154
flhfloating head0.147
gata5GATA-binding protein 50.125
id1inhibitor of DNA binding 10.117
dkk1bdickkopf 1b0.116
tob1atransducer of ERBB2, 1a0.112
frzbfrizzled-related protein0.110
irx3biroquois homeobox protein 3b0.109
wlswntless homolog (Drosophila)0.105
grem1agremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)0.105
wnt3wingless-type MMTV integration site family, member 30.104
map2k4amitogen-activated protein kinase kinase 4a0.103
eya1eyes absent homolog 10.102
epb4.1l4erythrocyte protein band 4.1-like 40.101
cdh6cadherin 60.097
lama5laminin, alpha 50.090
lft2lefty20.089
osr2odd-skipped related 2 (Drosophila)0.086
krt8keratin 80.083
her5hairy-related 50.080
mapk12mitogen-activated protein kinase 120.080
dharmadharma0.075
egr1early growth response 10.073
sox2SRY-box containing gene 20.071
nkx2.2aNK2 transcription factor related 2a0.071
tshbthyroid stimulating hormone, beta subunit0.069
sfrp1bsecreted frizzled-related protein 1b0.069
gbx1gastrulation brain homeobox 10.065
tp63tumor protein p630.062
wnt7aawingless-type MMTV integration site family, member 7Aa0.061
ndr2nodal-related 20.060
dspadesmoplakin a0.060
wnt7bbwingless-type MMTV integration site family, member 7Bb0.058
og9xOG9 homeobox gene0.056
pomcaproopiomelanocortin a0.056
pea3ETS-domain transcription factor pea30.052
prkciprotein kinase C, iota0.050
lef1lymphocyte enhancer binding factor 10.050
nanos3nanos homolog 30.050
nrarpanotch-regulated ankyrin repeat protein a0.049
krt4keratin 40.049
restRE1-silencing transcription factor0.049
foxb1.2forkhead box B1.20.048
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.048
gyltl1bglycosyltransferase-like 1b0.047
foxa3forkhead box A30.047
ccnb1cyclin B10.047
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.047
dlddeltaD0.045
bmp2bbone morphogenetic protein 2b0.044
arl4abADP-ribosylation factor-like 4ab0.042
sdprbserum deprivation response b0.040
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.040
lsrlipolysis stimulated lipoprotein receptor0.038
phox2apaired-like homeobox 2a0.037
barhl1.2BarH-like 1.20.037
bucbucky ball0.036
scn1bbsodium channel, voltage-gated, type I, beta b0.036
wnt3awingless-type MMTV integration site family, member 3A0.035
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.035
vasavasa homolog0.035
ndr1nodal-related 10.034
fzd10frizzled homolog 100.034
myf5myogenic factor 50.033
alas2aminolevulinate, delta-, synthetase 20.033
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.033
jupjunction plakoglobin0.033
wif1wnt inhibitory factor 10.033
map2k4bmitogen-activated protein kinase kinase 4b0.033
klf2aKruppel-like factor 2a0.032
sema3dsemaphorin 3d0.032
ntlano tail a0.032
pglyrp2peptidoglycan recognition protein 20.031
lamc1laminin, gamma 10.031
krt18keratin 180.031
notum3notum 30.031
tagln2transgelin 20.031
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
exc-5Protein EXC-50.316
lin-36Protein LIN-360.125
soc-2Protein SOC-20.091
magu-2Protein MAGU-20.070
ceh-20Protein CEH-200.067
unc-73Protein UNC-730.057
pry-1Protein PRY-10.050
mig-38Protein MIG-380.045
pqn-62Protein PQN-620.042
F26E4.7Protein F26E4.70.041
egl-18Protein EGL-180.034
pop-1Protein POP-10.033
elt-6Protein ELT-60.032
tag-297Protein TAG-2970.031
T12E12.3Protein T12E12.30.029
ptr-11Protein PTR-110.029
col-111Protein COL-1110.028
frm-7Protein FRM-70.027
nhr-45Protein NHR-450.027
col-173Protein COL-1730.026
dbl-1Protein DBL-10.025
vps-16Protein VPS-160.025
svh-2Protein SVH-20.025
F13B6.1Protein F13B6.10.024
dlg-1Protein DLG-10.024
mth-2Protein MTH-20.024
cki-1Protein CKI-10.024
hlh-30Protein HLH-300.024
CELE_F07E5.7Protein F07E5.70.023
clec-180Protein CLEC-1800.023
cfim-2Protein CFIM-20.023
rbc-1Protein RBC-10.022
B0511.2Protein B0511.20.022
F21A9.2Protein F21A9.20.022
let-23Protein LET-230.022
glo-4Protein GLO-40.021
ptr-2Protein PTR-20.021
F10G8.8Protein F10G8.80.021
bli-1Protein BLI-10.021
nhr-50Protein NHR-500.021
ptl-1Protein PTL-10.020
CELE_Y75B8A.4Protein Y75B8A.40.020
unc-64Protein UNC-640.020
C52E12.4Protein C52E12.40.020
elt-2Protein ELT-20.020
hda-1Protein HDA-10.020
math-26Protein MATH-260.019
H32K16.1Protein H32K16.10.019
wapl-1Protein WAPL-10.018
CELE_Y46G5A.29Protein Y46G5A.290.018
nhr-6Protein NHR-60.018
eor-1Protein EOR-10.018
M163.1Protein M163.10.018
mdt-30Protein MDT-300.018
T23F4.2Protein T23F4.20.018
pac-1Protein PAC-10.017
CELE_E01G4.6Protein E01G4.60.017
bah-1Protein BAH-10.017
math-27Protein MATH-270.017
nhr-25Protein NHR-250.017
nhr-2Protein NHR-20.017
F20C5.4Protein F20C5.40.016
abu-13Protein ABU-130.016
sma-3Protein SMA-30.016
ztf-22Protein ZTF-220.016
col-172Protein COL-1720.016
F57G12.1Protein F57G12.10.015
K10B4.3Protein K10B4.30.015
T26A5.6Protein T26A5.60.015
vhp-1Protein VHP-10.015
cst-2Protein CST-20.015
swsn-7Protein SWSN-70.015
osm-8Protein OSM-80.015
sas-4Protein SAS-40.014
dos-2Protein DOS-20.014
plc-2Protein PLC-20.014
CELE_ZK1025.2Protein ZK1025.20.014
F55C10.4Protein F55C10.40.014
C05C9.1Protein C05C9.10.014
C37C3.2Protein C37C3.20.014
mltn-12Protein MLTN-120.014
cnd-1Protein CND-10.014
ztf-2Protein ZTF-20.014
R07B1.7Protein R07B1.70.014
smp-1Protein SMP-10.014
egl-8Protein EGL-80.014
nrd-1Protein NRD-10.014
tag-196Protein TAG-1960.014
sad-1Protein SAD-10.013
C02B10.5Protein C02B10.50.013
let-60Protein LET-600.013
cls-1Protein CLS-10.013
mes-3Protein MES-30.013
T28F4.4Protein T28F4.40.013
CELE_T10D4.6Protein T10D4.60.013
exp-2Protein EXP-20.013
tag-260Protein TAG-2600.013
mtm-1Protein MTM-10.013
F10C2.3Protein F10C2.30.013
nhr-67Protein NHR-670.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mysmyospheroid0.089
NNotch0.041
crbcrumbs0.037
roboroundabout0.026
sdscalloped0.020
tshteashirt0.015
fz2frizzled 20.013
kniknirps0.011
enengrailed0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FHL2four and a half LIM domains 21.000
ENGendoglin0.960
BMP2bone morphogenetic protein 20.958
FN1fibronectin 10.938
HCFC1host cell factor C1 (VP16-accessory protein)0.916
EGR1early growth response 10.902
PXNpaxillin0.892
PDIA3protein disulfide isomerase family A, member 30.859
CTNND1catenin (cadherin-associated protein), delta 10.839
FOXD3forkhead box D30.820
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.769
EGR3early growth response 30.759
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.757
FBXW11F-box and WD repeat domain containing 110.741
SP1Sp1 transcription factor0.739
FLNAfilamin A, alpha0.733
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.631
WWP2WW domain containing E3 ubiquitin protein ligase 20.538
EGR2early growth response 20.490
CD63CD63 molecule0.481
SCHIP1schwannomin interacting protein 10.464
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.397
FOSFBJ murine osteosarcoma viral oncogene homolog0.370
ITGB4integrin, beta 40.364
TLN1talin 10.340
NR4A1nuclear receptor subfamily 4, group A, member 10.325
PSEN1presenilin 10.320
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.320
FHL3four and a half LIM domains 30.301
PTPRCprotein tyrosine phosphatase, receptor type, C0.271
ARandrogen receptor0.250
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.250
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.243
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.233
ITGA6integrin, alpha 60.206
IER2immediate early response 20.206
CTGFconnective tissue growth factor0.195
SOX2SRY (sex determining region Y)-box 20.191
BBS10Bardet-Biedl syndrome 100.184
CD9CD9 molecule0.183
WNT3Awingless-type MMTV integration site family, member 3A0.165
JUPjunction plakoglobin0.157
ELF5E74-like factor 5 (ets domain transcription factor)0.138
CDH3cadherin 3, type 1, P-cadherin (placental)0.124
GLIS2GLIS family zinc finger 20.119
NR4A2nuclear receptor subfamily 4, group A, member 20.113
ATF3activating transcription factor 30.108
SMURF1SMAD specific E3 ubiquitin protein ligase 10.104
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.098
FRZBfrizzled-related protein0.094
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.093
APCadenomatous polyposis coli0.092
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.080
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.079
SNAI1snail homolog 1 (Drosophila)0.075
CYR61cysteine-rich, angiogenic inducer, 610.073
BTRCbeta-transducin repeat containing0.067
ITGB1BP1integrin beta 1 binding protein 10.067
WNT5Awingless-type MMTV integration site family, member 5A0.067
PDLIM5PDZ and LIM domain 50.066
PSEN2presenilin 2 (Alzheimer disease 4)0.066
ITGB5integrin, beta 50.065
TCF4transcription factor 40.063
COL1A1collagen, type I, alpha 10.060
MAP4K4mitogen-activated protein kinase kinase kinase kinase 40.058
THBS1thrombospondin 10.057
ACP5acid phosphatase 5, tartrate resistant0.057
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.056
NAB2NGFI-A binding protein 2 (EGR1 binding protein 2)0.055
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.052
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.051
TNCtenascin C0.051
VCAM1vascular cell adhesion molecule 10.050
EMDemerin0.047
ADAM9ADAM metallopeptidase domain 90.047
OTX2orthodenticle homeobox 20.046
PTPRJprotein tyrosine phosphatase, receptor type, J0.044
EHFets homologous factor0.043
LGALS1lectin, galactoside-binding, soluble, 10.043
DUSP2dual specificity phosphatase 20.043
CD22CD22 molecule0.042
JAG1jagged 10.042
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.042
FOXO1forkhead box O10.042
NCOA2nuclear receptor coactivator 20.041
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.041
SIN3ASIN3 homolog A, transcription regulator (yeast)0.041
EZRezrin0.041
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.040
NR4A3nuclear receptor subfamily 4, group A, member 30.040
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.040
TGFB1transforming growth factor, beta 10.037
EPS8epidermal growth factor receptor pathway substrate 80.037
BIN1bridging integrator 10.036
SERTAD1SERTA domain containing 10.036
DUSP6dual specificity phosphatase 60.034
ZHX2zinc fingers and homeoboxes 20.033
SFRP1secreted frizzled-related protein 10.033
PKP4plakophilin 40.033
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 20.969
Otx2orthodenticle homolog 2 (Drosophila)0.880
Sox2SRY-box containing gene 20.819
Shhsonic hedgehog0.731
Sall4sal-like 4 (Drosophila)0.697
Gli3GLI-Kruppel family member GLI30.685
Fgf8fibroblast growth factor 80.547
Pax6paired box gene 60.396
Nr0b1nuclear receptor subfamily 0, group B, member 10.329
Emx2empty spiracles homolog 2 (Drosophila)0.308
Fgfr2fibroblast growth factor receptor 20.308
Foxc1forkhead box C10.258
Emx1empty spiracles homolog 1 (Drosophila)0.242
Lhx1LIM homeobox protein 10.238
Nodalnodal0.200
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.175
Hmx3H6 homeobox 30.162
Bmp4bone morphogenetic protein 40.158
Lhx3LIM homeobox protein 30.150
Otx1orthodenticle homolog 1 (Drosophila)0.145
Nr5a1nuclear receptor subfamily 5, group A, member 10.144
NanogNanog homeobox0.140
Sall3sal-like 3 (Drosophila)0.132
Nkx2-1NK2 homeobox 10.128
Sox3SRY-box containing gene 30.127
Pitx2paired-like homeodomain transcription factor 20.113
Eya1eyes absent 1 homolog (Drosophila)0.112
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.107
Chd7chromodomain helicase DNA binding protein 70.107
Tgfbr2transforming growth factor, beta receptor II0.102
Isl1ISL1 transcription factor, LIM/homeodomain0.100
Gbx2gastrulation brain homeobox 20.098
Ctnnb1catenin (cadherin associated protein), beta 10.097
Hes5hairy and enhancer of split 5 (Drosophila)0.097
Pax8paired box gene 80.097
Sall1sal-like 1 (Drosophila)0.088
Tcfcp2l1transcription factor CP2-like 10.088
Vangl2vang-like 2 (van gogh, Drosophila)0.087
Zic3zinc finger protein of the cerebellum 30.081
Tcfap2atranscription factor AP-2, alpha0.081
Nognoggin0.076
Smad4MAD homolog 4 (Drosophila)0.067
Pou5f1POU domain, class 5, transcription factor 10.064
Pax3paired box gene 30.061
Atoh7atonal homolog 7 (Drosophila)0.061
Dlx5distal-less homeobox 50.060
Lmx1aLIM homeobox transcription factor 1 alpha0.054
Ptprqprotein tyrosine phosphatase, receptor type, Q0.051
Sox9SRY-box containing gene 90.050
Pou4f2POU domain, class 4, transcription factor 20.047
Chrdchordin0.047
Wnt7awingless-related MMTV integration site 7A0.047
Nab2Ngfi-A binding protein 20.046
Ptpn11protein tyrosine phosphatase, non-receptor type 110.045
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.044
Insm1insulinoma-associated 10.042
Lmx1bLIM homeobox transcription factor 1 beta0.041
Matn3matrilin 30.040
Foxd2forkhead box D20.039
Jag1jagged 10.039
Gdnfglial cell line derived neurotrophic factor0.038
Tsc1tuberous sclerosis 10.038
Atoh1atonal homolog 1 (Drosophila)0.038
Zic2zinc finger protein of the cerebellum 20.037
Hoxa1homeobox A10.037
Hoxd13homeobox D130.035
Tgfbr1transforming growth factor, beta receptor I0.034
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.034
Tbx10T-box 100.033
Foxh1forkhead box H10.033
Cxadrcoxsackie virus and adenovirus receptor0.032
Sox1SRY-box containing gene 10.032
Foxe3forkhead box E30.032
Vax1ventral anterior homeobox containing gene 10.032
Pou3f1POU domain, class 3, transcription factor 10.031
Egr1early growth response 10.031
Wnt3awingless-related MMTV integration site 3A0.030
Sim1single-minded homolog 1 (Drosophila)0.030
Lrp2low density lipoprotein receptor-related protein 20.030
Pthlhparathyroid hormone-like peptide0.029
Grhl2grainyhead-like 2 (Drosophila)0.029
Nr2e1nuclear receptor subfamily 2, group E, member 10.029
Inhbbinhibin beta-B0.028
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.028
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.028
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.027
Tbx1T-box 10.027
Tcfap2ctranscription factor AP-2, gamma0.026
Tlx2T-cell leukemia, homeobox 20.026
En1engrailed 10.026
Sox21SRY-box containing gene 210.026
Fgf3fibroblast growth factor 30.026
Cdx1caudal type homeobox 10.025
Dlx6distal-less homeobox 60.024
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.024
Fgfr3fibroblast growth factor receptor 30.023
Pou3f2POU domain, class 3, transcription factor 20.023
Hand1heart and neural crest derivatives expressed transcript 10.022
Wt1Wilms tumor 1 homolog0.022
Pplperiplakin0.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism