The network for 'regulation of endothelial cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of endothelial cell proliferation

Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.

NameDescriptionProbabilityFunc Analog Organism
bmp4bone morphogenetic protein 40.986
bmp2bbone morphogenetic protein 2b0.985
notch3notch homolog 30.795
col2a1acollagen type II, alpha-1a0.616
tie2endothelium-specific receptor tyrosine kinase 20.558
ccm2cerebral cavernous malformation 20.541
kdrlkinase insert domain receptor like0.534
dlx5adistal-less homeobox gene 5a0.509
sox9aSRY-box containing gene 9a0.443
hsp47heat shock protein 470.383
nf1aneurofibromin 1a0.382
junbljun B proto-oncogene, like0.378
nrp1aneuropilin 1a0.371
prox1bprospero-related homeobox gene 1b0.351
nf1bneurofibromin 1b0.314
wtipWilms tumor 1 interacting protein0.289
ca2carbonic anhydrase II0.281
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.280
h2afvlH2A histone family, member V, like0.280
ptprbprotein tyrosine phosphatase, receptor type, b0.273
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.257
hey2hairy/enhancer-of-split related with YRPW motif 20.241
zgc:111961zgc:1119610.219
bocbrother of CDO0.215
ntn1anetrin 1a0.211
msxdmuscle segment homeobox D0.205
hmgb2ahigh-mobility group box 2a0.204
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.199
hmgb2bhigh-mobility group box 2b0.191
tll1tolloid-like 10.187
klf2aKruppel-like factor 2a0.182
epas1bendothelial PAS domain protein 1b0.179
sox7SRY-box containing gene 70.178
edn1endothelin 10.151
col4a6collagen, type IV, alpha 60.143
mmrn2amultimerin 2a0.143
atp5ibATP synthase, H+ transporting, mitochondrial F0 complex, subunit e, duplicate b0.141
lama5laminin, alpha 50.141
s1pr1sphingosine-1-phosphate receptor 10.133
ccbe1collagen and calcium binding EGF domains 10.133
sdprbserum deprivation response b0.130
ptgdsprostaglandin D2 synthase0.128
fgfr2fibroblast growth factor receptor 20.127
si:ch73-60e21.1si:ch73-60e21.10.125
mgpmatrix Gla protein0.125
mcambmelanoma cell adhesion molecule b0.124
col9a3collagen, type IX, alpha 30.118
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.117
dab2disabled homolog 2 (Drosophila)0.115
tcf7transcription factor 7 (T-cell specific, HMG-box)0.114
wlswntless homolog (Drosophila)0.113
shhasonic hedgehog a0.113
rbp4retinol binding protein 4, plasma0.111
dll4delta-like 4 (Drosophila)0.109
vhlvon Hippel-Lindau tumor suppressor0.109
mrc1amannose receptor, C type 1a0.108
col1a1acollagen, type I, alpha 1a0.108
fgf24fibroblast growth factor 240.107
si:ch211-212m21.5si:ch211-212m21.50.105
socs3asuppressor of cytokine signaling 3a0.103
lamb1alaminin, beta 1a0.102
ptch2patched 20.100
cpn1carboxypeptidase N, polypeptide 10.096
notch2notch homolog 20.096
uqcrbubiquinol-cytochrome c reductase binding protein0.096
odc1ornithine decarboxylase 10.095
bmperBMP binding endothelial regulator0.093
vegfaavascular endothelial growth factor Aa0.092
tie1endothelium-specific receptor tyrosine kinase 10.091
podxlpodocalyxin-like0.090
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.090
fzd9bfrizzled homolog 9b0.089
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.088
wu:fv91b12wu:fv91b120.086
chdchordin0.085
nog3noggin 30.084
thbs1thrombospondin 10.080
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.079
col9a2procollagen, type IX, alpha 20.078
zbtb16azinc finger and BTB domain containing 16a0.078
sox19aSRY-box containing gene 19a0.077
ahr2aryl hydrocarbon receptor 20.077
rhagRhesus blood group-associated glycoprotein0.073
vegfcvascular endothelial growth factor c0.073
angptl2angiopoietin-like 20.073
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.073
zgc:85866zgc:858660.072
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.070
esamaendothelial cell adhesion molecule a0.069
fgf8afibroblast growth factor 8 a0.069
ptgs2aprostaglandin-endoperoxide synthase 2a0.068
emx2empty spiracles homeobox 20.067
atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 10.065
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.063
emilin1aelastin microfibril interfacer 1a0.063
fgfr3fibroblast growth factor receptor 30.062
pabpc1bpoly A binding protein, cytoplasmic 1 b0.062
cdh5cadherin 50.061
si:dkey-12o15.1si:dkey-12o15.10.060
fn1fibronectin 10.058
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.996
FGFR2fibroblast growth factor receptor 20.986
CAV1caveolin 1, caveolae protein, 22kDa0.985
FGF1fibroblast growth factor 1 (acidic)0.963
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.956
PTPN1protein tyrosine phosphatase, non-receptor type 10.927
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.909
BMPR1Abone morphogenetic protein receptor, type IA0.902
CCR5chemokine (C-C motif) receptor 50.899
RARAretinoic acid receptor, alpha0.895
TGFB1transforming growth factor, beta 10.832
NRP1neuropilin 10.829
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.776
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.718
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.708
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.700
FGFR1fibroblast growth factor receptor 10.674
PRKCAprotein kinase C, alpha0.660
NCF1neutrophil cytosolic factor 10.587
CCL5chemokine (C-C motif) ligand 50.577
BMP2bone morphogenetic protein 20.576
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.557
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.530
EGR1early growth response 10.520
EGR3early growth response 30.516
FKBP1AFK506 binding protein 1A, 12kDa0.493
JAK2Janus kinase 20.491
IL2RBinterleukin 2 receptor, beta0.479
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.464
RXRAretinoid X receptor, alpha0.422
NR4A2nuclear receptor subfamily 4, group A, member 20.409
EGR2early growth response 20.392
NR4A3nuclear receptor subfamily 4, group A, member 30.389
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.382
CCL4chemokine (C-C motif) ligand 40.372
NCOA1nuclear receptor coactivator 10.361
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.356
RND1Rho family GTPase 10.354
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.347
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.333
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.328
METmet proto-oncogene (hepatocyte growth factor receptor)0.319
CXCL9chemokine (C-X-C motif) ligand 90.312
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.295
CCL2chemokine (C-C motif) ligand 20.273
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.265
NOXA1NADPH oxidase activator 10.259
CCR7chemokine (C-C motif) receptor 70.251
HPhaptoglobin0.247
MED25mediator complex subunit 250.233
INSRinsulin receptor0.227
CTGFconnective tissue growth factor0.227
THBS1thrombospondin 10.225
IL6interleukin 6 (interferon, beta 2)0.224
IFNGinterferon, gamma0.220
IL8interleukin 80.219
IL1Binterleukin 1, beta0.212
JAK1Janus kinase 10.211
FSTL1follistatin-like 10.210
COL5A1collagen, type V, alpha 10.210
CCR4chemokine (C-C motif) receptor 40.209
BMPR1Bbone morphogenetic protein receptor, type IB0.198
FEZ1fasciculation and elongation protein zeta 1 (zygin I)0.192
GDF5growth differentiation factor 50.191
LZTS2leucine zipper, putative tumor suppressor 20.185
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.176
CTNND1catenin (cadherin-associated protein), delta 10.172
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.163
CXCL13chemokine (C-X-C motif) ligand 130.161
FYNFYN oncogene related to SRC, FGR, YES0.159
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.154
FASLGFas ligand (TNF superfamily, member 6)0.148
ANGangiogenin, ribonuclease, RNase A family, 50.147
CCL22chemokine (C-C motif) ligand 220.147
CCL8chemokine (C-C motif) ligand 80.141
COL1A1collagen, type I, alpha 10.135
PDGFCplatelet derived growth factor C0.135
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.132
SOCS3suppressor of cytokine signaling 30.129
DSG2desmoglein 20.127
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.125
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.124
MAPK8mitogen-activated protein kinase 80.124
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.123
COL4A1collagen, type IV, alpha 10.122
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.120
CXCL2chemokine (C-X-C motif) ligand 20.118
RNASE4ribonuclease, RNase A family, 40.117
GSK3Bglycogen synthase kinase 3 beta0.117
CCL13chemokine (C-C motif) ligand 130.115
APOC1apolipoprotein C-I0.114
LATlinker for activation of T cells0.113
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.113
CDH5cadherin 5, type 2 (vascular endothelium)0.112
CD2CD2 molecule0.110
NR4A1nuclear receptor subfamily 4, group A, member 10.110
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.104
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.103
CSNK1A1casein kinase 1, alpha 10.103
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.908
Shhsonic hedgehog0.895
Fgfr2fibroblast growth factor receptor 20.893
Fgfr3fibroblast growth factor receptor 30.854
Bmp4bone morphogenetic protein 40.792
Vegfavascular endothelial growth factor A0.762
Ppargperoxisome proliferator activated receptor gamma0.746
Rb1retinoblastoma 10.686
FosFBJ osteosarcoma oncogene0.619
Nos3nitric oxide synthase 3, endothelial cell0.582
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.577
Adrb1adrenergic receptor, beta 10.566
Flt4FMS-like tyrosine kinase 40.553
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.544
Acvr1activin A receptor, type 10.527
Wnt5awingless-related MMTV integration site 5A0.422
Apcadenomatosis polyposis coli0.351
Cav1caveolin 1, caveolae protein0.336
Dusp1dual specificity phosphatase 10.313
Acvrl1activin A receptor, type II-like 10.297
Fbn1fibrillin 10.296
Prrx1paired related homeobox 10.290
Ror2receptor tyrosine kinase-like orphan receptor 20.273
Leprleptin receptor0.263
Pnpla2patatin-like phospholipase domain containing 20.257
Tgfb2transforming growth factor, beta 20.256
Tlr4toll-like receptor 40.237
Col1a1collagen, type I, alpha 10.236
Adrb3adrenergic receptor, beta 30.232
Foxc1forkhead box C10.230
Gli3GLI-Kruppel family member GLI30.228
Notch2Notch gene homolog 2 (Drosophila)0.223
Jag1jagged 10.223
Bmpr1abone morphogenetic protein receptor, type 1A0.214
Ctnnb1catenin (cadherin associated protein), beta 10.194
Efnb2ephrin B20.182
Kdrkinase insert domain protein receptor0.171
Apoeapolipoprotein E0.168
Cdh5cadherin 50.165
Ptprbprotein tyrosine phosphatase, receptor type, B0.154
Snai1snail homolog 1 (Drosophila)0.153
Foxh1forkhead box H10.150
Pax2paired box gene 20.147
Fgfr1fibroblast growth factor receptor 10.142
Egr1early growth response 10.136
Lepleptin0.135
Cd44CD44 antigen0.135
Hrh1histamine receptor H10.129
Nodalnodal0.127
Nognoggin0.125
Engendoglin0.124
Rargretinoic acid receptor, gamma0.123
Tcf21transcription factor 210.121
Ccl2chemokine (C-C motif) ligand 20.119
Nos1nitric oxide synthase 1, neuronal0.115
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.111
Ptch1patched homolog 10.106
Sox9SRY-box containing gene 90.103
Tbx3T-box 30.103
Zfp36zinc finger protein 360.099
Smad4MAD homolog 4 (Drosophila)0.099
Klklotho0.095
Ptgs2prostaglandin-endoperoxide synthase 20.094
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.092
Chrdchordin0.091
Itgb1integrin beta 1 (fibronectin receptor beta)0.089
Cyr61cysteine rich protein 610.088
Cdkn1bcyclin-dependent kinase inhibitor 1B0.082
Lmnalamin A0.082
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.080
Pax3paired box gene 30.079
Ghrgrowth hormone receptor0.077
Gscgoosecoid homeobox0.076
Pkdccprotein kinase domain containing, cytoplasmic0.076
Thrbthyroid hormone receptor beta0.075
Arandrogen receptor0.075
Smad6MAD homolog 6 (Drosophila)0.073
Ccr1chemokine (C-C motif) receptor 10.072
Map3k14mitogen-activated protein kinase kinase kinase 140.072
Zeb1zinc finger E-box binding homeobox 10.072
Cox8ccytochrome c oxidase, subunit VIIIc0.070
Htr75-hydroxytryptamine (serotonin) receptor 70.069
Dmddystrophin, muscular dystrophy0.069
Foxc2forkhead box C20.067
Edn3endothelin 30.066
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.065
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.064
Btg2B-cell translocation gene 2, anti-proliferative0.064
Foxp3forkhead box P30.063
Smad3MAD homolog 3 (Drosophila)0.062
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.059
Egfrepidermal growth factor receptor0.057
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.057
Cckbrcholecystokinin B receptor0.056
Drd2dopamine receptor D20.056
Ccr5chemokine (C-C motif) receptor 50.055
Smad7MAD homolog 7 (Drosophila)0.054
Ptpn11protein tyrosine phosphatase, non-receptor type 110.054
Tbx1T-box 10.054
FcrlaFc receptor-like A0.053
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Albalbumin0.055
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.040
Fgafibrinogen alpha chain0.038
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.030
Ahsgalpha-2-HS-glycoprotein0.029
Col8a1collagen, type VIII, alpha 10.029
Itih4inter alpha-trypsin inhibitor, heavy chain 40.027
Itih3inter-alpha trypsin inhibitor, heavy chain 30.024
Apohapolipoprotein H (beta-2-glycoprotein I)0.023
FosFBJ osteosarcoma oncogene0.023
Apoa2apolipoprotein A-II0.022
Pzppregnancy-zone protein0.018
Gpr116G protein-coupled receptor 1160.018
Apcsamyloid P component, serum0.017
Gcgroup specific component0.017
A2malpha-2-macroglobulin0.016
Emcnendomucin0.016
Tnni1troponin I type 1 (skeletal, slow)0.016
Nos3nitric oxide synthase 3, endothelial cell0.016
Hpxhemopexin0.016
Apoa5apolipoprotein A-V0.016
Ambpalpha-1-microglobulin/bikunin precursor0.015
LOC100361571keratin associated protein 1-3-like0.015
Errfi1ERBB receptor feedback inhibitor 10.014
Aqp9aquaporin 90.014
Dusp1dual specificity phosphatase 10.014
Vom1r97vomeronasal 1 receptor 970.013
F13a1coagulation factor XIII, A1 polypeptide0.013
Fabp1fatty acid binding protein 1, liver0.013
Nraddneurotrophin receptor associated death domain0.012
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.012
Adrb1adrenergic, beta-1-, receptor0.012
Cald1caldesmon 10.012
Vom2r44vomeronasal 2 receptor 440.012
C8bcomplement component 8, beta polypeptide0.011
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.011
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.011
Gpr182G protein-coupled receptor 1820.011
Gja1gap junction protein, alpha 10.011
Igf1insulin-like growth factor 10.011
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.010
Spp2secreted phosphoprotein 20.010
Ltb4rleukotriene B4 receptor0.010
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.010
Kng2kininogen 20.010
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.010
Crhr2corticotropin releasing hormone receptor 20.010
Jak1Janus kinase 10.010
Sfrp4secreted frizzled-related protein 40.010
Col17a1collagen, type XVII, alpha 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism